scholarly journals Ways of medicinal prevention and treatment of doxorubicin-induced cardiomyopathy in oncological patients

2021 ◽  
Vol 25 (1) ◽  
pp. 4-12
Author(s):  
V.A. Moroz ◽  
R.A. Al-Hadrawi ◽  
O.O. Andrieieva ◽  
Yu.V. Timchenko ◽  
A.M. Semenov
Keyword(s):  
Side Effects ◽  
Malignant Tumors ◽  
Beta Blockers ◽  
World Population ◽  
Treatment Regimens ◽  
Oncological Patients ◽  
Medicinal Treatment ◽  
The World ◽  
Prevention And Treatment ◽  
Anticancer Treatment

The high incidence of malignant tumors is currently supported by the general ageing of the world population and unfavorable environmental factors. In 2018, 18.1 million new cases of cancer and 9.6 million deaths from them were registered in the world. At the same time, a significant increase in the life expectancy of these patients after the treatment noted over the past 20 years highlights the problem of side effects of the anticancer therapy. One of the most serious side effects is the development of doxorubicin-induced cardiomyopathy (DRIC). In all three distinct clinical forms (acute, early and late) DRIC can develop in 58 % of patients after using anticancer treatment regimens with the inclusion of doxorubicin. The review provides a detailed analysis of medicinal treatment regimens and preparations (ACE inhibitors, beta-blockers, statins, etc.) currently used, and evaluates their effectiveness and expected results. Currently, several therapeutic strategies have been proposed for the prevention and treatment of DRIC, each of them has certain positive results. At the same time, some therapeutic methods used in the clinic have some disadvantages. Conclusions. The limitations of the results of DRIC prevention achieved by the existing therapeutic regimens, as well as the possibilities for their prediction, have been stated. The need for further research to improve the effectiveness of medicinal prevention and treatment of DRIC is emphasized.

scholarly journals Should Couch Potatoes Be Encouraged to Use Transcranial Direct Current Stimulation?

Neuroethics ◽  
2020 ◽  
Author(s):  
Francesca Minerva
Keyword(s):  
Side Effects ◽  
High Risk ◽  
Direct Current ◽  
Physical Inactivity ◽  
Health Conditions ◽  
World Population ◽  
Direct Stimulation ◽  
Major Side Effect ◽  
The World ◽  
Very High

Abstract A very high percentage of the world population doesn’t exercise enough and, as a consequence, is at high risk of developing serious health conditions. Physical inactivity paired with a poor diet is the second cause of death in high income countries. In this paper, I suggest that transcranial direct stimulation (tDCS) holds promise for “couch potatoes” because it could be used to make them more active, without causing any major side-effect. I also argue that other, less safe, tools could be used to achieve the goal of decreasing physical inactivity, insofar as they have overall fewer side-effects than physical inactivity.

Another look at dietary polyphenols: challenges in cancer prevention and treatment

2021 ◽  
Vol 28 ◽  
Author(s):  
Roberto Arrigoni ◽  
Andrea Ballini ◽  
Luigi Santacroce ◽  
Stefania Cantore ◽  
Angelo Inchingolo ◽  
...  
Keyword(s):  
Side Effects ◽  
Protective Effect ◽  
Cancer Prevention ◽  
Fruit And Vegetables ◽  
Dietary Polyphenols ◽  
Metabolic Interaction ◽  
The World ◽  
Prevention And Treatment ◽  
Prevention And Therapy

: Cancer is a pathology that impacts in a profound manner people all over the world. The election strategy against cancer often uses chemotherapy and radiotherapy, which more often than not can present many side effects and not always reliable efficacy. By contrast, it is widely known that a diet rich in fruit and vegetables has a protective effect against cancer insurgence and development. Polyphenols are generally believed to be responsible for those beneficial actions, at least partially. In this review, we highlight the metabolic interaction between polyphenols and our metabolism and discuss their potential for anticancer prevention and therapy.

The role of preoperative chemotherapy for colorectal cancer metastases in the liver with the lack of RAS mutations

2016 ◽  
Vol 21 (5) ◽  
pp. 238-243
Author(s):  
A. F Lazarev ◽  
K. G Mamontov ◽  
A. G Kotelnikov ◽  
Sergey L. Khays ◽  
V. A Lubennikov
Keyword(s):  
Colorectal Cancer ◽  
Malignant Tumors ◽  
Distant Metastases ◽  
Morbidity Rate ◽  
Cancer Metastases ◽  
Modern Drug ◽  
Medicinal Treatment ◽  
Common Causes ◽  
The World ◽  
The One

Colorectal cancer (CRC) is one of the most common malignancies, occupying the third place in the world among malignant tumors morbidity rate and the 4th place on the causes of death. Every year in the world there are diagnosed more than 1.3 millions of new cases of the disease. The mortality rate continues to be one of the most common causes in the structure of cancer incidence. In Russia, each year there are diagnosed more than 60 thousands of new cases of colorectal cancer. For the last time the incidence increased by 11%, out of them more than 17 thousands patients show newly diagnosed distant metastases. In the absolute majority of cases metastases in the liver are firstly detected in 2-3 years. Liver is the organ- the most commonly affected by metastases. Methods of medicinal treatment of CRC metastases are of great importance and allowed to greatly improve the life expectancy of patients. Median overall survival (OS) is 35-40 months. The one of the last achievement of the modern drug therapy of metastatic CRC was the appearance of the preparation Cetuximab. Blocking of the KRAS gene is a key compartment of the signaling pathways that transmit extracellular growth signals from the surface of the cell to the nucleus. Further signals are transmitted via the cascade into the cellular nucleus, regulating cell growth, proliferation, angiogenesis, invasion and metastasis. Results of the research of PRIME, PEAK and FIRE-3 confirm the advantage of supplement ofpanitumumab or cetuximab to chemotherapy regimens FOLFOX or FOLFIRI in patients with wild-type Ras.

scholarly journals Oesophageal-cancer-derived death in the population of Belgrade in a period 1989-2006

2009 ◽  
Vol 66 (7) ◽  
pp. 534-538
Author(s):  
Janko Jankovic ◽  
Isidora Ratkov ◽  
Sandra Sipetic ◽  
Jelena Marinkovic ◽  
Jadranka Maksimovic
Keyword(s):  
Oesophageal Cancer ◽  
Malignant Tumors ◽  
Mortality Rates ◽  
Oesophageal Carcinoma ◽  
Mortality Data ◽  
World Population ◽  
Age Group ◽  
Male Population ◽  
Female Population ◽  
The World

Background/Aim. Oesophageal cancer is the sixth most common cause of death from all malignant tumors in the world (fifth in men, eighth in women). This cancer was estimated to account for about 529 000 new cases and about 442 000 deaths in the year 2007. In the year 2002 the highest standardized mortality rates (per 100 000 habitants) of oesophageal carcinoma were noticed in the East Asia (men/women: 18.8/7.7) and East Africa (18.6/7.8), while the lowest were noticed in the Middle Africa (1.4/0.2) and West Africa (1.3/0.5). The aim of this descriptive epidemiologic study was to analyze epidemiologic situation of oesophageal cancer in Belgrade population during the period 1989-2006, using mortality data. Methods. Mortality data were collected from the City Organization for Statistics. In data analysis we used mortality rates which were standardized directly using those of the world population as the standard, and proportions. A denominator for mortality rates was calculated using the Belgrade population which was an average of the two latest register years (1991 and 2002). In order to analyze trend mortality from oesophageal cancer we used linear trend. Results. In Belgrade deaths from oesophageal cancer accounted for about 5.2% of all malignant tumors of intestinal system in male population, and 2.4% in female population. This cancer is, according to standardized mortality rates (per 100 000 habitants), on the fifth place in Belgrade population behind colorectal, stomach, pancreatic, liver and cholecystic cancer. During the period 1989-2006 in Belgrade 44 persons died from oesophageal carcinoma on the average each year, mainly men (75%), and the rest were women (25%). In male population during the same period we noticed a significant increase in trend mortality (y = 1.61 + 0.06x, p = 0.001), while in female population the increase of mortality was not significant. The male/female oesophageal cancer mortality ratio was 3:1. Mortality rates for oesophageal cancer rise with age in both sexes and they are highest in the age group of 70 and more years. Significant increase in mortality from oesophageal cancer was noticed in age groups 20-29 and over 70 in male population, and age group 40-49 in female population. Conclusion. Increasing trend in oesophageal mortality suggests the necessity for improving measures of primary prevention including education about risk factors for this carcinoma (smoking, alcohol consumption, hot food and drinks), early diagnosis, and treatment.

scholarly journals Oseltamivir induced sinus bradycardia: an area of potential concern

2018 ◽  
Vol 8 (1) ◽  
pp. 162
Author(s):  
Karan B. Shah ◽  
Bhavesh S. Shah ◽  
Supriya D. Malhotra ◽  
Pankaj R. Patel
Keyword(s):  
Side Effects ◽  
Drug Administration ◽  
Seasonal Influenza ◽  
Sinus Bradycardia ◽  
Case Series ◽  
Swine Flu ◽  
Cardiovascular Side Effects ◽  
The World ◽  
Prevention And Treatment ◽  
Influenza H1n1

Oseltamivir was approved for the prevention and treatment of influenza in 1999 by the USFDA (US Food and Drug Administration). The use of Oseltamivir is increasing rapidly all over the world, especially after the 2009 “Swine Flu” pandemic. Less data is published as far as the cardiovascular side effects of Oseltamivir are concerned, but it could be associated with some serious cardiovascular side effects. This study presented a case series of 5 cases suspected to be suffering from seasonal influenza H1N1 (“Swine Flu”), who developed sinus bradycardia while they were on Oseltamivir therapy.

scholarly journals Cancer incidence and mortality in Manizales 2003-2007

2012 ◽  
pp. 281-289
Author(s):  
Nelson Enrique Arias-Ortiz ◽  
Guillermo Antonio López-Guarnizo ◽  
Walter Antonio Arboleda-Ruiz
Keyword(s):  
Cancer Incidence ◽  
Malignant Tumors ◽  
Quality Standards ◽  
Population Projections ◽  
World Population ◽  
Incidence And Mortality ◽  
Gender And Age ◽  
The World ◽  
Information Method ◽  
National Estimates

Objective: To describe cancer incidence and mortality in Manizales during the 2003-2007 period from popu­lation-based information. Method: The information was obtained from the Manizales Cancer Registry and DANE. We analyzed new cases and cancer deaths of individuals residing in Manizales from 1 January 2003 to 31 December 2007. Cases reported correspond to primary invasive malignant tumors, in all locations, except basal cell carcinoma of the skin. We checked the internal consistency of the data and applied quality indicators suggested by the IARC. The population at risk was obtained from population projections (1985 -– 2020, DANE). Specific rates were estimated by gender and age (18 quinquennial groups), and standardized to the world population directly referenced. Results: There were 3.416 new cases and 1.895 deaths from cancer. The age- standardized incidence rate (ASR) per 100,000 people-years for all primary locations (except skin) was 162.4 in women and 166.2 in men. Cancer accounted for 19.8% of mortality in Manizales with ASR per 100,000 people-years of 92.1 in men and 83.6 in women. Conclusions: The risk of developing cancer or dying from cancer in Manizales is intermediate and similar to national estimates. The information generated by the PCR-M meets international quality standards, so it is necessary to ensure sustainability and improvement.

scholarly journals Panorama dos casos de câncer atendidos no hospital geral público de Palmas, Tocantins, Brasil

2017 ◽  
Vol 4 (3) ◽  
pp. 22
Author(s):  
Rodolfo Rezende das Neves ◽  
Nivaldo Mendonça Fernandes ◽  
Fernanda Resende Martins ◽  
Carlos Alberto Rodrigues Junior ◽  
Fellipe Camargo Ferreira Dias ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Retrospective Study ◽  
General Hospital ◽  
Surgical Procedures ◽  
World Population ◽  
Prevention Strategies ◽  
The Public ◽  
Cancer Hospital ◽  
The World ◽  
Prevention And Treatment

Estratégias de prevenção e tratamento contra o câncer progrediram nos últimos anos. No entanto, a incidência continua em crescimento progressivo, gerando elevados custos à população mundial. Foi realizado um estudo retrospectivo com o objetivo de determinar o perfil dos indivíduos internados por câncer no período de 2010 a 2015 no Hospital Geral Público de Palmas Dr. Francisco Ayres (HGPP), Tocantins, Brasil. Foram coletadas e avaliadas informações presentes no banco de dados da Comissão Hospitalar de Câncer do HGPP. Constatou-se que o tipo de câncer que apresentou maior ocorrência foi o de próstata, com 564 casos (15,38%), seguido por câncer de colo do útero, com 462 casos (12,60%), pele, com 403 casos (10,99%) e mama, com 381 casos (10,39%). Morreram 1.123 (30,63%) pacientes internados por câncer nesse período.  E 3.100 (84,56%) indivíduos foram submetidos a procedimentos cirúrgicos. Esses dados, portanto, podem possibilitar o direcionamento das estratégias de prevenção a serem adotadas ou melhoradas com o objetivo de diminuir a incidência de câncer e mortalidade por essa doença.   Palavras-chave: Neoplasias; Tocantins; Brasil. Strategies for prevention and treatment against cancer have progressed in recent years. However, the incidence continues to grow gradually, generating high costs to the world population. A retrospective study was carried out to determine the profile of individuals hospitalized for cancer in the period from 2010 to 2015 at the Public General Hospital of Palmas Dr. Francisco Ayres (PGHP), Tocantins, Brazil. Data were collected and evaluated in the PGHP Cancer Hospital Commission database. It was found that the type of cancer that presented the highest occurrence was prostate, with 564 cases (15,38%), followed by cervical cancer, with 462 cases (12,60%), skin, with 403 cases (10,99%) and breast, with 381 cases (10,39%). There were 1.123 (30.63%) patients hospitalized for cancer in this period. And 3.100 (84,56%) individuals underwent surgical procedures. These data, therefore, may enable the targeting of prevention strategies to be adopted or improved in order to reduce the incidence of cancer and mortality from this disease. Keywords: Neoplasms; Tocantins; Brazil.

scholarly journals Risk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase Inhibitors

2015 ◽  
Vol 10s3 ◽  
pp. BMI.S22430 ◽  
Author(s):  
Mark Reinwald ◽  
Tobias Boch ◽  
Wolf-Karsten Hofmann ◽  
Dieter Buchheidt
Keyword(s):  
Side Effects ◽  
Kinase Inhibitors ◽  
Kinase Inhibitor ◽  
Infectious Complications ◽  
Antibody Treatment ◽  
Treatment Regimens ◽  
Oncological Patients ◽  
Oncological Diseases ◽  
Potential Risks ◽  
Specific Pathway

Infectious complications are a major cause of morbidity and mortality in patients with hemato-oncological diseases. Although disease-related immunosuppression represents one factor, aggressive treatment regimens, such as chemotherapy, stem cell transplantation, or antibody treatment, account for a large proportion of infectious side effects. With the advent of targeted therapies affecting specific kinases in malignant diseases, the outcome of patients has further improved. Nonetheless, dependent on the specific pathway targeted or off-target activity of the kinase inhibitor, therapy-associated infectious complications may occur. We review the most common and approved kinase inhibitors targeting a variety of hemato-oncological malignancies for their immunosuppressive potential and evaluate their risk of infectious side effects based on preclinical evidence and clinical data in order to raise awareness of the potential risks involved.

scholarly journals Cutaneous Eruption due to Telaprevir

2015 ◽  
Vol 7 (3) ◽  
pp. 253-262 ◽  
Author(s):  
Eduardo Mastrangelo Marinho Falcão ◽  
Beatriz Moritz Trope ◽  
Mariana Marteleto Godinho ◽  
Leonardo Hoehl Carneiro ◽  
João Marcello de Araujo-Neto ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Side Effects ◽  
Skin Eruption ◽  
Early Recognition ◽  
World Population ◽  
Disease Evolution ◽  
Cutaneous Eruption ◽  
The World ◽  
Severe Rash

Hepatitis C virus (HCV) chronically infects 0.5-3% of the world population. A large group of patients develop cirrhosis and its complications. Since 2011, telaprevir and boceprevir are used, improving the disease evolution. One of the main side effects of these drugs is skin eruption. We report a 53-year-old patient with cirrhosis due to HCV who started the classic treatment associated with telaprevir. In the ninth week, he presented a severe rash that required the interruption of this drug. We emphasize the importance of early recognition and appropriate management of adverse skin reaction.

Hypovitaminosis D in the elderly: relationship with sarcopenia and dementia (review of literature)

2021 ◽  
Vol 66 (1) ◽  
pp. 5-9
Author(s):  
S. V. Bulgakova ◽  
E. V. Treneva ◽  
N. O. Zakharova
Keyword(s):  
Vitamin D ◽  
Geriatric Patients ◽  
Hypovitaminosis D ◽  
The Elderly ◽  
World Population ◽  
Review Of Literature ◽  
The World ◽  
Prevention And Treatment ◽  
Number Of Authors

The growth in the world population of elderly and senile people provokes interest in the processes and mechanisms leading to aging and age-associated diseases. Hypovitaminosis D is common in geriatric patients and has been suggested by a number of authors as a cause of diseases such as dementia and sarcopenia. This literature review is devoted to the analysis of the role of vitamin D in the development of the above diseases, their prevention and treatment.

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