Salvia officinalis L.: prospects of using the raw material as a source of herbal medicines with the antioxidant and antimicrobic activity

The main objective of this study was to intensify the extraction of total phenols from Salvia officinalis L. using instant controlled pressure drop (DIC) as a texturing pre-treatment. The effect of solvent type on Total Phenolic Content (TPC) was also studied. TPC was determined using spectrophotometric Folin-Ciocalteau method and external calibration with Gallic acid. The obtained results showed that water was the most efficient solvent to extract total phenols from Salvia officinalis L. Moreover, texturing and expansion by DIC pretreatment had a great impact on polyphenol yields and revealed greater extraction kinetics. Likewise, drying kinetics of DIC-treated sage was enhanced compared to the raw material. DIC-assisted extraction can be considered as a promising technology to use in the case of the Moroccan Salvia officinalis L. as an important Mediterranean source of natural phenols.

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SEED GERMINABILITY AND GRASS BIOLOGY OF MEDICINAL PLANT SALVIA (SALVIA OFFICINALIS L.)

EPRA International Journal of Research & Development (IJRD) ◽

10.36713/epra5276 ◽

2020 ◽

pp. 311-314

Author(s):

Egamyor Toshboevich Akhmedov ◽

Vakhob Tukhtamishevich Kaysarov ◽

Munira Zoidovna Yuldasheva

Keyword(s):

Salvia Officinalis ◽

Raw Material ◽

First Year ◽

Sowing Time ◽

Plant Seeds ◽

Plant Safety ◽

Mass Reproduction ◽

Generative Phase ◽

Salvia Officinalis L ◽

First Year Of Life

The article presents the data on seed germination of Salvia officinalis L. in laboratory and field conditions. The mass of 1000 seeds of the plant is 7-8g. It has been revealed that the optimal sowing time for S. officinalis L. is the spring period. At the same time, laboratory and soil germination of freshly harvested seeds of S. officinalis L. constitutes 70-85%. Plant seeds sprout 15-20 days after sowing. Plant safety in the conditions of Tashkent oasis in the aisles is 70-80%. In the first year of life, plants do not enter the generative phase of development. In recent time, a collection of this plant has been created and methods of mass reproduction, as well as agricultural measures, are being studied. KEYWORDS: Salvia officinalis L., field, generative, reproduction, seeds, biology, raw material.

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Comparative Quantitative Analysis of Diterpene Acids in Raw Material of Salvia officinalis, Salvia tesquicola and Salvia nutans

International Journal of Pharmacognosy and Phytochemical Research ◽

10.25258/phyto.v9i07.11154 ◽

2018 ◽

Vol 9 (07) ◽

Author(s):

Kurkin V A ◽

Ryzhov V. M. ◽

Shmygareva A. A. ◽

Nikandrova M. A.

Keyword(s):

Quantitative Analysis ◽

Related Species ◽

Raw Materials ◽

Salvia Officinalis ◽

Raw Material ◽

Minimal Amount ◽

Closely Related Species ◽

Diterpene Acids ◽

Salvia Officinalis L

The quantitative analysis of diterpene acids in raw materials of closely related species of genus Salvia was carried out. The objects of present research were Salvia officinalis L., Salvia tesquicola Klokov and Pobed., Salvia nutans L., which grow in neighboring south (Samara and Orenburg) regions. During analysis different raw materials, such as herbs and leaves, were studied. It was determined that total amount of diterpene acids varies from 1,04% to 1,32% in leaves of different species of Salvia and from 1,13% to 1,67% in herbs of different species of Salvia. The raw material of Salvia nutans contains minimal amount of diterpene acids, but in the raw material of Salvia tesquicola the quantitative analysis shows different results, which depend on the region. The medical raw material of Salvia officinalis, which is cultivated in Samara region, includes sufficient amount of diterpene acids.

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Yield and chemical composition of essential oil from Salvia officinalis L. in third year of cultivation

Herba Polonica ◽

10.2478/hepo-2014-0012 ◽

2014 ◽

Vol 60 (3) ◽

pp. 13-22 ◽

Cited By ~ 4

Author(s):

Grażyna Zawiślak

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Life Sciences ◽

Chemical Compounds ◽

Salvia Officinalis ◽

Raw Material ◽

Harvest Time ◽

The Third ◽

Salvia Officinalis L ◽

Main Components

Summary The study upon sage (Salvia officinalis L.) has been carried out at the Experimental Section of Department of Vegetables and Medicinal Plants, University of Life Sciences in Lublin. The aim of present study was to evaluate the yield and chemical composition of essential oil extracted from sage leaves harvested from a three-year plantation. The sage herb harvest date in the third year of cultivation had a significant impact on the yield of plants. Higher yield of fresh and dry herb, dry leaves, and essential oil was achieved in August (the second harvest time) than in May (the first harvest time). Chromatographic examination indicated the presence of 50 chemical compounds in sage essential oil. It was a variable percentage of essential oil components depending on the raw material harvest time. The main components of the sage essential oil were: 1,8-cineole (16.08-18.04%), α-thujone (10.40-21.51%) and camphor (5.24-18.08%).

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Development of technology for obtaining a liquid extract of medicinal sage ( Salvia officinalis L.)

BIO Web of Conferences ◽

10.1051/bioconf/20214003004 ◽

2021 ◽

Vol 40 ◽

pp. 03004

Author(s):

Anastasia Moldavanova ◽

Anastasia Malyutina ◽

Larissa Kozubova ◽

Valentina Kazakova ◽

Natalia Shestopalova

Keyword(s):

Inflammatory Diseases ◽

Raw Materials ◽

Extraction Process ◽

Salvia Officinalis ◽

Raw Material ◽

Optimal Time ◽

Processing Plant ◽

Plant Materials ◽

Liquid Extract ◽

Salvia Officinalis L

Inflammatory diseases of the female genital area are dominant among the total number of gynecological diseases. Among all the variety of medicinal plant materials used in official medicine, salvia medicinal draws attention to itself, which has repeatedly proved its effectiveness in the treatment of inflammatory diseases of the mucous membranes of various origins. That is why the goal was set to develop a technology for obtaining a liquid extract from the leaves of Salvia officinalis L. As a result of the study, a method was developed for obtaining a liquid extract by selecting the optimal extraction conditions. It was found that the optimal raw material-extractant ratio is 1:50, the optimal concentration of the extractant ethyl alcohol is 70%, the infusion time of the extract is 24 hours. To intensify the extraction process, the method of ultrasonic processing of raw materials at the soaking stage was used. The optimal time for processing plant materials with ultrasound was 45 minutes. As a result of using this method to obtain a liquid extract from the leaves of sage officinalis, the yield of phenolic compounds was doubled in comparison with obtaining an extract without sonication of raw materials and amounted to 182.7 mg / g of flavonoids in terms of luteolin-7-glycoside.

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Chemical composition of essential oils from leaves and twigs with leaves of two new varieties of common sage (Salvia officinalis L.)

Planta Medica ◽

10.1055/s-0030-1264353 ◽

2010 ◽

Vol 76 (12) ◽

Author(s):

A Aprotosoaie ◽

E Gille ◽

A Spac ◽

M Gonceariuc ◽

M Hancianu ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oils ◽

Salvia Officinalis ◽

New Varieties ◽

Salvia Officinalis L

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Contribution to the Optimization of a Gas Chromatographic Method by QbD Approach used for Analysis of Essential Oils from Salvia officinalis

Revista de Chimie ◽

10.37358/rc.19.6.7266 ◽

2019 ◽

Vol 70 (6) ◽

pp. 2015-2020

Author(s):

Silvia Robu ◽

Aurelia Romila ◽

Olimpia Dumitriu Buzia ◽

Adrian Florin Spac ◽

Camelia Diaconu ◽

...

Keyword(s):

Essential Oil ◽

Essential Oils ◽

Plant Material ◽

Mobile Phase ◽

Chromatographic Method ◽

Salvia Officinalis ◽

Salvia Officinalis L ◽

Gas Chromatographic Method

Numerous articles on Salvia officinalis L. have been published regarding the composition of their essential oil. The considerable variation found may be due to the quality of the plant material as well as to the methods used for analysis. A simple GC-MS method was developed and optimized in the QbD approach, for the determination of sage essential oils. The optimization of GC-MS analysis was performed using different mobile phase flows, injection volumes, split ratios and temperature programs. The optimized method proved to be simple and can be successfully applied for the determination of sage essential oils.

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Therapeutic Properties of Several Chemical Compounds from Salvia officinalis L. in Alzheimer’s Disease

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557521999201230200209 ◽

2020 ◽

Vol 21 ◽

Author(s):

Georgiana Uță ◽

Denisa Ștefania Manolescu ◽

Speranța Avram

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Side Effects ◽

Chemical Compounds ◽

Natural Compounds ◽

Salvia Officinalis ◽

Chemical Structures ◽

In Silico Studies ◽

Wide Range ◽

Salvia Officinalis L

Background.: Currently, the pharmacological management in Alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate (NMDA) receptor ligands, with still unclear molecular mechanisms, but severe side effects. For this reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side effects. Recently, the natural compounds, in particular certain chemical compounds identified in the essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible therapeutics. Objectives.: In this paper, we have summarized data from the recent literature, on several chemical compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease. Methods.: In addition to the wide range of experimental methods performed in vivo and in vitro, also we presented some in silico studies of medicinal compounds. Results. Through this mini-review, we present the latest information regarding the therapeutic characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease. Conclusion.: Thus, based on the information presented, we can say that phytotherapy is a reliable therapeutic method in a neurodegenerative disease.

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Identification and Determination of the Components of Garden Sage (Salvia officinalis L.) Essential Oil, Isolated by Different Extraction Methods

Journal of Analytical Chemistry ◽

10.1134/s1061934820110131 ◽

2020 ◽

Vol 75 (11) ◽

pp. 1451-1460

Author(s):

Z. A. Temerdashev ◽

V. V. Milevskaya ◽

L. P. Ryabokon’ ◽

N. N. Latin ◽

N. V. Kiseleva ◽

...

Keyword(s):

Essential Oil ◽

Extraction Methods ◽

Salvia Officinalis ◽

Salvia Officinalis L

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Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.)

International Journal of Molecular Sciences ◽

10.3390/ijms22147382 ◽

2021 ◽

Vol 22 (14) ◽

pp. 7382

Author(s):

Nancy Chiang ◽

Shahla Ray ◽

Jade Lomax ◽

Sydney Goertzen ◽

Slavko Komarnytsky ◽

...

Keyword(s):

Liquid Chromatography ◽

Neurotrophic Factor ◽

High Performance ◽

Memory Function ◽

Brain Derived Neurotrophic Factor ◽

Salvia Officinalis ◽

C6 Glioma Cells ◽

Medicinal Uses ◽

Bdnf Signaling ◽

Salvia Officinalis L

Culinary sage (Salvia officinalis L.) is a common spice plant in the mint family (Lamiaceae) well known for its distinctive culinary and traditional medicinal uses. Sage tea has been used traditionally as a brain-enhancing tonic and extracts from sage have been reported to have both cognitive and memory enhancing effects. Brain-derived neurotrophic factor (BDNF) is an endogenous signaling molecule involved in cognition and memory function. In this study, activity-guided fractionation employing preparative reverse-phase high performance liquid chromatography (RP-HPLC) of culinary sage extracts led to the discovery of benzyl 6-O-β-D-apiofuranosyl-β-D-glucoside (B6AG) as a natural product that upregulates transcription of neurotrophic factors in C6 glioma cells. Purified B6AG showed a moderate dose response, with upregulation of BDNF and with EC50 at 6.46 μM. To better understand the natural variation in culinary sage, B6AG was quantitated in the leaves of several commercial varieties by liquid chromatography-mass spectrometry (LC-MS). The level of B6AG in dried culinary sage was found to range from 334 ± 14 to 698 ± 65 μg/g. This study provided a foundation for future investigations, including quantitative inquiries on the distribution of B6AG within the different plant organs, explorations in optimizing post-harvest practices, and aid in the development of sage varieties with elevated levels of B6AG.

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