scholarly journals Effect of Fermented Millet Flour Ibyer Supplemented with Ginger Powder on Hematological indices and Body Weight of Wister Albino Rats

2020 ◽  
pp. 1-7
Author(s):  
Ogori Akama Friday ◽  
Keyword(s):  
Body Weight ◽  
Albino Rats ◽  
Feeding Trial ◽  
Hematological Indices ◽  
Ginger Powder ◽  
Wistar Albino Rats

In this study, fermented millet flour supplemented with ginger powder were formulated in the ratio 100% millet flour: 0% ginger flour, 95% millet flour:5% ginger flour, 90% millet flour:10% ginger flour, 85% millet flour:15% ginger flour, 80% millet flour:20% ginger flour, 75% millet flour: 25% ginger flour, and 70% millet flour:30% ginger flour respectively for the production of “Ibyer”. The blends were subjected to feeding trial using male wistar albino rats of 3 weeks old, weighing 100g to 130g obtained.

scholarly journals Effect of Curcuma longa (Turmeric) on serum creatine kinase-MB and troponin I in isoproterenol induced myocardial infarction in wistar albino rats

2018 ◽  
Vol 13 (2) ◽  
pp. 47-53
Author(s):  
Sharmin Nahar ◽  
Qazi Shamima Akhter
Keyword(s):  
Myocardial Infarction ◽  
Body Weight ◽  
Troponin I ◽  
Curcuma Longa ◽  
Heart Weight ◽  
Control Group ◽  
Albino Rats ◽  
Creatine Kinase Mb ◽  
The Mean ◽  
Wistar Albino Rats

Background: The prevalence of myocardial infarction (MI) is increasing day by day in Bangladesh due to socioeconomic transition. Spices and herbs are important source of remedy for various diseases in human. Curcuma longa suggested to be used as an indigenous medicine for the prevention and treatment of cardiovascular disease. Objective: To observe the effect of Curcuma longa in isoproterenol induced myocardial infarction in Wistar albino rats. Methods: This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka during 2015. Twenty one Wistar albino male rats, weighing 100 to 150 g (initial body weight); aged 85 to 100 days were selected for the study. After acclimatization for 14 days, the rats were divided into BC (Baseline control group), ISP-TC (Isoproterenol treated control group) and CLP-ISPT (Curcuma longa pretreated and isoproterenol treated group). Each group consisted of 7 rats. After experiment, on the 10th day, final body weight was taken, rats were sacrificed and blood samples were collected from the heart. The heart was removed and weighed. Serum creatine kinase-MB (CK-MB) level was estimated by ELISA method and Troponin I (cTnI) level by AxSYM method. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable. Results: In this study, the mean percent (%) change of body weight (p<0.01), mean serum CK-MB (p<0.001) and cTnI (p<0.001) levels were significantly higher but mean heart weight was non significantly higher in ISP-TC in comparison to those of BC. Again, the mean percent (%) change of body weight (p<0.01), mean heart weight (p<0.01), mean serum CK-MB (p<0.01) and cTnI (p<0.001) levels were significantly lower in CLP-ISPT than those of ISP-TC group. Conclusion: From the results, it can be concluded that Curcuma longa may have cardioprotective effect. J Bangladesh Soc Physiol. 2018, December; 13(2): 47-53

scholarly journals The absorption of [58Co]cyanocobalamin by unweaned rats

1968 ◽  
Vol 22 (2) ◽  
pp. 297-301 ◽  
Author(s):  
D. L. Williams ◽  
G. H. Spray
Keyword(s):  
Body Weight ◽  
Test Dose ◽  
Albino Rats ◽  
Vitamin B ◽  
Newborn Rats ◽  
Stomach Tube ◽  
Body Counting ◽  
Total Body ◽  
Wistar Albino Rats

1. ‘58Co’cyanocobalamin was given by stomach tube to Wistar albino rats aged between 6 h and 24 days. The fraction of the dose absorbed was assessed by measuring the amount retained by the animals after 7 days, by total body counting.2. Rats up to 4 days old absorbed about 90% of the test dose, compared with a mean of 83% at the age of 8 days, 66% at 16 days and 47% at 24 days.3. The proportion of the test dose absorbed did not appear to be affected by starvation for up to 24 h, by increasing the dose from 0·05 ng to 0·25 ng/g body-weight, or by giving the ‘58Co’cyanocobalamin mixed with rat's milk.4. The results support earlier suggestions that newborn rats absorb vitamin B12 by a different mechanism from that in adults.

scholarly journals Biochemical and histological changes in liver and kidney in male Wistar albino rats following exposure to Solignum®: a permethrincontaining wood preservative

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Kingsley C. Patrick-Iwuanyanwu ◽  
Iniobong A. Charles
Keyword(s):  
Body Weight ◽  
Chronic Exposure ◽  
Histopathological Examination ◽  
Wood Preservative ◽  
Inflammatory Cells ◽  
Male Rats ◽  
Albino Rats ◽  
Dependent Manner ◽  
Histological Changes ◽  
Wistar Albino Rats

The present investigation was aimed to determine the effect of sub-chronic exposure to Solignum<sup>®</sup>, a permethrin-containing wood preservative on biochemical and histological changes in liver and kidneys of male Wistar albino rats. Thirty-two male rats were randomly divided into four groups: control and three treatment concentrations containing 8 rats each. The treatment groups were exposed to Solignum<sup>®</sup> at dose rates of 100, 200 and 400 mg/kg body weight (BW) respectively per day orally for four weeks. Data obtained from the study showed a progressive increase in the body weight of rats in control whereas, rats treated with different concentrations (100, 200 and 400 mg/kg BW) of Solignum<sup>®</sup> decreased significantly (≤0.05) especially at the end of the second and fourth week when compared with control. On the other hand, there was a significant decrease in the relative liver weights of rats treated with 100 and 200 mg/kg BW Solignum<sup>®</sup> while rats treated with 400 mg/kg BW showed a significant increase when compared with control. The relative weight of kidneys in experimental groups increased significantly when compared with control. Biochemical analysis results illustrated that there was a significant increase in marker enzymes namely alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activity at the end of the fourth week. Similarly, total bilirubin, serum urea, creatinine and electrolytes (Na<sup>+</sup>, K<sup>+</sup> and Cl<sup>-</sup>) levels increased in a dose dependent manner in treated rats when compared with untreated control group. Serum total protein decreased significantly in experimental rats when compared with control. However, cholesterol and triglycerides showed no significant difference when compared with control. Histopathological examination of hepatocytes in treated rats was characterized by mild periportal inflammatory cells and cytoplasmic degeneration. Furthermore, histopathological examination of rat kidneys revealed inflammatory cells, congested vessel and interstitial hemorrhage in rats treated with Solignum<sup>®</sup>. Therefore, this present study is aimed to evaluate the hepatotoxic and nephrotoxic potentials associated with sub-chronic exposure to the commercial pesticide Solignum<sup>®</sup>.

scholarly journals Effect of Cleome gynandra leaf extract on the estrous cycle and histology of the ovary and uterus of wistar albino rats

1970 ◽  
Vol 8 (1) ◽  
pp. 1385-1394
Author(s):  
Lemuel Ann Monima ◽  
Muhammad Buhari ◽  
Sodiq Lawal ◽  
Echoru Isaac ◽  
Ssempijja Fred ◽  
...  
Keyword(s):  
Body Weight ◽  
Estrous Cycle ◽  
Wistar Rat ◽  
First Trimester ◽  
Albino Rats ◽  
Average Weight ◽  
Cleome Gynandra ◽  
Group A ◽  
Wistar Albino Rats ◽  
Group B

Cleome gynandra is a medicinal plant that is used all over Uganda to hasten childbirth because, it possesses the ability to contract the uterus. It is also used as an abortifacient in the first trimester. In this study, the effects of Cleome gynandra were investigated on the estrous cycle and the histology of the ovary and uterus of adult Wistar rat. Twelve adult female Wistar rats of 130-140g average weight were used. These were divided into three groups of four animals each. Group A received distilled water only, while animals in groups B and C received 250mg/kg body weight and 500mg/kg body weight of extract, orally and daily respectively. Monitoring of estrous cycle continued throughout the three weeks of extract administration. After three weeks, the ovaries and uteri were excised and processed for histological examination. In the ovary, there was a reduction in number of primordia, primary, secondary and graafian follicles in the treated groups. Vacuolations were common to both the ovarian and uterine tissues of treated animals. The estrous cycle of Group B and C, showed a mild disruption when compared to animals in Group A. The results showed that the plant extract studied, exerted negative influences on the estrous cycle and histology of the ovary and uterus of Wistar albino rats, suggesting a disturbance on the reproductive health of the animals. Further studies to determine the mechanism of action of Cleome gynandra on the ovary and uterus and the levels of FSH, LH, estradiol and progesterone is recommended.Key Words: Cleome gynandra, estrous cycle, Wistar albino rats, ovarian follicles.

scholarly journals Membrane stabilization effect and histological changes in the heart in experimental myocardial rats with Zanthoxulym armatum fruit

2019 ◽  
Vol 8 (1) ◽  
pp. 19-26
Author(s):  
Malathi Mangalanathan ◽  
Tamiloli Devendhiran ◽  
Saraswathi Uthamaramasamy ◽  
Keerthika Kumarasamy ◽  
K Mohanraj ◽  
...  
Keyword(s):  
Body Weight ◽  
Albino Rats ◽  
Histological Changes ◽  
Adenosine Triphosphatases ◽  
Stabilization Effect ◽  
Membrane Bound ◽  
Wistar Albino Rats ◽  
Contraction And Relaxation ◽  
Hydroethanolic Extract ◽  
Membrane Bound Enzymes

Membrane bound adenosine triphosphatases (ATPases) shed a massive function into the contraction and relaxation of the heart muscle via keeping the normal ion levels within the myocyte. The current study aims to assess the potency of Zanthoxylum armatum (Z. armatum) fruit on membrane bound ATPases and ions in Isoproterenol (ISO) induced myocardial infracted rats. The hydroethanolic extract of Z. armatum fruit was administered at a dose of 200 and 400mg/kg body weight for 30 days to male Wistar albino rats. On 28th and 29th day, ISO (8.5mg/100g body weight) used to be administered to induce myocardial infarction (MI). ISO treated rats confirmed a significant increase in the levels of tissue sodium (Na+) and calcium (Ca2+) ions and membrane bound Ca2+ ATPase then Mg2+ ATPase activity. A significant decrease in tissue potassium (K+), Na +/K+ ATPase was observed which indicates membrane destabilization. Pretreatment with hydroethanolic extract of Z. armatum fruit to ISO induced rats significantly (p<0.05) prevented the altered membrane bound enzymes to near normal status. The findings of the present study indicate the protective effect of Z. armatum fruit on altered ion pumps and destabilization on the cardiac membrane into ISO induced MI rats which might also be due to the presence of phytoconstituents.

scholarly journals EFFECTS OF TELMISARTAN ON PLASMA INTERLEUKIN-6 AND C-REACTIVE PROTEIN LEVELS IN MONOSODIUM GLUTAMATE-INDUCED OBESITY IN WISTAR ALBINO RATS

2020 ◽  
pp. 146-148
Author(s):  
VENKATESH KM ◽  
SRIRAM BS ◽  
RAVICHANDRA V ◽  
RAJENDRA HOLLA
Keyword(s):  
Body Weight ◽  
Monosodium Glutamate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Albino Rats ◽  
Peroxisome Proliferator ◽  
C Reactive Protein ◽  
Peroxisome Proliferator Activated Receptor ◽  
Protein Levels ◽  
Reactive Protein ◽  
Wistar Albino Rats

Objectives: The objectives of this study were to evaluate the effects of telmisartan on plasma interleukin (IL)-6 and C-reactive protein (CRP) levels in monosodium glutamate (MSG)-induced obesity in Wistar albino rats. Methods: MSG at the dose of 500 mg/kg body weight is dissolved in distilled water and administered for 22 days. On the 9th day, telmisartan 7.5 mg/kg body weight is administered. After completion of experiment, body weight and biochemical parameters such as plasma IL-6 and CRP levels are measured using enzyme-linked immunosorbent assay. Results: Telmisartan significantly decreased plasma IL-6 and CRP levels in MSG-treated obese rats. Conclusion: Telmisartan, probably through its peroxisome proliferator-activated receptor-γ agonistic activity, produces significant anti-obesity effects in rats and may help in treating obese patients with metabolic syndrome.

scholarly journals Reductions in feed and water consumptions and body weight in rats consuming aqueous extracts or ground leptadenia pyrotechnic

2021 ◽  
Author(s):  
Bushra S. Alsahafi ◽  
◽  
Sawsan H. Mahassni ◽  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Folk Medicine ◽  
Body Weight Loss ◽  
Laboratory Animals ◽  
Control Group ◽  
Albino Rats ◽  
Therapeutic Uses ◽  
The Difference ◽  
Wistar Albino Rats

Leptadenia pyrotechnica (Forssk.) Decne. (LP) is used in folk medicine for the treatment of different ailments. No published studies on the affects of ground and aqueous LP extract in laboratory animals exist. Thus, this study is the first to investigate the difference between using ground or aqueous extract of LP on body weight parameters and consumptions of feed and water in young adult Wistar albino rats. Four groups (one rat of either sex for each group) were administered 25%, 50% and 75% ground LP mixed with the regular feed for 7 days, while the control rats were given the regular diet. Five groups (two rats of either sex for each group) were orally gavaged with 3, 9, 15 and 20 g LP extract/kg body weight, while the control group was gavaged with water, daily for 14 days. Findings were compared with the control groups. The mean body weight loss and feed inefficiency ratio s for the ground LP groups were higher, leading to lower feed and water intakes. Rats that consumed 15 and 20 g LP extract/kg had higher mean body weight loss and feed inefficiency ratio and lower water and feed intakes for the first but not for the second week. Therefore, both forms of LP affect weights and consumptions of water and feed during the first week. Thus, while using LP for any medicinal or therapeutic uses in humans, any affects on weight or feed and water consumptions may last only for a week.

scholarly journals Effects of Peanut (Arachis Hypogaea L.) and Its Combination with Propranolol in Isoproterenol Induced Myocardial Damage in Rats

2016 ◽  
Vol 11 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Farah Naz ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Mohammad Hayatun Nabi
Keyword(s):  
Body Weight ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Myocardial Damage ◽  
Ischemic Heart ◽  
Albino Rats ◽  
Initial Body Weight ◽  
Final Body Weight ◽  
Bonferroni Test ◽  
Wistar Albino Rats

Background: Ischemic heart disease is the interruption of blood supply to the heart causes several biochemical alterations which may lead to cardiac dysfunction and ultimately cell death. Medicinal plants and plant based foods such as peanut (Arachishypogaea L.) have received great attention for their salutary effects and potential to treat many aspects of ischemic heart disease due to their antioxidant property.Objective: To observe the effects of peanut (Arachishypogaea L.) and its combination with propranolol in isoproterenol induced myocardial damage in rats.Method: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka in 2012. For this purpose, 20 Wistar albino rats, age 85 to 100 days, weighing 120 to 150g (initial body weight) were included in the peanut treated group.They were sub-divided into CT-P (Cardiotoxic group with isoproterenol after peanut treatment) and CT-C (Cardiotoxic group with isoproterenol after combined treatment of peanut and propranolol). Age and weight matched 30 Wistar albino rats without any peanut supplementation were taken and sub-divided into three sub-groups, BC (Baseline control), CT (Cardiotoxic group with isoproterenol) and CT-PRO (Cardiotoxic group with isoproterenol after propranolol treatment). Each sub-group consisted of 10 rats. After taking final body weight all the rats were sacrificed on 22nd day. Blood was collected from heart & supernatant serum was preserved in deep freeze until analysis. For assessment of myocardial damage, some cardiac biomarker enzymes, like serum CK-MB & LDH were estimated by using immunoassay method. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable.Result: In this study, percent change from initial body weight to final body weight was significantly (p<0.01) lower both in CT-P and CT-C as compared to that of BC. Again, the mean serum CK-MB and LDH levels were significantly (p<0.01) higher in CT, CT-PRO, CT-P & CT-C in comparison to that of BC. On the other hand, the serum CK-MB and LDH levels were lower in CT-PRO, CT-P and CT-C when compared to that of CT though the differences were statistically significant (p<0.01, p<0.05) in case of CT-PRO and CT-C but not significant in case of CTP. Again, the values were also significantly lower in CT-C (p<0.01,p<0.05) as compared to that of CTP.Conclusion: The present study revealed that peanut can lower serum CK-MB & LDH levels towards normal in isoproterenol induced myocardial damaged rats. However, the combined therapy of peanut with propranolol showed synergistic effect on lowering serum CK-MB & LDH levels.Bangladesh Soc Physiol. 2016, December; 11(2): 74-79

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