scholarly journals MYOKINES, THEIR ROLE IN MUSCLE CONTRACTION

2021 ◽  
Vol 27 (1) ◽  
pp. 4-11
Author(s):  
Nikolay Mikhailovich Vladimirov ◽  

Skeletal muscles are the largest organ in the human body, making up 40–50% of the total human body weight. This work is devoted to the study of physical activity on the athlete’s body. Given that the muscular system is more multifunctional than previously thought, and is able to aff ect many systems of the body through the synthesis and secretion of cytokines-classical regulators of the immune system, classifi ed as myokines. In this review article, we summarize our current knowledge of the main identifi ed and characterized myokines, focusing on their biological activity and functions. Through regular exercise, muscle-induced factors called myokines can exert and play an important role in protecting against many diseases.

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 930
Author(s):  
Odysseas Androutsos ◽  
Maria Perperidi ◽  
Christos Georgiou ◽  
Giorgos Chouliaras

Previous studies showed that the coronavirus disease 2019 (COVID-19) lockdown imposed changes in adults’ lifestyle behaviors; however, there is limited information regarding the effects on youth. The COV-EAT study aimed to report changes in children’s and adolescents’ lifestyle habits during the first COVID-19 lockdown and explore potential associations between changes of participants’ lifestyle behaviors and body weight. An online survey among 397 children/adolescents and their parents across 63 municipalities in Greece was conducted in April–May 2020. Parents self-reported changes of their children’s lifestyle habits and body weight, as well as sociodemographic data of their family. The present study shows that during the lockdown, children’s/adolescents’ sleep duration and screen time increased, while their physical activity decreased. Their consumption of fruits and fresh fruit juices, vegetables, dairy products, pasta, sweets, total snacks, and breakfast increased, while fast-food consumption decreased. Body weight increased in 35% of children/adolescents. A multiple regression analysis showed that the body weight increase was associated with increased consumption of breakfast, salty snacks, and total snacks and with decreased physical activity. The COV-EAT study revealed changes in children’s and adolescents’ lifestyle behaviors during the first COVID-19 lockdown in Greece. Effective strategies are needed to prevent excessive body weight gain in future COVID-19 lockdowns.


1959 ◽  
Vol 196 (3) ◽  
pp. 512-516 ◽  
Author(s):  
Adam Anthony ◽  
Eugene Ackerman ◽  
G. K. Strother

Analyses were made of myoglobin content of rat skeletal and cardiac muscle following continuous exposure to simulated altitudes of 18,000 feet for a 2–10-week period. About five dozen rats were used. Acclimatization was associated with an increase in the myoglobin concentration of thigh, diaphragm, gastrocnemius and heart muscles. Total myoglobin content, however, increased during acclimatization in cardiac muscle but not in the three skeletal muscles. This finding together with the body weight changes and muscle weight changes suggested that the increases in myoglobin concentration of skeletal muscle may be merely a reflection of a decreased water content of muscles.


Author(s):  
Daniela Reyes-Olavarría ◽  
Pedro Ángel Latorre-Román ◽  
Iris Paola Guzmán-Guzmán ◽  
Daniel Jerez-Mayorga ◽  
Felipe Caamaño-Navarrete ◽  
...  

The association between the changes in lifestyle during coronavirus disease 2019 (COVID-19) confinement and body weight have not been studied deeply. Therefore, the aim of the present study was to determine lifestyle changes, such as eating habits and physical activity (PA) patterns, caused by confinement during the COVID-19 pandemic and to analyze its association with changes in body weight. Seven hundred participants (women, n = 528 and men, n = 172) aged between 18–62 years old of the Chilean national territory participated in the study. Food habits, PA, body weight, and sociodemographic variables were measured through a survey in May and June 2020. The body weight increase presented positive association with the consumption of fried foods ≥ 3 times per week (OR; 3.36, p < 0.001), low water consumption (OR; 1.58, p = 0.03), and sedentary time ≥6 h/day (OR; 1.85, p = 0.01). Conversely, fish consumed (OR; 0.67, p = 0.03), active breaks (OR; 0.72, p = 0.04), and PA ≥ 4 times per week (OR; 0.51, p = 0.001) presented an inverse association with body weight increase. Daily alcohol consumption (OR; 4.77, p = 0.003) was associated with PA decrease. Food habits, PA, and active breaks may be protective factors for weight increase during COVID-19 confinement.


Author(s):  
Svitlana Тymchik ◽  
Оleksandr Bryksin ◽  
Eugenia Omelyanchuk

In the modern world with the advent of devices that facilitate work (computer, technical equipment) has decreased sharply motor activity of people compared to previous decades. This, in the end, leads to a decrease in human functionality, as well as various diseases. Today, purely physical work does not play a significant role, it is replaced by mental. Intellectual work dramatically reduces the efficiency of the body. Lack of human energy expenditure leads to inconsistencies in the functioning of individual systems (muscular, skeletal, respiratory, cardiovascular) and the body as a whole with the environment, as well as reduced immunity and impaired metabolism. Exercise affects all muscle groups, joints, ligaments, which become strong, increase muscle volume, elasticity, strength and rate of contraction. Increased muscle activity forces the heart, lungs and other organs and systems of our body to work with additional load, thereby increasing the functional capabilities of man, his resistance to adverse environmental influences. Regular exercise primarily affects the musculoskeletal system, muscles. When you exercise, the muscles generate heat, to which the body responds by increased sweating. During exercise, blood flow increases: the blood brings oxygen and nutrients to the muscles, which in the process of life break down, releasing energy. When movements in the muscles additionally open reserve capillaries, the amount of circulating blood increases significantly, which causes an improvement in metabolism. In response to the reaction of the human body to exercise, the first place is occupied by the influence of the cerebral cortex on the regulation of the functions of the basic systems: there is a change in the cardiorespiratory system, gas exchange, metabolism, and others. Exercises enhance the functional restructuring of all parts of the musculoskeletal system, cardiovascular and other systems, improve tissue metabolism. Under the influence of moderate physical activity increases the efficiency of the heart, hemoglobin and red blood cell count, increases the phagocytic function of the blood. Improves the function and structure of the internal organs, improves chemical processing and promotion of food in the intestine. The combined activity of muscles and internal organs is regulated by the nervous system, the function of which is also improved by regular exercise. If the muscles do not work - their nutrition deteriorates, volume and strength decrease, elasticity and resilience decrease, they become weak, sluggish. Restrictions in movement (hypodynamia), passive lifestyle lead to various pre-pathological and pathological changes in the human body. So, the American doctors, having deprived volunteers of movements by imposing of high plaster and having kept to them a normal diet, were convinced that in 40 days at them muscle atrophy began and fat has accumulated. At the same time increased the reactivity of the cardiovascular system and decreased basal metabolism. However, during the next 4 weeks, when the subjects began to move actively (with the same diet), the above phenomena were eliminated, the muscles were strengthened and hypertrophied. Thus, due to physical exertion, recovery was possible both in functional and structural terms. Exercise has a multifaceted effect on the human body, increasing its resistance to adverse environmental influences. For example, physically trained people have better tolerance to oxygen starvation than untrained people. High ability to work at increase of body temperature over 38 ° C during physical exertions is noted. It has been noticed that radiologists who exercise have a lower degree of influence of penetrating radiation on the morphological composition of the blood. Animal experiments have shown that regular muscle training slows the development of malignant tumors. Regular exercise in physical education promotes good health and affects the various physiological adaptations of the neuromuscular, cardiovascular and respiratory systems of the human body. Types of physical activities are considered: aerobic, anaerobic, interval and hypoxic physical activities.


2019 ◽  
Vol 8 (3) ◽  
pp. 81
Author(s):  
Kürşat Hazar

The aim of this study was to investigate the effects of regular exercise on some motoric features in 7&ndash;12-year-old boys and girls in 8 weeks period of time. To the study 66 boys with an average age of 8, &plusmn; 7963, as 54 of them in research and 12 of them in control groups; 66 girls, 36 of them as research and 30 as control group, a total of 132 individuals who joins summer sports schools within the body of Muğla Sıtkı Ko&ccedil;man Directorate of Health, Culture and Sports with no health problems participated in the study. Two tests were applied to the children before and after the exercise program. Height, body weight, balance, flexibility, bounce force, explosive force, sit-up and 20m velocity measurements were performed to the participants. SPSS 21.00 package program was used for statistical evaluation of the obtained data. For paired comparisons, Paired Samples t test was applied to determine the effect of the independent variable on the dependent variable. In order to determine the difference between the groups, Independent samples t test was applied and the level of significance was set at p &lt;0.05 and 0.01. In the study, statistically significant differences were found in favor of the research group between the first and second measurement results of height, body weight, balance, flexibility, bounce force, explosive force, sit-up and velocity (p &lt;0.05, p &lt;0.01). As a result, in the light of the data obtained from the comparisons between the groups, it was determined that the regularly performed exercises positively affect the body weight, static balance, flexibility, bounce force, explosive force, sit-up and velocity values in 7&ndash;12 age group boys and girls.


2021 ◽  
Vol 100 (1) ◽  
pp. 55-59
Author(s):  
Nikolay A. Kashuba

Introduction. One of the features of lead is its high ability to disintegrate and significantly contaminate the environment. The contamination of hands or the whole body with lead creates a high probability of penetrating micro- and nanoparticles through the skin into the body. Nowadays, this process is not sufficiently studied. There is evidence that inorganic compounds or metallic particles of lead can penetrate through the skin into a human body. Material and methods. centrifuge 10000 rpm, laser emitter (wavelength 625-740 nm), optical microscope, voltampermetric analyzer ABA-2, Analysette 12 Dyna Sizer, magnetic stirrer, distiller, Na2S solution. The studies were conducted in 2017-2018 among the workers of battery sections of technical service stations in Ternopol - 17 people. The research results were processed by the statistical package SPSS 19. Results. The process of mechanical contamination by the skin with lead, rejection of micro particles from the surface of lead, and, to a lesser extent, ultrafine nanoparticles, which can penetrate the sweat glands, was established to occur. The studies have shown in the washings from the palms particles’ skin are detected mainly in the size of 1 μm - 100 nm. In the process of finding the particles of lead in the sweat glands, their length decreases to Nanoscale, allowing them freely entering the body. The decrease in particle size in the sweat glands occurs due to the formation of soluble lead compounds. Presumably, the main chemical contributing to this process is lactic acid. With increasing exposure, the size of lead particles in the sweat glands decreases. Intensive cleaning of the skin surface by mechanical methods, and detergents, followed by contamination with lead, promotes the penetration of lead particles into the sweat glands and its further spread in the body. The intense physical activity was established to contribute to a decrease in particle size, which suggests chemical interaction of lead with lactic acid and the formation of soluble lead lactate. The assumption is confirmed by studies of the composition of sweat, which is detected lead lactate. Conclusion. The lead ability to penetrating a human body transcutaneously in the form of nanoparticles and soluble compounds has been proven. Intense physical activity facilitates the penetration of lead into the body.


2018 ◽  
Vol 17 (2) ◽  
pp. 62-65
Author(s):  
Pamela Guggina

Purpose An area of workplace well-being, and thus performance, which is now being recognized more widely is the mental health of employees. Research today demonstrates that exercise is good for the body and dramatically affects the brain. While it is widely accepted that regular exercise can promote weight loss, lower blood pressure and decrease the risks of diabetes, heart disease and certain cancers, it is also becoming clear that exercise can improve mood, coping skills and even treat clinical depression and anxiety. These findings further support the upward trend of companies offering a wider range of health benefits to their employees. Design/methodology/approach One example of the combined research, Rethorst et al., published a large meta-analysis exploring the interaction between physical activity and depression. They examined 58 randomized trails and found that participants in the studies who had been randomized to use exercise as a treatment for depression had significantly lower depression scores than participants who had been randomized to the non-exercise or “control” group. Both clinically depressed and non-clinically depressed individuals reported lower depression scores if they participated in the exercise group. Findings Exercise can be as effective as medication in treating depression. Regular exercise can decrease the symptoms of clinical anxiety. Employers who incentivize physical activity can dramatically lower healthcare costs. Benefits packages which promote physical activity can increase productivity and decrease absenteeism. Originality/value There will always be people with an illness which requires medication, but there appears to be a group that will benefit greatly from getting out and moving with regular exercise. The hope is that physicians with patients who have symptoms of depression and anxiety will encourage their patients to get some exercise to see if it helps. This can be something that is done alone or as an adjunct to talk therapy and/or pharmacologic treatment. Exercise is not likely to change the circumstances that make life challenging, but it can help all humans cope better with these challenges.


2017 ◽  
Vol 51 (1) ◽  
pp. 52-70 ◽  
Author(s):  
M. M. I. Abdalla

Abstract The maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive. Th e body weight depends on the balance between the energy intake and energy expenditure. Increased food intake over the energy expenditure of prolonged time period results in an obesity. Th e obesity has become an important worldwide health problem, even at low levels. The obesity has an evil effect on the health and is associated with a shorter life expectancy. A complex of central and peripheral physiological signals is involved in the control of the food intake. Centrally, the food intake is controlled by the hypothalamus, the brainstem, and endocannabinoids and peripherally by the satiety and adiposity signals. Comprehension of the signals that control food intake and energy balance may open a new therapeutic approaches directed against the obesity and its associated complications, as is the insulin resistance and others. In conclusion, the present review summarizes the current knowledge about the complex system of the peripheral and central regulatory mechanisms of food intake and their potential therapeutic implications in the treatment of obesity.


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