scholarly journals Gambaran Profil Lipid pada Pasien Sindrom Koroner Akut di Rumah Sakit Khusus Jantung Sumatera Barat Tahun 2011-2012

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Fitri Zahara ◽  
Masrul Syafri ◽  
Eti Yerizel

AbstrakPenyakit kardiovaskuler merupakan penyebab kematian nomor satu secara global. Salah satu penyakit kardiovaskuler itu adalah Sindrom Koroner Akut (SKA) yang merupakan keadaan gawat darurat dari Penyakit Jantung Koroner (PJK). Salah satu faktor risiko SKA adalah perubahan dari kadar fraksi lipid yaitu kolesterol total, kolesterol LDL, kolesterol HDL, dan trigliserida yang dikaitkan dengan pembentukan plak aterosklerosis. Penelitian ini bertujuan untuk mengetahui gambaran profil lipid pada pasien SKA di rumah sakit khusus jantung Sumatera Barat tahun 2011-2012. Telah dilakukan penelitian deskriptif dengan bentuk cross sectional study dan pendekatan retrospective menggunakan data rekam medik mengenai hasil pemeriksaan profil lipid (kolesterol total, HDL, LDL, dan trigliserida) di rumah sakit khusus jantung Sumatera Barat untuk mengetahui gambaran profil lipid pada pasien SKA tahun 2011-2012. Hasil penelitian ini menemukan 98 kasus SKA. hasil ini menunjukkan bahwa pasien SKA dengan kadar kolesterol total tinggi adalah 44 orang (44,9%) dan normal sebanyak 54 orang (55,1%), pasien SKA dengan kadar kolesterol HDL rendah adalah 63 orang (64,3%) dan normal sebanyak 35 orang (35,6%), pasien SKA dengan kadar kolesterol LDL tinggi adalah 44 orang (44,9%) dan normal sebanyak 54 orang (55,1%), dan pasien SKA dengan kadar trigliserida tinggi adalah 21 orang (21,4%) dan normal sebanyak 77 orang (78,6%). Kejadian SKA terbanyak adalah STEMI sebanyak 51 kasus (52%), kemudian NSTEMI sebanyak 24 kasus (24,5%) dan yang paling sedikit adalah angina pektoris tak stabil sebanyak 23 kasus (23,5%) frekuensi umur terbanyak dari pasien SKA adalah 40-59 tahun, jenis kelamin terbanyak dari pasien SKA adalah laki-laki sekitar 74,5%. Penelitian menunjukkan jumlah bahwa pasien SKA yang memiliki kadar kolesterol total yang tinggi lebih sedikit daripada yang normal, kadar kolesterol HDL yang rendah lebih banyak daripada yang normal, kadar kolesterol LDL yang tinggi lebih sedikit daripada yang normal, kadar trigliserida yang tinggi lebih sedikit daripada yang normal, kasus SKA terbanyaKata kunci: Sindrom Koroner Akut, kolesterol total, kolesterol LDL, kolesterol HDL, trigliseridaAbstractCardiovascular diseases are the number one cause of death globally. One of the cardiovascular disease is Acute Coronary Syndrome (ACS) which is a state of emergency from Coronary Heart Disease (CHD). One of the risk factors for ACS is a change in the levels of lipid fractions such as total cholesterol, LDL Cholesterol, HDL Cholesterol and triglycerides which are associated with the formation of atherosclerotic plaque. This study aims to determine description of lipid profile in patients with acute coronary syndrome at the heart hospital of west sumatera 2011-2012. Descriptive research has been conducted with a a cross-sectional study and a retrospective approach using medical record about the result of lipid profile test (total cholesterol, HDL, LDL, and triglycerides) at the heart hospital of West Sumatera to describe the lipid profile in patients with ACS in 2011-2012. The results of this study found 98 cases of ACS. It showed that ACS patients with high total cholesterol levels are 44 people (44,9%) and normal are 54 people (55,1%), acute coronary syndrome patients with low levels of HDL cholesterol are 63 people (64,3%) and normal are 35 people (35,6%), acute coronary syndrome patients with high levels of LDL cholesterol are 44 people (44,9%) and normal are 54 people (55,1%), acute coronary syndrome patients with high levels of triglyceride are 21 people (21,4%) and normal are 77 people (78,6%), the highest incidence of SKA is STEMI with 51 cases (52%), then NSTEMI with 24 cases (24,5%) and the lowest incidence is unstable angina pectoris with 23 cases (23,5%), most age of the patients of ACS are 40-59 years old, the most gender of ACS are male about 74,5%. Research shows that the number of ACS patients who have a high level of total cholesterol are less than normal, low levels of HDL cholesterol are more than normal, high level of LDL cholesterol are less than normal, high level of triglyceride are less than normal, most incidens of ACS is STEMI then NSTEMI and the lowest is unstable angina pectoris, most age of ACS patients are 40-59 years, and most of gender are men.Keywords:acute myocardial infarction, total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Lamuna Fathila ◽  
Zulkarnain Edward ◽  
Rosfita Rasyid

AbstrakInfark Miokard Akut (IMA) merupakan nekrosis otot jantung akibat terganggunya kebutuhan dan suplai oksigen ke jantung secara mendadak. Faktor risikonya adalah perubahan profil lipid yaitu Kolesterol total, Kolesterol LDL. Kolesterol HDL, dan trigliserida yang dikaitkan dengan pembentukan plak aterosklerosis. Manfaat penelitian ini untuk mengetahui gambaran profil lipid pada pasien IMA. Tujuan penelitian ini untuk mengetahui gambaran profil lipid pada pasien IMA di RSUP M. Djamil Padang periode 1 Januari 2011-31 Desember 2012. Penelitian dilakukan dengan metode deskriptif dengan desain cross sectional study di bagian Rekam Medik RSUP M. Djamil Padang. Hasil penelitian menunjukkan umur terbanyak pasien IMA 45-59 tahun, Jenis kelamin terbanyak pasien IMA adalah laki-laki, perbandingannya adalah 2,7 : 1, Pasien IMA yang memiliki kadar kolesterol total tinggi 79 orang (38,92%) dan normal 124 orang (61,08%), Pasien IMA yang memiliki kadar kolesterol LDL tinggi 76 orang (37,44%) dan normal 127 orang (62,56%), Pasien IMA yang memiliki kadar kolesterol HDL rendah 145 orang (71,43%) dan normal 58 orang (28,57%), dan Pasien IMA yang memiliki kadar trigliserida tinggi 44 orang (21,67%) dan normal 159 orang (78,33%).Kata kunci: infark miokard akut, kolesterol total, kolesterol LDL, Kolesterol HDL, trigliserida AbstractAcute Myocardial Infarction (AMI) is a muscle necrosis of the heart through disruption of demand and supply of oxygen to the heart suddenly. Risk factors of AMI is a change of lipid profile (Total Cholesterol, LDL Cholesterol, HDL Cholesterol, and Triglycerides) associated with the formation of atherosclerotic plaque. The benefit of this research is to reveal the lipid profile in patients with AMI. The objective of this study was to determine the description of lipid profile in patients with AMI at RSUP M. Djamil Padang period January 1st, 2011-December 31th, 2012. The study was conducted with descriptive methods to the design of cross sectional study at the Medical Records Department of RSUP M. Djamil Padang. The results of this study indicate that the most age of the patients of AMI 45-59 years old, the most gender of AMI are male and the ratio 2.7 : 1, AMI patients with high total cholesterol levels 79 people (38.92%) and normal 124 people (61.08%), AMI patients with high LDL cholesterol levels 76 people (37,44%) normal 127 people (62.56%), AMI patients with low HDL cholesterol levels 145 people (71.43%) and normal 58 people (28.57%), and AMI Patients with high triglyceride levels 44 people (21.67%) and normal 59 people (78.33%).Keywords: acute myocardial infarction, total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride


2021 ◽  
Vol 29 (01) ◽  
pp. 82-87
Author(s):  
Syeda Sabahat Haider ◽  
Muhammad Shahid ◽  
Khalid Razaq ◽  
Shama Iqbal ◽  
Muhammad Tariq Ghafoor ◽  
...  

Objective: To determine the frequency of hypercholesterolemia in patients who are diagnosed with acute coronary syndrome and to also document the association of Non HDL-C with Acute coronary syndrome in these patients. Study Design: Observational Cross Sectional study. Setting: Department of Cardiology and Pathology of Sheikh Zayed Hospital, Rahim Yar Khan. Period: September 2019 to February 2020. Material & Methods: One hundred and thirty five patients with Acute coronary syndrome were included using non probability purposive sampling technique and equal number of patient who visited the outpatient department or admitted in indoor with complaints other than ACS were taken as control (n=135). Frequency and percentages were calculated and odd ratio was determined to see the association. Statistical significance was set at P-value<0.05. Results: Patient’s mean age was 55.5±12.4 years and there were 98(73%) male and 37(27%) female. Higher Non HDL-C (>130mg/dl) was found in 120(88.9%) cases and in 38(28.1%) controls with odd ratio 20.4211 at 95 %CI and p value <0.001.Hypercholesterolemiawas seen in 49(36.3%) of the cases while in 21(15.6%) of control group (without ACS) with odd ratio of 3.3 and p-value <0.001. Odds ratio was maximum for Non HDL cholesterol, followed by LDL cholesterol, HDL cholesterol and Total cholesterol. Conclusion: Non-HDL cholesterol showed a good association in patients with ACS than with primary target LDL-C or total cholesterol.


2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
J Correia ◽  
V Neto ◽  
J Santos ◽  
I Pires ◽  
L Goncalves ◽  
...  

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Several studies have suggested a relationship between dyslipidemia and atherogenesis, which displays a main role in the pathophysiology of Acute Coronary Syndrome (ACS). Aim To compare the lipid profile between younger (&lt;55 years) and older (≥55 years) patients admitted due to ACS. Methods A single-centre retrospective study was conducted, with inclusion of all consecutive patients admitted in the Cardiology Department due to ACS. Several analytical parameters were evaluated, including total cholesterol (CT), HDL cholesterol (HDL), LDL cholesterol (LDL) and triglycerides (TG) and CT/HDL, LDL/HDL and TG/HDL ratios were calculated. All parameters are presented in mg/dL. Afterwards, comparison of these data between younger (age &lt; 55 years, Group-A) and older (age≥55 years, Group-B) patients was done. Statistical analysis was performed with SPSS and a p value &lt; 0.05 was considered statistically significant. Results 1168 patients (70.1% male, mean age 69 ±12 years) were included in this study. 15.8% of patients were from Group-A. Mean levels of the analysed parameters were the following: CT 176 ± 55, LDL 111 ± 45, HDL 40 ± 12 and TG 137 ± 102. The following mean ratios were obtained: CT/HDL 4.6 ± 1.9, LDL/HDL 2.9 ± 1.4 and TG/HDL 3.8 ± 3.5. Comparison of the analysed parameters and calculated ratios is exhibited in table 1. Conclusion Overall, a worse lipid profile was observed in younger patients. This data reveals the role of dyslipidemia in coronary heart disease, which displays a main role in atherosclerosis at a younger age. This fact highlights the importance of adopting a healthy lifestyle and the adherence to primary and secondary prevention measures of cardiovascular events. Lipid profile: young vs old patient Group A Group B Total Cholesterol 199 ± 44 170 ± 56 p &lt; 0.001 LDL Cholesterol 128 ± 37 107 ± 46 p &lt; 0.001 HDL Cholesterol 39 ± 10 40 ± 12 p = 0.307 Triglycerides 195 ± 189 125 ± 66 p &lt; 0.001 CT/HDL 5.3 ± 1.5 6.8 ± 2.0 p &lt; 0.001 LDL/HDL 3.4 ± 1.1 2.8 ± 1.4 p &lt; 0.001 TG/HDL 5.6 ± 6.3 3.5 ± 2.5 p &lt; 0.001


Jurnal BIOMA ◽  
2015 ◽  
Vol 11 (2) ◽  
pp. 131
Author(s):  
Pratiwi Widyamurti ◽  
Rusdi Rusdi ◽  
Sri Rahayu

ABSTRACT Increased blood pressure more than 140/90 mmHg taken from three measurement in 24 hours can be diagnosed as hypertension. Abnormality of lipid values condition was found at many hypertensive. Based on this reason examination of lipid profile in hypertensive and normotensive should be done. The aim of this research was to measure and compare lipid profile on blood serum in hypertensive    and normotensive. Lipid profile was measured by Konelab 20XT clinical chemistry analyzer. Ex     Post Facto used as method and Cross-sectional used as design. A total of 50 blood samples collected from Hypertensive (N1=25) and normotensive (N2=25) from June to August 2014. SPSS 16.0 was used to analyze the data, T-test was used to compare value of LDL cholesterol, HDL cholesterol and total cholesterol while U Mann-Whitney test was used to compare value of triglyceride. The result      of this research showed that the mean value of triglyceride was 146.56 mg/dL in hypertensive and 143.92 mg/dL in normotensive (p=0.11). The mean value of LDL cholesterol was 129.80 mg/dL in hypertensive and 136.72 mg/dL in normotensive (p=0.62). The mean value of HDL cholesterol was  38.80 mg/dL in hypertensive and 45.04 mg/dL in normotensive (p=0.1). The mean value of total cholesterol was 201.04 mg/dL in hypertensive and 221.88 mg/dL in normotensive (p=0.25). In conclusion, there was no different of lipid profile on blood serum in hypertensive and normotensive.  Keywords: hypertension, lipid profile, normotensive


2021 ◽  
Vol 1 ◽  
pp. 140-144
Author(s):  
Omar Mohammed Al-Juboori

Background: Treatment modalities of acromegaly and disease control impact differently on glucose homeostasis and lipid changes, and consequently on cardiometabolic risk. Aim: To investigate the possible association of lipid profile changes with the glycemic control status in acromegaly patients treated with octreotide LAR. Methods: This cross-sectional study included 52 Iraqi patients with acromegaly treated with octreotide LAR and not using statins. Demographic, anthropometric, and clinical data were collected, as well as the duration of Octreotide LAR administration. The glycemic state was assessed and classified as DM, prediabetes, or normal. Plasma levels of triglycerides, LDL cholesterol, HDL cholesterol, and non-HDL were evaluated using standard methods. Results: Most of the participants presented with low levels of triglycerides, LDL cholesterol, and HDL cholesterol. The lipid profile variables were not significantly correlated with the glycemic control status after treatment with octreotide LAR. Conclusion: Lipid profile parameters were not associated with the different glycemic control status of acromegaly patients treated with octreotide LAR.


2008 ◽  
Vol 2 ◽  
pp. LPI.S848
Author(s):  
José-Luis Pérez-Castrillón ◽  
Manuel Gonzalez-Sagrado ◽  
Marta Gonzalez-Rozas ◽  
Maria Andres-Calvo ◽  
Elena Izquierdo-Delgado ◽  
...  

Objective To evaluate the relationship between cholesterol and triglycerides and bone mineral density in patients with vascular disease (hypertension and acute coronary syndrome). Methods The study included 217 patients (83 men and 134 women), aged between 36 and 76 (mean age 59 ± 10), with hypertension and acute coronary syndrome. Information obtained included anthropometric measurements, total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides; bone mineral density (BMD) was recorded at the lumbar spine. Results BMD was significantly lower in patients in the higher tertiles of cholesterol (p = 0.041). The effect was maintained after adjustment for age and Body Mass Index (BMI). However, there was no association between the range of triglycerides, LDL cholesterol, HDL cholesterol and bone mass. Conclusions A relationship was found between total cholesterol and bone mineral density in patients with vascular disease.


2016 ◽  
Vol 50 (suppl 1) ◽  
Author(s):  
José Rocha Faria Neto ◽  
Vivian Freitas Rezende Bento ◽  
Cristina Pellegrino Baena ◽  
Marcia Olandoski ◽  
Luis Gonzaga de Oliveira Gonçalves ◽  
...  

ABSTRACT OBJECTIVE To determine the distribution of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in Brazilian adolescents, as well as the prevalence of altered levels of such parameters. METHODS Data from the Study of Cardiovascular Risks in Adolescents (ERICA) were used. This is a country-wide, school-based cross-sectional study that evaluated 12 to 17-year old adolescents living in cities with over 100,000 inhabitants. The average and distribution of plasma levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were evaluated. Dyslipidemia was determined by levels of total cholesterol ≥ 170 mg/dl, LDL cholesterol ≥ 130 mg/dl, HDL cholesterol < 45 mg/dL, or triglycerides ≥ 130 mg/dl. The data were analyzed by gender, age, and regions in Brazil. RESULTS We evaluated 38,069 adolescents – 59.9% of females, and 54.2% between 15 and 17 years. The average values found were: total cholesterol = 148.1 mg/dl (95%CI 147.1-149.1), HDL cholesterol = 47.3 mg/dl (95%CI 46.7-47.9), LDL cholesterol = 85.3 mg/dl (95%CI 84.5-86.1), and triglycerides = 77.8 mg/dl (95%CI 76.5-79.2). The female adolescents had higher average levels of total cholesterol, LDL cholesterol, and HDL cholesterol, without differences in the levels of triglycerides. We did not observe any significant differences between the average values among 12 to 14 and 15- to 17-year old adolescents. The most prevalent lipid alterations were low HDL cholesterol (46.8% [95%CI 44.8-48.9]), hypercholesterolemia (20.1% [95%CI 19.0-21.3]), and hypertriglyceridemia (7.8% [95%CI 7.1-8.6]). High LDL cholesterol was found in 3.5% (95%CI 3.2-4.0) of the adolescents. Prevalence of low HDL cholesterol was higher in Brazil’s North and Northeast regions. CONCLUSIONS A significant proportion of Brazilian adolescents has alterations in their plasma lipids. The high prevalence of low HDL cholesterol and hypertriglyceridemia, especially in Brazil’s North and Northeast regions, must be analyzed in future studies, to support the creation of strategies for efficient interventions.


2018 ◽  
Vol 69 (2) ◽  
pp. 403-406
Author(s):  
Codrina Ancuta ◽  
Cristina Pomirleanu ◽  
Cristina Iordache ◽  
Magda Ecaterina Antohe ◽  
Rodica Chirieac ◽  
...  

Data about lipoprotein changes and their link with cardiovascular disease and atherosclerosis in systemic sclerosis (SSc) are still challenging. We aimed to evaluate serum lipid profile of patients with SSc and to identify potential relation with different disease specific characteristics (clinical, serological, inflammatory tests) in a cross-sectional study. Standard assessments comprised SSc-related parameters (disease subtype, clinical spectrum, immunological tests) and lipid metabolism (total cholesterol and fractions, triglycerides). Impaired lipid profile (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, slightly modification in total cholesterol level) significantly correlated with diffuse SSc, activity (EUSTAR) and severity (MEDSGER), as well as seropositivity for specific antibodies (anti-centromere and anti-topoisomerase 1). The dyslipidemic profile might represent a pathobiological pathway for atherosclerosis in SSc.


2021 ◽  
pp. 105477382110401
Author(s):  
Audai A. Hayajneh ◽  
Mohammad Rababa ◽  
Sami Al-Rawashedeh

The prevalence of prehospital delay is high among older adults with acute coronary syndrome (ACS). The current study aimed to examine the associated factors of prehospital delay among patients with ACS during the COVID-19 pandemic. This cross-sectional study was conducted on a convenience sample of 300 older adults with ACS admitted to the emergency department in Jordan. Data were collected from June 1 to September 1, 2020. Bivariate and multivariate analyses were used to explore the predictors of prehospital delay. Being widowed, educational level, pain intensity, the gradual onset of ACS symptoms, symptoms lasting for more than 30 minutes, patients’ feeling anxious about their ACS symptoms, patients’ perceiving their symptoms to be particularly dangerous, history of myocardial infarction (MI), and mode of transportation were associated with the time taken before seeking emergency care. Significant predictors of time to seek help were chief complaint of chest pain or palpitations, abrupt onset of symptoms, the associated symptom of vertigo, and a higher number of chronic illnesses; they explained about 17.9% of the variance in the time to seek care. The average time to seek care among patients with ACS during the COVID-19 pandemic was found to be longer than the average time reported by studies conducted prior the pandemic. Improved understanding of the associations between prehospital delay is crucial for optimal ACS patient outcomes under the impacts of the COVID-19 pandemic.


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