scholarly journals PERBANDINGAN PROFIL LIPID PADA SERUM DARAH PENDERITA HIPERTENSI DAN NORMOTENSI

Jurnal BIOMA ◽  
2015 ◽  
Vol 11 (2) ◽  
pp. 131
Author(s):  
Pratiwi Widyamurti ◽  
Rusdi Rusdi ◽  
Sri Rahayu
Keyword(s):  
Blood Serum ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Clinical Chemistry ◽  
Hdl Cholesterol ◽  
Mean Value ◽  
Cross Sectional ◽  
Ex Post ◽  
The Mean

ABSTRACT Increased blood pressure more than 140/90 mmHg taken from three measurement in 24 hours can be diagnosed as hypertension. Abnormality of lipid values condition was found at many hypertensive. Based on this reason examination of lipid profile in hypertensive and normotensive should be done. The aim of this research was to measure and compare lipid profile on blood serum in hypertensive    and normotensive. Lipid profile was measured by Konelab 20XT clinical chemistry analyzer. Ex     Post Facto used as method and Cross-sectional used as design. A total of 50 blood samples collected from Hypertensive (N1=25) and normotensive (N2=25) from June to August 2014. SPSS 16.0 was used to analyze the data, T-test was used to compare value of LDL cholesterol, HDL cholesterol and total cholesterol while U Mann-Whitney test was used to compare value of triglyceride. The result      of this research showed that the mean value of triglyceride was 146.56 mg/dL in hypertensive and 143.92 mg/dL in normotensive (p=0.11). The mean value of LDL cholesterol was 129.80 mg/dL in hypertensive and 136.72 mg/dL in normotensive (p=0.62). The mean value of HDL cholesterol was  38.80 mg/dL in hypertensive and 45.04 mg/dL in normotensive (p=0.1). The mean value of total cholesterol was 201.04 mg/dL in hypertensive and 221.88 mg/dL in normotensive (p=0.25). In conclusion, there was no different of lipid profile on blood serum in hypertensive and normotensive.  Keywords: hypertension, lipid profile, normotensive

scholarly journals Gambaran Profil Lipid pada Pasien Infark Miokard Akut di RSUP M. Djamil Padang Periode 1 Januari 2011 - 31 Desember 2012

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Lamuna Fathila ◽  
Zulkarnain Edward ◽  
Rosfita Rasyid
Keyword(s):  
Myocardial Infarction ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Muscle Necrosis

AbstrakInfark Miokard Akut (IMA) merupakan nekrosis otot jantung akibat terganggunya kebutuhan dan suplai oksigen ke jantung secara mendadak. Faktor risikonya adalah perubahan profil lipid yaitu Kolesterol total, Kolesterol LDL. Kolesterol HDL, dan trigliserida yang dikaitkan dengan pembentukan plak aterosklerosis. Manfaat penelitian ini untuk mengetahui gambaran profil lipid pada pasien IMA. Tujuan penelitian ini untuk mengetahui gambaran profil lipid pada pasien IMA di RSUP M. Djamil Padang periode 1 Januari 2011-31 Desember 2012. Penelitian dilakukan dengan metode deskriptif dengan desain cross sectional study di bagian Rekam Medik RSUP M. Djamil Padang. Hasil penelitian menunjukkan umur terbanyak pasien IMA 45-59 tahun, Jenis kelamin terbanyak pasien IMA adalah laki-laki, perbandingannya adalah 2,7 : 1, Pasien IMA yang memiliki kadar kolesterol total tinggi 79 orang (38,92%) dan normal 124 orang (61,08%), Pasien IMA yang memiliki kadar kolesterol LDL tinggi 76 orang (37,44%) dan normal 127 orang (62,56%), Pasien IMA yang memiliki kadar kolesterol HDL rendah 145 orang (71,43%) dan normal 58 orang (28,57%), dan Pasien IMA yang memiliki kadar trigliserida tinggi 44 orang (21,67%) dan normal 159 orang (78,33%).Kata kunci: infark miokard akut, kolesterol total, kolesterol LDL, Kolesterol HDL, trigliserida AbstractAcute Myocardial Infarction (AMI) is a muscle necrosis of the heart through disruption of demand and supply of oxygen to the heart suddenly. Risk factors of AMI is a change of lipid profile (Total Cholesterol, LDL Cholesterol, HDL Cholesterol, and Triglycerides) associated with the formation of atherosclerotic plaque. The benefit of this research is to reveal the lipid profile in patients with AMI. The objective of this study was to determine the description of lipid profile in patients with AMI at RSUP M. Djamil Padang period January 1st, 2011-December 31th, 2012. The study was conducted with descriptive methods to the design of cross sectional study at the Medical Records Department of RSUP M. Djamil Padang. The results of this study indicate that the most age of the patients of AMI 45-59 years old, the most gender of AMI are male and the ratio 2.7 : 1, AMI patients with high total cholesterol levels 79 people (38.92%) and normal 124 people (61.08%), AMI patients with high LDL cholesterol levels 76 people (37,44%) normal 127 people (62.56%), AMI patients with low HDL cholesterol levels 145 people (71.43%) and normal 58 people (28.57%), and AMI Patients with high triglyceride levels 44 people (21.67%) and normal 59 people (78.33%).Keywords: acute myocardial infarction, total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride

scholarly journals PERBANDINGAN KADAR KREATININ DAN ASAM URAT PADA SERUM DAN URIN PENDERITA HIPERTENSI DAN NORMOTENSI

Jurnal BIOMA ◽  
2015 ◽  
Vol 11 (2) ◽  
pp. 164
Author(s):  
Putri Octviani
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Clinical Chemistry ◽  
Mean Value ◽  
Cross Sectional ◽  
Ex Post ◽  
Ex Post Facto ◽  
Blood And Urine Samples ◽  
The Mean ◽  
Serum And Urine

ABSTRACT Hypertension is an increase  of  blood  pressure  over  140/90  mmHg.  Hypertensionin along  period of timecaninterfere withkidney function. Impaired kidney functioncan be caused byhigh levelsof uricacidin the bloodthatis directly associatedwithperipheralvascular resistanceandrenalvascular. Measurement ofrenal functioncan be measuredbycreatininetest, becauseconcentrations in serumandurineexcretionin24 hoursis relativelyconstant. The aim of this research was to measure and compare creatinine and uric acid on serum and urine in hypertensive and normotensive. The parameters were measured by Mindray BS-300 clinical chemistry analyzer. Ex Post Facto used as method and Cross- sectional used as design. A total of 36 blood and urine samples collected from Hypertensive (N1=18) and normotensive (N2=18) from February to March 2014. SPSS 16.0 was used to analyze the datas, t-test was used to compare value of creatinine urine and uric acid serum while U Mann-Whitney test was used to compare value of creatinine serum. The result of this research showed that the mean value of creatinine serum was 0.80 mg/dL in hypertensive and 0.86 mg/dL in normotensive (p=0.14). The mean value of creatinine urin was 87.28 mg/dL in hypertensive and 74.47 mg/dL in normotensive (p=0.35). The mean value of uric acid serum was 4.06 mg/dL in hypertensive and 4.5 mg/dL in normotensive (p=0.41). The resultsofthe urineuricacidwere foundnegativeofthe presence ofuricacid crystals.In conclusion, there was no different of creatinine and uric acid on serum and urine in hypertensive and normotensive.   Keywords: hypertension, normotensive, creatinine, uric acid

scholarly journals Deranged Serum Fasting Lipid Profile in Children and Adolescent with Thalassemia Major

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4899-4899 ◽  
Author(s):  
Sadia Sultan ◽  
Syed Mohammed Irfan ◽  
Rozina Zeeshan
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Ferritin ◽  
Total Lipid ◽  
Ldl Cholesterol ◽  
Hematological Parameters ◽  
Hdl Cholesterol ◽  
Thalassemia Major ◽  
Cholesterol Ratio ◽  
The Mean

Abstract Introduction: Serum fasting lipid profile has been studied in various clinical spectrum of β-thalassemia syndrome. Premature cardiac impairment in thalassemia major (TM) appears primarily due to iron accumulation and oxidative injury; however it might be a sequel of abnormal lipoprotein concentrations. Recent studies revealed impaired lipid profile and atherosclerosis in TM as an emerging complication in patients with prolonged survival. As these children are at risk of premature atherosclerosis, sub clinical atherosclerosis probably begins early in their life might evolve into coronary heart diseases in later life. The rational of this prospective cross sectional study is to analyze the serum fasting lipid profile in cardiovascular disease free thalassemia major patients and to establish any correlation with age, gender, hematological parameters, liver enzymes and serum ferritin. Method: The study group comprises of thirty six patients with β-thalassemia major, who were enrolled from March 2012 to March 2014. Fasting blood lipid levels (total lipid, cholesterol, triglycerides, HDL and LDL-cholesterol), liver function test and serum ferritin were measured in all study participants on Hitachi 912 through photometric assay (for lipid profile and liver function test) and by immunoturbidity methodology for serumferritin. Hematological parameters were determined by Cell Dyne Ruby (Abbot, Architect, USA). Patients were stratified in two groups, age ≤ 15 years and >15 years, to determine the possible lipid profile distinction in relation to increasing age. Results: Of the 36 patients, 17 were males (15.5±5.9 years) and 19 were females (10.1±4.5 years) with the mean age of 12.69±5.85 (range 5-24) years. Mean hemoglobin was 7.4±1.9gm/dl with the hematocrit of 23.1±5.7% while serum ferritin was markedly elevated 4699.7±3089ng/ml. The mean total lipid, cholesterol and triglycerides levels were 494.7 ± 114.5, 90.3 ±23.9 and 150.5±95.1 mg/dl respectively. High triglycerides were detected in 36.1%. While HDL cholesterol and LDL cholesterol were markedly low 17.7±9.2 and 42.3±22.0 mg/dl respectively. The mean total cholesterol to HDL ratio was significantly elevated, 6.21± 3.06 (normal <5.0). In addition, total-cholesterol to HDL-cholesterol ratios were increased irrespective of gender, that is 6.0±2.0 and 6.4± 3.8 in males and females respectively (P=0.6). Data analysis revealed that 22.2% females and 13.8% males had high triglyceride levels (P=0.05). No statistically significant difference was noted in two stratified age groups in respect to lipid profile (table-1). We established positive correlation of elevated total bilirubin with cholesterol, HDL and LDL cholesterol (P<0.05). Cholesterol ratio was also significantly high in patients with hemoglobin > 8gm/dl (P<0.05). Low HDL cholesterol was correlated positively with LDL cholesterol levels. While no significant correlation of serum lipid could be established with age, gender, high ferritins and with liver enzymes. Conclusion: Our study revealed that lipid profile impairment is not unusual in β-thalassemia major patients irrespective of age. Considerable deficiency of high density cholesterol and significantly high total-cholesterol to HDL-cholesterol ratio may strongly be associated with occurrence of coronary heart disease in later life. We propose that lipid profile should be regularly done in these patients particularly those with hemoglobin > 8gm/dl and high total bilirubin levels. Whilst total to HDL ratio, underlines as a significant diagnostic marker for future cardiac events in these patients. Keywords: β-thalassemia major, triglyceride, HDL-cholesterol, LDL-cholesterol. Table 1: Comparative analysis of serum lipid profile in relation to age Parameters Age ≤15 years n= 24 Age >15 years n= 12 P- value Total lipid 515.7± 121.1 452.9 ±90.6 0.1 * Cholesterol 95.0±17.6 80.9±32.1 0.09 * Serum triglyceride 168.1 ± 109.7 115.2± 40.1 0.1 * HDL cholesterol 19.4±10.2 14.4± 5.9 0.1 * LDL cholesterol 43.1±19.9 40.9±26.6 0.7 * Cholesterol ratio 6.3± 3.4 6.0 ±2.1 0.8 * *Not significant Disclosures No relevant conflicts of interest to declare.

scholarly journals Gambaran Profil Lipid pada Pasien Sindrom Koroner Akut di Rumah Sakit Khusus Jantung Sumatera Barat Tahun 2011-2012

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Fitri Zahara ◽  
Masrul Syafri ◽  
Eti Yerizel
Keyword(s):  
Acute Coronary Syndrome ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
High Level ◽  
Heart Hospital

AbstrakPenyakit kardiovaskuler merupakan penyebab kematian nomor satu secara global. Salah satu penyakit kardiovaskuler itu adalah Sindrom Koroner Akut (SKA) yang merupakan keadaan gawat darurat dari Penyakit Jantung Koroner (PJK). Salah satu faktor risiko SKA adalah perubahan dari kadar fraksi lipid yaitu kolesterol total, kolesterol LDL, kolesterol HDL, dan trigliserida yang dikaitkan dengan pembentukan plak aterosklerosis. Penelitian ini bertujuan untuk mengetahui gambaran profil lipid pada pasien SKA di rumah sakit khusus jantung Sumatera Barat tahun 2011-2012. Telah dilakukan penelitian deskriptif dengan bentuk cross sectional study dan pendekatan retrospective menggunakan data rekam medik mengenai hasil pemeriksaan profil lipid (kolesterol total, HDL, LDL, dan trigliserida) di rumah sakit khusus jantung Sumatera Barat untuk mengetahui gambaran profil lipid pada pasien SKA tahun 2011-2012. Hasil penelitian ini menemukan 98 kasus SKA. hasil ini menunjukkan bahwa pasien SKA dengan kadar kolesterol total tinggi adalah 44 orang (44,9%) dan normal sebanyak 54 orang (55,1%), pasien SKA dengan kadar kolesterol HDL rendah adalah 63 orang (64,3%) dan normal sebanyak 35 orang (35,6%), pasien SKA dengan kadar kolesterol LDL tinggi adalah 44 orang (44,9%) dan normal sebanyak 54 orang (55,1%), dan pasien SKA dengan kadar trigliserida tinggi adalah 21 orang (21,4%) dan normal sebanyak 77 orang (78,6%). Kejadian SKA terbanyak adalah STEMI sebanyak 51 kasus (52%), kemudian NSTEMI sebanyak 24 kasus (24,5%) dan yang paling sedikit adalah angina pektoris tak stabil sebanyak 23 kasus (23,5%) frekuensi umur terbanyak dari pasien SKA adalah 40-59 tahun, jenis kelamin terbanyak dari pasien SKA adalah laki-laki sekitar 74,5%. Penelitian menunjukkan jumlah bahwa pasien SKA yang memiliki kadar kolesterol total yang tinggi lebih sedikit daripada yang normal, kadar kolesterol HDL yang rendah lebih banyak daripada yang normal, kadar kolesterol LDL yang tinggi lebih sedikit daripada yang normal, kadar trigliserida yang tinggi lebih sedikit daripada yang normal, kasus SKA terbanyaKata kunci: Sindrom Koroner Akut, kolesterol total, kolesterol LDL, kolesterol HDL, trigliseridaAbstractCardiovascular diseases are the number one cause of death globally. One of the cardiovascular disease is Acute Coronary Syndrome (ACS) which is a state of emergency from Coronary Heart Disease (CHD). One of the risk factors for ACS is a change in the levels of lipid fractions such as total cholesterol, LDL Cholesterol, HDL Cholesterol and triglycerides which are associated with the formation of atherosclerotic plaque. This study aims to determine description of lipid profile in patients with acute coronary syndrome at the heart hospital of west sumatera 2011-2012. Descriptive research has been conducted with a a cross-sectional study and a retrospective approach using medical record about the result of lipid profile test (total cholesterol, HDL, LDL, and triglycerides) at the heart hospital of West Sumatera to describe the lipid profile in patients with ACS in 2011-2012. The results of this study found 98 cases of ACS. It showed that ACS patients with high total cholesterol levels are 44 people (44,9%) and normal are 54 people (55,1%), acute coronary syndrome patients with low levels of HDL cholesterol are 63 people (64,3%) and normal are 35 people (35,6%), acute coronary syndrome patients with high levels of LDL cholesterol are 44 people (44,9%) and normal are 54 people (55,1%), acute coronary syndrome patients with high levels of triglyceride are 21 people (21,4%) and normal are 77 people (78,6%), the highest incidence of SKA is STEMI with 51 cases (52%), then NSTEMI with 24 cases (24,5%) and the lowest incidence is unstable angina pectoris with 23 cases (23,5%), most age of the patients of ACS are 40-59 years old, the most gender of ACS are male about 74,5%. Research shows that the number of ACS patients who have a high level of total cholesterol are less than normal, low levels of HDL cholesterol are more than normal, high level of LDL cholesterol are less than normal, high level of triglyceride are less than normal, most incidens of ACS is STEMI then NSTEMI and the lowest is unstable angina pectoris, most age of ACS patients are 40-59 years, and most of gender are men.Keywords:acute myocardial infarction, total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride

scholarly journals Profil lipid wanita menopause di Panti Werdha Damai Manado

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Prisilia D. D. Sumoked ◽  
Hermie M. M. Tendean ◽  
Eddy Suparman
Keyword(s):  
Lipid Profile ◽  
Cholesterol Level ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Reference Value ◽  
Hdl Cholesterol ◽  
Mean Value ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Menopausal Women

Abstract: In Indonesia, women over the age of 50 years that will become menopause in 2020 are estimated as many as 30.3 million people. A decline in estrogen level at menopause will affect the functions of the female reproductive system as well as of the other body systems, including lipid metabolism. This study was aimed to determine the lipid profile of menopausal women at Panti Werdha Damai (senior housing) Manado. This was a descriptive, prospective, and observational study with a cross sectional design. There were 30 menopausal women obtained by using purposive sampling method. Lipid profile was examined at Prodia Laboratorium Manado. Data were analyzed by using SPSS 20. The results showed that most respondents (86.7%) were ≥65 years old. There were 21 women (70%) with total cholesterol level >200 mg/dl (mean value of 211.2 mg/dl); 27 women (90%) with LDL-cholesterol level >100 mg/dl (mean value of 137.8 mg/dl); 25 women (83.3%) with HDL cholesterol >40 mg/dl (mean value of 50.9 mg/dl); and 26 women (87.7%) with triglyceride level <150 mg/dl (mean value of 111.4 mg/dl). Conclusion: Most of the menopausal women at Panti Werdha Damai Manado were at the age of ≥65 years. The average values of total and LDL cholesterol were above the reference value, meanwhile the average values of HDL cholesterol and triglycerides were within normal limit. Keywords: menopausal women, lipid profile. Abstrak: Di Indonesia perempuan yang berusia lebih dari 50 tahun telah memasuki menopause pada tahun 2020 diperkirakan sebanyak 30,3 juta orang. Saat menopause terjadi penurunan estrogen yang tidak hanya memengaruhi fungsi sistem reproduksi wanita, tetapi juga terhadap sistem tubuh lainnya antara lain metabolisme lipid. Penelitian ini bertujuan untuk mengetahui profil lipid wanita menopause di Panti Werdha Damai Manado. Jenis penelitian ialah observasional serta deskriptif prospektif dengan desain potong lintang. Didapatkan 30 wanita menopause dengan menggunakan metode purposive sampling dan dilakukan pemeriksaan profil lipid di Laboratorium Prodia Manado. Data dianalisis menggunakan SPSS 20. Hasil penelitian memperlihatkan bahwa sebagian besar responden (86,7%) berusia ≥65 tahun. Kadar kolesterol total terbanyak ialah >200 mg/dl berjumlah 21 orang (70%) dengan nilai rerata 211,2 mg/dl. Kadar kolesterol LDL terbanyak ialah >100 mg/dl pada 27 orang (90%), nilai rerata 137,8 mg/dl. Kadar kolesterol HDL terbanyak ialah >40 mg/dl pada 25 orang (83,3%), nilai rerata 50,9 mg/dl. Kadar trigliserida terbanyak ialah <150 mg/dl pada 26 orang (86,7%), nilai rerata 111,4 mg/dl. Simpulan: Sebagian besar wanita menopause di Panti Werdha Damai Manado berusia ≥65 tahun dengan nilai rerata kolesterol total dan kolesterol LDL berada di atas nilai rujukan sedangkan nilai rerata kolesterol HDL dan trigliserida sesuai nilai rujukan.Kata kunci: wanita menopause, profil lipid

scholarly journals Correlation estradiol levels and physical activities with lipid profile levels of premenopausal women, in Padang city, Indonesia

2019 ◽  
Vol 7 (5) ◽  
pp. 1406
Author(s):  
Hafizah Hafizah ◽  
Afriwardi Afriwardi ◽  
Fika Tri Anggraini ◽  
Delmi Sulastri
Keyword(s):  
Physical Activity ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Ldl Cholesterol ◽  
Premenopausal Women ◽  
Hdl Cholesterol ◽  
Lipid Profiles ◽  
The Mean ◽  
Estradiol Levels

Background: In premenopausal women, low estradiol levels and lack of physical activity can result in dyslipidemia. Dyslipidemia is a risk factor for coronary heart disease (CHD). The incidence of CHD occurs a lot in premenopausal age compared to productive age, the percentage of women who experience higher CHD than men. Objective was to determine the correlation of estradiol levels and physical activity with lipid profiles in premenopausal women in Padang City.Methods: This research was carried out in Padang City. The study was observational, cross-sectional design. The study sample was 79 premenopausal women. Estradiol levels were assessed by the ELISA method, physical activity was assessed by an international physical activity (IPAQ) questionnaire, lipid profiles were assessed by colorimetric enzymatic methods. Correlation of estradiol levels with lipid profile levels were analyzed using the Pearson correlation test. Correlation of physical activity with lipid profile level using the ANOVA test.Results: The mean estradiol level of respondents was 144.68pg/ml, the mean physical activity of respondents is heavy physical activity as much as 41.8%, the mean cholesterol level of respondents was 194.76mg/dl, the mean triglyceride level of respondents was 118.75mg/dl, the mean LDL cholesterol level of respondents was 120.64mg/dl, the mean HDL cholesterol level was 53.18mg/dl.Conclusions: There were significant correlation between estradiol levels with triglyceride levels and LDL cholesterol. There was significant correlation physical activity with total cholesterol levels and triglyceride levels. There was no correlation between estradiol levels with total cholesterol and HDL cholesterol. There was no correlation physical activity with LDL cholesterol and HDL cholesterol.

ESTABLISHING REFERENCE INTERVALS FOR LIPID PROFILE IN HEALTHY ADULT POPULATION OF AMBALAPPUZHA NORTH GRAMA PANCHAYATH, ALAPPUZHA, KERALA.

2021 ◽  
pp. 7-11
Author(s):  
Saleena Prameela CR ◽  
Bindu Gopinathan Nair ◽  
Shamha Beegum M ◽  
Kezia Blessinda R
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Healthy Adult ◽  
Clinical Chemistry ◽  
Adult Population ◽  
Hdl Cholesterol ◽  
Reference Intervals ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Apparently Healthy

Introduction: We established reference intervals for serum lipids in an apparently healthy adult population of Ambalappuzha North Grama panchayath in Alappuzha district of Kerala. Methods: This cross-sectional study was done on 447 apparently healthy individuals of both sexes aged between 18-75 years who attended a health camp organized by the Department of Biochemistry, Government T.D. MedicalCollege in association with the Ambalappuzha North Grama Panchayath.Samples were analyzed in a Beckman Clinical chemistry analyzer. Mean, standard deviation, median,90% condence limits for th th th median and central 95 percentile were calculated. The 2.5 and 97.5 percentiles formed the lower and upper reference limits of population. Statistical analysis was done using SPSS ver.16 software. Results:Reference interval for Total cholesterol was 132.2-262 mg/dl, for HDL-cholesterol 28.2-62 mg/dl ,for LDL-cholesterol 66.2-175 mg/dl, for triglyceride 65-218.8 mg/dl, for VLDL 13-43.8 mg/dl and Total cholesterol/HDL-cholesterol ratio 2.67 – 6.4.Reference intervals for Total cholesterol,LDL-cholesterol and Triglyceride were higher than the desirable limits suggested by NCEP ATP III guidelines and the reference intervals established by many studies. There was a gradual increase in these parameters with age up to 60 years. The reference intervals for HDLcholesterol were lower in both males and females. Total cholesterol and LDL-cholesterol were higher in females compared to males. Conclusion:There exists difference in reference intervals for various populations and hence there is a need for more population studies so that reference ranges for lipid parameters can be established which will help in better health care.

scholarly journals Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints—A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine

2016 ◽  
Vol 62 (7) ◽  
pp. 930-946 ◽  
Author(s):  
Børge G Nordestgaard ◽  
Anne Langsted ◽  
Samia Mora ◽  
Genovefa Kolovou ◽  
Hannsjörg Baum ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Familial Hypercholesterolemia ◽  
Apolipoprotein B ◽  
Ldl Cholesterol ◽  
Clinical Chemistry ◽  
Hdl Cholesterol ◽  
Lipid Profiles ◽  
Apolipoprotein A1 ◽  
Lipoprotein A ◽  
Remnant Cholesterol

Abstract AIMS To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. METHODS AND RESULTS Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that the maximal mean changes at 1–6 h after habitual meals are not clinically significant [+0.3 mmol/L (26 mg/dL) for triglycerides; −0.2 mmol/L (8 mg/dL) for total cholesterol; −0.2 mmol/L (8 mg/dL) for LDL cholesterol; +0.2 mmol/L (8 mg/dL) for calculated remnant cholesterol; −0.2 mmol/L (8 mg/dL) for calculated non-HDL cholesterol]; concentrations of HDL cholesterol, apolipoprotein A1, apolipoprotein B, and lipoprotein(a) are not affected by fasting/non-fasting status. In addition, non-fasting and fasting concentrations vary similarly over time and are comparable in the prediction of cardiovascular disease. To improve patient compliance with lipid testing, we therefore recommend the routine use of non-fasting lipid profiles, whereas fasting sampling may be considered when non-fasting triglycerides are &gt;5 mmol/L (440 mg/dL). For non-fasting samples, laboratory reports should flag abnormal concentrations as triglycerides ≥2 mmol/L (175 mg/dL), total cholesterol ≥5 mmol/L (190 mg/dL), LDL cholesterol ≥3 mmol/L (115 mg/dL), calculated remnant cholesterol ≥0.9 mmol/L (35 mg/dL), calculated non-HDL cholesterol ≥3.9 mmol/L (150 mg/dL), HDL cholesterol ≤1 mmol/L (40 mg/dL), apolipoprotein A1 ≤1.25 g/L (125 mg/dL), apolipoprotein B ≥1.0 g/L (100 mg/dL), and lipoprotein(a) ≥50 mg/dL (80th percentile); for fasting samples, abnormal concentrations correspond to triglycerides ≥1.7 mmol/L (150 mg/dL). Life-threatening concentrations require separate referral for the risk of pancreatitis when triglycerides are &gt;10 mmol/L (880 mg/dL), for homozygous familial hypercholesterolemia when LDL cholesterol is &gt;13 mmol/L (500 mg/dL), for heterozygous familial hypercholesterolemia when LDL cholesterol is &gt;5 mmol/L (190 mg/dL), and for very high cardiovascular risk when lipoprotein(a) &gt;150 mg/dL (99th percentile). CONCLUSIONS We recommend that non-fasting blood samples be routinely used for the assessment of plasma lipid profiles. Laboratory reports should flag abnormal values on the basis of desirable concentration cutpoints. Non-fasting and fasting measurements should be complementary but not mutually exclusive.

scholarly journals A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup

2017 ◽  
Vol 21 (2) ◽  
pp. 73-75
Author(s):  
S Vinod Babu ◽  
Anusha R Jagadeesan ◽  
Jothimalar Ramalingam
Keyword(s):  
Comparative Study ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
P Value ◽  
Health Checkup ◽  
Group I ◽  
Significant Difference

ABSTRACT Introduction Obesity is emerging as an epidemic worldwide. Obesity is associated with a number of comorbid conditions, such as diabetes mellitus, hypertension, cancer, dyslipidemia, cardiovascular abnormalities, anemia, obstructive sleep apnea, and psychosocial abnormalities. Aim This study aims at comparing the lipid profile levels of obese and nonobese men. Materials and methods This was a case—control study conducted at a tertiary care center. Totally, 80 men in the age group of 20 to 47 years attending the master health checkup were included in the study, out of which 40 men with normal body mass index (BMI) of 18 to 25 belonged to group I and 40 men with increased BMI of 30 and above belonged to group II. Lipid profile parameters, such as triglycerides (TGLs), total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were estimated in them. The data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) software version 15.0. Results Statistically significant difference was found in the total cholesterol levels with a p-value of 0.040 while the difference in LDL cholesterol was statistically highly significant with a p-value of 0.040. Conclusion Among lipid profile parameters, only total cholesterol and LDL cholesterol showed significant difference between the obese and nonobese individuals. However, the other parameters like HDL cholesterol and TGLs did not show any significant difference. How to cite this article Babu SV, Jagadeesan AR, Ramalingam J. A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup. Indian J Med Biochem 2017;21(2):73-75.

scholarly journals Effects of Red Pitaya (Hylocereus polyrhizus) on Lipid Profile of Male White Rats (Rattus norvegicus) Receiving High Fat Diet

2018 ◽  
Vol 54 (1) ◽  
pp. 16 ◽  
Author(s):  
Wiwik Werdiningsih ◽  
Suhartati Suhartati
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Fruit Peel ◽  
Cholesterol Levels ◽  
White Rats ◽  
Wistar Strain ◽  
Dragon Fruit ◽  
Pap Method

Red dragon fruit (Hylocereus polyrhizus) peel contains anthocyanin, fiber and vitamin C, so it can be used to improve lipid profile in dyslipidemia. The peel of the dragon fruit is not durable, so in this study we used freeze-dried dragon fruit peel. The aim of this study was to prove that the administration of the red dragon fruit peel in a dose of 0.72 g/200 g BW, 1.08 g/200 g BW, and 1.44 g/200 g BW of rat per day for 28 days may improve lipid profile in male wistar strain white rats with high-fat diet. Lipid profiles were studied by examining of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. This was a pure experimental study using randomized post test only control group design. This study used experimental animal of 30 male wistar strain white rats which were divided into five groups. Measurements of total, LDL, and HDL cholesterol levels were done by CHOD-PAP method, while triglyceride level was measured with GPO-PAP method. Data were analyzed statistically by One Way Anova test. The results of this study indicated that giving the peel of red dragon fruit as much as 0.72 g lowered total cholesterol levels, 1.08 g lowered total and LDL cholesterol levels, and 1.44 g lowered total cholesterol, LDL cholesterol, triglyceride levels, and raised HDL cholesterol level. Red dragon fruit peel can be used alternatively to improve lipid profile in dyslipidemia.

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