scholarly journals Antifungal activity of Terminalia chebula fruit extracts

2020 ◽  
pp. 216-220
Author(s):  
P. Venkatachalam ◽  
C.V. Chittibabu
Keyword(s):  
Antifungal Activity ◽  
Trichophyton Mentagrophytes ◽  
Inhibition Zone ◽  
Phytochemical Analysis ◽  
Microsporum Gypseum ◽  
Terminalia Chebula ◽  
Dried Fruits ◽  
Methanol Extracts ◽  
Fruit Extracts ◽  
Methanolic Extracts

The present study was aimed to investigate the anticandidal and antifungal potential of dried fruit extracts of Terminalia chebula against Candida albicans, C. tropicalis C. glabrata, C. krusei, C. parapsilosis, and Aspergillus flavus, A. niger, A. fumigatus, Trichophyton mentagrophytes, T. rubrum, Microsporum gypseum. Phytochemical analysis of methanol extracts of T. chebula dried fruits showed the presence of flavonoids, alkaloids, glycosides, saponins, tannins, terpenoids and steroids. Among the tested four extracts, the methanol extracts of T. chebula dried fruits exhibited the highest antifungal activity and their inhibition zone was ranged between 7.5 to 19.5mm. MIC and MFC values were between 62.5-250μg/ml and 250-500μg/ml respectively. Zone of inhibition (19.5 mm), MIC (62.5µg/ml) and MFC (125µg/ml) values observed in methanolic extracts of T. chebula dried fruits against A. fumigates and T. mentagrophytes. Our findings proved that methanolic extracts of T. chebula dried fruits were possessed substantial anticandidal and antifungal properties.

scholarly journals Antifungal Activity of Euclea divinorum Root and Study of its Ethnobotany and Phytopharmacology

Processes ◽  
2019 ◽  
Vol 7 (10) ◽  
pp. 680 ◽  
Author(s):  
Al-Fatimi
Keyword(s):  
Antifungal Activity ◽  
Plant Root ◽  
Pathogenic Fungi ◽  
Microsporum Gypseum ◽  
Root Bark ◽  
Ethnobotanical Survey ◽  
Traditional Use ◽  
Absidia Corymbifera ◽  
Methanolic Extracts ◽  
Antibiotic Drug

The ethnobotanical survey of Euclea divinorum Hiern (Ebenaceae) was conducted on Soqotra Island, Yemen. The root bark is used to treat mouth, dental, dermal and blood diseases in the traditional medicine of the island. The study is the first report about the effect of the plant root barks against six human pathogenic fungi. The non-polar dichloromethane extract of Euclea divinorum root bark showed stronger antifungal activities compared to polar direct and sequential methanolic extracts. These extracts showed significant broad antifungal activity against Absidia corymbifera, Aspergillus fumigatus, Candida krusei, Microsporum gypseum, Mucor sp. and Trichophyton mentagrophytes compared to the standard antibiotic drug nystatin. Thin-layer chromatography (TLC) revealed the presence of the naphthoquinones in the extracts. The results showed an extraction process to separate most antifungal naphthoquinones from the root bark by using non-polar solvent dichloromethane, while flavonoids remained in the polar methanolic extracts; therefore, the polar sequential and direct methanolic extracts recorded higher antioxidant activity than the non-polar extracts with less toxicity. The biological and chemical results identified the presence of antifungal and antioxidant constituents in the root bark and confirm its traditional use in Soqotra Island as crude powder to treat dental and dermal diseases and to clean teeth. Moreover, our results are compared with literature review on ethnobotany and phytopharmacology of the E. divinorum to present a medicinal monograph about the plant.

scholarly journals Antifungal Activity of Fruit Extracts of Different Water Chestnut Varieties

2011 ◽  
Vol 3 (1) ◽  
pp. 61-64
Author(s):  
Mohammad ANOWAR RAZVY ◽  
Ahmad Humayan KABIR ◽  
Mohammad AMINUL HOQUE
Keyword(s):  
Antifungal Activity ◽  
Inhibition Zone ◽  
Fungal Species ◽  
Fruit Extracts ◽  
Water Chestnut ◽  
Wild Variety ◽  
And Control

The antifungal activity of three varieties (red, green and wild) of water chestnut fruit extracts was studied against a number of fungal species. A strong antifungal activity of ethanol and petroleum extract was found against the treated fungi resulting remarkable inhibition zone in comparison to both Dithane-M45 fungicide and control. It has also been evident that wild variety of water chestnut was comparatively more efficient in respect to antifungal activity compared to the red and green variety of the same plant.

scholarly journals ARGINASE INHIBITORY ACTIVITY OF STEM BARK EXTRACTS OF CAESALPINIA TORTUOSA ROXB

2018 ◽  
Vol 10 (1) ◽  
pp. 130
Author(s):  
Amirah Najid ◽  
Berna Elya ◽  
Arikadia Noviani
Keyword(s):  
Ethyl Acetate ◽  
Inhibitory Activity ◽  
Phenolic Content ◽  
Colorimetric Method ◽  
Stem Bark ◽  
Phytochemical Analysis ◽  
Standard Drug ◽  
Methanol Extracts ◽  
Methanolic Extracts ◽  
Ic50 Values

Objective: This study aimed to evaluate the arginase inhibitory activity of Caesalpinia tortuosa Roxb. stem bark extracts.Methods: C. tortuosa Roxb. stem bark extracts were obtained through reflux extraction using n-hexane, ethyl acetate, and methanol and theirinhibitory activity against arginase was measured using a microplate reader at 430 nm. Active extracts were subjected to phytochemical analysisand based on the qualitative phytochemical analysis, quantitative data regarding flavonoid and phenolic contents were obtained. The total flavonoidcontent of active extracts was determined using AlCl3 colorimetric method, and the phenolic content was determined using Folin–Ciocalteu method.Results: Ethyl acetate and methanol extracts of C. tortuosa Roxb. inhibited activity of arginase with IC50 values of 33.81 and 11.58 μg/mL,respectively, nor-NOHA acetate as standard drug inhibited arginase with IC50 values of I3.77 μg/mL. Both active extracts contained saponins,tannins, and flavonoids. Ethyl acetate and methanol extracts showed a total flavonoid content of 7.41 mgQE/g and 5.05 mgQE/g and totalphenolic content of 27.55 mgGE/g and 17.16 mgGE/g, respectively. Methanol extracts had a higher inhibitory activity than ethyl acetateextracts despite having flavonoid and phenolic content, thereby suggesting no correlation between arginase inhibitory activity and flavonoidor phenolic content.Conclusion: Ethyl acetate and methanolic extracts of C. tortuosa Roxb. stem barks containing flavonoids, tannins, and saponins displayed arginaseinhibitory activity, and no correlation was observed between arginase inhibitory activity and flavonoid and phenolic content.

scholarly journals In vitro antioxidant activity and qualitative phytochemical analysis of two Vismia (Hypericaceae) species collected in Los Andes, Venezuela

2016 ◽  
Vol 64 (4) ◽  
Author(s):  
Alexis Buitrago ◽  
Janne Del Carmen Rojas ◽  
Yonel Peñalosa
Keyword(s):  
Antioxidant Activity ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Methanol Extracts ◽  
Phenol Derivatives ◽  
Methanolic Extracts ◽  
High Concentrations

Vismia genus is distributed mainly in tropical and subtropical regions of Central, South America and some areas of Africa. According to previous investigations, antioxidant potential of Vismia species might be related to anthrones, anthraquinones, flavonoids and phenol derivatives biosynthesized by these plants. The aim of present study is to evaluate the free radical scavenging capacity, total phenolic and flavonoids content as well as the qualitative phytochemical screening of methanol extracts obtained from Vismia macrophylla (VM) and Vismia baccifera (VB) collected in Táchira and Mérida state, Venezuela. Phytochemical screening of VB and VM methanolic extracts carried out using various chemical assays revealed an abundant presence of anthraquinones in both species analyzed. Glycosides were also present while flavones and dehydroflavones were observed abundantly in VB but moderated in VM. Triterpenes were also detected and steroids showed to be abundant in VM but moderate in VB. On the other hand, antioxidant capacity measured by the DPPH radical scavenging assay showed that VM possesses a stronger antioxidant activity than VB with IC50 5.50 µg/mL. Phenol and flavonoid assays also revealed that methanol extracts of both VM and VB contain high concentrations of these metabolites. A relationship between the antioxidant activity, total phenol and flavonoids content of the extracts analyzed was demonstrated in present investigation since those samples with higher phenolic concentrations showed likewise higher antioxidant activity.

scholarly journals Phytochemical Analysis and Biochemical Characterization f Terminalia Chebula Extracts For its Medicinal use

2019 ◽  
Vol 12 (3) ◽  
pp. 1525-1529
Author(s):  
Praveen Kumar Vemuri ◽  
Lohitha Dronavalli ◽  
Poojitha Nayakudugari ◽  
Ankitha Kunta ◽  
Rishitha Challagulla
Keyword(s):  
Biochemical Characterization ◽  
Methanolic Extract ◽  
Radical Scavenging ◽  
Maximum Activity ◽  
Free Radical Scavenging ◽  
Phytochemical Analysis ◽  
Terminalia Chebula ◽  
Promising Candidate ◽  
Methanolic Extracts ◽  
Medicinal Use

Alternative medicine has become popular these days as it is gaining practices across the globe. Our studies aim to detect phytocompounds and biochemical activities of aqueous, dichloro methane, ethyl acetate and methanolic extracts of Terminalia chebula. Antioxidant, flurorescence and anitmicrobial studies were carried out for the phytocompounds. Methonolic extracts at 517nm exhibited maximum activity with 82% of free radical scavenging property. Methanolic extract also showed highest antimicrobial activity towards S.aureus of 7mm and S.pyogenes of 6mm respectiviely. Hence, it can be concluded that Terminalia chebula may be a promising candidate in pharmaceuticals and future medicine.

scholarly journals In vitro Antifungal Activity of Combination of Miconazole, Salicylic Acid and Benzoic Acid in Two Different Bases against Trichophyton mentagrophytes

2020 ◽  
pp. 56-61
Author(s):  
Hassan Thoulfikar A. Alamir ◽  
M. E. L. A. Shayoub ◽  
Wisal G. Abdalla ◽  
Eltayeb Suliman Elamin
Keyword(s):  
Salicylic Acid ◽  
Antifungal Activity ◽  
Synergistic Effect ◽  
Benzoic Acid ◽  
Trichophyton Mentagrophytes ◽  
Inhibition Zone ◽  
In Vitro Activity ◽  
Inhibition Zones ◽  
In Vitro Antifungal Activity

In vitro activity of miconazole, salicylic acid and benzoic acid against T.richophyton mentagrophytes was done on Sabouraud’s dextrose agar. The inhibition zones were measured in cm. 2.8 cm, 1.5 cm and no inhibition zone were reported for miconazole, salicylic acid and benzoic acid respectively. Synergistic effect of salicylic acid and benzoic acid against T. mentagrophytes was done using two different bases of cream lanette 20% and aqueous cream 30/70. Four different formula each one contain 2% miconazole with different concentrations of salicylic acid and benzoic acid were used. Biggest inhibition zone (5 cm) was observed of lanette cream which contains 2% miconazole, 3% salicylic acid and 6% benzoic acid.

scholarly journals FRAKSI ETANOL EKSTRAK KULIT DURIAN (Durio zibethinus L.) SEBAGAI ANTIFUNGI TERHADAP Trichophyton mentagrophytes DAN Candida albicans

1970 ◽  
pp. 28-38
Author(s):  
Yuli Wahyu Tri Mulyani ◽  
Subur Widodo ◽  
Lisa Selviani
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Trichophyton Mentagrophytes ◽  
Inhibition Zone ◽  
Positive Control ◽  
Negative Control ◽  
Bark Extract ◽  
Chromatography Method ◽  
Durio Zibethinus ◽  
Ethanol Fraction

Durian is a fruit that is in demand by the community, but during durian season environmental problems arise due to waste from skin of durian. The aimed of the study was to prove the antifungal activity of the ethanol fraction of durian skin against Trichophyton mentagrophytes and Candida albicans and to determine the active active compounds inhibiting T. mentagrophytes and C. albicans fungi. Durian skin was extracted by maceration method, then fractionated used ethanol, chloroform, and n-hexane solvents. Ethanol fraction was tested on T. mentagrophytes and C. albicans fungi used the disc method with a concentration of 10%, 20%, 40%, 60%, 80%, 100%, distilled water as a negative control, ketoconazole as a positive control. The best inhibition zone is fungi T. mentagrophytes concentration 100% ( 9.23 mm) negative control (0 mm), positive control (32.96 mm), fungi C. albicans the best inhibition zone is concentration of 100% (8.30 mm), positive control (17.17 mm) negative controls (0 mm).The ethanol fraction was screened by the Thin Layer Chromatography method and positively contained flavonoids (rf 0.7), tannins (rf 0.58), saponins (rf 0.76) and alkaloids (rf 0.64). Minimum Inhibitory Concentrations of T. mentagrophytes were 7% and C. albicans were 8%. The most effective active compound growht of T. mentagrophytes is tannins (rf 0.7) and for C. albicans is flavonoid (rf 0.6). The ethanol fraction of durian bark extract has antifungal activity against T. mentagrophytes and C. albicans. Keywords: Antifungi, Candida albicans, ethanol fraction skin of durian, Trichophytonmentagrophytes

scholarly journals Antifungal activity of ethanolic extract of Sphaeranthus indicus Linn. against Dermatophytes and Candida species

2020 ◽  
Vol 9 (11) ◽  
pp. 1646
Author(s):  
Preeja K. Sundaresan ◽  
Kala P. Kesavan
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
Skin Diseases ◽  
Ethanolic Extract ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Gypseum ◽  
Whole Plant ◽  
Antifungal Action ◽  
Sphaeranthus Indicus

Background: Sphaeranthus indicus as an entire plant or the specific parts like roots, leaves, flowers are used for treating helminthiasis, jaundice, diabetes, dyspepsia, fever, cough, hernia, gastritis, hemorrhoids, migraine, leprosy and skin diseases. The objective of this study was to evaluate the antifungal activity of ethanolic extract of the whole plant Sphaeranthus indicus Linn. Methods: The antifungal activity of ethanolic extract of the whole plant Sphaeranthus indicus Linn was evaluated by incorporating the extract in Sabourauds dextrose agar. This property was studied in vitro using the ethanolic extract on Candida albicans, Microsporum gypseum, Trichophyton mentagrophytes and Epidermophyton floccosum by using Clotrimazole as standard drug.Results: This study revealed that the ethanolic extract of Sphaeranthus indicus is having good antifungal activity against Dermatophytes and Candida species. Conclusions: This study demonstrates the promising antifungal action of ethanolic extract of whole plant of Sphaeranthus indicus Linn. This feature can be exploited in the development of a newer antifungal agent from plant. 

scholarly journals In Vitro Antifungal Activity of Hexahydropyrimidine Derivatives against the Causative Agents of Dermatomycosis

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Francislene J. Martins ◽  
César A. Caneschi ◽  
Mônica P. Senra ◽  
Gustavo S. G. Carvalho ◽  
Adilson D. da Silva ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Morphological Changes ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Scanning Electron Micrographs ◽  
Epidermophyton Floccosum ◽  
Synthetic Drugs ◽  
Causative Agents

Nitrogenated heterocyclic compounds are present in both natural and synthetic drugs, and hexahydropyrimidine derivatives may prove to be efficient in treating dermatomycosis causing fungi. This study evaluated the antifungal activity of four hexahydropyrimidine derivatives against the dermatomycosis causing fungi. These derivatives were synthesized, characterized, and assessed in terms of their activity against Trichophyton mentagrophytes, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Fusarium oxysporum, and Epidermophyton floccosum between concentrations 7.8 and 1,000 μg mL−1. Scanning electron micrographs were assessed for the active derivatives and reference drugs, and these micrographs revealed that new agents cause morphological changes in fungi. The derivatives HHP1, HHP3, and HHP4 revealed poor activity against the four fungal strains (MICs range 500–1000 μg mL−1). Compound HHP3 was found to be the best potential antifungal agent among those tested and was the most effective among all the active derivatives that caused morphological changes in the susceptible strains.

scholarly journals Antifungal Activity of Eugenia umbelliflora against Dermatophytes

2009 ◽  
Vol 4 (9) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Karina E. Machado ◽  
Valdir Cechinel Filho ◽  
Rosana C. B. Cruz ◽  
Christiane Meyre-Silva ◽  
Alexandre Bella Cruz
Keyword(s):  
Antifungal Activity ◽  
Betulinic Acid ◽  
Fungal Pathogens ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Epidermophyton Floccosum ◽  
Agar Dilution

Antifungal activities of Eugenia umbelliflora Berg. (Myrtaceae) were tested in vitro against a panel of standard and clinical isolates of human fungal pathogens (dermatophytes and opportunistic saprobes). Methanol extracts of leaves and fruits of E. umbelliflora were separately prepared and partitioned, to yield dichloromethane (DCM), ethyl acetate (EtOAc) and aqueous fractions (Aq). Three compounds (1-3) were obtained from the DCM extract using chromatographic procedures. Antifungal assays were performed using agar dilution techniques. Both extracts (fruits and leaves), their DCM and EtOAc fractions, and compound 2 (betulin and betulinic acid) presented selective antifungal activity against dermatophytes (Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Trichophyton mentagrophytes), with MIC values between 200 and 1000 μg/mL, and interestingly, inhibited 4/5 species with MIC values of ≤500 ≤g/mL. The aqueous fractions of fruits and leaves, and compounds 1 (α, β amyrin) and 3 (taraxerol) were inactive up to the maximum concentrations tested (1000 μg/mL).

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