Bone mineral density indices in Wistar female rats of different age with experimental hyperthyroidism

2018 ◽  
pp. 150-156
Author(s):  
В.В. Поворознюк ◽  
Н.В. Григорьева ◽  
И.В. Гопкалова
Keyword(s):  
Age Groups ◽  
Reproductive Age ◽  
Female Rats ◽  
Control Group ◽  
Mineral Density ◽  
Immature Female ◽  
X Ray ◽  
Hind Limbs ◽  
High Doses ◽  
Old Females

Гипертиреоз - одна из частых причин вторичного остеопороза. Изучение темпов потери костной ткани при гипертиреозе (тиреотоксикозе) в различных возрастных группах является важным и мало изученным процессом. Цель работы - изучение влияния длительного введения высоких доз L-тироксина на показатели минеральной плотности костной ткани самок-крыс в различные возрастные периоды. Методика. Исследование выполнено на 50 самках крыс Wistar 2 мес., 5-6 мес. и 24 мес. L-тироксин (25 мкг на 100 г) вводили внутримышечно в течение 30 сут. Животные были разделены на группы: неполовозрелые самки (контроль), неполовозрелые самки, получавшие L-тироксин; самки репродуктивного возраста (контроль), самки репродуктивного возраста, получавшие L-тироксин; старые самки (контроль), старые самки, получавшие L-тироксин. Прижизненное определение показателей минеральной плотности костной ткани (МПКТ) проводили на двухфотонном рентгеновском денситометре «Prodigy» (GE Mediсal systems, LUNAR, model 8743, 2005; USA; программа «Experimental animals») дважды (в начале эксперимента и через 30 сут.). Исследовали позвоночник, кости таза, задние конечности и показатель МПКТ всего скелета. Результаты. Установлено, что введение высоких доз L-тироксина статистически значимо увеличивает показатели МПКТ во всех отделах скелета только у неполовозрелых животных. У крыс репродуктивного возраста введение высоких доз L-тироксина вызывало снижение показателя МПКТ, при этом максимальная потеря костной ткани была выявлена на уровне позвоночника и задних конечностей. Снижение показателя МПКТ было статистически значимым не только по сравнению с соответствующим показателем контрольной группы, но и по сравнению с исходными значениями. У старых крыс гипертиреоз вызывал менее значимое повышение МПКТ. Заключение. Выявленные возрастные особенности динамики показателей МПКТ следует учитывать при интерпретации данных рентгеновской денситометрии, в частности при изучении экспериментального вторичного остеопороза вследствие тиреотоксикоза. Hyperthyroidism is one of the common causes of secondary osteoporosis in patients of different ages, so the study of the rate of bone loss in different age groups is very important and little studied. The purpose was to study the effect of prolonged administration of high doses of L-thyroxin on bone mineral density (BMD) parameters of different regions of the skeleton of Wistar female rats at different age periods. Methods. The study was performed on 50 female Wistar rats of three age groups (2 months, 5-6 months and 24 months). L-thyroxin in a dose of 25 mcg per 100 g of body weight, was administered intramuscularly for 30 days. The animals were divided into the following groups: immature females of the control group; Immature female rats who received L-thyroxine; rats of the reproductive age of the control group; rats of reproductive age who received L-thyroxine; Old females of the control group; Old females who received L-thyroxine. In-vivo determination of BMD parameters was performed on a two-photon x-ray densitometer «Prodigy» (GE Medial Systems, LUNAR, model 8743, 2005, USA, Experimental animals program) twice (at the beginning of the experiment and after 30 days). The following sections of the skeleton were examined: the spine, pelvic bones, hind limbs and the BMD index of the entire skeleton. Results. It was found that high doses of L-thyroxine significantly increases BMD indices in all parts of the skeleton only in immature female rats. High doses of L-thyroxine to the animals of reproductive age caused declines in BMD, maximum bone loss was detected at the level of the spine and hind limbs. The decline in BMD was statistically significant, not only in comparison with the corresponding index of the control group, but also in comparison with the baseline values. In old rats the hyperthyroidism caused less significant increase in BMD. Conclusion. Identified age features of the dynamics of BMD indices should be considered in the interpretation of X-ray densitometry data, in particular in the studies of the experimental secondary osteoporosis due to hyperthyroidism.

CTRP3 is Significantly Decreased in Patients with Primary Hyperparathyroidism and Closely Related with Osteoporosis

2019 ◽  
Vol 128 (03) ◽  
pp. 152-157
Author(s):  
Derya Demirtas ◽  
Fettah Acıbucu ◽  
Filiz Alkan Baylan ◽  
Erdinc Gulumsek ◽  
Tayyibe Saler
Keyword(s):  
Primary Hyperparathyroidism ◽  
Serum Levels ◽  
Dual Energy ◽  
Control Group ◽  
Mineral Density ◽  
Urine Calcium ◽  
X Ray ◽  
Complement C1q ◽  
Necrosis Factor

Abstract Background Adipokines derived from adipocytes are one of the important factors that act as circulating regulators of bone metabolism. Complement C1q/tumor necrosis factor-related protein-3 (CTRP3), a paralog of adiponectin, is are member of the CTRP superfamily. The aim of this study was to investigate the role of serum CTRP3 in the development of osteoporosis in patients with primary hyperparathyroidism. Methods This study included 53 patients with diagnosed primary hyperparathyroidism and 30 healthy controls. Laboratory tests for the diagnosis of primary hyperparathyroidism and serum levels of CTRP3 measured for all patients. Bone mineral density was obtained on lumbar spine 1 and 4 by dual energy X-ray absorptiometry. Results Serum CTRP3 levels were lower in patients with primary hyperparathyroidism than in the control group (p<0.001). In addition, primary hyperparathyroidism patients are were divided into two groups as, with and without osteoporosis; the levels of CTRP3 were lower in patients with osteoporosis than in patients without osteoporosis (p=0.004). In logistic regression analysis, only CTRP3 levels independently determined the patients to be osteoporosis (p<0.05). According to this analysis, decreased CTRP3 (per 1 ng/mL) levels were found to increase the risk of patients for osteoporosis by 6.9%. When the CTRP3 cut-off values were taken as 30 ng/mL, it determined osteoporosis with 76.4% sensitivity and 73.2% specificity. CTRP3 and urine calcium levels were independently associated with T score in dual energy X-ray absorptiometry. Conclusions CTRP3 levels were significantly decreased in patients with primary hyperparathyroidism, and it is also related to osteoporosis.

scholarly journals Effects of Greenshell Mussel (Perna canaliculus) Intake on Pathological Markers of Multiple Phenotypes of Osteoarthritis in Rats

2020 ◽  
Vol 10 (17) ◽  
pp. 6131
Author(s):  
Parkpoom Siriarchavatana ◽  
Marlena C. Kruger ◽  
Matthew R. Miller ◽  
Hong (Sabrina) Tian ◽  
Frances M. Wolber
Keyword(s):  
Normal Control ◽  
Control Diet ◽  
Female Rats ◽  
Control Group ◽  
Sham Operation ◽  
High Fat ◽  
Mineral Density ◽  
Perna Canaliculus ◽  
High Sugar ◽  
Ovx Rats

The prevalence of metabolic osteoarthritis has been increasing worldwide, particularly among women. The aim of this study was to investigate the effects of the New Zealand greenshell mussel (Perna canaliculus; GSM) on osteoarthritis (OA) prevention in a rat model. One-hundred-and-eight female rats aged 12 weeks were divided into four test groups, containing 24 rats each, plus an additional control group. Each test group received one of the four experimental diets: normal control diet (ND), normal control diet supplemented with GSM (ND + GSM), high fat/high sugar diet (HFHS), or high fat/high sugar diet supplemented GSM (HFHS + GSM), for 36 weeks (end of the study). After 8 weeks on experimental diets, half of each group was subjected to ovariectomy (OVX) and the remaining half received a sham operation (ovaries left intact). The study evaluated body composition, bone mass, plasma cytokines, adipokines, HbA1c, CTX-II, and knee joint’s histopathology. HFHS diet and OVX significantly induced body weight gain and leptin production. OVX rats lost bone mineral density but increased adiponectin, HbA1C, and MCP-1. The OVX rats fed HFHS showed the highest Mankin scores. Importantly, inclusion of GSM reduced these pathological features. In conclusion, GSM might be beneficial in halting the progression of OA.

scholarly journals Aortae of Young Rats with Metabolic Syndrome Exhibit Enhanced Vasoconstrictor Activity Than Older Rats

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R H Ali ◽  
N M B Gamil ◽  
A M Abdelrahman ◽  
M A Ahmed ◽  
G K Megahed ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Young Adult ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Functional Changes ◽  
Vasoconstrictor Response ◽  
Nitrite Content

Abstract Background Metabolic syndrome (MetS) causes pathological remodeling of the heart and adjacent vessels. The functional changes in the big vessels in different age groups had not been fully delineated. Aim of the work The present study was planned to investigate aortic vasodilator and vasoconstrictor reactivity in young, adult and old female rats with MetS. Design: The experimental study was performed on 90 female albino rats randomized into 6 groups: young, adult and old rats with MetS and their respective control groups. Methods MetS was induced by feeding rats 41% fructose -containing diet and giving fructose solution (5 g fructose in 4 ml distilled water/day) by gavage in two sessions (2 ml/session). On the 8th week, all rats were sacrificed and were subjected to determination of body weight (BW), body mass index (BMI), absolute and relative visceral fat weight (VF), fasting blood glucose (FBG), plasma insulin (PI), homeostasis model of insulin resistance (HOMA-IR) and plasma lipid profile. All rats’ aortae were subjected to study of vascular reactivity to Potassium chloride (KCL), phenylephrine (PE) and acetyl choline (A.Ch) as well as estimation of nitrite content. Results On the 8th week of the study, all MetS groups developed criteria of metabolic syndrome as evidenced by the significant increase in final BW, BMI, absolute and relative VF weights, FBG, PI and HOMA-IR compared to their control group values. Also, MetS rat groups exhibited evident dyslipidemia in the form of significant increase in plasma levels of triglycerides, total cholesterol and significant decrease in HDL-cholesterol compared to their control group values. Aortae of young and adult MetS rat groups showed significant increase in their vasoconstrictor response to KCl and PE and decrease in A.Ch/KCL% and A.Ch/PE % compared to their controls, while old MetS rat group showed significantly increased vasoconstrictor response only to KCL compared to their controls. When compared to each other, young age MetS group had significantly higher vasoconstrictor response to PE compared to old MetS group despite comparable nitrite content. Conclusion Met.S causes functional vascular changes in all age groups with unexpectedly enhanced vasoconstrictor response in the young group compared to old.

CIRCADIAN FLUCTUATIONS OF SERUM HORMONE LEVELS IN PREPUBERTAL MALE AND FEMALE RATS

1976 ◽  
Vol 83 (2) ◽  
pp. 269-279 ◽  
Author(s):  
K. D. Döhler ◽  
W. Wuttke
Keyword(s):  
Age Groups ◽  
Serum Testosterone ◽  
Female Rats ◽  
Serum Prolactin ◽  
Male And Female ◽  
Hormone Levels ◽  
Male And Female Rats ◽  
Serum Lh ◽  
Serum Hormone ◽  
Old Females

ABSTRACT Diurnal variations in serum hormone levels during 2 different stages of prepubertal development were investigated in male and female rats. Groups of 13 to 18 and 25 to 30 day old male and female rats were decapitated at 4-hour by intervals during a period of 24 h. Their blood was collected and hormones were measured by radio-immunoassay. FSH levels were constantly high in 13 to 18, but low in 25 to 30 day old females. FSH was low in younger males, and significantly higher but without diurnal fluctuations in the older males. Serum LH was low in approximately 40% of the 13 to 18 day old females, while 40% had moderately high levels, and the remaining females extremely high levels of the hormone. Most of the extremely high LH peaks were found at 15.00 h and some at 03.00 h. Older females and males of both age groups had constantly low serum LH levels. Serum oestradiol was high in males and females during days 13 to 18, but it was lower in the 25 to 30 day old animals. In the young females prolactin was slightly elevated between 15.00 h and 19.00 h, while in the males the serum prolactin fluctuations were not significant. Serum testosterone was low in females at all times. The 13 to 18 day old males had higher testosterone levels than the 25 to 30 day old males. Both groups showed slight, but insignificant fluctuations in serum testosterone. These results confirm result published previously and furthermore they demonstrate the existence of circasemedian or circadian rhythms for both the gonadotrophins and gonadal steroids. These results, also suggest that the maturation of the positive feedback action of oestradiol on gonadotrophin release in female rats occurs between day 10 and 20.

scholarly journals Bone changes during and after treatment of childhood acute lymphoblastic leukaemia

2021 ◽  
Vol 20 (1) ◽  
pp. 54-57
Author(s):  
S. Ragab ◽  
B. Montaser ◽  
N. El-Ashmawy ◽  
M. El-Hawy
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Normal Population ◽  
Serum Insulin ◽  
Lymphoblastic Leukemia ◽  
Dual Energy ◽  
Anthropometric Measurement ◽  
Control Group ◽  
Mineral Density ◽  
Childhood All ◽  
X Ray

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with a survival rate of 80%. Major complications of leukemia include osteoporosis that requires both a clinically significant fracture history and low bone mineral density (BMD). The present study aims to assess BMD among acute lymphoblastic leukemia patients and survivors using dual-energy x-ray absorptiometry and serum insulin growth factor binding protein 3. The study was approved by the Independent Ethics Committee and the Scientific Council of the Menoufia University, Egypt. Thirty patients with ALL and thirty survivors who were diagnosed with ALL but completely recovered were enrolled in this study. Sex and age matched normal controls while full history was taken. Patients and survivors were examined for anthropometric measurement. Laboratory including serum IGFBP3and dual-energy x-ray absorptiometry was done for all. It has been found out that patients and survivors showed a markedly lower BMD than normal population but no history of fracture was found in survivors. In this study, the prevalence of low BMD is 26/30 (86.6%) patients and 25/30 (83.3%) survivors. Also, there was a statistically significant decrease of DEXA scan measures in patients and survivors groups than the control group with a statistically significant decrease in both BMD and Z- score measures in patients and survivors groups than control group. Patients and long-term survivors of childhood ALL are at risk for morbidity associated with low BMD. They may benefit from interventions to optimize bone health as they age. 

Possibilities of using neodymium laser to improve the condition of vaginal mucosa in women of various ages with initial stages of genital prolapse

2021 ◽  
pp. 61-69
Author(s):  
Ekaterina Nikolaevna Zhumanova ◽  
Dagmara Isaevna Kolgaeva ◽  
Tatyana Vladimirovna Shapovalenko
Keyword(s):  
Mucous Membrane ◽  
Vaginal Discharge ◽  
Age Groups ◽  
Genital Prolapse ◽  
Neodymium Laser ◽  
Reproductive Age ◽  
Control Group ◽  
Vaginal Mucosa ◽  
Icd 10 ◽  
Special Complex

Genital prolapse is a sort of epidemic and is registered today in 30% to 56% of women of both reproductive and menopausal ages. Until now, the initial stages of prolapse were not taken into account; as a rule, the correction began immediately with surgical treatment, the results of which were not always satisfactory, and the recurrence rate with plastic correction with one’s own tissues ranged from 37 to 45%. One of the main manifestations of prolapse of the vaginal walls, especially n perimenopause, is vulvovaginal mucosal atrophy, which directly depends on the pH in the vagina. The study is devoted to the analysis of the effectiveness of using neodymium laser to improve the condition of the vaginal mucosa in women of different age groups with initial degrees of genital prolapse. Purpose: scientific substantiation of using neodymium laser in patients of different age groups with grade I–II cysto-rectocele. Material and research methods. Studies were carried out in 69 women aged 31 to 52 years with cysto-rectocele of grade I–II (ICD-10 code N81.6), with the duration of the disease from 4 to 15 years. All patients, depending on their age and the method of treatment used, were divided into 2 groups comparable in terms of clinical and functional characteristics — the main and control groups, each of which had 2 subgroups. In the main group: subgroup 1 included 27 patients of reproductive age with grade I–II cysto-rectocele, who underwent a neodymium laser course with Magic Gyno, consisting of 3 intravaginal procedures with an interval of 28 days; subgroup 2 included 22 patients of perimenopausal and menopausal age with grade I–II cysto-rectocele, who underwent a course of 3 intravaginal procedures with Magic Gyno neodymium laser with an interval of 28 days. The control group included 20 patients with grade I–II cysto-rectocele, who underwent a special complex of exercise therapy; depending on their age, they were also divided into two subgroups: 1 (10 patients) — of reproductive age, 2 (10 patients) — of perimenopausal and menopausal age. The results obtained indicate a pronounced effect of the course application of intravaginal exposure by a neodymium laser on the state of the vulvovaginal mucosa in patients with grade I–II cysto-rectocele, of both reproductive and, most importantly, peri-menopausal age, which was manifested in the normalization of the pH of vaginal discharge and elimination of signs of atrophy of the mucous membrane of the vulva and vagina and was confirmed by the data of pH-metry and the Vaginal Health Index Score. Conclusion. The course use of a neodymium laser in patients of different age groups with grade I–II cysto-rectocele contributes to the formation of a pronounced tropho-stimulating effect, which is manifested in the normalization of the pH of the vaginal discharge and the elimination of signs of atrophy of the mucous membrane of the vulva and vagina.

Peripheral and Central Bone Mineral Density in Charcot’s Neuroarthropathy Compared in Diabetic and Nondiabetic Populations

2012 ◽  
Vol 102 (3) ◽  
pp. 213-222 ◽  
Author(s):  
Robert M. Greenhagen ◽  
Dane K. Wukich ◽  
Rachel H. Jung ◽  
Vassilios Vardaxis ◽  
Robert M. Yoho
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Serum Vitamin ◽  
Control Group ◽  
Mineral Density ◽  
X Ray ◽  
Serum Vitamin D ◽  
Significant Difference ◽  
Patients With Diabetes

Background: This prospective study was performed to compare calcaneal and lumbar bone mineral density (BMD) in individuals with and without diabetes mellitus. We compared bone density with the time from onset of Charcot’s neuroarthropathy (CN) in patients with unilateral, nonoperative, reconstructive-stage CN. The final purpose was to investigate the role that sex, age, and serum vitamin D level may have in osseous recovery. Methods: Thirty-three individuals were divided into three groups: controls and patients with diabetes mellitus with and without CN. Peripheral instantaneous x-ray imaging and dual-energy x-ray absorptiometry were performed. Results: The calcaneal BMD of patients with diabetes mellitus and CN was lower than that of the control group (P &lt; .01) but was not significantly lower than that of patients with diabetes mellitus alone. There was no statistically significant difference in lumbar T-scores between groups. Women demonstrated lower BMD than did men (P = .02), but patients 60 years and older did not demonstrate significantly lower BMD than did patients younger than 60 years (P = .135). A negative linear relationship was demonstrated between time and BMD in patients with CN. Conclusions: The results of this study suggest that lumbar BMD does not reflect peripheral BMD in patients with diabetes mellitus and reconstructive-stage CN. This study has clinical implications when reconstructive osseous surgery is planned in patients with CN. (J Am Podiatr Med Assoc 102(3): 213–222, 2012)

Haematological and histopathological effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar female albino rats

2014 ◽  
Vol 34 (7) ◽  
pp. 755-768
Author(s):  
N Barlas ◽  
G Karabulut
Keyword(s):  
Ethinyl Estradiol ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Immature Female ◽  
Tissue Samples ◽  
Uterotrophic Assay

In this study, it is aimed to determine the histopathological and haematological effects of apigenin, phloretin and myricetin on Wistar immature female rats using Tier 2 of the uterotrophic assay. The female rats were divided into 17 groups with 6 rats in each group. There was a negative control group and positive control dose groups that contained 0.07 µg/kg/day, 0.7 µg/kg/day and 7 µg/kg/day of ethinyl estradiol (EE), 0.7 µg/kg/day 17α-ethinyl estradiol + 1 mg/kg/day tamoxifen and genistein. The other dose groups contain 1 mg/kg/day, 10 mg/kg/day and 100 mg/kg/day of apigenin, myricetin and phloretin. All chemicals had been given to Wistar immature female rats with oral gavage for three consecutive days. At the end of the study, blood samples were analysed for haematological parameters. Tissue samples that were taken from the liver, kidney, spleen and thyroid were histopathologically and histomorphometrically examined. There were no significant differences between oil control and other dose groups for glomerular histomorphometry. However, there were siginificant differences for thyroid histomorphometry. Especially, 10 and 100 mg/kg/day of phloretin dose groups had a siginificant increase in colloid surface area in thyroid compared with the 1 mg/kg/day of phloretin and oil control groups. Significant histopathological changes (congestion, degeneration, fibrosis and mononuclear cell infiltration) were noted in the tissue specimens obtained from the treatment groups compared with the control group. According to the results of the haematological analysis of the groups, especially the values of erythrocytes and haematocrit were increased significantly in most of the dose groups according to the oil control group.

scholarly journals Effects of hyperthyroidism on bone mass in women of reproductive age

2004 ◽  
Vol 57 (3-4) ◽  
pp. 111-115
Author(s):  
Jana Ilic ◽  
Branka Kovacev ◽  
Ljiljana Todorovic-Djilas
Keyword(s):  
Bone Mass ◽  
Adult Life ◽  
Reproductive Age ◽  
Control Group ◽  
Mineral Density ◽  
Women Of Reproductive Age ◽  
Anthropometric Parameters ◽  
Future Studies ◽  
Catabolic Rate ◽  
Increased Risk

Introduction Hyperthyroidism is one of the most frequent endocrinopathies in women of reproductive age. Consequently, increased risk of osteoporosis may be expected. Material and methods The research has included a group of 30 hyperthyroid women and a control group of 30 healthy women of reproductive age. Age and some clinical characteristics were analyzed, as well as some anthropometric parameters. Bone mass parameters were determined by measuring bone mineral density using ultrasound devices (SAHARA-Hologic). Results Bone mass parameters in hyperthyroid women are significantly lower than in controls (BUA: 63.25?12.17; 69.73?10.02 dB/MHz respectively; SOS:1523.90? 24.47; 1540.19?26.59 m/s respec. QUI/STIFF 79.78?13.95; 89.09?13.99 % respec.) Duration of hyperthyroidism affects bone density and reduces it. Discussion Obtained results were expected, having in mind that hyper- thyroidism is a condition characterized by increased bone catabolic rate. Also, negative correlation between the duration of hyperthyroidism and bone mass parameters (BUA, SOS) was expected, because it is logical that consolidation of bone mass in adult life cannot be maintained in circumstances in which metabolic rate is increased. During hyperthyroidism, bone loss is expected. In order to confirm this, future studies of bone markers are necessary. Conclusion Based on results obtained in the study, the following conclusions were made: hyperthyroidism is accompanied by decreased values of bone mass parameters; this effect depends on duration of hyperthyroidism. We confirmed that hyperthyroidism may be the cause of decrease in bone mass, particularly if it lasts more than a year. To prevent osteoporosis in women of reproductive age with hyperthyroidism and involution osteoporosis later in life, early diagnosis and effective therapy of hyperthyroidism is imperative.

scholarly journals BONE DENSITY PARAMETERS CHANGING IN POSTMENOPAUSAL WOMEN WITH DIFFUSE SITES NONTOXIC GOITER AND AUTOIMMUNE THYROIDITIS IN TREATMENTLOW-DOSE ESTROGEN-PROGESTOGENS MEDICATION

2015 ◽  
Vol 7 (3) ◽  
pp. 38-43
Author(s):  
V A Gromova ◽  
N V Vorokhobina ◽  
O F Malygina ◽  
A V Kuznetsova
Keyword(s):  
Autoimmune Thyroiditis ◽  
Low Dose ◽  
Bone Structure ◽  
Hormone Replacement ◽  
Control Group ◽  
Endocrine Glands ◽  
Mineral Density ◽  
X Ray ◽  
Nontoxic Goiter ◽  
Reliable Increase

Postmenopausal osteoporosis - multifactorial disease, on the pathogenesis of which affect not only the estrogen deficiency, but functional state of other endocrine glands, particularly the thyroid gland. The article presents the results of a research 74 women with autoimmune thyroiditis and diffuse nodular nontoxic goiter, which during perimenopause and menopause for 12 months received low-dose estrogen-progestin preparation containing 2 mg drospirenone and 1 mg of 17-estradiol. The control group consisted of 40 women of similar age without thyroid disease who were not receiving drugs hormone replacement therapy (HRT). To study the effect of HRT on bone metabolism all women at baseline and after 12 months of follow-conducted study of bone mineral density (BMD) with dual en ergy X-ray absorptiometry (DXA). As a result of the treatment received reliable increase in BMD in the lumbar spine L1-L4 9-10% (p <0.001) in the proximal femur - by 2.8-3.5% (p <0.01) in the bones forearm - by 1.8-2.1% (p <0.01).Conclusion: The use of low-dose estrogen-progestin drugs for 12 months in women with autoimmune thyroiditis and diffuse nodular nontoxic goiter in peri- and postmenopausal period helped gain in BMD in both trabecular and cortical bone structure.

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