scholarly journals Antitumor Activities of Flavonoids and Their Biological Activities on Human Health: الفلافونويدات المضادة للأورام ونشاطاتها البيولوجية على صحة الإنسان

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Hassan Mahmoud Moheisen
Keyword(s):  
Human Health ◽  
Biological Activities ◽  
Folk Medicine ◽  
Human Colon ◽  
Biological Properties ◽  
Present Review ◽  
Isolation And Identification ◽  
Human Colon Cancer ◽  
Active Constituents ◽  
Antitumour Agents

  Flavonoids are ubiquitous in photosynthesising cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey. Therefore, a significant quantity is consumed in our daily diet. These flavonoids are variously associated with the sensory and nutritional quality of our plant foods. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases. There have been many bioassay guided searches for cytotoxic antitumour agents in plants especially those known to be used in folk medicine for this purpose. This has led to the isolation and identification of quite a large number of active constituents from all the diferent flavonoid classes, e.g. catechins, flavans, dihydrochalcones, chalcones, flavanones, dihydro- flavonols, flavones, biflavonoids and flavonol. The purpose of the present review is to discuss recent developments in the biochemistry and medicinal aspects of the flavonoids. It is already well established that flavonoids make some contribution to disease resistance. Perhaps the most active area of flavonoid research at the present time is in the possible medicinal contribution that flavonoids make to human health, It is well known that some flavonoids can act as anti-spasmolytic agents, antibacterial activity, hepatoprotective agents and prevention of malaria. Recent research on the biological properties of flavonoids will therefore be a further subject of the present review. The activity of 17- β- estradiol, for example, have a pharmacologicalefficacy, at optimal concentrations, which is equivalent to the natural hormone. The compounds: 4´,7´´- di- O- methylamentofavone and 7´´- O- methylrobustafavone, were significantly cytotoxic against human cell lines including breast, lung, colon and prostate cancer, fibrosarcoma, glibostoma, oral epidermoid carcinoma and leukemia. Amongst the favonols, quercetagetin 6,7,3´ ,4´- tetramethyl ether, was found to show significant cytotoxicity against murine leukaemia, human non- small cell lung cancer, human colon cancer, and KB tumour cells.  

scholarly journals Medicinal Properties of Flavonoids: الفلافونويدات وخواصها الدوائية

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Hasan M. H. Muhaisen, Esraa M. M. Ali
Keyword(s):  
Protective Effect ◽  
Folk Medicine ◽  
Epidemiological Studies ◽  
Biological Properties ◽  
Antioxidant Effect ◽  
Present Review ◽  
Isolation And Identification ◽  
Active Constituents ◽  
Antitumour Agents ◽  
Positive Effects

  Flavonoids are ubiquitous in photosynthesizing cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, and honey. Therefore, a significant quantity is consumed in our daily diet. These flavonoids are variously associated with the sensory and nutritional quality of our plant foods. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases. There has been increasing interest in the research on flavonoids from plant sources because of their versatile health benefits reported in various epidemiological studies. Since flavonoids are directly associated with human dietary ingredients and health, there is need to evaluate structure and function relationship. There have been many bioassay guided searches for cytotoxic antitumour agents in plants especially those known to be used in folk medicine for this purpose. This has led to the isolation and identification of quite a large number of active constituents from all the different flavonoid classes, e.g. catechins, flavans, dihydrochalcones, chalcones, flavanones, dihydro-flavonols, flavones, biflavonoids and flavonol. The purpose of the present review is to discuss recent developments in the biochemistry and medicinal aspects of the flavonoids. Flavonoids have received a lot of interest in scientific research over the past 20 years and have had many beneficial and potential effects. Flavonoids have many great advantages as natural compounds compared to therapeutic agents because many diets are rich in polyphenols and are consumed daily and are easily absorbed in the intestines after ingestion, especially flavonoids, have positive effects on health: antioxidants, lethargy, allergies and bacteria, And cancer. The protective effect of flavonoids is primarily due to its antioxidant effect and inhibition of enzymes. The protective effect of flavonoids from diseases is mainly due to their antioxidant effect. Recent research on the biological properties of flavonoids will therefore be a further subject of the present review.

scholarly journals Trifostigmanoside I, an Active Compound from Sweet Potato, Restores the Activity of MUC2 and Protects the Tight Junctions through PKCα/β to Maintain Intestinal Barrier Function

2020 ◽  
Vol 22 (1) ◽  
pp. 291
Author(s):  
Amna Parveen ◽  
Seungho Choi ◽  
Ju-Hee Kang ◽  
Seung Hyun Oh ◽  
Sun Yeou Kim
Keyword(s):  
Tight Junctions ◽  
Sweet Potato ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Human Colon ◽  
Underlying Mechanism ◽  
Intestinal Barrier Function ◽  
Isolation And Identification ◽  
Human Colon Cancer ◽  
Mucin Production

Sweet potato (Ipomoea batata) is considered a superfood among vegetables and has been consumed for centuries. Traditionally, sweet potato is used to treat several illnesses, including diarrhea and stomach disorders. This study aimed to explore the protective effect of sweet potato on intestinal barrier function, and to identify the active compounds of sweet potato and their underlying mechanism of action. To this purpose, bioactivity-guided isolation, Western blotting, and immunostaining assays were applied. Interestingly, our bioactivity-guided approach enabled the first isolation and identification of trifostigmanoside I (TS I) from sweet potato. TS I induced mucin production and promoted the phosphorylation of PKCα/β in LS174T human colon cancer cells. In addition, it protected the function of tight junctions in the Caco-2 cell line. These findings suggest that TS I rescued the impaired abilities of MUC2, and protected the tight junctions through PKCα/β, to maintain intestinal barrier function.

Review on pharmacological and phytochemical prospects of traditional medicinal plant: Persicaria hydropiper (Smartweed)

2021 ◽  
Vol 21 ◽  
Author(s):  
Abdul Nasir ◽  
Atif Ali Khan Khalil ◽  
Muhammad Zeeshan Bhatti ◽  
Ashfaq Ur Rehman ◽  
Jiayi Li ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Northern Hemisphere ◽  
Biological Activities ◽  
Folk Medicine ◽  
Present Review ◽  
Polygonum Hydropiper ◽  
Wide Range ◽  
Pharmacological Data ◽  
Different Parts

: Persicaria hydropiper (L.) Delarbre (family Polygonacea), commonly known as Polygonum hydropiper, is a popular medicinal plant used in traditional medicine. The plant is indigenous to the tropical northern hemisphere and temperate zone including China, Bangladesh, India, and Japan. The plant is used in folk medicine for numerous ailments such as hemorrhoids, antifertility, diarrhea, and dyspepsia. Its medicinal usage in Unani, Ayurveda, Siddha, and other traditional medicine is well-recognized. So far, a wide range of active phytochemicals of this plant has been identified, such as flavonoids, sulphated flavonoids, terpenoids, anthraquinones, steroids, coumarin, simple phenolics, and others. Pharmacological data reported in the literature suggest that various parts of P. hydropiper exhibit antimicrobial, antioxidant, hypoglycemic, antidepressant, cardioprotective, hepatoprotective, anticancer, and antifertility effects. The present review aim is to compile the coherently document research on the phytochemical, pharmacological, and biological activities of P. hydropiper from different parts of the globe.

scholarly journals Synthesis and Biological Evaluation of Novel Aminochalcones as Potential Anticancer and Antimicrobial Agents

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4129 ◽  
Author(s):  
Joanna Kozłowska ◽  
Bartłomiej Potaniec ◽  
Dagmara Baczyńska ◽  
Barbara Żarowska ◽  
Mirosław Anioł
Keyword(s):  
Antimicrobial Activity ◽  
Cell Lines ◽  
Antimicrobial Agents ◽  
Human Colon ◽  
Biological Properties ◽  
Biological Evaluation ◽  
Human Colon Cancer ◽  
E Coli ◽  
Almost All ◽  
Ht 29

A series of 18 aminochalcone derivatives were obtained in yields of 21.5–88.6% by applying the classical Claisen-Schmidt reaction. Compounds 4–9, 14 and 16–18 with 4-ethyl, 4-carboxy-, 4-benzyloxy- and 4-benzyloxy-3-methoxy groups were novel, not previously described in the scientific literature. To determine the biological properties of the synthesized compounds, anticancer and antimicrobial activity assays were performed. Antiproliferative potential was evaluated on four different human colon cancer cell lines—HT-29, LS180, LoVo and LoVo/DX —using the SRB assay and compared with green monkey kidney fibroblasts COS7. Anticancer activity was described as the IC50 value. The best results were observed for 2′-aminochalcone (1), 3′-aminochalcone (2) and 4′-aminochalcone (3) (IC50 = 1.43–1.98 µg·mL−1) against the HT-29 cell line and for amino-nitrochalcones 10–12 (IC50 = 2.77–3.42 µg·mL−1) against the LoVo and LoVo/DX cell lines. Moreover, the antimicrobial activity of all derivatives was evaluated on two strains of bacteria: Escherichia coli ATCC10536 and Staphylococcus aureus DSM799, the yeast strain Candida albicans DSM1386 and three strains of fungi: Alternaria alternata CBS1526, Fusarium linii KB-F1 and Aspergillus niger DSM1957. In the case of E. coli ATCC10536 almost all derivatives hindered the bacterial growth (∆OD = 0). Furthermore, the best results were observed in the presence of 4′-aminochalcone (3), that completely limited the growth of all tested strains at the concentration range of 0.25–0.5 mg·mL−1. The strongest bacteriostatic activity was exhibited by novel 3′-amino-4-benzyloxychalcone (14), that prevented the growth of E. coli ATCC10536 with MIC = 0.0625 mg·mL−1.

Helenalin - A Sesquiterpene Lactone with Multidirectional Activity

2019 ◽  
Vol 20 (4) ◽  
pp. 444-452 ◽  
Author(s):  
Joanna Drogosz ◽  
Anna Janecka
Keyword(s):  
Sesquiterpene Lactone ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Folk Medicine ◽  
Biological Properties ◽  
Pathological Conditions ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Minor Injuries

Sesquiterpene lactones, secondary metabolites of plants, present in a large number of species mostly from the Asteracea family, are used in the traditional medicine of many countries for the treatment of various pathological conditions. They exert a broad range of activities, including antiinflammatory, anti-bacterial and anti-cancer properties. The best-known sesquiterpene lactones which are already used as drugs or are used in clinical trials are artemisinin, thapsigargin and parthenolide. Yet another sesquiterpene lactone, helenalin, an active component of Arnica montana, known for its strong anti-inflammatory activity, has been used for centuries in folk medicine to treat minor injuries. Unfortunately, helenalin’s ability to cause allergic reactions and its toxicity to healthy tissues prevented so far the development of this sesquiterpene lactone as an anticancer or anti-inflammatory drug. Recently, the new interest in the biological properties, as well as in the synthesis of helenalin analogs has been observed. This review describes helenalin's major biological activities, molecular mechanisms of action, its toxicity and potential for further research.

scholarly journals Syzygium Samarangense : A Review on its Pharmacognostical, Pharmacological and Phytochemical Proৎile

2020 ◽  
Vol 11 (4) ◽  
pp. 6066-6078
Author(s):  
Greeshma G Nair ◽  
Sathianarayanan S
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Human Colon ◽  
Salmonella Typhi ◽  
Cytotoxic Activities ◽  
Human Colon Cancer ◽  
Whole Plant ◽  
The Family ◽  
Anti Oxidant ◽  
Anti Inflammatory

The objective of this review is to document briefly about the chemical constituents, pharmacognostical evaluation and biological activities of Syzygium samarangense belongs to the family Myrtaceae. It is generally called Java Apple, Wax Apple, Blume, Chambekka etc. Syzygium samarangense traditionally used as an astringent. It is also used to treat fever and halt diarrhea. The whole plant contains flavonoids, terpenoids, tannins, phenolic compounds, gallic acid, ellagic acid, squalene, botulin, lupeol, sitosterol, mixture of cycloartenol stearate, lupenyl stearate, β-sitosterol stearate, vitamins and minerals which bearing anti-oxidant, anti- microbial, hypoglycemic, anti-inflammatory, Immunomodulatory, CNS, Anti- diarrheal, anthelmintic and cytotoxic activities. In this review, different parts of the plant, their phytochemical constituents and their corresponding biological activities have been explored. The literatures reported that the fruit part contains carotene, anthocyanin and vescalagin which is used as antioxidant, anti- microbial and hypoglycemic effect. The leaf part contains myricetin, strobopinine, epigallocatechin, aurentiacin which bearing anti-inflammatory and immunomodulatory effect. The alcoholic extracts of leaves, seeds, root bearing analgesic, anti- inflammatory effect in lipopolysaccharide, antioxidant, cytotoxic activity against human colon cancer cell, the studies revealed that the extracts showed a potent anti- microbial activity against salmonella typhi, Escherichia coli, pseudomonas aeruginosa, bacillus subtilis, candida albicans etc. The aqueous extract of fruit prevents diabetes mellitus in rats.

scholarly journals Emerging source of bioactive compounds from Arecaceae family: a systematic review

2021 ◽  
Vol 10 (10) ◽  
pp. e426101018994
Author(s):  
Ricardo Sérgio da Silva ◽  
Paulo Henrique Oliveira de Miranda ◽  
Luciclaudio Cassimiro de Amorim ◽  
Paulo Henrique Eloi Fernandes ◽  
Elias Vinícius Ferreira do Amaral ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Acids ◽  
Phenolic Compounds ◽  
Human Health ◽  
Traditional Knowledge ◽  
Lauric Acid ◽  
Biological Activities ◽  
Biological Properties ◽  
The Family ◽  
Comprehensive Search

The use of plants for medicinal purposes is performed empirically by traditional knowledge with the use of preparations that seek to extract their active principles, and are considered to be fundamental to human health. In this context, the aim of the present study was to of this study was to carry out a systematic review of the biological activities of the Arecaceae family distributed throughout Brazil. This research was carried out through a comprehensive search using the following databases, Scopus, Portal Periódicos Capes, PubMed, Google Scholar and Science Direct, using the following descriptors: “Arecaceae” and “Biological properties of the family Arecaeae”, checked at <www.theplantlist.org/> to check synonyms. It was possible to identify numerous biological activities in the arecaceae family, among the most recurring ones, the antioxidant, antimicrobial and anti-inflammatory activity. These activities are justified by the presence of fatty acids, phenolic compounds, alkaloids and terpenes. Studies routinely report lauric acid as a major in the plants of this family, which makes it a potential compound to cure or assist in the treatment of various diseases.

1,8-Naphthyridine derivatives: A privileged scaffold for versatile biological activities

2020 ◽  
Vol 20 ◽  
Author(s):  
Madhwi Ojha ◽  
Divya Yadav ◽  
Avinash Kumar ◽  
Suman Dasgupta ◽  
Rakesh Yadav
Keyword(s):  
Heterocyclic Compounds ◽  
Receptor Agonist ◽  
Biological Activities ◽  
Biological Properties ◽  
Present Review ◽  
Anti Psychotic ◽  
Cb2 Receptor ◽  
Research Groups ◽  
Anti Cancer ◽  
Privileged Scaffold

: 1, 8- Naphthyridine nucleus belongs to significant nitrogen-containing heterocyclic compounds which have garnered the interest of researchers due to its versatile biological activities. It is known to be used as an antimicrobial, anti-psychotic, anti-depressant, anti-convulsant, anti-Alzheimer’s, anti-cancer, analgesic, anti-inflammatory, antioxidant, anti-viral, anti-hypertensive, anti-malarial, pesticides, anti-platelets, and CB2 receptor agonist, etc. The present review highlights the framework of biological properties of synthesized 1, 8-naphthyridine derivatives developed by various research groups across the globe.

scholarly journals Bioavailability of lignans in human subjects

2006 ◽  
Vol 19 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Thomas Clavel ◽  
Joël Doré ◽  
Michael Blaut
Keyword(s):  
Human Health ◽  
Human Subjects ◽  
Intestinal Bacteria ◽  
Biological Properties ◽  
Present Review

Dietary lignans are phyto-oestrogens that possibly influence human health. The present review deals with lignan bioavailability, the study of which is crucial to determine to what extent metabolism, absorption and excretion of lignans alter their biological properties. Since intestinal bacteria play a major role in lignan conversion, for instance by producing the enterolignans enterodiol and enterolactone, emphasis is put on data obtained in recent bacteriological studies.

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