Anti-ulcer mechanism of the aqueous extract of Osyris quadripartite

Author(s):  
Dinesh Babu J ◽  
Akila CR ◽  
Sravan Kumar P ◽  
Vinaya B

Peptic ulcer disease, otherwise called as Ulcers, is the most noted disease in the world today. A large population that is affected with the ulcer disease is the age group of people between 20-50 years of age. This disease is not dreadful on its own but is responsible for the causation of many other problems and diseases in the body. This may be due to various factors like the long-term usage of potent drugs like NSAID's, nutrition deficiencies, and unhealthy lifestyle habits like smoking, stress etc. Herbs are being used to treat many diseases, and almost 50% of the population in the world uses herbal-based medicine. Medicinal plants are the primary sources of a cure for those diseases. Numerous plants have been researched and investigated for the anti-ulcer property, and various publications were made too in this respect. Aqueous extract of the plant, Osyris quadripartite was extracted and investigated for the anti-ulcer activity in the ethanol-induced ulcer disease method. The extracts were tested in three doses and compared to the standard drug, Omeprazole. The extract at a higher dose exhibited more significant activity when compared to that at a lower dose and also the standard drug.

Author(s):  
Ravichandran S ◽  
Bhavani J ◽  
Satheesh Kumar D ◽  
Chandrasekaran A R ◽  
Saraladevi V ◽  
...  

The ulcers are complications, and as a disease, it is called PUD (Peptic Ulcer Disease). In the current scenario, a large population around the world are suffering from the ulcers, which are ranging from 25-55 years the age. This is not so dangerous as such but can become most dreadful when untreated or unattended. PUD can become the causes for other diseases like malnutrition, stomach pain etc. there are a lot of factors that are responsible for causing an ulcer. Few of them are the prolonged use of pain medications, malnutrition, stress and free radicals. There are also medicinal plants that are used to treat ulcers and effectively cure them without causing significant side effects. Various research publications prove the antiulcer property of the herbs and plants. The ayurvedic tonic formulation was prepared using the herbs and sugar base. The formulation was investigated for the antiulcer activity in the Ethanol-induced ulcers method. The antiulcer activity was investigated using two doses and compared to the ayurvedic standard marketed formulation and the standard drug omeprazole.


2021 ◽  
Vol 3 (01) ◽  
pp. 65-94
Author(s):  
Rizki Pauziah Siregar

Testimony is a statement made by a witness who saw the incident by himself and was at the scene at that time. Nothing can escape this evidence in the afterlife, nor can it be manipulated in the slightest. So the source of the problem that will be discussed is how to witness the body and the interpretation of the rationality of the testimony of the limbs in QS. Yasin: 65. The research approach used by the author is a qualitative approach and is more inclined to follow library research and uses thematic analysis methods, this research will rely on the interpretation of Al-Jawahir Fi Tafsiril Qur'an by Tantawi Jauhari and books. as primary sources, research journals, and research theses as secondary sources. And what is relevant to this research, the results of the testimony of the limbs according to tantawi Jauhari are that the limbs will testify and it is not only in the afterlife, the body can testify against its owner. but even in the law that applies in the world, the limb that can be used to prove it, to reveal a crime such as murder or abuse. Here the limbs are like hands, it can help to expose the crime. One of them uses a DNA or fingerprint test, and only Allah will see what the testimony on the Day of Judgment is.


Author(s):  
Iyabo M. ◽  
Adebisi . ◽  
Abba Abubakar ◽  
Kabiru Abubakar ◽  
Tijjani R. ◽  
...  

Objective: To evaluate the analgesic effect and anti-inflammatory properties of Boswellia dalzielii (Burseraceae), a medicinal plant commonly used in northern Nigeria as an anti-diarrhoeal, antipyretic, analgesic and anti-inflammatory agent.Methods: Three doses (25 mg/kg, 50 mg/kg and 100 mg/kg) of the crude aqueous extract of Boswellia dalzielii were evaluated for analgesic and anti-inflammatory activities using the acetic acid-induced writhing test, formalin-induced nociception and formalin-induced hind paw oedema in rats. The acute oral toxicity was carried out using the up and down procedure as described by the OECD guidelines.Results: All doses (25, 50 and 100 mg/kg) of the extract tested were effective against acetic acid induced abdominal constrictions producing a percentage inhibition of (55.43, 69.56 and 71.73%) respectively. A percentage inhibition of the formalin-induced nociception of (7.31, 31.70 and 48.78%-early phase) and (12.82, 21.79 and 48.71%-late phase) respectively was also produced. For the acetic acid writhing test, the percentage inhibition obtained at the dose of 50 and 100 mg/kg (69.56 and 71.73%) were higher than that of the standard drug (Piroxicam, 10 mg/kg) (59.78%). For formalin-induced nociception, the test extract at 100 mg/kg showed a higher percentage inhibition compared to Piroxicam, in early (48.78 and 43.90%) and late phase (48.71 and 39.74 %) respectively. The extract, however, did not show a significant activity against formalin-induced paw oedema at all the doses used.Conclusion: The present study demonstrated that Boswellia dalzielii has significant analgesic properties comparable to that of the standard drug (10% Piroxicam), thus validating the traditional claim of its antinociceptive property.


Author(s):  
Ramesh M ◽  
Vincent Vidyasagar J ◽  
Tharun Kumar G ◽  
Akhila C R

Diabetes Mellitus shortly called as DM is a metabolic disorder which is due to the improper secretion of the insulin by the pancreas. The insensitivity in the reuptake of insulin also causes diabetes. This increases the blood glucose level and affects physiological functions. The majority of the population that is suffering from DM are generally obese or following unhealthy lifestyle habits. There are about half of the world population is suffering from DM and related complications. DM secondary complications include nephropathy, neuropathy, retinopathy and vascular complications like PVD and PAD. Considering the activity of herbs and the safety of the same, an ayurvedic formulation was prepared using herbs, and the same is investigated for the antidiabetic activity. The ayurvedic formulation that is designed in the study is an ayurvedic churnam preparation out of the texts of the Ayurveda books. The polyherbal churnam that is prepared showed a significantly better activity compared to the standard drug and the marketed ayurvedic formulation too. The higher dose of the extract showed higher activity compared to the lower dose of the preparation.


Author(s):  
Vishal N. Kushare ◽  
Sagar V. Ghotekar ◽  
Manmeet S. Mandloi

Ulcers are one of the dreadful and technically known as Peptic Ulcer Disease (PU Disease). Around 10million people around the world are suffering from the disease, and the majority of the people are about 20-50 years of age. This is not a dangerous disease on its own. Still, the ulcers are responsible for the resulting in other diseases like indigestion stomach pain etc. there are various reasons for the causation of ulcer. They are excessive use of pain killers and anti-inflammatory drugs, malnutrition, and unhealthy food habits, stress and steroids. Almost half of the world population relies on herbs for the treatment, and the major sources of the chemical leads that treat diseases are in the medicinal plants only. Many plants have been investigated and reported for their potential antiulcer benefits and are published too for that. The plant parts of Malvastrum tricuspidatum were extracted using distilled water and were investigated for the antiulcer activity in 3 doses like 100,200 and 400mg. The Extract at a higher dose showed better activity than other lower doses. The activity was compared with the standard drug and showed a significantly better activity that the standard and other doses of Extract too.


2010 ◽  
Vol 88 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Md. Salahuddin ◽  
Sunil S. Jalalpure ◽  
Navneet B. Gadge

The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normoglycemic and STZ-induced diabetic rats included the effect of the aqueous extract on oral glucose tolerance, fasting blood glucose, body weight, serum lipids, liver glycogen, serum insulin, and glycosylated haemoglobin. Oral administration of the aqueous extract of C. glauca bark at a dose of 500 mg/kg significantly reduced the effect of external glucose load. In a chronic treatment model, aqueous extract and glibenclamide (0.25 mg/kg) were administered for 21 days. At the end of the treatment, there was a significant increase in liver glycogen, serum insulin, and HDL cholesterol for both treatments. A significant decrease in fasting blood glucose, glycosylated haemoglobin, total cholesterol, and serum triglycerides was also observed. The body weights of the animals were observed to be consistent throughout the study. The findings showed the significant antidiabetic potential of the extract in ameliorating the diabetic condition in the diabetic rats. No significant activity was found in the normoglycemic rats.


2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1197-1203
Author(s):  
Abdulaziz Khaled Hasan ◽  
Rakesh Kumar Jat ◽  
Abdul Mannan Khan

The present study was to estimate the anti-diabetic and antihyperlipidemic activity of aqueous extract of leaves of plant Aloe barbadensis.In alloxan-induced diabetes in rats, the research examined six groups of six male wister rats every to value the hypoglycaemic effect of the barbadensis (ALEC) exposed to hostile to diabetic action in rodents where alloxan monohydrates were utilized as a portion of 120.00 mg/kg in intraperitoneal portion as a diabetogenic specialist to an acquainted diabetic with test rodents. In sub intense, treatment, bunch blood glucose levels are seen on 14.00th, 21.00th and 30.00th-day present treatment compare on typical control in diabetic control checked expanded blood glucose level was watched, with dosages of 100.00, 250.00 and 500.00 mg/kg b.w. A portion of 500.00 mg/kg b.w/day was seen as having the most significant activity. Glibenclamide was applied as a standard drug, and the outcome was compared about it. In the antihyperlipidemic activity, serum cholesterol levels were recorded at aqueous extracts of 100.00, 250.00 and 500.00 mg/kg, on 30.00th-day post-treatment. Serum cholesterol levels were ordinary benchmark groups was 107.70±01.21 mg/dl diabetic control 178.50±01.04 mg/dl and standard medications treatment bunches was 111.30±02.40 mg/dl and ALEC treatment bunches were 171.20±01.03 mg/dl, 145.80±02.92 mg/dl and 118.80±03.86 mg/dl for 100.00, 250.00 and 500.00 mg/kg separately. The results show that the aqueous extract of Aloe barbadensis has significant and continuous oral hypoglycaemic activity, equivalent to the hypoglycaemic result of glibenclamide, a sulfonylurea derivative and hyperlipidemic activity. Extracts also confirmed antihyperlipidaemic possible of the plant extract is establish to be comparable with that of the standard.


Author(s):  
O. Faroon ◽  
F. Al-Bagdadi ◽  
T. G. Snider ◽  
C. Titkemeyer

The lymphatic system is very important in the immunological activities of the body. Clinicians confirm the diagnosis of infectious diseases by palpating the involved cutaneous lymph node for changes in size, heat, and consistency. Clinical pathologists diagnose systemic diseases through biopsies of superficial lymph nodes. In many parts of the world the goat is considered as an important source of milk and meat products.The lymphatic system has been studied extensively. These studies lack precise information on the natural morphology of the lymph nodes and their vascular and cellular constituent. This is due to using improper technique for such studies. A few studies used the SEM, conducted by cutting the lymph node with a blade. The morphological data collected by this method are artificial and do not reflect the normal three dimensional surface of the examined area of the lymph node. SEM has been used to study the lymph vessels and lymph nodes of different animals. No information on the cutaneous lymph nodes of the goat has ever been collected using the scanning electron microscope.


Author(s):  
Pramukti Dian Setianingrum ◽  
Farah Irmania Tsani

Backgroud: The World Health Organization (WHO) explained that the number of Hyperemesis Gravidarum cases reached 12.5% of the total number of pregnancies in the world and the results of the Demographic Survey conducted in 2007, stated that 26% of women with live births experienced complications. The results of the observations conducted at the Midwife Supriyati Clinic found that pregnant women with hyperemesis gravidarum, with a comparison of 10 pregnant women who examined their contents there were about 4 pregnant women who complained of excessive nausea and vomiting. Objective: to determine the hyperemesis Gravidarum of pregnant mother in clinic. Methods: This study used Qualitative research methods by using a case study approach (Case Study.) Result: The description of excessive nausea of vomiting in women with Hipermemsis Gravidarum is continuous nausea and vomiting more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the body weight decreases and interferes with daily activities days The factors that influence the occurrence of Hyperemesis Gravidarum are Hormonal, Diet, Unwanted Pregnancy, and psychology, primigravida does not affect the occurrence of Hyperemesis Gravidarum. Conclusion: Mothers who experience Hyperemesis Gravidarum feel nausea vomiting continuously more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the weight decreases and interferes with daily activities, it is because there are several factors, namely, hormonal actors, diet, unwanted pregnancy, and psychology.


2018 ◽  
Vol 8 (1) ◽  
pp. 49-66
Author(s):  
Monika Szuba

The essay discusses selected poems from Thomas Hardy's vast body of poetry, focusing on representations of the self and the world. Employing Maurice Merleau-Ponty's concepts such as the body-subject, wild being, flesh, and reversibility, the essay offers an analysis of Hardy's poems in the light of phenomenological philosophy. It argues that far from demonstrating ‘cosmic indifference’, Hardy's poetry offers a sympathetic vision of interrelations governing the universe. The attunement with voices of the Earth foregrounded in the poems enables the self's entanglement in the flesh of the world, a chiasmatic intertwining of beings inserted between the leaves of the world. The relation of the self with the world is established through the act of perception, mainly visual and aural, when the body becomes intertwined with the world, thus resulting in a powerful welding. Such moments of vision are brief and elusive, which enhances a sense of transitoriness, and, yet, they are also timeless as the self becomes immersed in the experience. As time is a recurrent theme in Hardy's poetry, this essay discusses it in the context of dwelling, the provisionality of which is demonstrated in the prevalent sense of temporality, marked by seasons and birdsong, which underline the rhythms of the world.


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