scholarly journals Overview Of The Psysical Environment And The Nutritional Status Of Patient with Pulmonary Tuberculosis In The Lung Polyclinic Ngudi Waluyo Wlingi General Hospital at Desember 2014

2015 ◽  
Vol 2 (3) ◽  
pp. 248-254
Author(s):  
Enik Sulistyowati
Keyword(s):  
Elementary Education ◽  
Pulmonary Tuberculosis ◽  
Nutritional Status ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Government Programs ◽  
Pulmonary Tb ◽  
Home Ventilation ◽  
Direct Observations ◽  
The Subject

Pulmonary Tuberculosis (TB) is an infectious disease that still become a problem in the world.In Indonesia, pulmonary TB become one of the major public health problem and has yet to be handleddespite tight TB control efforts through government programs. This study aimed to describe the physicalenvironment and the nutritional status of patients with pulmonary TB in the lungs RSU Poly NgudiWaluyo Wlingi. This was a descriptive study, the subject of the research was pulmonary TB patients inRSU Ngudi Waluyo Wlingi, Blitar. Data obtained by using questionnaires and direct observations onnutritional status. There were 40 subjects, 67.3% were male sex, 20%, of the respondents came fromGandusari region, 37.5% were aged between 36–45 years, 45% of respondents had elementary education,37.5% working 37.5% Farmers and private work. Physical environment or home environmentshowed results better home lighting 77.5%, 82.5% home ventilation was not good, the density of residents90% was not good and 90% good home floor. The state of nutritional status shows 60% BMI in thecategory thin. This study shows that patients with pulmonary TB in the lungs RSU Poly Ngudi WaluyoWlingi, have homes that did not meet health requirements, especially in home ventilation componentsand occupant density, but it also had an excellent nutritional status was not indicated by the majorityof BMI into the category of thin.

scholarly journals PULMONARY TUBERCULOSIS - A PROSPECTIVE ANALYSIS OF HEMATOLOGICAL CHANGES

2018 ◽  
Vol 11 (4) ◽  
pp. 169
Author(s):  
Sonti Sulochana ◽  
Subhashini V ◽  
Chitra Srinivasan
Keyword(s):  
Pulmonary Tuberculosis ◽  
Communicable Disease ◽  
Public Health Problem ◽  
Prospective Analysis ◽  
Major Public Health Problem ◽  
Common Condition ◽  
Pulmonary Tb ◽  
Acid Fast Bacilli ◽  
Childhood Tb ◽  
Hematological Changes

 Objective: This study was a prospective analysis of hematological changes in pulmonary tuberculosis (TB). The objectives of this study are (1) to study the changes in different parameters of hemogram in association of sputum-positive pulmonary TB, (2) to evaluate the disease severity and patient infectivity, (3) to determine the most common type and severity of anemia in pulmonary TB patients, and (4) to count platelets in pulmonary TB patients. TB is an important communicable disease in the world and is a major public health problem in India. Hematogical abnormalities associated with TB have been completely investigated in the literature though it is a common condition in India.Methods: A total of 150 patients of acid-fast bacilli-positive cases were included, and disseminated TB, childhood TB, and patients receiving anti-TB drugs were excluded from this study.Results: Among the 150 patients, anemia was observed in 116 cases, normocytic normchromic and microcytic hypochromic picture, leukocytosis in 68 patients, thrombocytosis in 50 patients, thrombocytopenia in 5 patients, and ESR levels were elevated in more than 82% of patients.Conclusion: A complete hemogram has been demonstrated in patients with acid-fast bacilli-positive cases in the present study. Since there was a paucity of literature in the hematological changes associated with TB, this study aimed at reinforcing the fact that they can be valuable tools in monitoring pulmonary TB.

scholarly journals Mantoux test results and BCG vaccination status in TB-exposed children

2015 ◽  
Vol 55 (1) ◽  
pp. 7
Author(s):  
Fadilah Harahap ◽  
Ridwan M. Daulay ◽  
Muhammad Ali ◽  
Wisman Dalimunthe ◽  
Rini Savitri Daulay
Keyword(s):  
Pulmonary Tuberculosis ◽  
Nutritional Status ◽  
Household Contact ◽  
Mantoux Test ◽  
Skin Tests ◽  
Sputum Smear ◽  
Test Results ◽  
Time Duration ◽  
Pulmonary Tb ◽  
Bcg Vaccination

Background Tuberculosis (TB) infection is highly prevalent in Indonesia. The source of transmission of TB to a child is usually via an adult with sputum smear-positive pulmonary tuberculosis. The Mantoux test is a diagnostic tool for tuberculosis infection. The BCG vaccine has been used for the prevention of TB, but its efficacy is still debated. Objective To assess for an association between Mantoux test results and BCG vaccination in children who had contact with adult pulmonary tuberculosis and to assess for differences in Mantoux test induration with regards to nutritional status, age, type of TB contact, and time duration since BCG vaccination in BCG-vaccinated and BCG-unvaccinated children. Methods A cross-sectional study was conducted in FebruaryMarch 2011 on infants and children (aged 3 months to five years), who had household contact with adult pulmonary TB. We performed tuberculin (Mantoux) skin tests to detect TB infection in the children. Subjects were consisted of two groups: BCG-vaccinated and BCG-unvaccinated. Results Subjects were 100 children (50 BCG-vaccinated and 50 BCG-unvaccinated subjects). Positive Mantoux test results were observed in 9 vaccinated subjects and 33 unvaccinated subjects. The mean diameters of induration in the vaccinated and unvaccinated groups were 7.6 mm and 9.6 mm, respectively (95%CI of difference -4.25 to 0.20; P=0.074). In children who had household contact with sputum smear-positive adult pulmonary TB, BCG vaccination was a protective factor against TB infection, with an odds ratio (OR) of 0.113 (95%CI 0.045 to 0.286; P=0.0001). There were no significant differences in Mantoux test induration associated with nutritional status, age, type of TB contact, and duration since BCG vaccination, between the two groups. Conclusion BCG vaccination has a protective effect on TBexposed children, based on Mantoux test results. However, there are no differences in Mantoux test induration associated with nutritional status, age, type of TB contact, or duration since BCG vaccination, between the BCG-vaccinated and BCGunvaccinated groups.

scholarly journals SEANUTS: the nutritional status and dietary intakes of 0.5–12-year-old Thai children

2013 ◽  
Vol 110 (S3) ◽  
pp. S36-S44 ◽  
Author(s):  
Nipa Rojroongwasinkul ◽  
Kallaya Kijboonchoo ◽  
Wanphen Wimonpeerapattana ◽  
Sasiumphai Purttiponthanee ◽  
Uruwan Yamborisut ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Nutritional Status ◽  
Rural Areas ◽  
Urban Areas ◽  
Vitamin A Deficiency ◽  
Public Health Problem ◽  
Rural Children ◽  
Major Public Health Problem ◽  
Serum Retinol

In the present study, we investigated nutritional status and health-related factors in a multistage cluster sample of 3119 Thai urban and rural children aged 0·5–12·9 years. In a subsample, blood samples were collected for the measurement of Hb, transferrin receptor, vitamin A and vitamin D concentrations. The prevalence of stunting and underweight was higher in rural children than in urban children, whereas the wasting rate was similar in both rural and urban areas. Among children aged 3·0–5·9 years, the prevalence of overweight was significantly higher in urban areas than in rural areas and so was the obesity rate in children aged 6·0–12·9 years. Protein intakes of all age groups were relatively high in both the areas. Intakes of Ca, Fe, Zn and vitamin C were significantly higher in urban areas than in rural areas. The prevalence of anaemia in rural areas was twice as high as that in urban areas, particularly in infants and young children. However, the prevalence of Fe-deficiency anaemia was similar in both urban and rural areas. While the prevalence of vitamin A deficiency (by serum retinol cut-off < 0·7 μmol/l) seemed to be very low, vitamin A insufficiency (by serum retinol cut-off < 1·05 μmol/l) was more prevalent (29·4–31·7 %) in both the areas. The prevalence of vitamin D insufficiency ranged between 27·7 and 45·6 % among the children. The present study indicates that the double burden of malnutrition is still a major public health problem in Thailand. Further studies need to explore the associated risk factors for these nutrient deficiencies. Effective strategies and actions are needed to tackle the nutritional problems in Thai children.

scholarly journals Nutritional Status of Children and Its Associated Factors in Selected Earthquake-Affected VDCs of Gorkha District, Nepal

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Asmita Shrestha ◽  
Chet Kant Bhusal ◽  
Binjwala Shrestha ◽  
Kiran Dev Bhattarai
Keyword(s):  
Nutritional Status ◽  
Associated Factors ◽  
Age Groups ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Anthropometric Measurement ◽  
Major Public Health Problem ◽  
Cross Sectional ◽  
Nutritional Status Of Children ◽  
Food Insecure Households

Background. Malnutrition is a major public health problem and most enveloping cause of morbidity and mortality among children and adolescents throughout the world. This study was aimed at assessing the nutritional status and associated factors among 6-10-year-old children in selected earthquake-affected areas of Gorkha district, Nepal. Methods. A community-based cross-sectional study among 420 mothers having children of age groups 6-10 years (with anthropometric measurement among children) was conducted using a mixed method in selected earthquake-affected areas of Gorkha district, Nepal, from October 2015 to April 2016. Gorkha was selected purposively from 14 earthquake-affected districts. Two village development committees were selected randomly among 6 having severe impact. Randomly, 5 wards were selected from each of the 2 village development committees. As the sample was 420, 42 children were selected randomly from every ward. Result. Among the 420 children, 31.9% were underweight, 51.9% were stunted, and 2.9% were wasted after the earthquake. Children who were more prone to being underweight were the following: male children (RR=1.34 95% CI: 1.01-1.78) and children from illiterate mothers (RR=2.49, 95% CI: 1.85-3.36), illiterate fathers (RR=1.73, 95% CI: 1.32-2.27), and homemaker mothers (RR=0.28, 95% CI: 0.20-0.38); children whose families were using nonimproved sources of water (RR=2.60, 95% CI: 1.07-6.60); and households having food insecurity (RR=12.97, 95% CI: 3.29-51.18). Similarly, children of illiterate fathers (RR=1.67, 95% CI: 1.41-1.97), children of illiterate mothers (RR=2.32, 95% CI: 1.91-2.83), children of homemaker mothers (RR=0.59, 95% CI: 0.49-0.70), children whose family were using treated water (RR=0.32, 95% CI: 0.15-0.67), and children from food insecure households (RR=10.52, CI: 4.05-27.33) were found to be stunted. After adjustment, children from households consuming nonimproved water were 6 times more likely (OR=6.75; 95% CI: 1.59-28.62) to be wasted. Conclusion. Illiterate mothers, illiterate fathers, mothers engaged in occupation other than household work, and food insecure households were found to be independent predictors of underweight and stunting. Nonimproved source of drinking water was found to be independent predictors of wasting.

scholarly journals Adjunct therapy of Jivantyadi Ghrita with Anti Tubercular drugs in Rajyakshama (Pulmonary Tuberculosis) – A Case Report

2020 ◽  
Vol 8 (04) ◽  
Author(s):  
Nandkishor Bhaurao Kale
Keyword(s):  
Side Effects ◽  
Pulmonary Tuberculosis ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Adjunct Therapy ◽  
Significant Clinical Improvement ◽  
Wbc Count ◽  
Anti Tubercular Therapy ◽  
Present Case Study

Rajyakshma is oldest disease known to mankind as its first reference found in oldest literature Rugveda. It is called as King of Diseases, which indicates its severity. Tuberculosis remains major public health problem not only in India but also in world. According to WHO one third of global population is suffering from tuberculosis. Anti-tubercular therapy is long lasting and has many side effects, so it is necessary to develop adjunct therapy which will minimize the hazards and help patient to improve the immune status. Aims and objective – To evaluate the toxicity reduction and early restoration by adjunct therapy of Jivantyadi Ghrit.  Methodology - In the present case study DOTs therapy in the dose of 3 tablets once per day was given as an adjunct with Jivantyadi Ghrit 10 ml BD per day was administered for a period of 6 months in the diagnosed case of pulmonary tuberculosis. Assessment was recorded. Results – WBC count and ESR rate reduced to normal, Haemoglobin level increased, SGPT and Sr. Bilurubin level remains normal. Also significant resolution of lung Koch’s lesions was noted radiologically. Conclusion - Jivantyadi Ghrit as an adjunct therapy with DOTs reduces the side effects (especially hepatic) of DOTs therapy and also shows significant clinical improvement in sign and symptoms of PTB.

scholarly journals PENGARUH TERAPI ACTIVE CYCLE OF BREATHING TECHNIQUE (ACBT) TERHADAP FREKUENSI PERNAFASAN (RESPIRATORY RATE) PADA PENDERITA TUBERKULOSIS PARU DI RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN

2021 ◽  
Vol 4 (2) ◽  
pp. 499-506
Author(s):  
Eka Nugraha Varida Naibaho ◽  
Sri Mega Herlina Kabeakan
Keyword(s):  
Pulmonary Tuberculosis ◽  
Quantitative Research ◽  
Public Health Problem ◽  
Respiratory Frequency ◽  
Wilcoxon Test ◽  
Major Public Health Problem ◽  
Breathing Patterns ◽  
Tuberculosis Patients ◽  
A Value ◽  
Post Test

Pulmonary tuberculosis is a major public health problem in the world and is the second leading cause of death from infectious diseases. The purpose of this study was to determine the effect of active cycle of breathing technique (ACBT) therapy on breathing frequency in patients with pulmonary tuberculosis. Quantitative research method, with a Quasi Experimental research design with a pre-test and one-group post-test approach. The study was carried out in the Orchid room of the Imelda Indonesian Workers General Hospital in Medan in July - August 2021. The study population was 45 patients with pulmonary tuberculosis and the sample technique of this study was Nonprobability Sampling. The number of samples was 41 pulmonary tuberculosis patients according to the researcher's criteria. The data analysis technique used is Wilcoxon test analysis. The results of the study There was an effect of breathing patterns before the administration of active cycle of breathing technique (ACBT) Therapy on the improvement of respiratory frequency in patients with pulmonary tuberculosis with a value of M ± SD = 17.1081 ± 2.94188. There is an effect of breathing pattern after administration of active cycle of breathing technique (ACBT) Therapy on the respiratory frequency of Pulmonary Tuberculosis Patients with a value of M ± SD = 27.0400 ± 2.82076. There is a difference in the effect of breathing patterns before and after administration of active cycle of breathing technique (ACBT) therapy on the Improvement of respiratory frequency in pulmonary tuberculosis patients with a significant value of 0.000 < 0.005.   Abstrak Tuberkulosis paru adalah masalah pokok kesehatan pada masyarakat didunia dan merupakan penyebab kematian ke dua dari penyakit infeksi. Tujuan penelitian untuk mengetahui pengaruh pemberian terapi active cycle of breathing technique (ACBT) terhadap frekuensi pernafasan pada penderita tuberkulosis paru. Metode penelitian kuantitatif, dengan desain penelitian Quasi Eksperiment dengan pendekatan pre test dan post test one group. Penelitian dilaksanakan di ruangan Anggrek Rumah Sakit Umum Imelda Pekerja Indonesia Medan pada bulan Juli - Agustus 2021. Populasi penelitian sebanyak 45 orang pasien Tuberkulosis Paru dan teknik sampel penelitin ini adalah Nonprobability Sampling. Jumlah sampel 41 orang pasien tuberkulosis paru sesuai dengan kriteria peneliti. Teknik analisa data yang digunakan adalah analisis uji Wilcoxon. Hasil penelitian ada pengaruh pola nafas sebelum pemberian terapi active cycle of breathing technique (ACBT) terhadap perbaikan frekuensi pernafasan pada penderita tuberkulosis paru dengan nilai M ± SD =17.1081 ± 2.94188. Ada pengaruh pola nafas sesudah pemberian terapi active cycle of breathing technique (ACBT) terhadap frekuensi pernafasan pasien tuberkulosis paru dengan nilai M ± SD = 27.0400 ± 2.82076. Ada perbedaan pengaruh pola nafas sebelum dan sesudah pemberian terapi active cycle of breathing technique (ACBT) terhadap perbaikan frekuensi pernafasan pasien tuberkulosis paru dengan nilai signifikan 0,000 < 0,005.

scholarly journals DETERMINANTS OF NUTRITIONAL STATUS OF UNDER 5 YEARS CHILDREN

2019 ◽  
Vol 17 (1) ◽  
pp. 6-10
Author(s):  
Hira Ejaz ◽  
Nirmal Walicha ◽  
Saba Rizwan ◽  
Sadaf Javeria ◽  
Sana Iqbal ◽  
...  
Keyword(s):  
Public Health ◽  
Nutritional Status ◽  
Family Structure ◽  
Family System ◽  
Nuclear Family ◽  
Age Groups ◽  
Public Health Problem ◽  
Severe Malnutrition ◽  
Major Public Health Problem ◽  
Cross Sectional

Background: Malnutrition continues to be a major public health problem in developing and underdeveloped countries. The objectives of the study were to determine the determinants of nutritional status of under 5 years children in our population. Materials & Methods: This analytical cross sectional study was conducted by the Department of Public Health, Islamabad, Federal College, Islamabad, from November 2016 to March 2017. Sample size was 200 selected by convenient sampling. Demographic variables were sex, age-groups, socio-economics status, family structure. Research variable was nutritional status. The data collection was done in urban slums of Islamabad on a structured questionnaire. Statistical analysis was done by using SPSS software. Results: Out of 200 children, 117(58.5%) were boys and 83(41.5 %) were girls. One hundred (50%) children were of 6 to 24 months and 100(50%) were of 25 to 59 months of age. Eighty three (41.5%) were rich and 117(58.5%) were poor. One hundred and fifty eight (79%) children were from joint family system and 42(21%) were living in nuclear family system were children. One hundred and fifty one (75.50%) were normal, 39(19.50%) were mild and 10(5%) were having severe malnutrition. Conclusion: Except age all the other factors including sex, socio-economics status and family structure were associated with nutritional status of under 5 year children.

scholarly journals COMPARATIVE ASSESSMENT OF BIOCHEMICAL AND IMMUNOLOGICAL MARKERS IN TUBERCULOSIS

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Abhijit Ninghot ◽  
Kanchan Mohod ◽  
Mohd. Sameer Khan ◽  
Azmat Kamal Ansari ◽  
Satish Kumar
Keyword(s):  
Pulmonary Tuberculosis ◽  
Adenosine Deaminase ◽  
Sensitivity And Specificity ◽  
Sputum Sample ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Immunological Markers ◽  
Tuberculosis Antigen ◽  
Commercial Kits ◽  
Antigen Antibody

Introduction: Pulmonary tuberculosis is major public health problem in developing countries like India.Millions of people have died from tuberculosis. Many times it is difficult to get sputum sample from the patients. Some tests lack specificity, some other lack sensitivity. Hence, there is need of precise and faster diagnosis for patients attending hospitals. In this study, we compared the detection potential of biochemical and immunological markers(ADA, LDH and Mycobacterium tuberculosis H37Ra ES-31 & EST-6 antigens & antibodies based ELISAs) in pulmonary tuberculosis. Methods: 50 pulmonary tuberculosis cases confirmed by sputum examinationfor acid fast bacilli (AFB) and 50 age and sex matched control subjects were included in this study.ADA & LDH were estimated by using commercial kits. Tubercular antigens and antibodies were detected by ELISA method. Results: SerumADA detected pulmonary tuberculosis with sensitivityand specificityof 94%. Sensitivity and specificity of serum LDH in detecting pulmonary tuberculosis was found to be 94% and 36% respectively.Serumtubercular antigens detected pulmonary tuberculosis with sensitivity and specificity of 88%. Sensitivity and specificity of serum tubercular antibodies in detecting pulmonary tuberculosis was found to be 80% and 90% respectively. Conclusion: Adenosine deaminase has better detection potential over other markers in pulmonary tuberculosis. Keywords: Adenosine deaminase, Lactate dehydrogenase, Tuberculosis antigen-antibody

Kebutuhan Psikososial Keluarga yang Mempunyai Anggota Keluarga MenderitaTB Paru

1970 ◽  
Vol 3 (1) ◽  
Author(s):  
Noor Indyah Rachmawati ◽  
Suryani S ◽  
Chandra Isabella
Keyword(s):  
Pulmonary Tuberculosis ◽  
Public Health Problem ◽  
Sampling Technique ◽  
Treatment Programs ◽  
Psychosocial Needs ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Healthy Environment ◽  
The World ◽  
Development Goals

TB paru masih menjadi masalah kesehatan di Indonesia dan dunia. Upaya pengendalian TB paru menjadi perhatian dunia dan menjadi salah satu indikator dalam pencapaian tujuan pembangunan global. Peran keluarga dalam pengobatan TB paru sangat besar yaitu sebagai PMO, pemberi dukungan psikis dan menciptakan lingkungan yang sehat untuk mencegah penularan. Keluarga yang mempunyai anggota keluarga menderita TB paru sering mendapat stigma negatif sehingga bisa menyebabkan kegagalan dalam merawat pasien. Penelitian ini dilakukan untuk mengetahui gambaran kebutuhan psikososial keluarga yang mempunyai anggota keluarga menderita TB Paru di RS X. Jenis penelitian deskriptif kuantitatif dengan total sampling keluarga pasien TB Paru yang sedang dirawat sebanyak 57 orang. Hasil penelitian menunjukkan bahwa seluruh responden membutuhkan kebutuhan psikososial yang meliputi kebutuhan interaksi sosial, emosi, pengetahuan dan spiritual. Kebutuhan psikososial yang paling banyak dibutuhkan adalah dalam hal pengetahuan. Hal ini menunjukkan bahwa pengetahuan sangat berpengaruh terhadap peran keluarga sebagai PMO dan dalam merawat anggota keluarganya yang menderita TB paru. Kebutuhan dengan nilai persentase tertinggi adalah dalam hal spiritual pada item adanya harapan untuk kesembuhan anggota keluarga yang menderita TB paru. Berdasarkan hasil penelitian ini, diharapkan RS X berupaya meningkatkan pemenuhan kebutuhan psikososial keluarga, dengan cara menambah frekuensi penyuluhan, mengembangkan metode pemberian informasi untuk menguatkan pengetahuan atas informasi yang diberikan, kemudahan konsultasi dengan teknik konseling dapat diberikan untuk meningkatkan pengetahuan dan partisipasi keluarga dalam program pengobatan. Kata kunci: Kebutuhan psikososial, keluarga, TB Paru. Family’s Psychosocial Needs of Pulmonary Tuberculosis Patients AbstractPulmonary TB is still a public health problem in Indonesia and the world. Efforts in controlling TB desease are becoming a focus of the world and become one of the indicators in achieving global development goals. A families roles in TB treatment is very important as Supervisors to take medicine, giving psychological support and create a healthy environment to prevent desease spread. A family that has a member with TB desease oftenly receaved negative stigma hance it could result in treatment failure. This study was conducted to describe family’s psychosocial needs among pulmonary tuberculosis patients at X Hospital. This study is descriptive quantitative, using total sampling technique with family respondents pulmonary TB patients are being cared for as many as 57 people. The results showed that all respondents required psychosocial needs include the need for social interaction, emotional, knowledge and spiritual. This shows that the knowledge is very influential toward a families roles as Supervisor to take medicine and in caring for family members who suffer from tuberculosis. Needs with the higest percentage in terms of spiritual item is hope to recover from TB. Based on these results, it is expected X Hospital seeks to improve the fulfillment of the families psychosocial needs by way of to increase the frequency of health information, developed a method of providing information to strengthen knowledge on the information provided, ease of consultation with counseling techniques can be given to increase family participation in treatment programs. Key words: Family, psychosocial needs, pulmonary TB.

scholarly journals Evaluation of Risk Factors for Hepatotoxicity in Patients Receiving Antitubercular Four Drugs Regimen in Initial Two Months

2015 ◽  
Vol 14 (1) ◽  
pp. 15-18
Author(s):  
Saifun Nahar Faiz ◽  
Nasreen Chowdhury ◽  
Md Aminul Haque Khan ◽  
Rukhsana Parvin
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Alcohol Intake ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
High Alcohol ◽  
Drug Induced ◽  
Study Results ◽  
Pre Treatment ◽  
High Alcohol Intake

Background: Tuberculosis (TB) is a major public health problem in Bangladesh since long before. Standard first line drugs are isoniazid, rifampicin, pyrazinamide and ethambutol. Of these, isoniazid, rifampicin and pyrazinamide have been observed to have hepatotoxic potentials. Drug Induced Hepatotoxicity (DIH) is an important and commonly encountered adverse effect with anti-TB treatment. A higher risk of hepatotoxicity has been reported in Bangladeshi patients than in their western counterparts. The reasons for the higher rate of hepatotoxicity in Bangladeshi patients are unclear. Objectives: To know the possible risk factors for the development of drug induced hepatotoxicity and to see their association with hepatoxicity in patients receiving antitubercular treatment as per National Tuberculosis Control Programme. Materials and Methods: In this cross sectional prospective study, 100 freshly diagnosed pulmonary tuberculosis patients attending the Medicine Outpatient Department, admitted in Chittagong Medical College Hospital, DOTS center in the hospital were selected for the study. Results: In this study we found twenty percent patients (20%) developed Antituberculosis Treatment (ATT) induced hepatotoxicity and most of them were in the age group of 50–65 years. Among the patients who developed hepatotoxicity (DIH) 27% patients were in BMI 18.5 group. The patients presenting with radiologically severe Pulmonary Tuberculosis (PTB) developed higher hepatotoxicity than patients with milder disease. The patients with history of high alcohol intake and with pre-treatment hypoalbuminemia were also found to have higher drug induced hepatotoxicity as compared to non-alcoholics and normal serum albumin level respectively. This study showed the evidence of ATT induced liver damage in twenty percent (20%) patients. Among them 05% cases developed overt drug induced hepatotoxicity (DIH) and remaining 15% cases had asymptomatic elevation of serum ALT, AST and bilirubin levels. The remaining 80% cases did not show any significant change in their serum bilirubin and/or enzyme levels as compared to pre-treatment levels. Conclusion: Advanced age, high alcohol intake, radiologically severe disease before treatment and pretreatment hypoalbuminemia are predisposing factors for the development of ATT induced hepatotoxicity.DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22873 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 15-18

Sign in / Sign up

Export Citation Format

Share Document