scholarly journals Association of Chest X-Rays Features with the Length of Stay in Suspected COVID-19 Status

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Zulmansyah Zulmansyah ◽  
Gaga Irawan Nugraha ◽  
Dwi Agustian ◽  
Dida Akhmad Gurnida
Keyword(s):  
Linear Regression ◽  
Length Of Stay ◽  
Severe Acute Respiratory Syndrome ◽  
General Hospital ◽  
Pearson Correlation ◽  
Strong Association ◽  
P Value ◽  
X Rays ◽  
New Variant ◽  
The Subject

Coronavirus disease 2019 (COVID-19) is a new type of respiratory infection that first emerged in December 2019 in Wuhan, Hubei, China. COVID-19 is caused by a new variant of virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Examining the chest x-rays is one technique to diagnose COVID-19. This study aims to determine the association of chest x-rays features in suspected COVID-19 patients with the length of stay at Al-Ihsan Regional General Hospital West Java Province and Banten Regional General Hospital in June–November 2020. The subject was 29 COVID-19 people were confirmed, whereas 31 people were not. The statistical analysis used Pearson correlation and multi-linear regression. This study found that tuberculosis had a strong association with length of stay (p value=0.048, association=0.4), and also there is a robust association between bilateral pneumonia and duration of stay (p value=0.028, association=0.873). A linear regression model discovery of TB photo on the subject raises the treatment by 0.5867 days. In addition, the discovery of bilateral pneumonia increases the length of stay of treatment by 0.32218 days more than the discovery of unilateral pneumonia. In general, tuberculosis, bacterial pneumonia, viral pneumonia, and bilateral pneumonia together affected the outcome of length of stay of patients with suspected COVID-19. ASOSIASI GAMBARAN RONTGEN TORAKS DENGAN LAMA RAWAT PADA PASIEN SUSPEK COVID-19Coronavirus disease 2019 (COVID-19) adalah jenis infeksi saluran pernapasan baru yang pertama kali mewabah pada Desember 2019 di Wuhan, Hubei, Cina. COVID-19 disebabkan oleh varian virus baru yang disebut severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pemeriksaan rontgen toraks merupakan salah satu teknik mendiagnosis COVID-19. Penelitian ini bertujuan mengetahui asosiasi gambaran rontgent toraks pada pasien suspek COVID-19 dengan lama rawat inap di RSUD Al-Ihsan Provinsi Jawa Barat dan RSUD Banten pada Juni–November 2020. Subjek penelitian adalah 29 orang terkonfirmasi COVID-19 dan 31 orang tidak. Analisis statistik menggunakan korelasi Pearson dan regresi multilinier. Penelitian ini menemukan bahwa tuberkulosis memiliki hubungan yang kuat dengan lama perawatan (p=0,048; asosiasi=0,4) dan juga terdapat hubungan yang kuat antara pneumonia bilateral dan lama perawatan (p=0,028; asosiasi=0,873). Penemuan model regresi linier foto TB pada subjek meningkatkan risiko perawatan 0,5867 hari lebih lama. Selain itu, penemuan pneumonia bilateral meningkatkan risiko perawatan 0,32218 hari lebih lama dibanding dengan penemuan pneumonia unilateral. Secara umum, tuberkulosis, pneumonia bakteri, pneumonia viral, dan pneumonia bilateral secara bersama-sama berpengaruh terhadap luaran lama rawat inap pasien suspek COVID-19.

scholarly journals May Mutation of SNP rs1800947 Affects Length of Stay Outcome of COVID-19 suspects?

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1278
Author(s):  
Zulmansyah Zulmansyah ◽  
Gaga Irawan Nugraha ◽  
Dwi Agustian ◽  
Dida Akhmad Gurnida
Keyword(s):  
At Risk ◽  
Length Of Stay ◽  
Pearson Correlation ◽  
Strong Association ◽  
P Value ◽  
Length Of Treatment ◽  
New Type ◽  
The Subject ◽  
The Relationship ◽  
Very High

Coronavirus disease 2019 (COVID-19) is a new type of respiratory infection that first emerged in December 2019 in Wuhan, Hubei, China. COVID-19 is caused by a new type of virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aims to determine the association of SNP CRP rs1800947 gene in suspected COVID-19 patients to length of stay at Al Ihsan Hospital, and Banten Hospital in June-November 2020. This study used data from 60 patients, all patients were suspect COVID-19. The subject was  29 COVID-19 people were confirmed, whereas 31 people were not. A statistics analysis due to pearson correlation and linear multi regretion. This study found a significant assosiation between the subject. The results of this study were the relationship between SNP rs1800947 and outcome, a fairly strong association level relationship was found in the SNP rs1800947 (p-value= 0.045, association= 0.537). The association between length of stay and CRP levels has a low level of association (p-value=0.015, association=0.378). The SNP genotype rs1800947 G had a longer treatment duration of 0.14778 days compared to the SNPrs1800947 C genotype. CRP levels showed that higher CRP levels increased the length of treatment compared to normal CRP levels. Where high CRP levels are at risk of 0.6330 days longer than normal CRP while very high CRP is at risk of 2.9561 days longer than Normal CRP levels. In general, the gene SNP rs1800947 and CRP levels, together affect the outcome of patients with suspected COVID-19.

scholarly journals 1412. The utility of respiratory viral panel testing for nosocomial fever in the neonatal intensive care unit

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S713-S713
Author(s):  
Carlo Fopiano Palacios ◽  
Eric Lemmon ◽  
James Campbell
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Linear Regression ◽  
Length Of Stay ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
P Value ◽  
Fisher Exact Test ◽  
The Mean ◽  
Pcr Test

Abstract Background Patients in the neonatal intensive care unit (NICU) often develop fevers during their inpatient stay. Many neonates are empirically started on antibiotics due to their fragile clinical status. We sought to evaluate whether the respiratory viral panel (RVP) PCR test is associated with use of antibiotics in patients who develop a fever in the NICU. Methods We conducted a retrospective chart review on patients admitted to the Level 4 NICU of the University of Maryland Medical Center from November 2015 to June 2018. We included all neonates who developed a fever 48 hours into their admission. We collected demographic information and data on length of stay, fever work-up and diagnostics (including labs, cultures, RVP), and antibiotic use. Descriptive statistics, Fisher exact test, linear regression, and Welch’s ANOVA were performed. Results Among 347 fever episodes, the mean age of neonates was 72.8 ± 21.6 days, and 45.2% were female. Out of 30 total RVP samples analyzed, 2 were positive (6.7%). The most common causes of fever were post-procedural (5.7%), pneumonia (4.8%), urinary tract infection (3.5%), meningitis (2.6%), bacteremia (2.3%), or due to a viral infection (2.0%). Antibiotics were started in 208 patients (60%), while 61 neonates (17.6%) were already on antibiotics. The mean length of antibiotics was 7.5 ± 0.5 days. Neonates were more likely to get started on antibiotics if they had a negative RVP compared to those without a negative RVP (89% vs. 11%, p-value < 0.0001). Patients with a positive RVP had a decreased length of stay compared to those without a positive RVP (30.3 ± 8.7 vs. 96.8 ± 71.3, p-value 0.01). On multivariate linear regression, a positive RVP was not associated with length of stay. Conclusion Neonates with a negative respiratory viral PCR test were more likely to be started on antibiotics for fevers. Respiratory viral PCR testing can be used as a tool to promote antibiotic stewardship in the NICU. Disclosures All Authors: No reported disclosures

scholarly journals Hubungan waktu tunggu dan length of stay (LOS) Dengan kepuasan pasien di instalasi Gawat darurat rsud jombang

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Siti Maghfiroh ◽  
Ratna Puji Priyanti ◽  
Alik Septian Mubarrok
Keyword(s):  
Quality Of Service ◽  
Length Of Stay ◽  
Emergency Room ◽  
General Hospital ◽  
Waiting Time ◽  
Statistical Tests ◽  
P Value ◽  
Spearman Rank ◽  
R Value

Introduction: Waiting time and length of stay ( LOS ) is one of indicators the quality of service in emergency room (ER ) that affects satisfaction patients, where speed and the accuracy is the essence service in ER. Research aims to understand the relations of waiting time and LOS with satisfaction patients in of emergency room Jombang general hospital. Method: This research using correlational design with cross sectional approached. The technique sampling is accidental sampling. The population were 1.204 people. And the sample size 60 people. Data collection used a questionnaire for measuring satisfaction patients and observation stopwatch a use for measuring waiting time and LOS. Data analyzed by statistical tests the spearman rank. Result: The results of the study obtained 31 people ( 51.7 % ) of respondents with waiting time slow, 24 people ( 40,0 % ) of respondents with los slow, while for the satisfaction of patients 31 people ( 51.7 % ) of a patient is satisfied with service. Statistical tests the spearman rank showsed that waiting time with satisfaction obtained  r value = 0,666, p value = 0,000. To LOS with satisfaction the r value = 0,350, p value = 0,006. There is a significant relation exists between waiting time and LOS with satisfaction patients. Discussion: Waiting time and LOS significant correlated with satisfaction patients in ER Jombang general hospital. The ER in Jombang general hospital is expected to have strong commitment, to give priority to the quality of service and interests of patients. Health workers is expected to give rapid service, right and respond to the problem of patients. And advanced research required about satisfaction patients in ER and the supporting factors.

scholarly journals HUBUNGAN PEMANFAATAN DANA BANTUAN OPERASIONAL KESEHATAN TERHADAP PENINGKATAN CAKUPAN PEMERIKSAAN KEHAMILAN DAN PERSALINAN DI FASILITAS KESEHATAN

2020 ◽  
Vol 11 (1) ◽  
pp. 79-88
Author(s):  
Suparmi Suparmi ◽  
Iram Barida Maisya ◽  
Anissa Rizkianti ◽  
Ika Saptarini ◽  
Ario Baskoro
Keyword(s):  
Public Health ◽  
Maternal Health ◽  
Linear Regression ◽  
Antenatal Care ◽  
Health Workers ◽  
Pearson Correlation ◽  
Health Facilities ◽  
P Value ◽  
Correlation Test ◽  
Pearson Correlation Test

Abstract Background: Health Operational Assistance (BOK) is a central government fund allocation to support the operation of Health Center (Puskesmas) to increase promotive and preventive activities related to public health, including maternal health. Objective: This study aims to determine the relationship of BOK utilization on maternal health service coverage. Method: The study used secondary data from the Ministry of Health e-Renggar Planning and Budget Bureau, Statistics Indonesia, the Ministry of Finance and the 2018 Public Health Development Index (IPKM) report. The unit of analysis is districts. Bivariate analysis was performed by Pearson correlation test, while multivariate analysis was performed by linear regression using SPSS software version 15. Results: The result of Pearson correlation test showed that BOK utilization was positively correlated with an increase in the antenatal care coverage (r = 0.294; p-value = 0,000) and coverage of deliveries by health workers in health facilities (r = 0.227; p-value = 0,000). The results of linear regression analysis showed BOK utilization, the percentage of poverty and the adequacy of posyandu have a significant relationship with antenatal care coverage and coverage of delivery assisted by health workers in health facilities. Conclusion: The health operational fund utilization increase antenatal care coverage and coverage of delivery assisted by health workers in health facilities. Therefore, it is necessary to optimize the use of BOK for the achievement of priority public health programs, especially for innovative activities that have a high degree of leverage towards the achievement of SDGs so that the target in reducing Maternal Mortality Rate (MMR) can be achieved. Keywords: health operational fund, maternal health, coverage, services   Abstrak Latar Belakang: Bantuan Operasional Kesehatan (BOK) merupakan salah satu sumber pembiayaan dari pemerintah pusat untuk menunjang operasional Puskesmas dalam meningkatkan upaya promotif dan preventif terkait kesehatan masyarakat, salah satunya kesehatan ibu. Tujuan: Studi ini bertujuan untuk mengetahui hubungan pemanfaatan BOK terhadap cakupan pelayanan kesehatan ibu. Metode: Studi ini menggunakan data sekunder dari laporan e-renggar Biro Perencanaan dan Anggaran Kementerian Kesehatan, Badan Pusat Statistik, Kementerian Keuangan dan laporan Indeks Pembangunan Kesehatan Masyarakat (IPKM) tahun 2018. Unit analisis adalah Kabupaten/Kota. Analisis bivariate dilakukan dengan uji korelasi pearson, sedangkan analisis multivariate dilakukan dengan regresi linier menggunakan software SPSS versi 15. Hasil: Hasil analisis uji korelasi pearson menunjukkan bahwa persentase realisasi BOK berkorelasi positif dengan peningkatan cakupan pemeriksaan kehamilan K4 (r=0,294; p-value=0,000) dan cakupan persalinan oleh tenaga kesehatan di fasilitas kesehatan (r=0,227; p-value=0,000). Hasil analisis regresi linier menunjukkan pemanfaatan BOK, persentase penduduk miskin dan kecukupan posyandu mempunyai hubungan bermakna dengan cakupan K4 dan cakupan persalinan ditolong oleh tenaga kesehatan di fasilitas kesehatan. Kesimpulan: Pemanfaatan BOK berhubungan dengan peningkatan cakupan K4 dan cakupan persalinan ditolong oleh tenaga kesehatan di fasilitas kesehatan. Optimalisasi pemanfaatan BOK untuk pencapaian program prioritas kesehatan masyarakat diperlukan, terutama untuk kegiatan-kegiatan inovatif yang memiliki daya ungkit tinggi terhadap pencapaian SDGs sehingga target dalam menurunkan Angka Kematian Ibu (AKI) dapat tercapai. Kata kunci: bantuan operasional kesehatan, kesehatan ibu, cakupan, pelayanan

scholarly journals Correlations of Prostate Volume with PSA Levels in BPH Patients at Ulin General Hospital Banjarmasin

2021 ◽  
Vol 17 (1) ◽  
pp. 15
Author(s):  
Nur Ramadhanti Cindy Levissa ◽  
Eka Yudha Rahman ◽  
Dewi Indah Noviana Pratiwi ◽  
Heru Prasetya ◽  
Siti Kaidah
Keyword(s):  
Data Analysis ◽  
General Hospital ◽  
Correlation Coefficient ◽  
Strong Correlation ◽  
Prostate Volume ◽  
Pearson Correlation ◽  
P Value ◽  
Analytic Method ◽  
Pearson Correlation Coefficient ◽  
Cross Sectional

Abstract: This study aims to determine the association between prostate volume and PSA levels in BPH patients at Ulin Hospital Banjarmasin. This study used a cross-sectional retrospective approach and analytic method. A total of 52 samples were obtained by purposive sampling based on inclusion and exclusion criterias. The highest prostate volume of  20.00-39.99 cc was obtained from 16 patients (30.7%) and the lowest volume of  60.00-79.99 cc was obtained from 10 patients (19.2%). Examination of PSA levels were highest at 2.6-9.9 ng/mL from 24 patients (46.2%) and the lowest at >20.0 ng/mL (5.8%) from 3 patients. Data analysis using Pearson correlation coefficient showed a positive correlation between prostate volume and PSA levels in BPH patients at Ulin Hospital Banjarmasin with a p value = 0,000 and r = 0.616 (positive and strong correlation). Keywords: BPH, Prostate volume, PSA

scholarly journals EFFECT OF SEPARATION OF INITIAL ASSESSMENT DOCUMENTS ON THE LENGTH OF STAY IN EMERGENCY INSTALLATION IN KENDARI CITY GENERAL HOSPITAL

2021 ◽  
Vol 3 (2) ◽  
pp. 14-19
Author(s):  
Tono Sumanto ◽  
Sunarsih Sunarsih ◽  
Timbul Supodo
Keyword(s):  
Length Of Stay ◽  
Emergency Room ◽  
General Hospital ◽  
Sampling Technique ◽  
Initial Assessment ◽  
P Value ◽  
City Hospital ◽  
Number Of Patients ◽  
Post Test ◽  
Number Of Visits

Background: A preliminary survey of prospective researchers in  the Kendari City General Hospital especially in the Emergency Installation (ER), the number of emergency room visits has decreased in the last 3 years, in 2017 the total number of patients treated in the ER was 10.869 patients, then in 2018 the number of visits decreased to 10.768 patients, and in 2019 the number of visits fell to 9.747 patients. Meanwhile, based on the data in the last few months in 2020 there was a very large spike in decline in the last month, in January 2020 the number of patient who visited,  were  849 people, then in February 2020 the number of the patient were  1202 patients, March 2020 the number of visits was 1216 patients and finally in April 2020 it fell to 451 people. The purpose of this study is to analyse the effect of separation of the initial assessment documents on Length of Stay in Emergency Installation in Kendari City General Hospital. Methods: The research design was experimental with design pretest post-test one group design. The research location was in the Emergency Room of the Kendari City Regional General Hospital which was carried out during February 2021. The population of all patients who were hospitalized was> 17 years old while the sample was 18 people with the sampling technique of separated random sampling. Result: This study found separation of the initial assessment documents affected significantly to  Length of Stay patients in Emergency room in Kendari City General Hospital (p- value =  0.045 < 0.05). Conclusion: Separation technique of the initial assessment documents on Length of Stay was effective to reduce the Length of Stay patients in Emergency room in Kendari City Hospital.

scholarly journals Analysis The Level of Compliance of Hospital Human Resources in Writing The Status of Inpatient Medical Record Dr Sayidiman Hospital and The Influences Factors

2020 ◽  
Vol 3 (2) ◽  
pp. 423-433
Author(s):  
Ratnawati Ratnawati
Keyword(s):  
Linear Regression ◽  
Human Resources ◽  
General Hospital ◽  
Medical Record ◽  
Health Professionals ◽  
Medical Records ◽  
Regional Hospital ◽  
P Value ◽  
The Status

The quality of medical records in hospitals also determines the quality of service, completeness of writing Medical Records documents correctly and correctly is very important. The purpose of this study was to analyze the level of compliance of hospital human resources in writing the status of the inpatient Medical Record Dr. Sayidiman Magetan Regional Hospital and the factors that influence it. The design of this study was an observational quantitative study with a cross section approach with the focus of the research directed to be analyzing the level of compliance of hospital human resources in writing the status of the inpatient Medical Record Dr Sayidiman Magetan Regional Hospital and the factors that influenced it with a sample of 192 respondents taken with the Simple Random Sampling technique. The findings found that most of the respondents have high motivation that is 144 respondents (75%). Most of the respondents care to write in the medical record that is 160 respondents (83.3%). Most of the respondents have a high appreciation of 136 respondents (70.8%). Most of the respondents did not comply doing medical record writing of 107 respondents (55.7%). Based on the Linear Regression analysis the motivation variable on compliance p-value 0.015 <0.05, the variable concern for compliance p-value 0.025 <0.05 then H0 is rejected so there is the influence of motivation and concern for compliance with medical record writing by health professionals in Regional General Hospital Dr. Sayidiman Magetan. Linear regression variable rewards for compliance shows that the p-value of 0.665> 0.05 then H0 is accepted so it is concluded that there is no effect of rewards on compliance with writing medical records by health professionals at the Dr Sayidiman Magetan Regional General Hospital. It is expected that respondents can comply to fill out medical records so that the delivery of care to passion can be well integrated

scholarly journals Hubungan Tingkat Kecemasan Dengan Lama Hari Rawat Pada Pasien Akut Miokard Infark (AMI) DI Ruang ICVCU RSUD DR. Moewardi Surakarta

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Armada Karima ◽  
Yuyun Setyorini
Keyword(s):  
Myocardial Infarction ◽  
Length Of Stay ◽  
General Hospital ◽  
Sampling Technique ◽  
Cross Sectional ◽  
Cardiovascular Patients ◽  
Collection Data ◽  
The Subject ◽  
The Relationship ◽  
Test Result

Abstract : Myocardial Infarction, Anxiety, Length of Stay. The purpose of nursing care of cardiovascular patients are to repair hemodynamic, to suffice oxygen need and to decrease anxiety. AMI patients who are undergoing treatment can use anxiety and may the length of stay. Research purpose to determine the relationship between the anxiety and length of stay in myocardial infarction patients at ICVCU Dr. Moewardi General Hospital. This study is descriptive analytic correlation using cross sectional approach. The subject is all AMI patients. The sampling technique using in this research is total sampling. A questionnaire was constructed to collect data. The collection data was analyzed by using spearman. Retrieved from 30 respondents, it is the average age of patients with myocardial infarction is 51-65 (63,3%) and the majority of the majority of the male gender with percentage 63,3%. Majority of AMI patients moderate anxiety with percentage 43,3% and long of stay fast with a percentage 56,7%. Analysis of test result obtained probality value 0.41. Based on the analysis it can be concluced that there is a significant relationship between anxiety and length of day in myocardial infarction patient at ICVCU Dr. Moewardi General Hospital Surakarta.

scholarly journals Facial Injury Severity Scale Score as a Predictor of Length of Stay for Maxillofacial Fracture at Sanglah General Hospital, Denpasar, Bali, Indonesia

2020 ◽  
Vol 8 (B) ◽  
pp. 291-294
Author(s):  
Esther Felicita Tambayong ◽  
Nengah Kuning Atmadjaya ◽  
Nyoman Golden ◽  
Ketut Wiargitha ◽  
Gede Bagus Mahadewa Tjokorda
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Length Of Stay ◽  
General Hospital ◽  
Injury Severity ◽  
Linear Regression Analysis ◽  
Facial Injury ◽  
Severity Scale ◽  
Operating Characteristics ◽  
Maxillofacial Fracture

INTRODUCTION: Maxillofacial fracture is the most common trauma that happened in the developing countries. One of the methods to evaluate the severity of maxillofacial fracture is by using the Facial Injury Severity Scale (FISS) score. Maxillofacial trauma causes multiple injuries, thus resulted in various periods of hospitalization. AIM: The aim of this study is to use the employment of the FISS score to predict a patient’s length of stay. METHODS: This research was a retrospective cohort and cross-sectional study on maxillofacial fracture patients whom treated in Sanglah General Hospital, Denpasar, Bali. As much as 89 subjects were included in this study and information about their age, gender, mechanism of injury, FISS score, treatments, and length of stay was collected. The data were statistically analyzed using bivariate, receiver operating characteristics (ROC), and linear regression analysis. RESULTS: A total of 89 subjects were included in this study. Among them, 50 subjects had a high FISS score, and 39 subjects had low FISS score. The average age was 28.9 ± 13.3 years with a mean length of stay 6.39 ± 4.29 days. Bivariate analysis showed that the patients with high FISS score have 5.3 times higher risk to get a longer length of stay compared to those with low FISS score (95% CI: 2.289–12.289; p = 0.001). The mean of length of stay in subjects with a high FISS score was significantly higher compared to subjects with a low FISS score (mean for subjects with high score: 8.46 ± 4.63; mean for subjects with low score: 3.74 ± 1.46; p = 0.001) with a correlation value r = 0.718 (p = 0.001). ROC analysis represented that FISS score ˂4 was categorized as mild. The linear regression analysis showed that the length of stay for maxillofacial fracture patients was able to be predicted by LOS = 1.476 + 1.032 × FISS score. CONCLUSION: The FISS score can predict the length of stay for patients with maxillofacial fracture.

scholarly journals NCOG-51. CORRELATION BETWEEN TUMOR VOLUME AND SERUM PROLACTIN AND IMPACT OF TUMOR CELLULAR DENSITY ON PROLACTINOMA SURGICAL OUTCOMES IN A COHORT OF 181 PATIENTS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii140-ii141
Author(s):  
Matheus Pereira ◽  
Taemin Oh ◽  
Rushikesh Joshi ◽  
Alexander Haddad ◽  
Kaitlyn Pereira ◽  
...  
Keyword(s):  
Linear Regression ◽  
Tumor Volume ◽  
Pearson Correlation ◽  
Strong Association ◽  
Serum Prolactin ◽  
Residual Volume ◽  
Cellular Density ◽  
Remission Rates ◽  
Pearson Correlation Analysis ◽  
Biochemical Remission

Abstract INTRODUCTION Prolactinomas are common pituitary adenomas managed medically or surgically. METHODS Reviewed 181 prolactinomas resected transsphenoidally 2012-2019. Tumor volumes were quantified using BrainLab Smartbrush. Pearson correlation analysis and linear regression were used to identify associations between tumor volumes and serum prolactin. Tumor density was defined as serum prolactin divided by tumor volume. RESULTS Mean tumor volume was 6.33cm3 and mean pre-op prolactin was 803.4ug/L, with men having larger (12.11 vs 2.93cm3;p&lt; 0.001) and women having denser (173.9 vs 107.6ug/L/cm3;p=0.011) prolactinomas. Pearson correlation (R=0.688;p&lt; 0.001) and linear regression revealed a strong association between pre-op volume and prolactin levels, with 96.9g/L increase in prolactin/cm3 increase in volume (p&lt; 0.001); this holds true for men (R=0.584;p&lt; 0.001) and women (R=0.939;p&lt; 0.001), with women demonstrating greater prolactin/cm3 tumor density (186.5 vs 75.0ug/L;p&lt; 0.001). MiB index did not correlate with pre-op volume (p=0.449) or pre-op prolactin (p=0.452). Logistic regression showed decreased biochemical remission with increasing pre-op volume (OR=0.891;p&lt; 0.001). Increased MiB index (p=0.971) and p53 (p=0.525) staining did not affect remission rates. Positive PIT-1 staining was associated with higher remission rates (OR=2.508;p=0.005). Patients without remission had denser tumors (149.9 vs. 100.6ug/L/cm3;p=0.013), with Pearson correlation yielding R=0.736 between pre-op volume and pre-op prolactin (p&lt; 0.001), and R=0.476 between residual volume and post-op prolactin (p&lt; 0.001). Patients without remission exhibited 142.9ug/L increase in prolactin/cm3 of pre-op volume (p&lt; 0.001), higher than the 58.9ug/L increase in prolactin/cm3 in patients with remission (p&lt; 0.001). Patients without remission had residual tumors with 68.4ug/L increase in prolactin/cm3 of remaining volume after resection (p&lt; 0.001). CONCLUSION Our analysis revealed significant correlation between prolactinoma volume and serum prolactin levels. Patients without remission had greater tumor cellular density than those with remission. The volume-prolactin correlation persisted post-operatively, although surgery reduced tumor density. These results could identify prolactinomas for which surgery could achieve biochemical remission.

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