scholarly journals Biochemical parameters of blood plasma of the male population living on the territory of the Aral Sea

2020 ◽  
Vol 100 (4) ◽  
pp. 100-105
Author(s):  
Zhanbol Sabirov ◽  
◽  
Aliya Eshmagambetova ◽  
Gul'zhazira Turlybekova ◽  
Nazira Duzbayeva ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Biochemical Parameters ◽  
Negative Impact ◽  
Metabolic Stress ◽  
The Body ◽  
Ecological Crisis ◽  
Aral Sea ◽  
Male Population ◽  
Significant Percentage

The Aral Sea ecological disaster zone affects the health status of the population living in this zone. Biochemical parameters are indicators of the metabolic functionality of the body. The article presents data about the biochemical parameters of blood plasma in the male population living in the ecological crisis zone of the Aral Sea region. It is shown that when determining the majority of indicators of biochemical analysis within the physiological norm, there is a significant percentage of people with deviations in these indicators. Such data make it possible to assume about the factors that can affect the entire population and have massive manifestations. Certainly, these factors, include the negative impact of the environment on public health. An increase in gamma — glutamyltransferase was found in 41 % of the subjects, an increase in cholesterol in 38 % and an increase in triglycerides in 34 %. In the inhabitants of the Aral Sea, a correlation was found between the biochemical parameters of blood serum from the dose of chemicals. It was shown that long-term chemical load in the crisis zone of the Aral Sea region causes a deviation of protein metabolism. The results obtained indicate a significant percentage of people with metabolic stress in the process of adaptation to high chemical load.

scholarly journals MORPHOLOGICAL COMPOSITION OF BLOOD AND BIOCHEMICAL PROCESSES IN THE ORGANISM OF FEMALE RATS F1 UNDER LONG-TERM EXPOSURE OF CITRIC ACID

2020 ◽  
Vol 21 (2) ◽  
pp. 183-188
Author(s):  
U. І. Теsarinska ◽  
R. S. Fedoruk ◽  
S. Ya. Маrtynyk ◽  
Т. V. Yurynec ◽  
V. А. Smuk ◽  
...  
Keyword(s):  
Citric Acid ◽  
Biochemical Parameters ◽  
Group Analysis ◽  
Relative Content ◽  
The Body ◽  
Female Rats ◽  
Control Group ◽  
Study Results ◽  
Morphological Composition

The paper considers the effect on rats of long-term feeding of an aqueous solution of citric acid (C6H12O6 x H2O, "chemically pure.") in the amount of 8 mg/l. The study was performed on 10 laboratory female rats F1 of the Wistar line, obtained from F0 females. Two groups were set up: control and experimental, 5 animals in each. Animals were under standard conditions with natural light regime day/night, aqueous solutions of citrate, water, and feed received ad libitum. Were determined the morphological composition and biochemical parameters of the blood of female F1 rats. The results of the study indicate the absence of an unfavorable effect of citric acid on red blood cells. Concerning white blood, there is a decrease in the number of leukocytes, which may be due to the development of an adaptive response of the body to citric acid or the inhibition of citric acid's immune response to long-term adaptive action. There is a significant increase in the relative content of eosinophils in females F1, which probably may be due to the action of citric acid. The analysis of the obtained results of blood biochemical parameters indicates a certain tendency to decrease, in terms of control, the content of serum iron, as well as its total and unsaturated Fe-binding capacity. Ferrum saturation of serum transferrin was present at the level of animals in the control group. Analysis of the study results indicates no changes in control in the activity of enzymes: Alkaline phosphatase ALT and AST, also have no statistically significant confirmation of differences in the control group. The level of urea was statistically not significantly higher in terms of control. Thus, long-term watering of citric acid to female rats in the generation F0 and F1 during their physiological and sexual gestation and pregnancy reveal un-favorable effects in female rats F1. However, there was distinguished the adaptive immune-biological response of the animals organism. The immunological response was supported by a decrease in the number of leukocytes and a significant increase in the relative content of eosinophils. The results of biochemical studies of serum indicate the absence of statistically significant differences in animals of the control group.

Changes in biochemical parameters in workers exposed to chemical production factors (heptane and hexane)

2021 ◽  
Vol 61 (6) ◽  
pp. 379-384
Author(s):  
Marina A. Zemlyanova ◽  
Juliya V. Koldibekova ◽  
Ekaterina V. Peskova ◽  
Victor M. Ukhabov
Keyword(s):  
Blood Serum ◽  
Blood Plasma ◽  
Biochemical Parameters ◽  
Comparison Group ◽  
Processing Plant ◽  
Observation Group ◽  
Chemical Production ◽  
Production Factors ◽  
Nasal Secretions

Introduction. Long-term constant exposure to certain representatives of aliphatic hydrocarbons during the extraction and processing of potash ore can lead to pathological changes on critical organs and systems in production workers. The study aims to evaluate the change in biochemical parameters in workers exposed to chemical production factors (heptane and hexane). Materials and methods. The study of the content of hexane, heptane in the air of the working area and the urine of workers, the establishment of changes in several biochemical (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, glutamyltransferase, epinephrine, and norepinephrine) and general clinical (eosinophils, neutrophils and the eosinophilia index) indicators, modeling of cause-and-effect relationships. Results. Specialists found in the observation group relative to the comparison group: increased levels of heptane and hexane in the urine up to 1.7 times; increased levels of adrenaline and norepinephrine in the blood plasma up to 1.8 times, up to 1.4 times ALAT and γ-GT in the blood serum, up to 1.9 times neutrophils in the nasal secretions associated with increased concentrations of heptane and hexane in the urine; an increase of up to 4.4 times in the frequency of diseases of the nervous system, respiratory organs, and digestion. Conclusions. In the air of the working area of the workers of the flotation shop of the sylvinite processing plant, the concentrations of the studied limit hydrocarbons were below the detection limit; there is an increased concentration of heptane and hexane in the urine. In the workers of the studied production, an increase of 1.4-1.8 times in the level of adrenaline and norepinephrine in blood plasma, 1.2-1.4 times in ALAT and γ-GT in blood serum, 1.9 times in the content of neutrophils in nasal secretions, which characterizes adverse effects from the respiratory, digestive and nervous systems. We proved the dependence of the increased frequency of diseases of the listed organs and systems on the increased concentration of heptane in the urine (R2=0.26-0.43; p=0.0001-0.028).

scholarly journals Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects

2021 ◽  
Vol 12 ◽  
Author(s):  
Lise Verbruggen ◽  
Lindsay Sprimont ◽  
Eduard Bentea ◽  
Pauline Janssen ◽  
Azzedine Gharib ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Therapeutic Potential ◽  
Negative Impact ◽  
Chronic Administration ◽  
Systemic Circulation ◽  
The Body ◽  
Ample Evidence ◽  
Anti Inflammatory ◽  
First Time

Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system xc− in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this context, a lot of research has been performed using the EMA- and FDA-approved drug sulfasalazine (SAS). Even though this molecule is already on the market for decades as an anti-inflammatory drug, serious side effects due to its use have been reported. Whereas for the treatment of the main indications, SAS needs to be cleaved in the intestine into the anti-inflammatory compound mesalazine, it needs to reach the systemic circulation in its intact form to allow inhibition of system xc−. The higher plasma levels of intact SAS (or its metabolites) might induce adverse effects, independent of its action on system xc−. Some of these effects have however been attributed to system xc− inhibition, calling into question the safety of targeting system xc−. In this study we chronically treated system xc− - deficient mice and their wildtype littermates with two different doses of SAS (160 mg/kg twice daily or 320 mg/kg once daily, i.p.) and studied some of the adverse effects that were previously reported. SAS had a negative impact on the survival rate, the body weight, the thermoregulation and/or stress reaction of mice of both genotypes, and thus independent of its inhibitory action on system xc−. While SAS decreased the total distance travelled in the open-field test the first time the mice encountered the test, it did not influence this parameter on the long-term and it did not induce other behavioral changes such as anxiety- or depressive-like behavior. Finally, no major histological abnormalities were observed in the spinal cord. To conclude, we were unable to identify any undesirable system xc−-dependent effect of chronic administration of SAS.

scholarly journals RELATIONSHIP OF ADOLESCENTS BEHAVIOR TO CONSUMPTION OF SOFT DRINKS IN SMPN 5 PEKANBARU YEAR 2016

1930 ◽  
Vol 7 (02) ◽  
pp. 53-60
Author(s):  
Alhidayati ◽  
Nurhapipa ◽  
Rahma Putri
Keyword(s):  
Negative Impact ◽  
Calcium Deficiency ◽  
Soft Drinks ◽  
The Body ◽  
P Value ◽  
Negative Effects ◽  
Chi Square ◽  
Cross Sectional ◽  
The Impact

Behavior consumption of soft drinks are the actions or deeds regarding how often consume soft drinks per week is calculated. Carbonated drinks consumption habits will have a negative impact when it accumulates in the long term. Have been many studies that explain the negative effects of soft drinks, including carcinogenic benzene in soft drinks is very high, high phosphate content of vital minerals in the body that can trigger heart disease (magnesiumdeficiency), osteoporosis (calcium deficiency) and more. Based on the survey results of the sale of soft drinks in the cafeteria, 5 schools with the highest sales level, is SMP N 5 Pekanbaru selling 6-7 boxes per month. This type of research is quantitative with cross sectional design which was held on 16-18 May 2016 in SMP N 5 Pekanbaru. The population of this research is all student grades 7 and 8 SMP N 5 Pekanbaru which amounted to 541 people, with a sample size of 115 people. Data collected technique by stratified random sampling use questionnaire measuring instrument. Univariate data analysis and use your bivariate chi-square test. The results showed that there was a relationship between the knowledge obtained value (p value = 0.001 value POR = 2.14), Effect of friends (p value = 0.006 value POR = 3.45), Access (p value = 0.029 value POR = 2.70), And advertisement (p value = 0:01 value POR = 3.20) with the consumption of soft drinks. Suggested to the relevant instance, that is SMP N 5 Pekanbaru to provide education and information to as many students on the impact of consuming soft drinks for health when consumed in the long term and excessive, and form healthy canteen, or supervise the beverage products , to minimize the beverage products are bad for health.

scholarly journals A Review of Metal Exposure and Its Effects on Bone Health

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Juliana Rodríguez ◽  
Patricia Mónica Mandalunis
Keyword(s):  
Soft Tissues ◽  
Negative Impact ◽  
The Body ◽  
Short Exposure ◽  
Metal Exposure ◽  
Metal Type ◽  
High Concentrations ◽  
Bone Dynamics ◽  
Cadmium Zinc

The presence of metals in the environment is a matter of concern, since human activities are the major cause of pollution and metals can enter the food chain and bioaccumulate in hard and soft tissues/organs, which results in a long half-life of the metal in the body. Metal intoxication has a negative impact on human health and can alter different systems depending on metal type and concentration and duration of metal exposure. The present review focuses on the most common metals found in contaminated areas (cadmium, zinc, copper, nickel, mercury, chromium, lead, aluminum, titanium, and iron, as well as metalloid arsenic) and their effects on bone tissue. Both the lack and excess of these metals in the body can alter bone dynamics. Long term exposure and short exposure to high concentrations induce an imbalance in the bone remodeling process, altering both formation and resorption and leading to the development of different bone pathologies.

scholarly journals HEMATOLOGICAL PROFILE OF RATS IN THE STUDY OF CUMULATIVE PROPERTIES OF NANOSTRUCTURED ZEOLITE

2021 ◽  
Vol 246 (2) ◽  
pp. 128-132
Author(s):  
Yu.V. Larina ◽  
◽  
L.R. Kayumova ◽  
V.O. Ezhkov ◽  
A.M. Ezhkova ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Chronic Toxicity ◽  
The Body ◽  
Laboratory Animals ◽  
Feed Additive ◽  
Hematological Profile ◽  
White Mongrel ◽  
Positive Effect

The authors of this work investigated the chronic toxicity of the feed additive. Chronic tox-icity was studied in white mongrel rats with daily intragastic administration in various doses for 28 days. The results of the studies showed that the feed additive doses not exhibit its toxic properties on the body of laboratory animals during long-term use. This experiment, no cases of intoxication and death of animals were noted. The positive effect of the drug on some indicators of morphologi-cal and biochemical parameters of blood was determined.

Comorbidities of Physical and Psychiatric Syndromes in Later Life

2018 ◽  
Author(s):  
Lydia K. Manning ◽  
Lauren M. Bouchard ◽  
James L. Flanagan
Keyword(s):  
Older Adults ◽  
Chronic Conditions ◽  
Negative Impact ◽  
Later Life ◽  
The Body ◽  
Chronic Obstructive ◽  
Multiple Chronic Conditions ◽  
Obstructive Pulmonary Disease ◽  
Complex Interactions

There is a great deal of concern about the increasing number of older adults who suffer from chronic disease. These conditions result in persistent health consequences and have an ongoing and long-term negative impact on people and their quality of life. Furthermore, the probability that a person will experience the onset of multiple chronic conditions, known as comorbidities, increases with age. Despite the prevalence of comorbidity in later life, scant research exists regarding specific patterns of disease and the co-occurrence and complex interactions of the chronic conditions most closely associated with aging. It is important to review the body of literature on comorbidities associated with physical and psychiatric syndromes in later life to gain an overview of some of the most commonly seen disorders in older adults: hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, arthritis, depression, and dementia. Specific patterns of disease and the co-occurrence and complex interactions of chronic conditions in later life are explored. In conclusion, we consider the need for a more informed understanding of comorbidity, as well as a related plan for addressing it.

scholarly journals CONTROL OF FINE MOTOR SKILLS IN WOMEN ENGAGED IN RECREATIONAL PHYSICAL CULTURE: BILATERAL INDICATORS

2021 ◽  
pp. 129-138
Author(s):  
Ashot Chatinyan ◽  
Elena Hakobyan
Keyword(s):  
Negative Impact ◽  
Self Regulation ◽  
Movement Control ◽  
The Elderly ◽  
The Body ◽  
Fine Motor ◽  
Physical Culture ◽  
Reduced Mobility ◽  
Health Care Safety

The issue of studying the features of movement control among elderly people and the disclosureof ways to reduce the negative impact of involutional processes on the body functions areup-to-dateand relevant in terms of ensuring long-term health care safety and wellbeingfor the population in that age group. The reduced mobility of central nervous system forces older people to spend more time preparing, organizing and managing their own actions. First of all, self-regulation processes of the finest movements weaken: the elderly become unable to effectively control the movements of hands and especially fingers. In this regard, the issue of studying the influenceof recreational physical cultureon the indicators of fine movements control among the elderly is of scientific interest.

scholarly journals CYTOGENETIC CHANGES IN SCHOOLCHILDREN RESIDING IN ECOLOGICALLY ADVERSE REGIONS OF KAZAKHSTAN

2020 ◽  
Vol 17 (35) ◽  
pp. 1137-1147
Author(s):  
Sholpan BAKHTIYAROVA ◽  
Bolatbek ZHAKSYMOV ◽  
Unzira KAPYSHEVA ◽  
Oksana CHEREDNICHENKO
Keyword(s):  
Environmental Pollution ◽  
Industrial Development ◽  
Negative Impact ◽  
Genetic Load ◽  
Test Site ◽  
The Body ◽  
Aral Sea ◽  
Semipalatinsk Test Site ◽  
Wide Range ◽  
Younger Generation

In Kazakhstan, due to the strengthening of the geopolitical role in the international arena and active industrial development, negative environmental impacts have intensified in recent years. Many regions are environmentally unfavorable and carry the risk of an increase in the incidence of living in these conditions of the population. Numerous deviations in the health of the community create the conditions for genetic polymorphism and the growth of certain groups of diseases characteristic of regions with environmental pollution. Long-term environmental pollution is the reason for the increase in the rate of the mutation process and the volume of the genetic load in the human population. The purpose of this study is to show the influence of dominant environmental factors in distant regions of Kazakhstan on cytogenetic disturbances in the body of the younger generation. Students from different schools aged 16 to 18 years living near the Semipalatinsk test site of the East Kazakhstan region and in the Aral region of the Kyzylorda region took part in the studies. The results of the study show that the oral epithelial cells in two-thirds of the examined adolescents living in environmentally unfavorable conditions either near the Semipalatinsk Test Site or in the Aral Sea region of Kazakhstan revealed a wide range of cytogenetic disorders. The most significant percentage of violations associated with the formation of micronuclei, protrusions, and apoptosis, was detected in urban students living 150 km from the Semipalatinsk Test Site. When comparing the data of urban and rural students, the predominant development of cytological disorders was revealed, such as nuclear destruction (karyorrhexis, karyolysis, and apoptosis) in rural adolescents, which indicates the ongoing negative impact of the closed Semipalatinsk Test Site and the salinization of the Aral Sea on the health of the younger generation of children.

Long-Term Accumulation of Metals in the Skeleton as Related to Osteoporotic Derangements

2020 ◽  
Vol 27 (40) ◽  
pp. 6837-6848 ◽  
Author(s):  
Geir Bjorklund ◽  
Lyudmila Pivina ◽  
Maryam Dadar ◽  
Yuliya Semenova ◽  
Salvatore Chirumbolo ◽  
...  
Keyword(s):  
Negative Impact ◽  
Age Groups ◽  
Body Burden ◽  
The Body ◽  
Metal Species ◽  
Metal Exposure ◽  
Accumulation Of Metals ◽  
Cadmium Lead ◽  
Total Body

The concentrations of metals in the environment are still not within the recommended limits as set by the regulatory authorities in various countries because of human activities. They can enter the food chain and bioaccumulate in soft and hard tissues/organs, often with a long half-life of the metal in the body. Metal exposure has a negative impact on bone health and may result in osteoporosis and increased fracture risk depending on concentration and duration of metal exposure and metal species. Bones are a long-term repository for lead and some other metals, and may approximately contain 90% of the total body burden in birds and mammals. The present review focuses on the most common metals found in contaminated areas (mercury, cadmium, lead, nickel, chromium, iron, and aluminum) and their effects on bone tissue, considering the possibility of the long-term bone accumulation, and also some differences that might exist between different age groups in the whole population.

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