scholarly journals The significance of hypoxia as a molecular and cellular event in patients with toxic and non-toxic goitre: A statistical inference based on cross-sectional analytic of Iraqi patients

2018 ◽  
Vol 9 (5) ◽  
pp. 44-49
Author(s):  
Mohammed Assi ◽  
Samia Elewi ◽  
Ahmed Al-Imam ◽  
Basem Ahmed
Keyword(s):  
Thyroid Gland ◽  
Research Question ◽  
Thyroid Tissue ◽  
Hypoxia Inducible Factors ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Oxygen Homeostasis ◽  
Number Of Patients ◽  
Males And Females ◽  
Made In

Background: Disorders of the thyroid gland, including toxic and non-toxic goitre, are more common in adult female patients. Hypoxia-inducible factors, including HIF-1 and HIF-2, represent transcriptional activators that function as regulators of oxygen homeostasis. Rapid progress is being made in clarifying the homeostatic functions of HIFs in several physiological systems. However, there are much to be learned in connection with the thyroid gland and its pathologies.Aims and Objectives: To assess the biochemical and clinical significance of hypoxia-inducible factors in patients with multinodular goitre.Materials and Methods: The study is observational and cross-sectional analytic conducted among a population of individuals with diffuse and nodular thyroid goitre including clinically toxic and non-toxic patients. It will attempt to answer the research question concerning the significance of HIFs, via applying techniques of immunohistochemistry to histological samples of resected thyroid tissue, and in pertinence with the demographic and clinical parameters of patients.Results: The total number of patients was forty-three,and most was in their fifth decades of life. The percentile contribution of males and females was 11.63% and 88.37% respectively. Individuals with toxic goitres accounted for 13.95%, and those had significantly higher levels of both HIF-1 and HIF-2 than non-toxic patients (p=0.019, p=0.072). Clinically-toxic patients also had notably more elevated levels of HIF-1 as they grew older when compared to non-toxic patients.Conclusion: There is an evident inadequacy of published literature on hypoxia-inducible factors in patients with goitre. There are no studies whatsoever in correspondence to the research questions explored in this study. Future attempts should explore experimental designs while using human as well as animal models and from an interdisciplinary perspective.Asian Journal of Medical Sciences Vol.9(5) 2018 44-49

scholarly journals Investigating the compliance of COVID-19 protocols in the workplaces of Ardabil, Iran

Work ◽  
2021 ◽  
pp. 1-7
Author(s):  
Asghar Lotfollahzadeh ◽  
Leila Rastgoo ◽  
Islam Shirinzadeh ◽  
Seyedeh Melika Kharghani Moghadam ◽  
Hossein Ebrahimi
Keyword(s):  
Inverse Relationship ◽  
Prevention Programs ◽  
Health Centers ◽  
Personal Hygiene ◽  
Medical Sciences ◽  
Observation Level ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Current Outbreak

BACKGROUND: Workplaces are prone to the current outbreak- of COVID-19. Despite the production of the COVID-19 vaccine, due to some challenges in vaccinating all people worldwide, adherence to health protocols is still one of the ways to prevent infection. OBJECTIVE: This study was conducted with the purpose of investigating the compliance of COVID-19 protocols in the workplaces of Ardabil, Iran. METHODS: This was a cross-sectional research conducted on the workplaces affiliated to Ardabil University of Medical Sciences between August and September, 2020. A researcher-designed checklist was completed once in early August and once at the end of September for the workplaces. Accordingly, these workplaces were inspected for any compliance with the COVID-19 prevention protocols by health centers during August and September. In addition, the number of patients with COVID-19 was determined for each one of the workplaces. RESULTS: The results showed that the highest increase was related to screening (57.8%) and the lowest change was related to personal hygiene (1.3%). The rates of increase in performance for small workshops, offices and industries were 35.4%, 33.1%and 12.4%, respectively. Moreover, a linear and inverse relationship was found between the incidence of COVID-19 and the level of observance of the OVID-19 prevention protocols. CONCLUSIONS: Based on the results of this study, the inspection made by legal authorities led to the increased commitment of workplace managers to implement prevention programs, thereby increasing the observation level of these protocols in the workplace and reducing the incidence of COVID-19.

scholarly journals The Effect of Methimazole on Thyroid Gland Uptake of Technetium in Hyperthyroid Patients

2012 ◽  
Vol 1 (1) ◽  
pp. 8-12
Author(s):  
Farshid Gheisari ◽  
Gholamreza Pishdad ◽  
Mehrdad Emami ◽  
Kasra Behdad ◽  
Aida Karimpour ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Adverse Effects ◽  
Region Of Interest ◽  
Medical Sciences ◽  
Time Saving ◽  
Peripheral Tissues ◽  
Technetium 99M ◽  
Thyroid Scan ◽  
Number Of Patients ◽  
The Difference

Introduction: The aim of this study was to investigate the effect of methimazole on Technetium-99m reabsorbing by thyroid gland , it may be possible to perform thyroid scan when the patients are on the methimazole, this can be time saving and decrease the adverse effects of discontinuing methimazole. Patients and Methods: Among all the patients with hyperthyroidism who referred to nuclear medicine ward of Shiraz University of medical sciences, 50 patients were randomly selected. we asked the patients who were on Methimazole, to discontinue the usage of all drugs (not Methimazole) and foods which are effective on thyroid gland for 1 week, after that thyroid scan was performed for these patients. In The other episode, we asked them to discontinue the usage of all drugs (also Methimazole) and foods which are effective on thyroid gland for 1 week and then thyroid scan was performed again .Revealed data was analyzed under supervision of statistical specialist with descriptive methods on SPSS. Results: 34 patients were males (68%) and other was females. Mean age of the patients was 53.5 years. (Min: 39 years and max: 75 years) Although The ROI (Region of Interest) of thyroid was increased in the patients who used methimazole before scan 398.72(SD: 191.73) than the patients who discontinued for one week 380.15 (SD: 112.49), but the difference wasn’t statistically significant. The ROI of peripheral tissue of the thyroid was decreased in the patients who used methimazole before scan 26.44(SD: 5.42) than the patients who discontinued for one week 27.0414 (SD: 5.57), but the difference wasn’t statistically significant. Discussion: In conclusion, we demonstrated that methimazole pretreatment does not interfere with either the efficacy of ROI and reabsorbing of Technetium-99m in thyroid gland and peripheral tissues. A possible limitation of this study is the number of patients in the sample.So it seems that it may be possible to perform thyroid scan when the patients are on the methimazole, this can be time saving and decrease the adverse effects of discontinuing methimazole. [GMJ. 2012;1(1):8-12]

scholarly journals Identifying the Factors Affecting the Incidence of Medication Errors of Nurses in Teaching Hospitals of Shiraz University of Medical Sciences

2021 ◽  
Author(s):  
Ali Reza Yusefi ◽  
Parnian Nikmanesh ◽  
Zahra Kavosi ◽  
Ahmad Sadeghi
Keyword(s):  
Human Factors ◽  
Medication Errors ◽  
Pearson Correlation ◽  
Cross Sectional Study ◽  
Employment Relationship ◽  
Teaching Hospitals ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Heavy Workload

Background: Medication errors are one of the major causes of injury to patients while receiving medical care. This study aimed  to investigate the effective causes of medication errors in nurses in educational hospitals affiliated with Shiraz University of Medical Sciences. Methods: This descriptive-analytical and cross-sectional study was conducted in 2020 on 340 nurses from 10 educational  hospitals affiliated to Shiraz University of Medical Sciences. The data collection tool was a questionnaire. Data were analyzed using t-test, ANOVA and Pearson correlation coefficient were analyzed using SPSS23 software . Results: According to the results, human factors have been the most important factor in the occurrence of medication errors. The most important causes of medication errors with respect to human, managerial and environmental factors include fatigue due to overwork (3.13 ± 1.16), method of supervision (3.06 ± 0.98) ,and heavy workload (3.00 ± 1.19), respectively. There was a statistically significant relationship between human factors and  age (p = 0.024), gender (p = 0.013), employment relationship (p = 0.016), and marital status (p = 0.027), and between management factors and employment relationship (p = 0.034) and the number of patients under observation (p = 0.011). Conclusion: Considering the most important causes of medication errors, including fatigue due to overload, supervision methods, and heavy workload, using strategies to reduce fatigue due to workload, such as balancing nurses' work shifts and also holding workshops on supervision methods is recommended in order to improve the level of managerial competencies of nurses.

scholarly journals Compilation and testing the reliability of questionnaires about the fear of blood extraction (venipuncture) among students of Medical Faculty of Kragujevac

2021 ◽  
Vol 38 (1) ◽  
pp. 85-95
Author(s):  
Suzana Milutinović ◽  
Ana Stanković ◽  
Sunčica Ivanović ◽  
Sanja Trgovčević ◽  
Tatjana Kilibarda
Keyword(s):  
High Reliability ◽  
Public Health Problem ◽  
Adverse Outcomes ◽  
Blood Collection ◽  
Medical Sciences ◽  
Symptom Scale ◽  
Good Reliability ◽  
Cross Sectional ◽  
Blood Samples ◽  
Number Of Patients

It is of particular importance to use validated questionnaires to remove fear of needles and blood collection, as this public health problem has been observed in a large number of patients and may inadequately affect medical healthcare. The aim of the study was to conduct a research on the reliability of the questionnaire on the fear of blood sampling among students of the Faculty of Medical Sciences in Kragujevac. The method used in this research was a cross-sectional study. The sample involved the students of medicine, pharmacy, dentistry and professional studies of health care at the Faculty of Medical Sciences in Kragujevac (Republic of Serbia), a total of 300 students, which was 20% of the student population at the aforementioned faculty. The research instrument was the questionnaire The Blood-Injection Symptom Scale (BISS) which contained 22 questions. The research lasted one month during 2016. Statistical data processing was performed using IBM SPSS Statistics 21. Cronbach's Alpha value - 0.894 and other parameters used to determine reliability showed a high reliability of this questionnaire. After explorative factor analysis, three factors that most affect adverse outcomes for venepuncture were obtained - vasovagal symptoms that occur as a result of fear, fear of needles and consequences of puncture, and the fear of hospitals and personnel who take blood samples. The BISS questionnaire showed good reliability in the population of students of the Faculty of Medicine in Kragujevac and can be used in the general population for examining the fear of needles, the consequences of needle stings, fear of hospitals and people who take blood samples, and therefore to prevent these symptoms.

scholarly journals Clinical analysis of cardiac failure in post-myocardial infarction patients

2018 ◽  
Vol 5 (3) ◽  
pp. 587
Author(s):  
R. Jaya Prakash Reddy ◽  
P. Vijaya Narasimha Reddy
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Failure ◽  
Clinical Analysis ◽  
Cross Sectional Study ◽  
Anterior Wall ◽  
Prior History ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Number Of Patients ◽  
History Of

Background: Cardiac failure is one of the common complications of Acute Myocardial Infarction. As CAD is the leading cause of death and post MI Cardiac failure also causing increase in rate of Mortality. It directs us to assess the complications of MI and to evaluate the precautionary & preventive steps of cardiac failure.Methods: The present study comprises of 50 cardiac failure patients with history of MI in the past and who presented with myocardial infarction with cardiac failure were included in this study. We excluded the patients who presented with Cardiac failure without Prior history of MI. This hospital based cross sectional study was conducted at Rajiv Gandhi Institute of Medical Sciences (RIMS), Ongole, Prakasam District, Andhra Pradesh. The study was carried out for a period of 1 year with informed consent.Results: In present study majority number of patients (33) show hypokinesia and 10 are found to have dyskinesia and only 4 are akinesia. In this study More than 50% patients are with history of anterior wall involvement. 36(72%) patients have elevated JVP, 34(68%) have cardiomegaly, 38 patients presented with PND. 29(58%) patients are DM and 35(70%) are HTN and only 6(12%) patients are neither DM, nor HTN.Conclusions: Cardiac failure is a common complication after MI. Most common presentations are breathlessness, chest pain, PND, JVP etc. Anterior wall MI on ECG either isolated or associated with other walls is the leading cause of post MI cardiac failure.

scholarly journals Time of maximum uptake of Technetium-99m pertechnetate (TcO4) in the thyroid gland and its correlation with thyroid functional status

2017 ◽  
Vol 8 (1) ◽  
pp. 1-6
Author(s):  
Md Mizanur Rahman ◽  
Shankar Kumar Dey
Keyword(s):  
Thyroid Gland ◽  
Functional Status ◽  
Count Rate ◽  
Medical Physics ◽  
Technetium 99M ◽  
Thyroid Scan ◽  
Number Of Patients ◽  
Males And Females ◽  
Age Range ◽  
Healthy Persons

During thyroid scan with Technetium-99m (Tc-99m) Pertechneate, the maximum uptake is supposed to occur after 15 to 20 minutes of intravenous administration for normal healthy persons. The purpose of this study is to determine the time of maximum uptake of Technhetium Pertechneate by measuring counts over the thyroid gland during thyroid scan and to correlate the time of maximum uptake with thyroid functions measured biochemically. The number of patients studied was 136 of which 113 were females and 23 were males with the age range between 7 to 70 years. Among all, about 46% cases showed maximum count in the interval of 10-25 minutes. Though 38.2% of patients showed maximum uptake of tracer after 25 minutes, the count rate did not increase significantly after this time which justifies the conventional time of thyroid scanning. In general, the time of maximum uptake was earlier in females than males. Percentage of patients with hyperthyroidism is almost same for both males and females (13% and 12% respectively) but for females occurrence of hypothyroidism is higher than males (26% vs 17%). The total uptake of Tc-99m Pertechnetate for hyperthyroidism patients in each interval is greater than that of euthyroid patients but the time of maximum uptake is random for both males and females without any correlation with thyroid function.Bangladesh Journal of Medical Physics Vol.8 No.1 2015 1-6

scholarly journals Sonographic assessment of thyroid gland in patients with chronic kidney disease undergoing hemodialysis

2017 ◽  
Vol 5 (1) ◽  
pp. 4 ◽  
Author(s):  
Maisa Elzakil ◽  
Awadia Gareeballah ◽  
Moawia Gameraddin ◽  
Mowada Burai ◽  
Fathelrehman Alagab
Keyword(s):  
Chronic Kidney Disease ◽  
Thyroid Gland ◽  
Kidney Disease ◽  
Thyroid Nodules ◽  
Kidney Diseases ◽  
Morphological Changes ◽  
Thyroid Tissue ◽  
Thyroid Volume ◽  
Cross Sectional Study ◽  
Cross Sectional

Background: Thyroid gland morphology and disorders were affected with chronic kidney diseases (CKD). The study aims to assess thyroid gland disorders and morphology in patients with CKD on regular hemodialysis.Materials and methods: A cross-sectional study included 71 participants divided into two groups. The study group included 51 patients with known chronic kidney disease on hemodialysis and healthy group included 20 participants. The exclusion criteria were thyroid disorders. The thyroid gland was scanned with ultrasound using a 7 MHz probe.Results: The thyroid is enlarged in 21.57% of patients and heterogeneous echotexture in 31.4%. The prevalence of thyroid nodules and cysts were 9.8% and 7.8% respectively. A positive linear correlation existed between duration of hemodialysis and thyroid volume. Thyroid volume and echotexture were significantly increased with duration of hemodialysis (p = .001 and .00 respectively). Thyroid nodules and cysts were not significantly correlated with duration of hemodialysis (p = .06 and .28 respectively).Conclusions: In conclusion, enlargement of thyroid gland and heterogeneity of thyroid tissue were the most common morphological changes in patients with chronic renal failure undergoing hemodialysis. The prevalence increased with longer duration of hemodialysis. Periodic ultrasound assessment of thyroid volume and texture are recommended in hemodialyzed patients to avoid complications.

scholarly journals Mentoring in Medicine: Introducing a structured programme in a Medical College in Delhi

2017 ◽  
Vol 16 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Ayesha Ahmad ◽  
Arifa Anwar Elahi ◽  
Aruna Nigam ◽  
Rohan Kapoor
Keyword(s):  
Medical Science ◽  
Cross Sectional Study ◽  
New Delhi ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Medical College ◽  
Allocation Process ◽  
Males And Females ◽  
Personal Meeting ◽  
The Relationship

Objectives: To evaluate the response to mentoring amongst medical students after introduction of a structured mentorship programme.Methods: This was a cross sectional study conducted at Hamdard Institute of Medical Sciences and Research, [HIMSR] New Delhi. A pre validated confidential questionnaire, designed as both open and closed ended questions was utilised to obtain responses from a sample size of 300 students, both males and females. Our questionnaire solicited the following information: clarity of the concept to the mentee, duration of being involved in the programme, preferred mentoring model, comments on intended benefits and those obtained, frequency of meetings, forms of communication used and preferred place of interaction. All students in 1st, 2nd and 3rd year at HIMSR who agreed to participate in the study were included.Results: A total of 231 students returned their questionnaire, making the response rate of 77%. Different forms of communication were being used, of which personal meeting was most frequent. Both males and females were contacting their mentors in person. Majority of students preferred the mentorship model to be 1:1 and faculty members as mentors instead of senior students. Most of the students wanted the relationship to be mutual on both the sides, with both mentors and mentees having a say in the allocation process. There was no preference to gender for most of the students.Conclusions: The mentorship programme found good acceptance with medical students.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.29-34

scholarly journals Attitude towards Mental illness and Psychiatry among the Medical students and Interns in a University Medical College

2013 ◽  
Vol 52 (190) ◽  
Author(s):  
Ajay Risal ◽  
Pushpa Prasad Sharma ◽  
Seshananda Sanjel
Keyword(s):  
Mental Illness ◽  
Medical Students ◽  
Rating Scales ◽  
Negative Attitude ◽  
University Hospital ◽  
Medical Sciences ◽  
Cross Sectional ◽  
First Semester ◽  
Medical College ◽  
Males And Females

Introduction: Medical students tend to have a neutral or negative attitude to Psychiatry as a discipline. This study was initiated to explore the attitude towards Mental illness and Psychiatry among the Medical students and Interns in Kathmandu University School of Medical Sciences (KUSMS).Method: A cross-sectional Questionnaire based study was conducted among the Medical students and Interns at Dhulikhel Hospital (Kathmandu University Hospital). Two self-rating scales; Attitudes towards psychiatry (ATP-30) and Attitudes to mental illness (AMI) were used to assess attitudes towards mental illness and Psychiatry among the total 159 subjects. Descriptive statistics and independent sample t-test applied using SPSS-16 for analysis.Results: Among the total 159 subjects, 56.6% were males and 27.7% were Interns. Comparison of means of each item in ATP-30 and AMI was done between Males and Females, Medical students and Interns, First semester and Ninth semester students. Most of the subjects showed neutral attitude towards all the scoring items; though there were a few significant differences in mean scores of some items in group wise comparison.                                                             Conclusions: Overall attitudes towards Mental illness and Psychiatry among the Medical students and Interns in our Medical School were positive or neutral. A further study with medical students from different institutions is needed to get a detail nationwide picture.                                  Key words: Attitude, Interns, Medical Students, Mental illness, Psychiatry.  

scholarly journals Mammalian oxygen sensing, signalling and gene regulation

2000 ◽  
Vol 203 (8) ◽  
pp. 1253-1263 ◽  
Author(s):  
R.H. Wenger
Keyword(s):  
Oxygen Supply ◽  
Oxygen Sensing ◽  
Beta Subunit ◽  
Hypoxia Inducible Factors ◽  
Cell Type ◽  
Hypoxic Conditions ◽  
Oxygen Homeostasis ◽  
Number Of Genes ◽  
Made In ◽  
Limited Oxygen

Oxygen is essential to the life of all aerobic organisms. Virtually every cell type is able to sense a limited oxygen supply (hypoxia) and specifically to induce a set of oxygen-regulated genes. This review summarizes current concepts of mammalian oxygen-sensing and signal-transduction pathways. Since the discovery of the hypoxia-inducible factors (HIFs), a great deal of progress has been made in our comprehension of how hypoxia induces the expression of oxygen-regulated genes. The alpha subunit of the heterodimeric transcription factors HIF-1, 2 and 3 is unstable under normoxia but is rapidly stabilized upon exposure to hypoxic conditions. Following heterodimerization with the constitutively expressed beta subunit, HIFs activate the transcription of an increasing number of genes involved in maintaining oxygen homeostasis at the cellular, local and systemic levels.

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