scholarly journals Sexual Dimorphism in Maxillary First Molar among Nepalese Population of Eastern Nepal

2021 ◽  
Vol 6 (2) ◽  
pp. 1492-1495
Author(s):  
Sanjib Kumar Sah ◽  
Suman Pokhrel ◽  
Umesh Kumar Mehata ◽  
Raju Kumar Chaudhary ◽  
Rajesh Kumar Shah
Keyword(s):  
Sexual Dimorphism ◽  
P Value ◽  
Eastern Region ◽  
Tooth Crown ◽  
Male And Female ◽  
Full Size ◽  
Dental Examination ◽  
Best Parameter ◽  
Maxillary Arch ◽  
Shape And Size

Introduction: Sexual dimorphism refers to differences in size, stature and appearance between male and female. It is a known fact that tooth crown is formed to full size in childhood even before eruption into oral cavity. The shape and size of the teeth permits an interesting dimension of study for sexual dimorphism, we aimed to delineate the sexual dimorphism by measuring the mesiodistal (MD) and buccolingual (BL) diameters of permanent maxillary first molar in Nepalese population of Eastern Nepal. Objectives: The aim of this study was to evaluate the sexual dimorphism in maxillary first molar among Nepalese population of eastern Nepal Methodology: 100 participants of either sex (50 males & 50 females) aged between 17 to 25 years were enrolled in the study. After thorough dental examination, impression of the maxillary arch was made and MD diameter and BL diameters were measured with the help of vernier caliper. A P value of <0.05 was considered as statistically significant. Results: Sexual dimorphism was found in MD and BL diameters of maxillary first molar in males measuring higher than females. Right mesiodistal showed the highest sexual dimorphism, whereas right buccolingual showed the least. Conclusions: This study confirms that permanent maxillary first molar shows significant sexual dimorphism, out of which mesiodistal measurement stands out to be the best parameter in Nepalese population of Eastern region.

No functional sexual dimorphism in Minorcan horse assessed by geometric morphometric methods

2015 ◽  
Vol 56 ◽  
pp. 91-95 ◽  
Author(s):  
Pere M. Parés-Casanova ◽  
C. Allés
Keyword(s):  
Sexual Dimorphism ◽  
Lateral View ◽  
Geometric Morphometric ◽  
Male And Female ◽  
Size And Shape ◽  
Morphometric Methods ◽  
Nw Mediterranean ◽  
Nw Mediterranean Sea ◽  
Age Range ◽  
Shape And Size

SummaryThe existence of sexual dimorphism in the Minorcan horse, an autochthonous breed from Minorca Island in the Balearic archipelago (NW Mediterranean Sea), is established in the official standard, with females being shorter and longer than males as well as having slenderer necks and a squarer croup. However, no study so far has explored the size and shape components of this dimorphism separately. The aim of this study was to analyse the morphology of this breed using geometric morphometric methods in order to find size and shape differences between sire lines. The analysis was based on landmarks digitized in lateral view from 38 registered adult Minorcan horses (20 males and 18 females) within an age range of 3–14 years (average 7 years) with different performance goals. The analyses did not reveal any significant differences between the “shape” and “size” of male and female animals, for the landmarks studied, so the sexes are functionally similar.

Comparative assessment of average clinical smile parameters in male and female patients with orthognathic occlusion

2020 ◽  
Vol 25 (2) ◽  
pp. 121-126
Author(s):  
V. G. Galonsky ◽  
N. V. Tarasova ◽  
V. V. Aliamovskii ◽  
I. S. Leonovich
Keyword(s):  
Sexual Dimorphism ◽  
Male And Female ◽  
Young Males ◽  
Young Females ◽  
Female Patients ◽  
Evaluation Of Parameters ◽  
Distinguishing Features ◽  
Vertical Size ◽  
Relative Concept ◽  
The Ideal

Relevance. Separate issues in anthropomorphic sizes of relative norm of the ideal smile, its qualitative and qualitative parameters have not been addressed to sufficiently and are not properly reflected in scientific literature.Purpose. To determine distinguishing features in average smile parameters of the smile in male and female patients with orthognathic occlusion.Materials and methods. A clinical and anthropometric evaluation of parameters in main smile types was carried out for 150 young males and 150 young females aged 19-24 who had identical physiological development parameters.Results. It has been revealed that occurrence frequency of main smile types in patients with orthognathic occlusion has pronounced signs of sexual dimorphism which in over one half of the cases lies in predominance of the incisal smile type in males (52.7%) and the fascial type in females (55.3%). Occurence frequency of the cervical smile type totaled 25% among the studied patients of both genders. Average vertical size parameters in the incisal smile lies within the diapason of 3.91-4.91mm with surpassing by 1mm in males. Analogical data for the fascial smile type form the diapason of 6.21-6.73mm with surpassing by 0.52mm in females. The cervical smile type is characterised by larger vertical size forming the diapason of 7.94-8.91mm with surpassing by 0.97mm in males.Conclusion. The results of the study have shown that the “beautiful and ideal smile” is a relative concept having varied anthropometric characteristics and pronounced signs of sexual dimorphism lying in a broad spectrum of the dentofacial system norm notion with specific vectors for individual morphological deviations.

scholarly journals Sex-dependent dynamics of metabolism in primary mouse hepatocytes

2021 ◽  
Author(s):  
Luise Hochmuth ◽  
Christiane Körner ◽  
Fritzi Ott ◽  
Daniela Volke ◽  
Kaja Blagotinšek Cokan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amino Acid ◽  
Sexual Dimorphism ◽  
New Drugs ◽  
Model Systems ◽  
Specific Gene ◽  
Primary Hepatocytes ◽  
Alcoholic Fatty Liver ◽  
Male And Female ◽  
Primary Mouse

AbstractThe liver is one of the most sexually dimorphic organs. The hepatic metabolic pathways that are subject to sexual dimorphism include xenobiotic, amino acid and lipid metabolism. Non-alcoholic fatty liver disease and hepatocellular carcinoma are among diseases with sex-dependent prevalence, progression and outcome. Although male and female livers differ in their abilities to metabolize foreign compounds, including drugs, sex-dependent treatment and pharmacological dynamics are rarely applied in all relevant cases. Therefore, it is important to consider hepatic sexual dimorphism when developing new treatment strategies and to understand the underlying mechanisms in model systems. We isolated primary hepatocytes from male and female C57BL6/N mice and examined the sex-dependent transcriptome, proteome and extracellular metabolome parameters in the course of culturing them for 96 h. The sex-specific gene expression of the general xenobiotic pathway altered and the female-specific expression of Cyp2b13 and Cyp2b9 was significantly reduced during culture. Sex-dependent differences of several signaling pathways increased, including genes related to serotonin and melatonin degradation. Furthermore, the ratios of male and female gene expression were inversed for other pathways, such as amino acid degradation, beta-oxidation, androgen signaling and hepatic steatosis. Because the primary hepatocytes were cultivated without the influence of known regulators of sexual dimorphism, these results suggest currently unknown modulatory mechanisms of sexual dimorphism in vitro. The large sex-dependent differences in the regulation and dynamics of drug metabolism observed during cultivation can have an immense influence on the evaluation of pharmacodynamic processes when conducting initial preclinical trials to investigate potential new drugs.

Game efficiency of elite male sitting volleyball players with regard to athletes’ physical impairment

2017 ◽  
Vol 13 (3) ◽  
pp. 383-390 ◽  
Author(s):  
Jolanta Marszałek ◽  
Bartosz Molik ◽  
Miguel-Angel Gomez
Keyword(s):  
Classification System ◽  
P Value ◽  
Female Group ◽  
Anthropometric Parameters ◽  
Male And Female ◽  
Game Analysis ◽  
Current Classification ◽  
Continue Research ◽  
Classification Procedures ◽  
Game Performance

The aim of this study was to illustrate differences in game efficiency in sitting volleyball of male and female elite athletes in terms of players’ impairment. Game analysis was conducted during World Championships in Sitting Volleyball in 2014. Modified Game Performance Sheet for Sitting Volleyball was used to assess players’ actions: attack, serve, block, block of serve, defense, and ball receiving. Coleman’s formulas were counted to obtain game efficiency of athletes. In statistics, Kruskal–Wallis test and Bonferroni correction were used (p value was set equal .005 and .003, respectively, in male and female group). 128 male and 91 female sitting volleyball athletes were included into this study. They were divided into groups in terms of impairment. There were no statistically significant differences in anthropometric parameters in male and female groups of players. Also, there were not statistically significant differences in game efficiency between players with different impairments in male as well as in female groups. This study did not confirm the current classification system in sitting volleyball (division into minimal disabled and disabled athletes). There is a need to continue research and find more evidences to substantiate or to change the current classification procedures in classification system in sitting volleyball.

Abstract P392: The Effect Of Cell Sex On Magnetic Nanoparticle Uptake Of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Morteza Mahmoudi ◽  
Vahid Serpooshan ◽  
Phillip C Yang ◽  
Mahyar Heydarpour
Keyword(s):  
Heart Failure ◽  
Actin Filaments ◽  
Electromechanical Coupling ◽  
Critical Role ◽  
Induced Pluripotent Stem Cell ◽  
Patient Specific ◽  
P Value ◽  
Male And Female ◽  
Cell Therapies ◽  
Human Cardiomyocytes

Introduction: It is well understood that the occurrence, progress, and treatment of heart failure, which is a leading cause of death worldwide, is sex-specific. Over the past decade, the majority of efforts in myocardial regeneration have been centered on cell-based cardiac repair. A promising cell source for these efforts is patient-specific human cardiomyocytes (CMs) differentiated from human inducible pluripotent stem cells (hiPSCs). However, successful use of hiPSC-CMs faces a major limitation, the poor engraftment and electromechanical coupling of transplanted cells with the host myocardial tissue. Magnetic nanoparticles (NPs) demonstrate great potential to address this challenge for treating heart failure via cell therapies. In particular, superparamagnetic iron oxide NPs (SPIONs) have been used to label hiPSC-CMs and, with the aid of external magnetic field, improve their engraftment and electromechanical coupling in the heart tissue. However, the critical role of cell sex in the uptake and labeling efficacy of NPs has not been evaluated. Hypothesis: Significant differences in the molecular and structural (e.g., actin structures and distribution) characteristics of male and female hiPSC-CMs affect their labeling efficacy with SPIONs. Methods and Results: To test our hypothesis, we first performed RNA-Seq analysis on three male and three female (healthy) hiPSC-CM lines. The normalized outcomes were analyzed by edgeR package. We next calculated gene-expression differential between male and female CMs. The results revealed 58 genes with significant differences between the male and female cells (p-value < 0.01). The highest observed sex-specific variation in genes was related to tophit gene (MEG3: logFC = 7.32, P-value = 5.63e -06 ), which is the maternally expressed imprinted gene with a great role in cardiac angiogenesis. Among the identified genes, a number of those were related to the cellular cytoskeletal structures including actin. We probed possible structural differences between actin filaments organization and distribution of male and female hiPSC-CMs using the stochastic optical reconstruction microscopy (STORM) technique. The results demonstrated substantial differences in organization, distribution, and morphology of actin filaments between male and female CMs. Incubation of SPIONs with male and female hiPSC-CMs revealed higher uptake of NPs (~ 3 folds) in female cells as compared to the male cells. The significant differences in the uptake of SPIONs by male vs. female cells could be attributed to the distinct organization, distribution, and morphology of actin in male vs. female cells. Conclusions: Our results indicate that male and female hiPSCs-CMs respond differently to the labeling SPIONs.

The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia

2021 ◽  
Vol 13 (590) ◽  
pp. eabd6434
Author(s):  
Patrick Sweeney ◽  
Michelle N. Bedenbaugh ◽  
Jose Maldonado ◽  
Pauline Pan ◽  
Katelyn Fowler ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Feeding Behavior ◽  
Critical Role ◽  
Brain Regions ◽  
Sexually Dimorphic ◽  
Male And Female ◽  
Female Mice ◽  
Bidirectional Regulation ◽  
Fear And Anxiety ◽  
Agouti Related Protein

Ablation of hypothalamic AgRP (Agouti-related protein) neurons is known to lead to fatal anorexia, whereas their activation stimulates voracious feeding and suppresses other motivational states including fear and anxiety. Despite the critical role of AgRP neurons in bidirectionally controlling feeding, there are currently no therapeutics available specifically targeting this circuitry. The melanocortin-3 receptor (MC3R) is expressed in multiple brain regions and exhibits sexual dimorphism of expression in some of those regions in both mice and humans. MC3R deletion produced multiple forms of sexually dimorphic anorexia that resembled aspects of human anorexia nervosa. However, there was no sexual dimorphism in the expression of MC3R in AgRP neurons, 97% of which expressed MC3R. Chemogenetic manipulation of arcuate MC3R neurons and pharmacologic manipulation of MC3R each exerted potent bidirectional regulation over feeding behavior in male and female mice, whereas global ablation of MC3R-expressing cells produced fatal anorexia. Pharmacological effects of MC3R compounds on feeding were dependent on intact AgRP circuitry in the mice. Thus, the dominant effect of MC3R appears to be the regulation of the AgRP circuitry in both male and female mice, with sexually dimorphic sites playing specialized and subordinate roles in feeding behavior. Therefore, MC3R is a potential therapeutic target for disorders characterized by anorexia, as well as a potential target for weight loss therapeutics.

scholarly journals New Geometric Morphometric Insights in Digital Taphonomy: Analyses into the Sexual Dimorphism of Felids through Their Tooth Pits

2021 ◽  
Vol 11 (17) ◽  
pp. 7848
Author(s):  
Darío Herranz-Rodrigo ◽  
Silvia J. Tardáguila-Giacomozzi ◽  
Lloyd A. Courtenay ◽  
Juan-José Rodríguez-Alba ◽  
Antonio Garrucho ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Geometric Morphometrics ◽  
Applied Statistics ◽  
Panthera Tigris ◽  
Panthera Pardus ◽  
Geometric Morphometric ◽  
Male And Female ◽  
New Horizons ◽  
Carnivore Species ◽  
Felid Species

Recent studies using geometric morphometrics for taphonomy have yielded interesting results, opening new horizons of research in both archaeological and paleontological sites. Here we present the analysis of tooth pits left by male and female individuals of two different carnivore species (Panthera tigris and Panthera pardus) in order to see if sexual dimorphism influences the morphology of tooth pit marks. In the process, 3D-scanning and applied statistics were used. Based on samples derived from two individuals of different sexes, the present results indicate sexual dimorphism in these felid species to not be a conditioning factor of tooth pit morphology.

scholarly journals Do Males and Females Differ in Terms of Their KAP Regarding Halal Pharmaceuticals?

2014 ◽  
Vol 3 (3) ◽  
pp. 163
Author(s):  
Saleha Sadeeqa ◽  
Azmi Sarriff
Keyword(s):  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male And Female ◽  
Males And Females

<p><strong></strong>There is an increasing awareness amongst Muslim consumers to avoid all items containing  non-Halal ingredients including medications. Male and female are different both biologically and psychologically, it therefore, needed for a study to compare KAP of males and females regarding  Halal pharmaceuticals. Methods<strong>:</strong>This was a cross-sectional study using a structured , self-administered questionnaires to compare the knowledge, attitude &amp; perception regarding Halal pharmaceuticals, among males and females in Penang state of Malaysia. Results<strong> </strong>revealed that there is no significance difference in the knowledge, attitude and perception of males and females. This is concluded that males and females are equally aware and have same attitude and perception regarding Halal pharmaceuticals. P value of .05 or less was taken as statistically significant.</p>

scholarly journals Performance, but not size, of hindleg weaponry is sexually dimorphic in the giant mesquite bug (Thasus neocalifornicus)

2020 ◽  
Author(s):  
Zackary A. Graham ◽  
Nicole Kaiser ◽  
Alexandre V. Palaoro
Keyword(s):  
Sexual Dimorphism ◽  
Muscle Mass ◽  
Sexually Dimorphic ◽  
Aggressive Interaction ◽  
Body Parts ◽  
Single Measure ◽  
Male And Female ◽  
Aggressive Interactions ◽  
Sexual Dimorphisms

ABSTRACTIn many species, males possess specialized weaponry that have evolved to confer a benefit during aggressive interactions. Because male weaponry is typically an exaggerated or extreme version of pre-existing body parts, females often possess reduced or weaponry. Although much research has investigated sexual dimorphism in the sizes of such weapons, other weapon components, such as weapon performance or alternative weapon forms can also explain the evolution of weapon sexual dimorphisms. Here, we investigated the allometry and variation of multiple weapon components of hindleg weaponry in the male and female giant mesquite bugs, Thasus necalifornicus. Despite theory predicating greater allocation in male weaponry, we found that females allocated more into the lengths of their hindlegs compared to males. Despite this allocation, males possess relatively wider hindlegs, which likely increase area of muscle mass. Indeed, the squeezing performance of male hindlegs was much greater than that of female hindlegs. Lastly, we also described the allometry and variation in a male weapon component, prominent tibial spines, which likely are used to damage competitors during aggressive interaction. Overall, our findings highlight the intricacies of weapon sexual dimorphism and demonstrate the importance of measuring multiple weapon components and not a single measure.

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