scholarly journals Clinical profile of Spondarthritis in females as compared to male patients with reference to HLAB27: A single center study from Nepal

2013 ◽  
Vol 2 (1) ◽  
pp. 3-5 ◽  
Author(s):  
Binit Vaidya ◽  
Shweta Nakarmi ◽  
Pujan Batajoo
Keyword(s):  
Clinical Manifestations ◽  
Spinal Pain ◽  
Clinical Parameters ◽  
Hla B27 ◽  
Clinical Registry ◽  
Cross Sectional ◽  
Early Presentation ◽  
Female Ratio ◽  
Female Patients ◽  
Male Patients

Background and Aims-To study the differences in clinical parameters between male and female patients with spondarthritis (SpA) in Nepalese population; to study the prevalence of HLA B27 phenotype in Nepalese patients with SpA and to study the differences in clinical parameters in relation to HLA B27 phenotype. Methods- This is cross sectional observational study of 102 patients diagnosed with SpA attending rheumatology clinic at Alka Hospital, Nepal from September 2011 to February 2012. Electronic clinical registry was maintained and HLA B27 was performed by flowcytometry. Results- A total of 102 patients with SpA were enrolled in the study with male to female ratio of 1.8:1 . The mean age of male patients was 6±3 years lower than that of female patients (p=0.05). There were no other statistically significant differences in clinical parameters or prevalence of HLA B27 in both the genders. Of the total patients, 52.9% were HLA B27 positive. Presence of HLA B27 was associated with early presentation by 7.1±2.8 years and the occurrence of inflammatory spinal pain P <0.001. Statistically significant association of HLA B27 with other clinical manifestations of SpA were not seen. Conclusions- HLA B27 was present in 52.9% of patients with diagnosed SpA. The presence of HLA B27 was associated with earlier presentation of disease and occurrence of inflammatory spinal pain. However, there was no gender difference in clinical manifestation of SpA or prevalence of HLAB27 in our patients except for early age at presentation in male patients. Journal of Advances in Internal Medicine 2013;02(01):3-5 DOI: http://dx.doi.org/10.3126/jaim.v2i1.7628

scholarly journals Prevalence of Preoperative Anxiety in Preoperative Patients in Nepal Police Hospital: A Cross-sectional Descriptive Study

2021 ◽  
Vol 4 (1) ◽  
pp. 85-88
Author(s):  
Sundar Prasad Hyoju
Keyword(s):  
Descriptive Analysis ◽  
Sampling Technique ◽  
Descriptive Study ◽  
Negative Consequences ◽  
Cardiac Events ◽  
Cross Sectional ◽  
Female Patients ◽  
Pain Ratings ◽  
Male Patients ◽  
Preoperative Patient

Introduction: The possibility of undergoing anesthesia-assisted surgery can cause a great deal of anxiety in individuals. Excessive anxiety can have a number of negative consequences, including perioperative cardiac events, greater anesthetic needs, higher postoperative pain ratings, and a longer stay in the hospital. Anxiety levels during surgery might be influenced by a variety of reasons. The objective of the study was to estimate the prevalence of anxiety in adult patients scheduled for Surgery. Methods: This is Cross-sectional Descriptive Study conducted in Nepal police hospital with calculated sample size of 92 with round figure of 100, convenient sampling technique was used. Descriptive analysis was used for Analysis. Results: Prevalence of anxiety in preoperative patient was 31%. The prevalence in male patients and female patients were 21.2% and 39.5% respectively. Conclusions: When compared to many other research, the general prevalence of anxiety at Nepal Police Hospital was lower; nevertheless, the incidence was higher among female patients.

scholarly journals Prevalence and correlates of psychological distress among cancer patients in a tertiary care hospital in northern India

2019 ◽  
Vol 6 (5) ◽  
pp. 2223 ◽  
Author(s):  
Amita Mason ◽  
Ruchi Juyal ◽  
Sai Chandan Das ◽  
Deep Shikha ◽  
Sunil Saini ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Cancer Patients ◽  
Formal Education ◽  
Economic Status ◽  
Tertiary Care ◽  
Depression Scale ◽  
Care Hospital ◽  
Cross Sectional ◽  
Female Ratio ◽  
Female Patients

Background: Patients diagnosed with cancer are usually exposed to high level of mental stress and hence invariably lend in psychological distress. This study aimed to estimate the prevalence of psychological distress amongst cancer patients and determine its association with socio-demographic factors.Methods: This hospital based cross-sectional study was conducted at a cancer research institute of district Dehradun. Purposive sampling was used to select the hospital and recruiting patients. All eligible patients, giving written consent for the study were interviewed and distress related information was gathered using the Hospital Anxiety and Depression Scale (HADS). The data were collected for two months and sample size of 208 was achieved. Data was entered in SPSS 22.0 and association of different variables with psychological distress was determined by chi-square test..Results: The mean age of the surveyed cancer patients was 51.05±15.68 years and the male female ratio was 1.7. Prevalence of psychological distress was found to be 38.5% and significantly more female patients than male patients (47.4% and 33.3% respectively) had distress. The association between psychological distress and increasing age, sex, literacy and employment status was found to be significant.Conclusions: Approximately 39% of cancer patients had psychological distress (anxiety/ depression/ both). The prevalence of psychological distress was found to be significantly higher in female patients, older age, patients with no formal education, unemployment and lower socio-economic status. Appropriate psychiatric interventions/ counselling following diagnosis and during therapy may be effective in reducing distress and improving quality of life in cancer patients.

scholarly journals Socio-Demographic Characteristics of Acute Myocardial Infarction Patients in Bangladesh

2018 ◽  
Vol 29 (1) ◽  
pp. 16-20
Author(s):  
MMR Khan ◽  
NK Sana ◽  
PM Basak ◽  
BC Sarker ◽  
M Akhtarul Islam ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Smoking Habit ◽  
Premature Death ◽  
Demographic Characteristics ◽  
Age Group ◽  
Monthly Income ◽  
Female Ratio ◽  
Female Patients ◽  
Male Patients

Background: The impacts of socio-demographic characteristics on acute myocardial infarction (AMI) are not well understood and have not yet been studied much more in our country. Acute myocardial infarction is the most common form of coronary heart disease and the single most important cause of premature death worldwide.Objective: The aim of this study was to assess the impacts of the socio-demographic characteristics on AMI patients and to investigate the association between socioeconomic status and its various indicators and the risk of acute myocardial infarction (AMI). This study will help in awareness building in reducing AMI by early detection of socio-demographic variables.Patients and methods: This was a prospective observational study consisted of 325 persons of AMI patients who were aged >20 years. Patients with first time AMI arriving in Coronary Care Unit (CCU) of Rajshahi medical college during the period of 2012-2014, were included. Data were collected through interview.Results: Among the AMI patients, male were more sufferer than female (68.3% vs. 31.7%) and male and female ratio was 2.15:1.0. Highest percentage of education was up to primary level (53.85%). Most of studied subjects (92.0%) monthly income were ≤15000. More than half (59.38%) of the studied population were from rural area, mostly they were Muslim (94.46%) and smokers (50.15%). The mean±SD age of the acute Myocardial infarction patients was 53.75±11.64 years. Mean age of the female patients were a little bit higher than the male patients (female 54.28±11.78 vs. male 53.51±11.63). Highest percentage was in the age group 51-60 years (32%) followed by 41-50 (26.8%) and then age group >60 (23.7%). Among the male patients highest percentage was in the age group 51-60 years (31.1%) followed by 41-50 years (27%) and then age group >60 (24.3%). However, among the female patients, highest percentage were in the age group 51-60 years (34%) followed by 41-50 years (26.2%), and then age group >60 (22.3%). Acute Myocardial infarction patients was more in age group >40 years of age. Interestingly after 60 years of age occurrence of AMI was low in both sexes.Conclusion: Both sex and age influenced AMI. An association was also found among educational level, monthly income, residence area, religion, smoking habit and AMI.TAJ 2016; 29(1): 16-20

scholarly journals GAMBARAN KADAR KOLESTEROL, ALBUMIN DAN SEDIMEN URIN PENDERITA ANAK SINDROMA NEFROTIK

2018 ◽  
Vol 13 (2) ◽  
pp. 49
Author(s):  
Irda Handayani ◽  
B. Rusli ◽  
Hardjoeno Hardjoeno
Keyword(s):  
Nephrotic Syndrome ◽  
Descriptive Study ◽  
Albumin Concentration ◽  
Laboratory Examination ◽  
Female Ratio ◽  
Female Patients ◽  
Male Patients ◽  
Male To Female

Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia accompanied by oedema and hypercholesterolemia.Nephrotic syndrome is an often relapsing disease (75%) and often the diagnosis is too late. This disease is 15 times greater in childrenthan in adult and the male to female ratio is 2:1. Laboratory examination is needed to rapidly detect and evaluate the progress of thedisease for treatment. To know the distribution of NS based on aged, gender, cholesterol, and albumin concentration and the urinesediment profile. The data in this retrospective descriptive study were collected from 56 patients with NS at the Wahidin SudirohusodoHospital, Makassar, in the period of January 2004 – June 2006. NS were found in 36 male patients (64.3%) and 20 female patients(35.7%). Cholesterol concentrations were 250 mg/dl in 50 patients (89.3%) and 250 mg/dl in 6 patients (10.7%). Albuminconcentration was 2.5 g/dl in 21 patients (37.5%) and < 2.5 gr/dl in 35 patients (62.5%). In urine sediments, there were found in 23patients (41.1%) with positive proteinuria (+++), 51 patients (91.1%) with positive erythrocytes, 54 patients (96.4%) with positiveleucocytes, and 33 patients (58.9%) with positive cylinders such as rugged granular and fatty cost. More NS were found in male patientsin comparison to female, and many were aged + 6 years. Hypercholesterolemia, hypoalbuminemia, proteinuria, hematuria, leucocyturia,and positive cylinder (rugged granular and fatty cast) were found in the urine of most of the NS patients.

scholarly journals Scoring system to distinguish between rotavirus and non-rotavirus diarrhea in children

2017 ◽  
Vol 56 (6) ◽  
pp. 338
Author(s):  
Atika Akbari ◽  
Hasri Salwan ◽  
Achirul Bakri ◽  
Erial Bahar
Keyword(s):  
Multivariate Analysis ◽  
Scoring System ◽  
Clinical Manifestations ◽  
Area Under The Curve ◽  
Cross Sectional Study ◽  
Clinical Parameters ◽  
Cross Sectional ◽  
Physical Examinations ◽  
Roc Area ◽  
Rotavirus Diarrhea

Background Distinguishing rotavirus from non-rotavirus diarrhea is helpful for managing the illness. However, definitively diagnosing rotavirus diarrhea from serology is difficult and expensive.Objectives To distinguish between the clinical manifestations of rotavirus and non-rotavirus diarrhea, and to assess the accuracy of using such clinical manifestations to predict the type of diarrhea in children.Methods A cross-sectional study was performed from April to October 2015 in all children less than five years of age who presented with acute diarrhea at the Pediatric Outpatient Clinic of the Department of Child Health and Emergency Department, Dr. Mohammad Hoesin and Bari Hospitals, Palembang, South Sumatera. Clinical manifestations were collected from history and physical examinations; stool specimens were examined by immunochromatography. Clinical parameters were analyzed by multivariate analysis, and scores given to each significant parameter. The accuracy of the scoring system based in these parameters was analyzed by means of receiver-operating characteristic (ROC) area under the curve (AUC).Results Of 184 children, 92 had rotavirus and 92 had non-rotavirus diarrhea. Multivariate analysis showed 3 clinical parameters commonly seen in the rotavirus diarrhea cases: male sex (OR 2.718; 95%CI 1.373 to 5.382), cough (OR 3.500; 95%CI 1.788 to 6.582), and yellow-greenish stool (OR 4.009; 95%CI 2.061 to 7.797). A scoring system was constructed based on the parameters: male (score of 1), cough (score of 2), and yellow-greenish stool (score of 3). From ROC analysis, the AUC was 0.755. Using a cut-off score of > 3, the sensitivity was 81.5%, specificity 51.1%, and PPV 62.5%.Conclusion Cough, yellow-greenish stool, and male are significant parameters for differentiating rotavirus from non-rotavirus diarrhea. A scoring system from these parameters is sensitive for predicting rotavirus vs. non-rotavirus diarrhea in children less than five years of age.

scholarly journals A 10-year cross-sectional retrospective study on Kawasaki disease in Iranian children: incidence, clinical manifestations, complications, and treatment patterns

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Payman Sadeghi ◽  
Anahita Izadi ◽  
Sayed Yousef Mojtahedi ◽  
Leila Khedmat ◽  
Mohsen Jafari ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Kawasaki Disease ◽  
Serum Sodium ◽  
Clinical Manifestations ◽  
Cardiac Complications ◽  
Second Line ◽  
First Line ◽  
Cross Sectional ◽  
Female Ratio ◽  
Iranian Children

Abstract Background Kawasaki disease (KD) as an acute, systemic vasculitis is the leading cause of acquired heart disease in children under the age of 5 years. Methods A 10-year cross-sectional retrospective study was designed to assess 190 Iranian children with KD during 2008–2018. Demographic data, clinical and laboratory manifestations from the onset of symptoms to diagnosis, clinical signs and symptoms, and subsequent treatments were evaluated to predict hospitalization stay, complications, and response to treatment. Results Children with KD had a male-to-female ratio of 1.18:1 and an average age of 36 months. There was an insignificantly more incidence of KD in cold seasons. The most frequent symptoms were fever (92.6%), oral mucus membrane changes (75.8%), bilateral bulbar conjunctival injection (73.7%), polymorphous skin rash (73.2%), peripheral extremity changes (63.7%), and cervical lymphadenopathy (60.0%). The rate of gastrointestinal, cardiac, joint, and hepatic complications was determined to be 38.4, 27.9, 6.8, and 4.2%, respectively. 89.5% of patients received intravenous immunoglobulin (IVIG) plus aspirin as the first line of treatment, while, 16.3% of them needed an extra second line of treatment. Significantly low serum sodium levels and high platelet counts were detected in KD patients with cardiac complications. Cardiac complications often were more encountered in patients who did not respond to the first line of treatment. Higher platelet count, lower serum sodium amount, and C-reactive protein (CRP) level were significantly associated with a need for an additive second line of treatment. A significant relationship between hospitalization stay and hemoglobin level was found. Conclusion As most of the clinical manifestations and complications were following other reports released over the past few years, such data can be confidently used to diagnose KD in Iran. Seasonal incidence and a positive history of recent infection in a notable number of patients may provide clues to understand possible etiologies of KD. Laboratory markers can successfully contribute to health practitioners with the clinical judgment of the need for additional treatments, possible complications, and hospitalization duration.

scholarly journals Frequency of asthenopia and its association with refractive errors

2015 ◽  
Vol 74 (1) ◽  
Author(s):  
Samuel O. Wajuihian
Keyword(s):  
High School Students ◽  
Primary School Children ◽  
Common Symptom ◽  
Refractive Errors ◽  
School Students ◽  
Cross Sectional ◽  
Female Patients ◽  
School Aged Children ◽  
Male Patients ◽  
And Performance

Background: Asthenopia is a common complaint amongst patients who attend eye care settings. Owing to associated discomfort or distress, asthenopia affects efficient reading and performance of near tasks.Purpose: To study the prevalence of asthenopia and any association with refractive errors in a clinical setting.Methods: In this cross-sectional practice-based study, the clinic records of 1109 school-aged children (mean age and standard deviation 14.39 ± 3.39 years) were analysed. The sample comprised 427 (38.5%) male and 682 (61.5%) female patients between the ages of 6 and 19 years. Refractive errors were classified into various types, and the association between these refractive types and symptoms in asthenopia were explored.Results: The most common symptom of asthenopia was headaches (40.8%), of which temporal headaches were the most frequent type (15.7%). Various symptoms were significantly associated with mainly astigmatism.Conclusion: Headaches were the most frequent complaint amongst patients who attended the author’s optometric practice. Astigmatism was the most frequent cause of asthenopia. Female patients were more likely than male patients to complain of asthenopia, whilst high school students were more likely than primary school children to complain of asthenopia. Further studies to relate asthenopia to binocular anomalies will be relevant in enhancing our understanding of the relationship between asthenopia and vision anomalies.

scholarly journals Pattern of Common Inherited Coagulation Disorders: Evaluation of 100 Cases

2020 ◽  
Vol 15 (1) ◽  
pp. 64-66
Author(s):  
Mohammed Nuruzzaman Bhuiyan ◽  
Maj Gen Susane Giti ◽  
Mohammed Mosleh Uddin ◽  
Monwar Tarek ◽  
Lutfunnahar Khan
Keyword(s):  
Clinical Manifestations ◽  
Cost Effective ◽  
Armed Forces ◽  
Fresh Frozen Plasma ◽  
Haemophilia A ◽  
Age Group ◽  
Coagulation Disorders ◽  
Cross Sectional ◽  
Female Ratio ◽  
Coagulation Defect

Introduction: The bleeding disorders having inherited abnormality of haemostasis may present with significant difficulties in diagnosis and management. The overall frequency of these disorders in the general population is low. Objectives: To study the frequency of inherited coagulation disorders and their prevalent clinical manifestations. Materials and Methods: A prospective cross sectional study of one hundred patients of all age group and both sexes was organized as both in-patient and out-patient based in the Department of haematology, Armed Forces Institute of Pathology (AFIP) from July 2012 to June 2013. Results: In this study, out of 100 patients, haemophilia A, diagnosed in 75% patients, was the most common disorder. Age group ranging from 5-15 years constituted 48% of total patients. Male to female ratio of patients having hereditary coagulation defect was 73:2 in haemophilia A whereas 2:3 in vWD. Consanguinity was documented in 60% of vWD and 24% of haemophilia A. The most common clinical symptom in hereditary coagulation defect (HCD) was echymosis (60%). The most common presenting feature of haemophilia was haematoma (57.95%) whereas menorrhagia was the most common presentation of female patients with vWD. Among 97 patients of haemophilia and vWD, 59(60.82%) cases were in mild form and 04(4.12%) cases were found to have severe coagulation defect. Fresh frozen plasma (FFP) is the most common modality of treatment in HCD. Conclusion: It has become the need of the time to find out such a cost effective diagnostic parameter to make an early diagnosis of inherited coagulation disorders. Journal of Armed Forces Medical College Bangladesh Vol.15 (1) 2019: 64-66

scholarly journals GAMBARAN KADAR ALBUMINURIA PADA SUBJEK DIABETES MELITUS DENGAN DAN TANPA PENYAKIT JANTUNG KORONER

e-CliniC ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Sandy Cendra ◽  
Emma Moeis ◽  
Yuanita Langi
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Renal Physiology ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Female Patients ◽  
Patients With Diabetes ◽  
Male Patients ◽  
Diabetes Melitus

Abstract: Albuminuria is a marker of the decline in renal physiology and function of endothelial. Endothelial dysfunction is an early pathogenesis of coronary heart disease (CHD). High coronary heart disease complications in patients with diabetes mellitus (DM). Objective To know the description and differences in levels of albuminuria in diabetic patients with and without CHD inpoli Metabolic and Endocrine and poli Heart BLU. RSU. Prof. dr. R. D Kandou Manado. Research Method: Cross Sectional descriptive analytic study conducted in patients with diabetes mellitus pieces with and without coronary heart disease in Poli Endocrine Metabolic and poli heart BLU. RSU. Prof. dr. R. D Kandou Manado period November 2012 - November 2013. Results: From 34 patients with diabetes mellitus found the number of diabetic patients with CHD were 17 patients and 17 patients for diabetes without CHD, which consisted of 14 male patients and 20 female patients. The distribution of the sample based on CHD and sex, showed that diabetic patients with CHD were 9 men (26.47%) and 8 women (23.53%). As for diabetic patients without CHD as many as 5 male patients (14.70%) and 12 female patients (35.30%). Distribution of the study sample by CHD and RAKU categories showed diabetic patients with CHD were 7 patients (20.59%) and normal RAKU 10 patients (29.41%) RAKU abnormal. As for diabetic patients without CHD by 16 patients (47.06%) and 1 patient RAKU normal (2.94%) RAKU abnormal. Conclusion: Albuminuria occurs more frequently in patients with diabetes mellitus with coronary heart disease than diabetes mellitus without coronary heart diseaseKeywords: Albuminuria, diabetes mellitus, coronary heart disease.    Abstrak: Albuminuria merupakan petanda terjadinya penurunan faal ginjal dan disfungsi endotel. Disfungsi endotel merupakan patogenesis awal penyakit jantung koroner (PJK). Komplikasi penyakit jantung koroner tinggi pada pasien diabetes melitus (DM). Tujuan: Untuk mengetahui gambaran dan perbedaan kadar albuminuria pada pasien DM dengan dan tanpa PJK di Poli Endokrin Metabolik dan Poli Jantung BLU. RSU. Prof. dr. R. D Kandou  Manado. Metode Penelitian: Dilakukan penelitian deskriptif analitik lintang potong pada penderita diabetes melitus dengan dan tanpa penyakit jantung koroner di Poli Endokrin Metabolik dan Poli Jantung BLU.RSU. Prof. dr. R. D Kandou  Manado periode November 2012 – November 2013. Hasil: Dari 34 pasien Diabetes Melitus ditemukan jumlah pasien DM dengan PJK sebanyak 17 pasien dan 17 pasien untuk DM tanpa PJK, yang terdiri atas 14 orang pasien laki-laki dan 20 pasien wanita. Distribusi sampel berdasarkan PJK dan jenis kelamin, didapatkan hasil pasien DM dengan PJK yaitu sebanyak 9 orang laki-laki (26,47 %) dan 8  orang perempuan (23,53%). Sedangkan untuk pasien DM tanpa PJK yaitu sebanyak 5 orang pasien laki-laki (14,70%) dan 12 orang pasien perempuan (35,30%). Distribusi sampel penelitian berdasarkan PJK dan RAKU Kategori didapatkan hasil pasien DM dengan PJK sebanyak 7 pasien (20,59%) RAKU normal dan 10 pasien (29,41%) RAKU abnormal. Sedangkan untuk pasien DM tanpa PJK sebanyak 16 pasien (47,06%) RAKU normal dan 1 pasien (2,94%) RAKU abnormal. Simpulan: Albuminuria lebih banyak terjadi pada pasien diabetes melitus dengan penyakit jantung koroner dibandingkan diabetes melitus tanpa penyakit jantung koroner Kata kunci: Albuminuria, diabetes melitus, penyakit jantung koroner.

scholarly journals Influence of IL-6 and TNF-α on clinical manifestations, activity and comorbidity in a group of patients with psoriatic arthritis

2020 ◽  
Author(s):  
Carlos Montilla ◽  
Gómez-Lechón Luis ◽  
Esther Toledano ◽  
Elisa Acosta ◽  
Olga Compán ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Disease Activity ◽  
Clinical Manifestations ◽  
Tender Joint Count ◽  
Hla B27 ◽  
Tender Joint ◽  
Cross Sectional ◽  
Tnf Α ◽  
Biologic Dmard ◽  
Clinical Variants

Abstract Objectives To relate the levels of IL-6 and TNF-α in patients with psoriatic arthritis (PsA) with the clinical variants, the disease activity and the presence of comorbidities. Methods Cross-sectional observational study that included 184 patients with PsA according to CASPAR criteria. IL-6 and TNF-α levels were determined. As clinical variables, the clinical form (peripheral, axial or mixed), the presence of dactylitis, the severity of psoriasis measured by PASI and HLA-B27 were determined. Disease activity was measured by the tender joint count, swollen joint count, entheses affected, the severity of psoriasis measured by PASI, ESR, and CRP. The minimum disease activity (MDA) was also measured. Cardiovascular risk markers such as waist /hip ratio (w/ h) and analytical variables: apolipoprotein A, apolipoprotein B, lipoprotein a, insulin, insulin resistance (HOMA-R) and microalbuminuria in urine 24 hours (MA) were included in comorbidity. The presence of fatty liver was measured by ultrasound and fatigue by the FACIT-F questionnaire. Results The mean age of the patients was 55.12 years (SD: 11.29). One hundred and one were men (54.89%). 14.67% of the patients were on treatment with biologic DMARD (bDMARD). One hundred and two patients had peripheral involvement (55.43%), 69 mixed (37.5%) and 13 (7.07%) exclusively axial. 17.93% of the patients had a positive HLA-B27. 53.26% of the patients achieved a MDA. In the analysis of IL-6, we found a correlation with CRP (R: 0.32; P = 0.001), in addition, in patients with positive HLA-B27 we found lower concentrations of IL-6 (3.25 + 2, 26 Vs 5.81 + 7.23) -p < 0.001). We found no association with other variables related to inflammatory activity and / or comorbidity. TNF-α concentrations were higher in patients receiving TNF-α inhibitors ((178.89 SD: 181.31 vs 10.42 SD: 11.15; P < 0.001). Excluding these patients, we only found a correlation with the MA (R: 0.39; p < 0.001). Conclusions In our patients, the presence of HLA-B27 influenced IL-6 concentrations. TNF-α could be considered as a marker of subclinical renal damage.

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