scholarly journals A study of hematological parameters in patients with COVID-19 infection at a tertiary care centre

2021 ◽  
Vol 11 (1) ◽  
pp. 1852-1858
Author(s):  
Keval Arvindbhai Patel ◽  
Bimal Patel ◽  
Riddhi A Parmar ◽  
Bhawana S Sharma ◽  
Mansi Thacker ◽  
...  
Keyword(s):  
World Literature ◽  
Virus Disease ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Absolute Lymphocyte Count ◽  
World Health ◽  
Total Leukocyte Count ◽  
Tertiary Care Centre ◽  
Male Predominance ◽  
Health Organization

Background: The corona virus disease 2019 is caused by the virus SARS-CoV-2 and is declared as a global pandemic by World Health Organization. Alterations in various hematological parameters have been recently documented in the world literature in SARS-Cov-2 infection. However, still there is paucity of hematological data in these patients. Hence this study is an attempt to evaluate the pattern of the hematological parameters in COVID-19 patients in the Indian population in our region. The objective of the study is to see the pattern of alteration in hematological parameters with emphasis on total leukocyte count, absolute lymphocyte count and platelet count in COVID 19 positive patients.Materials and Methods: This is an observational study in 50 patients with laboratory-confirmed COVID-19 status admitted to G.K. General Hospital & Gujarat Adani Institute of Medical Sciences, Bhuj, from 1st April 2020 to 30th June 2020. Statistical analysis of the data was carried out, and relevant findings were presented.Results: Among the 50 patients, there were 35 (70%) males and 15 (30%) females with an age range from 6 months to 82 years with twenty-five patients above 50 years. There was lymphopenia in 18 patients (36%), leukopenia in 2 patients (4%) and thrombocytopenia in 8 (16%) patients.Conclusions: Majority of the patients were elderly, and there was a male predominance. There was moderate to severe lymphopenia and mild thrombocytopenia.

scholarly journals A pilot study comparing pattern of damage sustained among instruments from different surgical units in a tertiary care centre in Nepal – reappraising the role of instrument reprocessing in retaining their value

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 102
Author(s):  
Sunil Munakomi ◽  
Roshan Shah ◽  
Sangam Shrestha
Keyword(s):  
Tertiary Care ◽  
Health Spending ◽  
Pivotal Role ◽  
World Health ◽  
Tertiary Care Centre ◽  
Surgical Equipment ◽  
Surgical Units ◽  
Wear And Tear ◽  
Health Organization

Background: The quality of instruments plays a pivotal role in governing safe operating room culture. The reprocessing system followed in the institution determines their durability thereby ensuring patient safety as well as minimizing health spending. Rigorous reprocessing in a centralized instrument reprocessing department by well trained staff following formulated guidelines helps to achieve the target of “safe surgery saves lives” as formulated by the World Health Organization. Methods: We sought to determine the patterns of wear and tear sustained among sets of surgical equipment from two surgical units that had been sent to the repair department within a year of their purchase. Analysis of similar changes in the joints of the instrument, as well as pattern of fractures sustained was performed. Results: All patterns of wear and tear were common in both the general surgical arm and neurosurgical counterpart, with the exception of fractures and mal-alignments. Similar study was performed examining changes in the joints. Stains were the most commonly observed change pattern in both sets of instruments. Fractures were most frequent in the working ends in both sets of instruments. Conclusion: There is an alarming incidence of wear and tear patterns in the instruments used in the surgical units, even within the first year of their use. This supports the strict implementation of reprocessing guidelines by well trained workers and their quality assessments via audit checks. The quality of the purchased instruments also plays a pivotal role.

Study of Absolute Lymphocyte Count as a Marker of COVID 19 Disease Severity in Tertiary Care Centre, Suryapet

2021 ◽  
Vol 8 (23) ◽  
pp. 1960-1965
Author(s):  
Bellala Venkata Anuradha Devi ◽  
Cigiri Saritha ◽  
Ravuri Swarupa ◽  
Jeshtadi Anunayi
Keyword(s):  
Disease Severity ◽  
Lymphocyte Count ◽  
Complete Blood Count ◽  
Tertiary Care ◽  
Absolute Lymphocyte Count ◽  
World Health ◽  
Total Leucocyte Count ◽  
Global Public Health ◽  
Tertiary Care Centre ◽  
Absolute Lymphocyte Counts

BACKGROUND The World Health Organization (WHO) has declared Coronavirus disease 2019 (COVID - 19) as a global public health pandemic. Clinical and laboratory biomarkers to predict the severity of corona virus 2019 are essential in this pandemic. Lymphocyte count has been a marker of interest in order to investigate the association of lymphocyte count and severity of COVID-19. We would like to analyse the relationship between absolute lymphocyte count (ALC) & COVID-19 disease severity. METHODS We performed a retrospective study on patients admitted to Government general hospital, Suryapet for COVID-19 illness from September 1st 2020 to September 16th 2020. Age, gender and complete blood count of patients admitted in the hospital was collected. Haemoglobin, total leucocyte count (TLC), absolute neutrophilic count (ANC), absolute lymphocyte count (ALC) and platelet counts were compared between ICU and Non-ICU groups and comparison of absolute lymphocyte counts in each group - ICU alive, ICU death and non-ICU groups was carried out. RESULTS 134 patients who were admitted in the hospital were analysed. Mean age and gender were compared between ICU and Non-ICU groups. We compared ALC between ICU alive, ICU death and non-ICU groups. Mean ALC in ICU death group was 0.81, in ICU alive group 1.04 and in non-ICU as 1.75. We found that patients with disease severity have lower absolute lymphocyte counts. In addition to this we also found that there was neutrophilia and lower haemoglobin levels in ICU patients. CONCLUSIONS We conclude that lymphopenia, defined as absolute lymphocyte count less than 1.1 x 109 /L may be useful in predicting the severity of COVID-19 illness. KEYWORDS COVID-19, Absolute Lymphocyte Count (ALC), Lymphopenia, SARS COV2

scholarly journals Clinical and epidemiological profile of patients infected by COVID-19 at a tertiary care centre in North India

2020 ◽  
Vol 90 (4) ◽  
Author(s):  
Sadanand Prakash ◽  
Manas Mani Agrawal ◽  
Rajendra Kumar ◽  
Shubhangi Yadav
Keyword(s):  
World Health Organization ◽  
Indian Subcontinent ◽  
Tertiary Care ◽  
North India ◽  
World Health ◽  
Contact Tracing ◽  
Care Centre ◽  
Indian Government ◽  
Tertiary Care Centre ◽  
Health Organization

A worldwide outbreak of a respiratory illness, first detected in December 2019 in Wuhan city, Hubei province, China is ongoing. The disease is caused by a novel coronavirus, SARS-CoV-2 and on February 11, 2020, was officially named Coronavirus Disease 2019 (COVID-19) by the World Health Organization. Within few weeks, it has spread globally to the extent that World Health Organization declared it as a global pandemic on March 11, 2020. India’s first positive case was reported on January 30th in Kerala. Before March 3rd, India had 3 cases of coronavirus in Kerala all of which were treated and discharged. On March 3rd, India’s 4th case was diagnosed in the state of Rajasthan. Indian government had announced a number of preventive measures to minimize the entry and spread of coronavirus. On March 3rd, India announced the suspension of all visas issued to Italy, Iran, South Korea and Japan. India banned international flights from March 22nd. A 21-day lockdown across the country was imposed from March 26th, which later got further extended. Rigorous contact tracing and tracking of COVID patients and monitoring home quarantine helped in preventing community transmission. The aim of this work is to describe the experience with clinical and epidemiologic features, as well as with the management of COVID-19 patients in north India. This is a descriptive study of the 17 COVID-19 infected patients confirmed with polymerase chain reaction (PCR) and admitted to a tertiary care centre in India from March 11th 2020 to April 16th 2020. The present work also provides insight in to treatment provided and final outcome of the patients infected with COVID-19 in India. Laboratory investigations in COVID-19 patients in the Indian subcontinent reveal lymphopenia as predominant finding in hemogram. Patients with older age and associated comorbidities (COPD, hypertension and diabetes) seem to have greater risk for lung injury, thereby requiring oxygen support during the course of disease.

scholarly journals AB0339 THE IMPORTANCE OF THERAPEUTIC COMPLIANCE: ADHERENCE TO METHOTREXATE AND ITS ROLE IN IMMUNOGENICITY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1468.2-1468
Author(s):  
P. García ◽  
M. González Fernández ◽  
M. N. Rivas ◽  
J. Duruelo ◽  
E. Garmendia ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Diseases ◽  
Tertiary Care ◽  
Daily Practice ◽  
World Health ◽  
Dependent Manner ◽  
Tertiary Care Centre ◽  
Secondary Failure ◽  
Health Organization ◽  
Dose Dependent

Background:Immunogenicity against adalimumab leads to loss of response and secondary failure to biologic therapy; however, concomitant use of methotrexate (MTX) seems to reduce the development of anti-drug antibodies (ADAbs) in a dose-dependent manner. Suboptimal adherence to MTX may favour ADAbs appearance.Objectives:To evaluate the relationship between MTX adherence and ADAbs development.Methods:Observational study among adult patients with chronic inflammatory arthropathy, followed in a tertiary care centre, who were in treatment with MTX and adalimumab. ADAbs formation in relation to MTX adherence was assessed.Results:33 patients were included, with a MTX adherence overall mean of 82.13 (12.45%-100%, median adherence 92.19%). Only 9.09% (n=3) of the patients developed ADAbs, being its MTX adherence mean of 60.95% (46.47%-70%, median adherence 66.39%); ADAbs negative group showed an average MTX adherence of 84.23% (12.45%-100%, median adherence 94.29%). A statistically significant result (p<0.05) between groups was found.Table 1.Baseline characteristics of the patients with RA (n=450), mean±SD/n(%)nAdherence meanADAbs (+)3 (9.09%)60.95%p<0.05ADAbs (-)30 (90.91%)84.23%Total33 (100%)82.13%No statistically significant differences (p>0.05) involving MTX adherence and its dose were found.Conclusion:While the sample is small, this study suggests that ADAbs development may be influenced by MTX adherence, thereby promoting adequate MTX adherence should be a priority in the daily practice of every rheumatologist.References:[1]World Health Organization. Adherence to long term therapies: evidence for action. 2003.[2]Krieckaert CL, Nurmohamed MT, Wolbink GJ. Methotrexate reduces immunogenicity in adalimumab treated rheumatoid arthritis patients in a dose dependent manner. Annals of the Rheumatic Diseases. 2012;71:1914-1915.[3]Zhang J, Xie F, Delzell E, et al. Impact of biologic agents with and without concomitant methotrexate and at reduced doses in older rheumatoid arthritis patients. Arthritis Care Res (Hoboken). 2015;67(5):624–632. doi:10.1002/acr.22510[4]Jani M, Barton A, Warren RB, Griffiths CE, Chinoy H. The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases. Rheumatology (Oxford). 2014;53(2):213–222. doi:10.1093/rheumatology/ket260.Disclosure of Interests:Paula García: None declared, Marta González Fernández: None declared, Mayra Nathali Rivas: None declared, Javier Duruelo: None declared, Elena Garmendia: None declared, Javier Arostegui Lavilla: None declared, Fernando Perez-Ruiz Consultant of: AmgenLilly, Speakers bureau: Amgen, Alberto Alonso: None declared, Consuelo Modesto: None declared, Boris Anthony Blanco Cáceres: None declared

scholarly journals A clinical study of anemia in children aged 6 months–5 years in a tertiary care center, Bengaluru, Karnataka, India

2021 ◽  
Vol 8 (10) ◽  
pp. 367-370
Author(s):  
Siva Saranappa ◽  
Jennifer Wu
Keyword(s):  
Nutritional Status ◽  
Care Center ◽  
Tertiary Care ◽  
Age Groups ◽  
World Health ◽  
Deficiency Anemia ◽  
Age Group ◽  
Female Ratio ◽  
Male Predominance ◽  
Health Organization

Background: Anemia is the most commonly observed hematological diseases in children. The World Health Organization (WHO) has estimated that globally, 1.62 billion people are anemic, with the highest prevalence of anemia (47.4%) among preschool-aged children. Of these 293 million children, 89 million live in India. Aim: This study aims to evaluate the factors causing anemia in children aged between 6 months and 5 years and its prevalence within this age group. Methods: This study is a prospective observational study conducted in KIMS Hospital, Bengaluru, Karnataka. A total of 200 children in the age group of 6 months–5 years with features of anemia or having hemoglobin <11 g/dl were included in the study for a duration of 18 months between January 2019 and June 2020. Detailed history was recorded and examination findings were noted. The data collected were tabulated and statistically analyzed accordingly. Results: About 57.5% of the children with anemia fell between the age group of 6 months and 2 years and 42.5% of children were in the age groups of 2–5 years. A male predominance was seen (61%) with male-to-female ratio of approximately 1.56:1. Most of the children were found to have mild (46%) and moderate anemia (46%) with only a minority (8%) presenting with severe anemia. About 56.5% of the children had a normal nutritional status while 41% were malnourished and 2.5% had both wasting and stunting. Exclusive breastfeeding (for 6 months) history was present in 59% of the children. These children belonged mostly to the upper lower (45%) and lower middle (41%) socioeconomic status. This study also showed anemia in children most commonly presented majorly with concurrent involvement of the respiratory system (31%) followed by infectious diseases (30%) and gastrointestinal disorders (23%). Conclusion: The current study concludes that iron deficiency anemia is a multifactorial hematological disease. Learning about the predisposing risk factors can help to adopt the necessary precautions to prevent anemia in these children. Improving the nutritional status of the children by involving parents and counseling them regarding important feeding practices can help to prevent anemia.

scholarly journals Real Time-PCR (RT-PCR) Positivity for SARS-CoV-2 in Suspected COVID-19 Patients Presented in a Tertiary Care Hospital

2020 ◽  
pp. 67-70 ◽  
Author(s):  
Sarmistha Biswas ◽  
Khan Abul Kalam Azad ◽  
Mohammad Mahfuzul Hoque ◽  
Syed Ghulam Mogni Mowla ◽  
Sultana Shahana Banu ◽  
...  
Keyword(s):  
Virus Disease ◽  
Tertiary Care ◽  
Early Period ◽  
High Rate ◽  
World Health ◽  
Care Hospital ◽  
Rt Pcr ◽  
College Hospital ◽  
Cross Sectional ◽  
Male Predominance

Introduction: Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a newly emergent virus. World Health Organization declared COVID-19 as pandemic on March 11, 2020 for its rapid spreading. Not only to diagnose the disease (confirm case) but also to control and contain the transmission; test, trace and isolation are fundamental. RT-PCR for SARS-CoV-2 is used to detect and diagnose COVID-19 which started in Dhaka Medical College Hospital (DMCH) on 2nd April 2020. In this study we described our observation of RT-PCR done in patients presented in DMCH in the first month after starting the test. Methods: This observational, cross sectional study was done to find out the rate of RT-PCR positivity in suspected COVID -19 patients presented to DMCH from 2nd April to 3rd May, 2020 by the Department of Medicine in association with the Department of Virology. Data was collected from the registry book of the Department of Virology. The rate of RT-PCR for SARS-CoV-2 positivity among the suspected COVID-19 patients and demographical variable was observed. Results: Among the total studied patients (n=3206), 58.8% (n=1886) was male and mean age was 37.7(±14.38784) years. RT-PCR for SARS- CoV-2 was positive in 26.9% (n=864). Mean age was higher in patients positive for test (39.6± 15.9 year vs. 37±14.4 year). Male predominance was more marked in patients with positive PCR test (68.4 vs. 55.9). Conclusion: High rate of positivity of RT PCR for SARSCoV- 2 among the suspected patient for COVID 19 indicated high disease burden and transmission in this highly populated area in the early period of pandemic which should be considered as was alarming. J Bangladesh Coll Phys Surg 2020; 38(0): 67-70

scholarly journals Prospective study to evaluate the risk factors associated with male infertility at tertiary care centre

2018 ◽  
Vol 5 (8) ◽  
pp. 2862
Author(s):  
Junaid Alam ◽  
Pawan Choudhary ◽  
Mohammad Aslam
Keyword(s):  
Risk Factors ◽  
Erectile Dysfunction ◽  
Male Infertility ◽  
Sperm Count ◽  
Tertiary Care ◽  
International Committee ◽  
World Health ◽  
Tertiary Care Centre ◽  
Factors Associated ◽  
Health Organization

Background: Infertility is a condition with psychological, economic, medical implications resulting in mental trauma, stress particularly in social set up like ours, with strong emphasis on child bearing. According to the International Committee for Monitoring Assisted Reproductive Technology, World Health Organization (WHO), Infertility is disease of reproductive system defined by failure to achieve the clinical pregnancy after 12 months or more of regular unprotected sexual intercourse.Methods: This study was conducted in Department of Surgery in Jawaharlal Nehru Medical College, Aligarh from January 2017 to December 2017 on 120 patients to study the clinical profile, causes of male infertility and to evaluate the risk factors associated with it.Results: There were 54 (45%) patients with azoospermia and 66 (55%) had oligospermia. Out of them 52 (43.3%) had sperm counts of 1-8 millions/ml and 14 (11.6%) had sperm count between >9-15 millions/ml. 46 (38.3%) patients had low testosterone level. 86 of cases had motility <50% after one hour, remaining 34 had motility >50%. Out of 120 cases of male infertility, 12 (10%) had Obesity and rest 108 (90%) had normal BMI. Out of 120 cases of male infertility, 8 (6.6%) were known Diabetics rest 112 (93.3%) had normal blood sugar levels. Out of 120 cases of male infertility, 36 (30%) had Erectile dysfunction and rest 84 (70%) were normal.Conclusions: The study concluded that Erectile dysfunction was the most common cause of male infertility. Varicoceles and small sized testes were the most common clinical abnormalities seen in infertile males. Smoking, Alcohol and Tobacco use were frequently associated with most infertile males.

COVID 19: REALS AND CHALLENGES AGAINST DOCTORS

2020 ◽  
Vol 2 (1) ◽  
pp. 65-87
Author(s):  
Zen Ahmad
Keyword(s):  
Virus Disease ◽  
Clinical Manifestations ◽  
World Health ◽  
Unknown Etiology ◽  
Wuhan City ◽  
Traditional Markets ◽  
Pneumonia Case ◽  
The World ◽  
New Type ◽  
Health Organization

Corona Virus Disease (Covid-19) is a contagious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was discovered in December 2019 in China. This disease can cause clinical manifestations in the airway, lung and systemic. The World Health Organization (WHO) representative of China reported a pneumonia case with unknown etiology in Wuhan City, Hubei Province, China on December 31, 2019. The cause was identified as a new type of coronavirus on January 7, 2020 with an estimated source of the virus from traditional markets (seafood market). ) Wuhan city

Histopathological Study of Lesions of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in a Tertiary Care Centre, Visakhapatnam over a Period of 2 Years

2021 ◽  
Vol 8 (33) ◽  
pp. 3054-3059
Author(s):  
Rajendra Prasad Jagannadham ◽  
Lakshmi Latchupatula ◽  
Sravani Ponnada ◽  
Neelima Lalam ◽  
Raghunadhababu Gudipudi ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Malignant Tumours ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Male Predominance

BACKGROUND A variety of non - neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasopharynx and these are very common lesions encountered in clinical practice. Histopathological examination of these lesions is the gold standard for diagnosis because management and prognosis vary among different lesions. The aim of the present study was to evaluate the histopathological study of the lesions of the nasal cavity, paranasal sinuses and nasopharynx in relation to their incidence, age, gender and site wise distribution and to compare the results with the available data. METHODS A study of 88 cases was conducted for a period of 2 years from August 2017 to July 2019. After fixation, Processing and Haematoxylin and Eosin staining and special stains histopathological diagnosis was made. RESULTS Among 88 total cases, 58 were males and 30 were females. A male predominance was observed with a male to female ratio of 1.93 : 1. They were more common in third, fourth and fifth decade of life. Malignant nasal lesions were seen after fourth decade of life. Nasal lesions were more common in nasal cavity (67.05 %), followed by paranasal sinuses (18.18 %) and nasopharynx (14.75). Out of 88 total cases, 39 (44.32 %) were non - neoplastic, 30 (34.09 %) were benign and 19 (21.59 %) were malignant nasal lesions. CONCLUSIONS Sinonasal lesions and nasopharyngeal lesions can have various differential diagnoses. A complete clinical, radiological and histopathological correlation helps to categorize these sinonasal lesions into various non - neoplastic and neoplastic types. But histopathological examination remains the mainstay of definitive diagnosis. KEYWORDS Nasal Cavity, Paranasal Sinuses, Nasopharynx, Benign Tumours, Malignant Tumours, Histopathological Examination

Sign in / Sign up

Export Citation Format

Share Document