scholarly journals CLINICAL MANAGEMENT OF PATIENTS WITH COVID-19. “LIVE” CLINICAL INSTRUCTION (2021)

2021 ◽  
Author(s):  
Садов’як Ірина Дмитрівна
Keyword(s):  
Medical Care ◽  
Clinical Management ◽  
Randomized Clinical Trials ◽  
Clinical Guideline ◽  
Clinical Instruction ◽  
Health Care Practices ◽  
The World ◽  
Legislative Changes ◽  
Based Medicine ◽  
Who Guideline

SUMMARY. In response to the challenges posed by the coronavirus (COVID-19) pandemic, Ukraine has undergone the necessary legislative changes, harmonized with international approaches, which in turn have led to significant changes in health care practices. The Law of Ukraine “On Amendments to Some Legislative Acts of Ukraine on Provision of Treatment of Coronavirus Disease (COVID-19)” № 539-IX, the Order of the Ministry of Health “On Approval of the Procedure for Prescribing and Using Medicines for the Treatment of Coronavirus Disease (COVID-19)” of 30.06.2020 № 1482, registered in the Ministry of Justice of Ukraine on July 08, 2020 for № 641/34924, establish the conditions of use of registered medicines according to the indications not specified in the instructions for medical use (off label), and unregistered medicines, recommended by the relevant official bodies outside Ukraine for the treatment of COVID-19. In pursuance of legislative acts, the Standard of Emergency Care “Coronavirus Disease (COVID-19)”, the Standards of Medical Care “Coronavirus Disease (COVID-19)”, the Standard of Pharmaceutical Care “Coronavirus Disease (COVID-19)”, the Protocol “Provision of medical care for the treatment of coronavirus disease (COVID-19)” were developed, approved and updated in accordance with the established procedure. At the same time, in order to assist the doctor and the patient in making a rational decision in different clinical situations, a clinical guideline “CLINICAL MANAGEMENT OF PATIENTS WITH COVID-19. “LIVE” CLINICAL INSTRUCTION” was developed – a document containing systematic provisions on medical and medico-social assistance, developed using the methodology of evidence-based medicine on the basis of reliability and proof confirmation. The basis of this clinical guideline is the WHO guideline “Clinical management of COVID-19: interim guidance” (27.05.2020), supplemented by the provisions of other WHO documents, as well as clinical guidelines of Great Britain, Belgium, USA and Australia. This guideline, as a living guideline, is a WHO innovation driven by the urgent need for global collaboration to provide reliable data and guidance emerging in the world as the result of numerous randomized clinical trials on COVID-19. The clinical guideline reflects the sequence of evidence on COVID-19 treatment in the world during a pandemic, on the basis of which the treatment strategy depending on the stage of the disease was formed and the decisions to include and exclude drugs in the protocol for COVID-19 treatment were justified, and will be further updated.

Rekindling the Flame: Zoroastrianism in Iraqi Kurdistan

2019 ◽  
Vol 7 (2) ◽  
pp. 161-188
Author(s):  
Samme Dick
Keyword(s):  
Historical Context ◽  
Islamic State ◽  
Organisational Structure ◽  
Kurdistan Region ◽  
Legislative Change ◽  
Iraqi Kurdistan ◽  
The World ◽  
Legislative Changes ◽  
New Religion

This article examines the emergence of Zoroastrianism in the Kurdistan Region of Iraq since 2015 as a new religion inspired by Kurdish nationalism, feminism, ecologism and humanism. The author argues that the emergence of Zoroastrianism at this particular time is due to a combination of the rise of the Islamic State in Iraq and the Levant in 2014, legislative change and the importance some Kurdish nationalists historically attached to Zoroastrianism as the suggested original religion of the Kurds. The article outlines the historical context of Zoroastrianism in Kurdistan, and then explores the origins, beliefs and organisational structure of Kurdish Zoroastrianism. Also discussed are the legislative changes enabling the rise of the movement since 2015. This study draws on interviews with Kurdish Zoroastrian leaders as well as with representatives from the World Zoroastrian Organization, the Kurdistan Regional Government’s Ministry of Endowments and Religious Affairs and the Alliance of Iraqi Minorities.ABSTRACT IN KURMANJIJi nû ve pêxistina agir: Baweriya Zerduştî li Kurdistana IraqêEv gotar, li ser peydabûna Zerduştiyê li Herêma Kurdistanê ya Iraqê hûr dibe, ku ji 2015an vir ve wek dînekî nû yê ji netewegeriya kurd, femînîzm, ekolojîzm û humanîzmê îlham wergirtî tê dîtin. Nivîskar îddia dike ku peydabûna Zerduştiyê ya bi taybetî wê demê ji ber hejmareke sedeman e: di 2014an de peydabûn û xurtbûna Dewleta Îslamî li Iraqê û Levantê, guherîna qanûnî û girîngiya nêrîna hin netewegerên kurd ku ji aliyê dîrokî Zerduştiyê wek dînê resen ê kurdan dibînin. Gotar, çarçoveya dîrokî ya Zerduştiyê li Kurdistanê bi kurtî rave dike û paşê li kok, bawerî û avahiya rêxistinî ya Zerduştiya kurdî dikole. Ji hêleke din, nîqaş dike ku guherînên hiqûqî ji 2015an vir ve rê li ber xurtbûna tevgerê vekiriye. Ev xebat xwe dispêre hevpeyvînên bi rêberên Zerduştiyên kurd re ligel hin şandeyên ji Rêxistina Zerduştiyan a Cîhanê, Wezareta Bexş û Karên Dînî ya Hikumeta Herêma Kurdistanê û Hevpeymaniya Kêmîneyên Iraqê.ABSTRACT IN SORANIGeşandinewey agireke: Zerdeştêtî le Kurdistanî ÊraqdaEm babete timaşay rewşî  wediyarkewtinî Zerdeştêtî dekat le Kurdistanî Êraqda, le sall 2010da wek ayînêkî nwê debînrêt ke le netewegerîy kurdî, fêmênîzm, jîngeparêzî û mirovparêzî îlham werdegirêt. Nûser bangeşey ewe dekat ke derkewtinî Zerdeştêtî lem kateda ke Dewlletî Îslamî Da'îş le Şam û Êraq le 2013 ser helldeda û be yasa rêgey pê dedirêt, şitêkî giringe  bo gerranewey kurd bo  ayînî neteweyî xoy wek ewey ke hendêk kurdî neteweperist  basî deken.  Babeteke rîşey mêjûyî Zerdeştêtî le Kurdistan nîşan dedat, herwaş rîşey  bawerr û binaẍey damezrawey Zerdeştêtî dedate ber roşnayî. Dîsan guftugoy gorranî yasa lew bareyewe bote hoyî derkewtinî em ayîne le 2015da. Em babete legell serok û bawerrdaranî Zerdeştîy le Kurdistan û damezrawey Zerdeştîyanî cîhanî û legell wezaretî karubarî ayînî le ḧukumetî herêmî Kurdistan û damezrawey kemînekanî Êraqda çawpêkewtinî encam dawe.ABSTRACT IN ZAZAKINewe ra geşkerdişê adirî: Kurdîstanê Îraqî de zerduştîyeNa meqale qayîtê zerduştîye kena ke sey bawerîya newîye serra 2015î ra nat Herêmê Kurdîstanî yê Îraqî de vejîyaye û hetê neteweperwerîya kurdan, femînîzm, dorûverperwerîye û merdimperwerîye ra îlham girewt. Nuştox musneno ke vejîyayîşê zerduştî yê ê demî çend sebeban ra qewimîya: hêzdarbîyayîşê DAÎŞ yê serra 2014î, vurîyayîşê qanûnî û tayê neteweperwerê kurdan ê ke tarîx de giranî daye zerduştîye ser ke aye sey dînê kurdan o eslî pêşnîyaz bikerê. Na meqale xulasaya kontekstê tarîxî yê zerduştîya Kurdîstanî dana û dima esl, bawerî û awanîya rêxistinan yê zerduştîya kurdan ser o cigêrayîş kena. Ser o kî vurîyayîşê qanûnî munaqeşe benê. Nê vurîyayîşî serra 2015î ra nat vejîyayîşê tevger kerd mumkîn. No cigêrayîş roportajanê bi serekanê kurdan ê zerduştîye û bi temsîlkaranê Rêxistina Zerduştîyan a Dinya, Wezaretê Ewqaf û Kar û Barê Dînî yê hukmatê Herêmê Kurdîstanî û Yewîya Eqalîyetanê Îraqî esas gêno

Explore the Possible Impact of BCG Vaccination Policy on the Morbidity, Mortality, and Recovery Rates due to COVID-19 Infection. (Preprint)

2020 ◽  
Author(s):  
Yue-Cune Chang
Keyword(s):  
Odds Ratio ◽  
Randomized Clinical Trials ◽  
Vaccination Policy ◽  
Bacille Calmette Guerin ◽  
Recovery Rates ◽  
Bcg Vaccination ◽  
The World ◽  
New Form ◽  
The Relationship ◽  
Disease Specific

BACKGROUND The Coronavirus Disease-19 (COVID-19) is the new form of an acute infectious respiratory disease and has quickly spread over most continents in the world. Recently, it has been shown that Bacille Calmette-Guerin (BCG) might protect against COVID-19. This study aims to investigate the possible correlation between BCG vaccination and morbidity/mortality/recovery rate associated with COVID-19 infection. OBJECTIVE Our findings confirm that the BCG vaccination might protect against COVID-19 virus infection. METHODS Data of COVID-19 confirmed cases, deaths, recoveries, and population were obtained from https://www.worldometers.info/coronavirus/ (Accessed on 12 June, 2020). To have meaningful comparisons among countries’ mortality and recovery rates, we only choose those countries with COVID-19 infected cases at least 200. The Poisson regression and logistic regression were used to explore the relationship between BCG vaccination and morbidity, mortality and recovery rates. RESULTS Among those 158 countries with at least 200 COVID-19 infected cases, there were 141 countries with BCG vaccination information available. The adjusted rates ratio of COVID-19 confirmed cases for Current BCG vaccination vs. non-Current BCG vaccination was 0.339 (with 95% CI= (0.338,0.340)). Moreover, the adjusted odds ratio (OR) of death and recovery after coronavirus infected for Current BCG vaccination vs. non-Current BCG vaccination were 0.258 (with 95% CI= (0.254,0.261)) and 2.151 (with 95% CI= (2.140,2.163)), respectively. CONCLUSIONS That data in this study show the BCG might provide the protection against COVID-19, with consequent less COVID-19 infection and deaths and more rapid recovery. BCG vaccine might bridge the gap before the disease-specific vaccine is developed, but this hypothesis needs to be further tested in rigorous randomized clinical trials. INTERNATIONAL REGISTERED REPORT RR2-https://doi.org/10.1101/2020.06.14.20131268

Essential Dental Public Health

2013 ◽  
Author(s):  
Blánaid Daly ◽  
Paul Batchelor ◽  
Elizabeth Treasure ◽  
Richard Watt
Keyword(s):  
Public Health ◽  
Health Promotion ◽  
Vital Role ◽  
Evidence Based ◽  
Dental Public Health ◽  
Oral Health Promotion ◽  
Dental Practitioners ◽  
The World ◽  
The Subject ◽  
Based Medicine

Public health is a key concern of modern dental practitioners as they continue to play a vital role in the health of populations across the world. The second edition of Essential Dental Public Health identifies the links between clinical practice and public health with a strong emphasis on evidence-based medicine. Fully revised and updated for a second edition, this textbook is split into four parts covering all the need-to-know aspects of the subject: the principles of dental public health, oral epidemiology, prevention and oral health promotion, and the governance and organization of health services. Essential Dental Public Health is an ideal introduction to the field for dentistry undergraduates, as well as being a helpful reference for postgraduates and practitioners.

scholarly journals COVID-19: Role of Nutrition and Supplementation

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 976
Author(s):  
Fiorenzo Moscatelli ◽  
Francesco Sessa ◽  
Anna Valenzano ◽  
Rita Polito ◽  
Vincenzo Monda ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Viral Infections ◽  
Overweight And Obesity ◽  
Shortness Of Breath ◽  
Nutritional Interventions ◽  
The World ◽  
Diet Regimen ◽  
Specific Diet

At the end of 2019, a new coronavirus (COVID-19) appeared on the world scene, which mainly affects the respiratory system, causing pneumonia and multi-organ failure, and, although it starts with common symptoms such as shortness of breath and fever, in about 2–3% of cases it leads to death. Unfortunately, to date, no specific treatments have been found for the cure of this virus and, therefore, it is advisable to implement all possible strategies in order to prevent infection. In this context, it is important to better define the role of all behaviors, in particular nutrition, in order to establish whether these can both prevent infection and improve the outcome of the disease in patients with COVID-19. In the literature, it is widely shown that states of malnutrition, overweight, and obesity negatively affect the immune system, leading to viral infections, and several studies have shown that nutritional interventions can act as immunostimulators, helping to prevent viral infections. Even if several measures, such as the assumption of a specific diet regimen, the use of dietary supplements, and other similar interventions, are promising for the prevention, management, and recovery of COVID-19 patients, it is important to highlight that strong data from randomized clinical trials are needed to support any such assumption. Considering this particular scenario, we present a literature review addressing several important aspects related to diet and SARS-CoV-2 infection, in order to highlight the importance of diet and supplementation in prevention and management of, as well as recovery from COVID-19.

scholarly journals Optimizing COVID-19 testing capabilities and clinical management using pathology informatics

JAMIA Open ◽  
2020 ◽  
Author(s):  
Srikar Chamala ◽  
Sherri Flax ◽  
Petr Starostik ◽  
Kartikeya Cherabuddi ◽  
Nicole M Iovine ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Management ◽  
World Health ◽  
University Of Florida ◽  
Pathology Informatics ◽  
Large Numbers ◽  
The World ◽  
Health Organization ◽  
The University ◽  
Reporting Data

Abstract Coronavirus disease 2019, first reported in China in late 2019, has quickly spread across the world. The outbreak was declared a pandemic by the World Health Organization on March 11, 2020. Here, we describe our initial efforts at the University of Florida Health for processing of large numbers of tests, streamlining data collection, and reporting data for optimizing testing capabilities and superior clinical management. Specifically, we discuss clinical and pathology informatics workflows and informatics instruments which we designed to meet the unique challenges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We hope these results benefit institutions preparing to implement SARS-CoV-2 testing.

scholarly journals Recombinant Human Adenovirus-p53 Therapy for the Treatment of Oral Leukoplakia and Oral Squamous Cell Carcinoma: A Systematic Review

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 438
Author(s):  
Jagadish Hosmani ◽  
Shazia Mushtaq ◽  
Shahabe Saquib Abullais ◽  
Hussain Mohammed Almubarak ◽  
Khalil Assiri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Oral Cancer ◽  
Adverse Events ◽  
Randomized Clinical Trials ◽  
Oral Leukoplakia ◽  
Research Articles ◽  
Original Research ◽  
Therapeutic Effects ◽  
The World

Background and Objectives: Oral cancer is the 6th most common cancer in the world and oral leukoplakia is an oral potentially malignant disorder that could develop into oral cancer. This systematic review focusses on randomized clinical trials for recombinant adenovirus p-53 (rAD-p53) therapy for the treatment of oral leukoplakia and cancer. Materials and Methods: We searched for research articles on various databases such as Pubmed/Medline, Embase, CNKI (China National Knowledge Infra-structure), Springerlink, cochrane and Web of sciences from 2003 to 2020. MeSH (Medical Subject Headings) terms were used for the search. Inclusion criteria included original research, randomized clinical trials and articles only in English language. Exclusion criteria were any articles that were not research articles, not randomized trials, non-human studies, etc. The articles were further graded on the Jadad scale. Results: 578 articles were assessed from various databases; only 3 articles were found to be appropriate for this review. Thus, meta-analysis was not performed because of heterogeneity and lack of data. In the three studies, whether rAD-p53 was used as a standalone therapy or with other therapies, there was a beneficial effect of the therapy. Furthermore, there were no serious adverse events and the only adverse events reported were fever, pain at the local injection site, flu-like symptoms and lowered WBC count. Conclusions: Thus, we can conclude that this therapy has a potential for beneficial therapeutic effects and further clinical trials with more patients need to be performed to get better understanding of the effect of rAD-p53 therapy, which probably will pave the way to its approval in other parts of the world.

scholarly journals A probability model for evaluating the bias and precision of influenza vaccine effectiveness estimates from case-control studies

2014 ◽  
Vol 143 (7) ◽  
pp. 1417-1426 ◽  
Author(s):  
M. HABER ◽  
Q. AN ◽  
I. M. FOPPA ◽  
D. K. SHAY ◽  
J. M. FERDINANDS ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Medical Care ◽  
Randomized Clinical Trials ◽  
Probability Model ◽  
Control Design ◽  
Case Control ◽  
Vaccine Effectiveness ◽  
Case Control Studies ◽  
Respiratory Illnesses ◽  
Study Designs

SUMMARYAs influenza vaccination is now widely recommended, randomized clinical trials are no longer ethical in many populations. Therefore, observational studies on patients seeking medical care for acute respiratory illnesses (ARIs) are a popular option for estimating influenza vaccine effectiveness (VE). We developed a probability model for evaluating and comparing bias and precision of estimates of VE against symptomatic influenza from two commonly used case-control study designs: the test-negative design and the traditional case-control design. We show that when vaccination does not affect the probability of developing non-influenza ARI then VE estimates from test-negative design studies are unbiased even if vaccinees and non-vaccinees have different probabilities of seeking medical care against ARI, as long as the ratio of these probabilities is the same for illnesses resulting from influenza and non-influenza infections. Our numerical results suggest that in general, estimates from the test-negative design have smaller bias compared to estimates from the traditional case-control design as long as the probability of non-influenza ARI is similar among vaccinated and unvaccinated individuals. We did not find consistent differences between the standard errors of the estimates from the two study designs.

The impact of humanitarian aid on conflict development

1998 ◽  
Vol 38 (323) ◽  
pp. 319-333 ◽  
Author(s):  
Pierre Perrin
Keyword(s):  
Medical Care ◽  
Sharp Increase ◽  
Humanitarian Aid ◽  
Humanitarian Organizations ◽  
The People ◽  
The World ◽  
Local Services ◽  
The Impact

The proliferation of crises around the world has led to a sharp increase in the scale of humanitarian aid required to meet the vital needs of the people affected by them for food, water, medical care and shelter. Humanitarian organizations can either meet those needs directly or support local services engaged in the same work. In most cases, both approaches are used.

Clinical Management Updates for Novel Corona Virus (COVID-19)

2021 ◽  
Vol 14 (3) ◽  
pp. 5449-5456
Author(s):  
Yogesh Chand Yadav ◽  
Ramakant Yadav ◽  
Sushant Kumar
Keyword(s):  
Clinical Management ◽  
Respiratory Illness ◽  
Symptomatic Treatment ◽  
Structural Features ◽  
Therapeutic Agents ◽  
Human Coronavirus ◽  
Transmission Potential ◽  
The World ◽  
Severe Respiratory Illness ◽  
Droplet Transmission

The SARS-CoV-2 virus was first detected in Wuhan, China in December 2019 and was known to produce acute severe respiratory illness in humans which rapidly spread almost throughout the world within a few months. This human coronavirus has seven strains and they commonly produce illness in the nervous system, respiratory system and hepato- intestinal systems. This present review is an attempt to illustrate recent reports pertaining to the management of SARS-CoV-2. Further, it also highlights the diagnosis and clinical management of COVID-19. Various search engines like Scopus, Pubmed and WHO databases were accessed and literature on current advances about COVID-19 including structural features, replication, possible pathogenic, symptoms, diagnosis, prognosis, methods of prevention and possible therapeutic agents used for treatment of patients was reviewed. Current studies indicate that COVID-19 is very infectious with droplet transmission potential. The key modalities to prevent the infection is by keeping social distancing, respiratory/hand hygiene, detection of infection and subsequent quarantine of the infected persons. Presently, either no vaccine for prevention or specific treatments available, however, COVID-19 patients may be managed by using some repositioned drugs and symptomatic treatment.

Organization of primary medical care for patients with osteoporosis

2021 ◽  
Vol 25 (2) ◽  
pp. 7-17
Author(s):  
Elena N. Gladkova
Keyword(s):  
High Risk ◽  
Medical Care ◽  
Hip Fractures ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Subsequent Treatment ◽  
Primary Medical Care ◽  
Screening Programs ◽  
Active Identification ◽  
The World

The author revises the latest evidence in the literature regarding of organizing medical care for patients with osteoporosis in primary medical care. In the world, there is an increase in the group of older people (60 years and older), therefore, the problem of osteoporosis and osteoporotic fractures becomes very urgent. In Russia, the number of hip fractures will increase by 70% by 2050 compared to 2015. The article provides an overview of studies demonstrating the clinical and cost-effectiveness of population-based screening programs for the identification and subsequent treatment of patients at high risk of fractures, and discusses the issues of secondary prevention of fractures. With the active identification of patients at high risk of fractures and the initiation of antiosteoporotic therapy, a decrease in the incidence of osteoporotic fractures, including hip fractures, is expected.

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