scholarly journals ASSESSMENT OF CLINICAL AND LABORATORY PARAMETERS IN TYPHOID FEVER IN PEDIATRIC CASES ADMITTED TO NMCH, PATNA

2020 ◽  
Vol 4 (8) ◽  
Author(s):  
Samiksha Sharma ◽  
Girijanand Jha ◽  
Binod Kr Singh ◽  
Saroj Kumar
Keyword(s):  
Developing Countries ◽  
Typhoid Fever ◽  
Clinical Laboratory ◽  
Positive Culture ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Serological Tests ◽  
Laboratory Parameters ◽  
Medical College ◽  
Pediatric Age Group

India has a very high disease burden (214.2 per 1,00,000 individuals/year), primarily affecting children 5 to 15 years. Recently, there have been concerns of increasing proportion of infections in very young children, rising paratyphoid infections, and emerging drug resistance. Also, there are challenges in diagnosis and management of enteric fever due to lack of laboratory-based investigations. While blood culture remains the gold standard of diagnosis, the mainstays in developing countries are serological tests, which are suboptimal due to lack of standardization and uniformity. Hence based on above condition the present study was planned for Assessment of Clinical and Laboratory Parameters in Typhoid Fever in Pediatric Cases Admitted to NMCH, Patna. The present study was planned in Department of Pediatrics, Nalanda Medical College and Hospital, Patna, Bihar, India. The study was planned from January 2018 to November 2018. In the present study 50 childrens of age up to 18 years having fever more than 7 days were enrolled. These cases were enrolled based on the Widal positive or positive culture were enrolled in the present study. The data generated from present study concludes that Typhoid fever manifestations are diverse. The most common symptoms apart from fever were anorexia, vomiting, pain abdomen, diarrhoea followed by headache and cough. Also the Serum parameters are also seen changed in the Thyphoid affected patients. Typhoid fever remains a major public health problem in the developing countries predominantly seen in school going children among pediatric age group. Keywords: Clinical, Laboratory Parameters, Typhoid Fever, Pediatric Cases, etc.

scholarly journals Evaluation of Typhidot (IgM) for Early Diagnosis of Typhoid Fever

2009 ◽  
Vol 3 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Zohra Begum ◽  
Md Akram Hossain ◽  
AKM Shamsuzzaman ◽  
Md Monjurul Ahsan ◽  
AKM Musa ◽  
...  
Keyword(s):  
Blood Culture ◽  
Typhoid Fever ◽  
Predictive Value ◽  
Serological Test ◽  
Public Health Problem ◽  
Salmonella Typhi ◽  
Major Public Health Problem ◽  
Medical College ◽  
Sensitivity Specificity ◽  
Culture Positive

Typhoid fever still continues to be a major public health problem, particularly in many developing countries. A simple, reliable, affordable and rapid diagnostic test has been a long-felt need of the clinicians. We, therefore, prospectively evaluated the sensitivity and specificity of Typhidot (IgM), a serological test to identify IgM antibodies against Salmonella typhi. The study was carried out in the department of Microbiology, Mymensingh Medical College, Mymensingh between June, 2006 and July, 2007, on a total of 100 samples from clinically suspected patients to have typhoid fever. Blood culture as well as Typhidot test were performed for each of the cases. Out of 100 clinically diagnosed typhoid fever, 14 were blood culture positive for S. typhi and 73 were Typhidot (IgM) positive. Among 14 culture positive cases, 13 (92.85%) were Typhidot (IgM) positive. The test was also positive in 04 (20%) out of 20 febrile controls. None of the healthy controls was positive by Typhidot (IgM). The sensitivity, specificity, positive predictive value and negative predictive value of the test using blood culture as gold standard were 92.85%, 90.00%, 76.47% and 97.29% respectively for typhoid fever. Typhidot (IgM) test is rapid, easy to perform and reliable test for diagnosing typhoid fever, and useful for small, less equipped laboratories as well as for the laboratories with better facilities. Key words: Typhoid fever, Salmonella typhi, Typhidot (IgM) test   doi: 10.3329/bjmm.v3i1.2964 Bangladesh J Med Microbiol 2009; 03 (01): 10-13

Development of Dengue Hemorrhagic Fever in a Patient within 2 Weeks of Contemporaneous Infection of Typhoid Fever and Primary Dengue Fever

2020 ◽  
Vol 11 (1) ◽  
pp. 78-81
Author(s):  
Gule Tajkia ◽  
Syed Khairul Amin ◽  
M Ekhlasur Rahman ◽  
Kuntal Roy ◽  
Soma Halder ◽  
...  
Keyword(s):  
Typhoid Fever ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Public Health Problem ◽  
Hemorrhagic Fever ◽  
Viral Disease ◽  
Clinical Aspects ◽  
Major Public Health Problem ◽  
Medical College ◽  
Dengue Epidemic

Dengue virus is the most important mosquito-borne viral disease in the world. Co-circulation of the four types of dengue viruses and expansion of dengue epidemic give rise to infection enhancement and a big expansion of clinical aspects of the disease. Besides dengue, typhoid fever is an ancient disease, have emerged as major public health problem in developing countries including Bangladesh. Here we report a case of 4 years old boy, who have developed Dengue Hemorrhagic Fever within 2 weeks of contemporaneous infection of Typhoid fever and Primary dengue fever. Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 78-81

Perforazione ileale da febbre tifoide

2021 ◽  
Vol 24 (9) ◽  
pp. 280-282
Author(s):  
Margherita Piqué ◽  
Elisabetta Ladisa ◽  
Luca Brasili ◽  
Giovanni Putoto ◽  
Lorenzo Iughetti
Keyword(s):  
Typhoid Fever ◽  
Public Health Problem ◽  
Wound Dehiscence ◽  
Exploratory Laparotomy ◽  
Watery Diarrhoea ◽  
Pelvic Cavity ◽  
Major Public Health Problem ◽  
General Malaise ◽  
X Ray ◽  
Clinical Conditions

Typhoid fever continues to be a major public health problem in developing countries and mortality is mainly related to its most frequent complication, namely: intestinal perforation. The paper presents the case of a 12-year-old girl with abdominal pain associated with watery diarrhoea, vomiting, fever and general malaise for two weeks. Typhoid fever was suspected, therefore therapy with ceftriaxone was started. Clinical conditions were worsening, so X-ray of the abdomen was performed with evidence of hydro-aerial levels and ultrasound showing abundant non-homogeneous echogenic material in the pelvic cavity, consistent with purulent ascites. Exploratory laparotomy was performed showing an isolated perforation of the ileus, which was sutured. In the postoperative period, antibiotic therapy was boosted with metronidazole and gentamicin. Due to the wound dehiscence, surgical revision with secondary tension sutures was necessary.

scholarly journals Analysis of clinical profile of women presenting with pyrexia in pregnancy

2018 ◽  
Vol 7 (4) ◽  
pp. 1406
Author(s):  
Surabhi Porwal ◽  
Amita Sharma
Keyword(s):  
Clinical Symptoms ◽  
Public Health Problem ◽  
Clinical Profile ◽  
Major Public Health Problem ◽  
Abdominal Wall Defects ◽  
Chi Square ◽  
Medical College ◽  
Central Nervous System Defects ◽  
High Risk Situation ◽  
In Pregnancy

Background: Pyrexia in pregnancy is major public health problem in India. Pyrexia in pregnancy is associated with resorption of the embryo, foetal deaths and potentially lethal malformations such as central nervous system defects, abdominal-wall defects, and cardiovascular malformations. This study was carried out to analyse clinical profile of women presenting with pyrexia during pregnancy.Methods: After approval by institutional ethical committee the prospective case control study was conducted in the department of obstetrics and gynecology, NSCB Medical College, Jabalpur (M.P.) from 1st June 2012 to 31st October 2013. Total 100 antenatal women with pyrexia taken as cases and 50 antenatal women without pyrexia taken as control were included and analyzed in this study. In women fulfilling inclusion criteria detailed history was taken and documented in proforma. Required investigations were sent to the department of pathology and virology laboratory of Indian Council of Medical Research, Jabalpur. Results were analyzed statistically by using t test and chi square test.Results: On analysis of clinical symptoms pyrexia, cough, malaise, rash, headache, nausea and vomiting, joint pain, anorexia, breathlessness and burning and frequency of micturition were significantly higher in cases as compare to control. Viral pathogens were responsible for most of the cases of pyrexia in pregnancy.Conclusions: Pyrexia in pregnancy is a high-risk situation, early identification and prompt treatment will reduce maternal and perinatal morbidity and mortality associated with pyrexia in pregnancy.

scholarly journals Multidrug-resistant typhoid fever: a review

2011 ◽  
Vol 5 (05) ◽  
pp. 324-337 ◽  
Author(s):  
Syed Ahmed Zaki ◽  
Sunil Karande
Keyword(s):  
Public Health ◽  
Typhoid Fever ◽  
English Language ◽  
Public Health Problem ◽  
Public Health Education ◽  
Abdominal Distension ◽  
Clinical Results ◽  
Multidrug Resistant ◽  
Major Public Health Problem ◽  
Handling Practices

Introduction: Multidrug-resistant typhoid fever (MDRTF) is defined as typhoid fever caused by Salmonella enterica serovar Typhi strains (S. Typhi), which are resistant to the first-line recommended drugs for treatment such as chloramphenicol, ampicillin and trimethoprim-sulfamethoxazole. Since the mid-1980s, MDRTF has caused outbreaks in several countries in the developing world, resulting in increased morbidity and mortality, especially in affected children below five years of age and those who are malnourished. Methodology: Two methods were used to gather the information presented in this article. First PubMed was searched for English language references to published relevant articles. Secondly, chapters on typhoid fever in standard textbooks of paediatric infectious diseases and preventive and social medicine were reviewed. Results: Although there are no pathognomonic clinical features of MDRTF at the onset of the illness, high fever ( > 104°F), toxaemia, abdominal distension, abdominal tenderness, hepatomegaly and splenomegaly are often reported. The gold standard for the diagnosis of MDRTF is bacterial isolation of the organism in blood cultures. Ciprofloxacin and ceftriaxone are the drugs most commonly used for treatment of MDRTF and produce good clinical results. Conclusion: MDRTF remains a major public health problem, particularly in developing countries. Mass immunization in endemic areas with either the oral live attenuated Typhi 21a or the injectable unconjugated Vi typhoid vaccine, rational use of antibiotics, improvement in public sanitation facilities, availability of clean drinking water, promotion of safe food handling practices and public health education are vital in the prevention of MDRTF. 

scholarly journals Knowledge, attitude and practice regarding various tobacco products and their effects on health and COTPA act among ≥15 years age group persons in urban field practice area of a medical college in Telangana

2020 ◽  
Vol 7 (6) ◽  
pp. 2180
Author(s):  
Jyothi Veleshala ◽  
Varun Malhotra
Keyword(s):  
Tobacco Use ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Community Based ◽  
Cross Sectional ◽  
Tobacco Products ◽  
Medical College ◽  
Attitudes And Practices ◽  
Supply And Distribution ◽  
Almost All

Background: Tobacco use is a major public health problem. The prevalence of tobacco use among men has been reported to be high (generally exceeding 50%) from almost all parts of India. “The Cigarettes and Other Tobacco Products (Prohibition of Advertisement and Regulation of Trade and Commerce, Production, Supply, and Distribution) Act 2003”, which came into effect since 1st May 2004. Information on knowledge, attitudes, and practices of population regarding COTPA is necessary to effectively implement the legislation. Hence the present study was undertaken.Methods: The present study was a cross-sectional community-based survey carried out in urban slums of Nalgonda town. Data was collected using a structured schedule by interviewing 300 participants, aged above 15 years.Results: The current use of any tobacco was reported by 45.7% of the participants. Overall awareness of COTPA was 58.2%. Marital status, type of family, unemployment, Illiterates, lower SES, and age had a significant influence on tobacco use. Television (77.05%) was the major source of awareness regarding COTPA. The majority of smokers were aware of various sections of COTPA (>50%). About 34.8% of the participants had a favorable attitude towards COTPA. The positive attitude was more (53.7%) towards the display of health warnings on tobacco products among smokers. 11.2% had paid penalty for violation of the act and 32.4% have noticed a reduction in their habit to some extent.Conclusions: A concerted effort has to be made to increase the awareness of the act amongst the vulnerable population.

scholarly journals Salmonella Hepatitis in Children : An Update

2020 ◽  
Vol 10 (2) ◽  
pp. 397-399
Author(s):  
Sadika Kadir ◽  
Tamanna Begum ◽  
Md Rafiqul Islam ◽  
Golam Nabi ◽  
Md Ashraful Haque ◽  
...  
Keyword(s):  
Typhoid Fever ◽  
Enteric Fever ◽  
Clinical Course ◽  
Clinical Importance ◽  
Positive Culture ◽  
Reticuloendothelial System ◽  
Bleeding Diathesis ◽  
Medical College ◽  
Time Index ◽  
Atypical Presentations

Salmonella hepatitis is one of the atypical presentations of typhoid fever and can be defined as reversible involvement of liver during the course of typhoid fever. There have been more than 150 cases of salmonella hepatitis reported both in developed and developing countries. The documented incidence varies widely from 1 to 26% of patients with Typhoid fever. It presents with jaundice and tender hepatosplenomegaly. Investigation shows slightly raised transaminase levels with or without 5 adenosine neucleosidase and or decreased prothombin time index. It complicates into hepatic encephalopathy and bleeding diathesis. A positive culture for Salmonella from blood or stool is essential to differentiate Salmonella hepatitis from other causes of acute hepatitis. Hepatic pathology is characterized by the presence of typhoid nodules with marked hyperplasia of reticuloendothelial system. The ALT/LDH ratio < 9 is suggestive of Salmonella hepatitis which is > 9 in viral hepatitis. The prognosis is usually good as Salmonella hepatitis responses with specific antibiotic therapy and jaundice resolves with clinical improvement. The clinical course can be severe with high mortality (20%) sometime. In our country where enteric fever is endemic, the recognition of Salmonella hepatitis is of clinical importance . Northern International Medical College Journal Vol.10 (2) Jan 2019: 397-399

scholarly journals Sífilis: Prevalência num Hospital de Lisboa

2016 ◽  
Vol 29 (1) ◽  
pp. 52 ◽  
Author(s):  
Leonor Lopes ◽  
Rita Ferro-Rodrigues ◽  
Samuel Llobet ◽  
Luís Lito ◽  
João Borges-Costa
Keyword(s):  
Clinical Laboratory ◽  
Transmitted Disease ◽  
Public Health Problem ◽  
Secondary Syphilis ◽  
Disease Classification ◽  
Serological Tests ◽  
Important Public Health Problem ◽  
Early Syphilis ◽  
Latent Syphilis

<p><strong>Introduction:</strong> Syphilis is a sexual and vertical transmitted disease. Its incidence is increasing in Europe, particularly, in Portugal.<br /><strong>Material and Methods:</strong> A descriptive, retrospective study was performed based on positive treponemal tests from January to December 2013, at the Santa Maria Hospital, Lisbon. In-patients and out-patients evaluated in medical appointments and at the emergency department were included. We proceeded to epidemiological characterization, disease classification and definition of risk factors.<br /><strong>Results:</strong> We obtained a sample of 580 patients, of whom 51 with no clinical data and 45 with false positive serologies were excluded. There was a predominance of male patients (75%) and a mean age of 47 years. Most (59%) had syphilis successfully treated in the past and 3.7% were in follow-up. We recorded 13 primaries syphilis, 71 cases of secondary syphilis, 40 cases of early latent syphilis, 49 unknown duration syphilis and five cases of late latent syphilis. In the early syphilis group, 42% (n = 124) were HIV-positive and, in 8% both diagnosis were done simultaneously.<br /><strong>Discussion:</strong> We emphasize the high prevalence of syphilis/HIV co-infection in patients with early syphilis, reinforcing the importance of promoting the use of preventive measures. We obtained 11% of patients with late clinical forms, which are notifiable since June 2014, in Portugal. All serological tests for the diagnosis of syphilis have limitations which emphasizes the importance of clinical-laboratory correlation.<br /><strong>Conclusion:</strong> Syphilis remains an important public health problem. It is necessary to establish education programs, screening and follow-up strategies to reduce their prevalence and to perform more efficient screening of the partners.</p>

scholarly journals Prevalence and outcome of anaemia among pregnant women attending tertiary care hospital in Visakhapatnam

2017 ◽  
Vol 5 (1) ◽  
pp. 203
Author(s):  
Radha Kumari Paladugu ◽  
Srinivas Jagath Pentakota ◽  
Sushma N.
Keyword(s):  
Socioeconomic Status ◽  
Developing Countries ◽  
Pregnant Women ◽  
Urban Areas ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Developed Countries ◽  
Major Public Health Problem ◽  
Care Hospital ◽  
Study Population

Background: Anaemia in pregnancy is now considered as a major public health problem, caused by iron deficiency. WHO has estimated that prevalence of anaemia in developed and developing countries in pregnant women is 14% in developed countries and 51 percent in developing countries and 65-75% in India. Various programmes regarding anaemia prophylaxis and maternal health have been implemented but still the prevalence of anaemia related complications among pregnant women continues to be high. Hence the present study was conducted to study the prevalence and pregnancy outcome as a result of anaemia in a tertiary care center in Visakhapatnam. Methods: A cross sectional descriptive study was carried out from June 2016 to August 2016 in the Department of Obstetrics and Gynecology among postnatal women in King George hospital, Visakhapatnam. A semi-structured questionnaire was prepared and information regarding age, socioeconomic status, parity, gestational age interval between pregnancies and outcome and complication of pregnancy were collected. Results: Mean age of study population is 22.4 years. Out of 100 women involved in the study 65 are from urban areas 29 from rural areas and 6 from tribal areas. Majority of the study population 66% were having HB% between 8-11% i.e. mild anaemia. When Outcome of pregnancy was seen in relation to anaemia majority of the women had live births (90%) followed by 7% IUDs and 2% still births. Conclusions: Majority of the women are in the age group of 20-24 years. Socioeconomic status is directly related to anaemic status of the women. Majority of the women had complication of puerperal sepsis. 

scholarly journals Study of association and prognostic correlation of cardiac troponin I estimation in acute decompensated heart failure patients

2020 ◽  
Vol 8 (1) ◽  
pp. 26
Author(s):  
Sunil Kumar Tripathi ◽  
Vikas A. Mishra ◽  
Amit B. Kinare ◽  
Vishwa Deepak Tripathi ◽  
Ravi Shankar Sharma
Keyword(s):  
Heart Failure ◽  
Troponin I ◽  
Acute Decompensated Heart Failure ◽  
Public Health Problem ◽  
Decompensated Heart Failure ◽  
Major Public Health Problem ◽  
Positive Group ◽  
Medical College ◽  
Follow Up Study

Background: Heart failure is a major public health problem since last few decades affecting significant number of people worldwide. Acute decompensated heart failure is a major cause of hospitalization in elderly people with a high mortality rate. Heterogeneity and non-specificity of symptoms makes diagnosis of heart failure by clinical presentation alone more challenging. Aim of current study was to investigate troponin biomarkers in diagnosis, prognosis and management of acute decompensated heart failure.  Methods: Present study was a prospective observational study conducted on 100 patients at Department of Cardiology, Superspeciality hospital, NSCB medical college Jabalpur and Department of cardiology Superspeciality hospital, SS medical college Rewa from October 2019 to August 2020. Patients were investigated for clinical, echocardiographic parameters and NYHA classification. Cardiac functions were analyzed by color doppler echocardiography. Results: According to study findings, 65.2% of TnI positive patients were males whereas 34.8% were females. Mean age of TnI positive group was observed to be higher. Majority of troponin positive patients were in NYHA class IV. Recurrent hospitalization was observed more in TnI positive group. Logistic regression analysis depicted systolic blood pressure reduced significantly (p<0.001) on follow up study in TnI positive patients, FBS was significantly more in TnI positive patients (131.4+42.9 mg/dl) (p=0.049). LVID was significantly more in TnI positive patients (p=0.022). Reduction in EF was statistically significant (p=0.03) at the three months follow up study.  Conclusions: A positive prognostic correlation was established between ADHF and troponin positivity, large prospective randomized trials are necessary to recommend quantitative troponin I determination in all patients of acute decompensated heart failure for prognosis and guiding therapy.

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