scholarly journals HISTOPATHOLOGICAL SPECTRUM OF NON NEOPLASTIC AND NEOPLASTIC LESIONS OF UTEROCERVIX IN NORTH WEST RAJASTHAN

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Gajendra Singh Tanwar ◽  
Vanita Kumar ◽  
Mradul Varshney
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Uterine Prolapse ◽  
Female Genital Tract ◽  
Reproductive Organs ◽  
Standard Test ◽  
Common Finding ◽  
North West ◽  
Embedded Blocks ◽  
A Prospective Study

Background: The female genital tract includes the uterine corpus, cervix, fallopian tubes and ovaries. Women worldwide suffer from gynaecologic and obstetric disorders that require hysterectomy as a treatment option. Hysterectomy is a definite treatment of pelvic pathology including fibroid, abnormal heavy bleeding, chronic pelvic pain, endometriosis, adenomyosis, uterine prolapse, pelvic inflammatory disease and cancer of reproductive organs. Hysterectomy specimens contribute a major component of histopathological work in Pathology laboratories. Methods: This is a prospective study carried out in the Department of Pathology, SPMC, Bikaner for two years from October 2018 to September 2020. All surgically excised hysterectomy specimens received by the department during study period were included in the study. Tissues were fixed and processed as per departmental protocols. Pieces taken from ectocervix, endocervix, uterine canal and fundus. Pieces also taken from any abnormal area. Tissue bits routinely processed 3 to 6 micron thick sections made from paraffin embedded blocks and were stained with H&E stain.  Special stains will be done whenever necessary. Results: We included a total of 148 cases of hysterectomies received to our department during the study period in our study. Of total 148 cases, 87.83% hysterectomies were abdominal and 12.16% were vaginal and TAHBSO was the commonest procedure. In myometrium the most common finding was leiomyoma and adenomyosis with 79.73% and 43.92% cases respectively. In cervix, most cases were inflammatory lesions with chronic nonspecific cervicitis was the most common histopathological finding. Two cases (1.37%) of carcinoma cervix were reported. Conclusions: Most of the cases which underwent hysterectomy were for symptomatic untreatable benign conditions and few for malignancies. Majority of the cases were histopathologically consistent with clinical diagnosis. Histopathological examination and its correlative study with preoperative clinical diagnosis is very important. Thus, histopathological examination is still the gold standard test to diagnose and rule out malignancy and must be compulsory for all the surgical specimens. Keywords: Hysterectomy, Uterocervix, Pathology

scholarly journals Sonographic and histopathological correlation and evaluation of causes of abnormal uterine bleeding in perimenopausal women

2019 ◽  
Vol 8 (10) ◽  
pp. 3920
Author(s):  
Garima Kumari ◽  
Kuldeep Poonia
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Transvaginal Ultrasound ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
First Line ◽  
Histopathological Correlation ◽  
Perimenopausal Women ◽  
Pathological Evaluation ◽  
A Prospective Study

Background: Perimenopausal period in a woman’s lifetime marks a transition from reproductive phase to that of menopause. Abnormal uterine bleeding (AUB) is a common problem among women in the reproductive age.Methods: It was a prospective study on 100 perimenopausal women in age group 39-51 years with abnormal uterine bleeding who underwent Hysterectomy at SMS Hospital, Jaipur. At the end clinical diagnosis, ultrasonographic findings and histopathological reports were correlated.Results: 42.0% cases had HMB menstrual pattern followed by 24.0% cases had HPMB and 18.0% of the cases had PB. Intermenstrual bleeding was seen in 2% cases.  In clinical finding, 71.0% cases had fibroid followed by 15.0% cases had adenomyosis and 6.0% of the cases had fibroid+adenomyosis. The clinical diagnosis was confirmed by ultrasonography. Ultrasound detected fibroid in 95.8% of the cases who were suspected to have fibroid on clinical examination. Out of the 15 patients who were clinically suspected to have adenomyosis, 53.3% confirmed on ultrasound, ultimate diagnosis was made on the basis of histology, so every hysterectomy specimen was sent for histopathological examination. Out of the 68 patients who were diagnosed to have fibroid uterus on ultrsonography, 66 patients were confirmed to have fibroid. Out of the 8 patients who were labelled as adenomyosis after ultrasound, 4 patients were diagnosed to have adenomyosis on histopathology and in rest 4 patients, no gross pathology was detected.Conclusions: A transvaginal ultrasound should be offered as the first line of imaging. Clinical, radiological and pathological evaluation correlated well to diagnose fibroids, however clinically as well as USG proved to be of little help in diagnosing adenomyosis.

TO FIND OUT ELECTRO-CARDIOGRAPHIC CHANGES & ECHO CHANGES IN ALUMINIUM PHOSPHIDE AND ETHYLENE DIBROMIDE POISONING

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Hemant Nargawe ◽  
Sumeet Sisodiya
Keyword(s):  
Biochemical Analysis ◽  
Histopathological Examination ◽  
Common Finding ◽  
Histopathological Changes ◽  
Ethylene Dibromide ◽  
Medical College ◽  
Aluminium Phosphide ◽  
Urine Examination ◽  
Cardiovascular Involvement ◽  
Careful Clinical Examination

Background & Method: The study was conducted in the Department of Medicine Shyam Shah Medical College and Associated Sanjay Gandhi Memorial Hospital, Rewa (M.P). History was followed by a careful clinical examination i.e. cardiovascular, respiratory and gastrointestinal and nervous system. Investigations had done included routine haematological examination, Biochemical analysis, urine examination, ECG, 2 D. Echo & Histopathological examination was done. Result: ST-T changes were most common finding in Aluminium phosphide poisoning in relation to mortality. However hyperkalemia was the most ominous finding associated with 100% mortality, ECG finding in EDB was normal ECG. The most ominous finding was arrhythmia which was associated with 100% mortality. Survivors of ethylene dibromide poisoning echocardiography was normal in 11 (84.61%) followed by pericardial effusion in 2 (15.38%) patients. Conclusion: Noteworthy finding was absence of correlation between cardiovascular involvement, histopathological changes and ECG findings. It was seen that even if ECG showed normal pattern there were significant histopathological changes in heart. Keywords: electro-cardiographic, Aluminium phosphide, ethylene dibromide & poisoning.

Evaluation of Breast Lumps by Ultrasound and Correlation with Histological Findings

2020 ◽  
Vol 23 (1) ◽  
pp. 10-12
Author(s):  
Nelema Jahan ◽  
Md. Mamunur Rahman ◽  
Mohammad Shahidul Alam ◽  
Md Saiful Islam
Keyword(s):  
Histopathological Examination ◽  
Breast Diseases ◽  
Histopathological Study ◽  
Common Symptom ◽  
Breast Lump ◽  
Histopathological Findings ◽  
Malignant Breast ◽  
Breast Lumps ◽  
One Year ◽  
A Prospective Study

Background: A breast lump is the most common symptom associated with both benign and malignant breast diseases. Therefore, a distinction of benign from malignant lump is of importance for proper management. Though a definitive diagnosis is possible with imaging for all the lesions, histopathological study is proven essential for confirming the diagnosis. Objective: The objective of this study was to evaluate the role of USG and histopathological findings of different breast lump in diagnosis and their comparison. Methods: A prospective study was conducted over a period of one year from January 2017 to December 2017. A total of 116 patients were included in this study. All breast lumps underwent surgery and the ultrasound findings of these lumps were compared with the histopathological findings. Data were collected from these patients by a preformed questionnaire and finally the data were analyzed. Results: Out of 116 patients only 21 cases were reported as malignant in ultrasound report but histopathology revealed 31 malignant patients. On histopathological examination 10 benign cases turned out to be malignant. Conclusion: The present study was undertaken to evaluate in diagnosing breast mass lesions individually by ultrasound and compared with histopathology for definitive management of a patient. Journal of Surgical Sciences (2019) Vol. 23 (1) : 10-12

Gout in the Axial Skeleton

2009 ◽  
Vol 36 (3) ◽  
pp. 609-613 ◽  
Author(s):  
RUKMINI M. KONATALAPALLI ◽  
PAUL J. DEMARCO ◽  
JAMES S. JELINEK ◽  
MARK MURPHEY ◽  
MICHAEL GIBSON ◽  
...  
Keyword(s):  
Facet Joint ◽  
Case Reports ◽  
Case Series ◽  
Lumbar Vertebrae ◽  
Axial Skeleton ◽  
Ct Images ◽  
Common Finding ◽  
Appendicular Skeleton ◽  
Pars Interarticularis ◽  
A Prospective Study

Objective.Gout typically affects the peripheral joints of the appendicular skeleton and rarely involves the axial joints. The literature on axial gout is limited to case reports and case series. This preliminary study was conducted to identify the frequency and characteristics of axial gout.Methods.Six hundred thirty medical records with ICD codes 274.0, 274.82, and 274.9 for peripheral gout were reviewed. Ninety-two patients had clinical or crystal-proven gout, of which 64 had prior computed tomography (CT) images of the spine performed for various medical reasons. These CT images were reviewed for features of axial gout, which include vertebral erosions mainly at the discovertebral junction and the facet joints, deposits of tophi, and erosions in the vertebral body, epidural space, ligamentum flavum and pars interarticularis.Results.Nine of the 64 patients had radiographic changes suggestive of axial gout. Lumbar vertebrae were most commonly involved, with facet joint erosions being the most common finding. Isolated involvement of the sacroiliac joints was seen in 2 patients. Axial gout had been diagnosed clinically in only one patient.Conclusion.Radiologic changes of axial gout were more common than recognized clinically, with a frequency of 14%. Since not all patients had CT images, it is possible that the frequency of axial involvement was even greater. A prospective study is needed to further define this process.

scholarly journals A prospective study of spectrum of pulmonary tuberculosis in HIV sero positive patients

2021 ◽  
Vol 8 (12) ◽  
pp. 1856
Author(s):  
Ganedi Seshu Kumari
Keyword(s):  
Miliary Tuberculosis ◽  
Cross Sectional Study ◽  
Common Finding ◽  
Hiv Positive ◽  
Cd4 Cells ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Male Predominance ◽  
Chest X Ray ◽  
A Prospective Study

Background: Tuberculosis is the leading cause of death in India contributing to 30% of total global burden. Approximately 0.5 million people dies of TB annually and 5% of the incident TB cases in India have HIV. So it is important to understand the effect of tuberculosis and HIV on each other. HIV epidemics have leads to increased number of tuberculosis cases with various presentations.Methods: It is an observational cross-sectional study of patients with HIV positive and pulmonary TB. Patients were investigated for HIV positivity by HIV coomb's test, if positive confirmed by capillaries and tridot method. Some patients, who are diagnosed as having pulmonary Koch, are sent for HIV testing. CD4 cells count as tested in all patients with HIV positive and severity of pulmonary TB and relation with CD count is studied in all patients.Results: In chest x-ray of patients we have observed that upper zone infiltration was found in 10 (16.67%) patients, mid and lower zone infiltration was found in 19 (31.67%) patients, bilateral infiltration and miliary tuberculosis was found in 22 (36.67%). We have found that 9 (15%) patients were presented with fibro cavitary lesion.Conclusions: From present study we can conclude that tuberculosis and HIV is common between 3rd and 5th decade of life with male predominance. It was more common in daily labourer and BMI was 18.22±3.21 kg/m2. Fever, weight loss and cough was most common presentation and present in more than 90% patients pallor and lymphadenopathy was common finding and present in more than 50% patients.

scholarly journals Solitary Schwannoma on the Hypothenar Region of the Hand: A Literature Review

2020 ◽  
Vol 5 (10) ◽  
pp. 449-452
Author(s):  
Kastanis G ◽  
Kapsetakis P ◽  
Magarakis G ◽  
Bachlitzanaki M ◽  
Christoforidis C ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Diagnosis ◽  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Benign Tumors ◽  
Rare Manifestation ◽  
Histopathological Evidence ◽  
Volar Surface

Schwannomas or neurilemmomas are the most common benign tumors of the neural sheaths of the peripheral nerves. Incidence of these tumors in the hand accounts to 0.8-2%. The majority of them appear as an isolated grown mass along the route of the nerves. Peripheral nerves benign tumors present many difficulties concerning the clinical diagnosis and only histopathological evidence provides the final diagnosis. In this case study, we present a 45 year old man with a grown asymptomatic mass on the volar surface of right hand (hypothenar) remained for two years and impinging the skin of the hand only the last months. Initial MRI results diagnosed the mass as gaglion cyst. Histopathological examination revealed a schwannoma. We present this case as a rare manifestation of a schwannoma in hypothenar area of the hand. A literature review of diagnoses and therapeutic management is also presented.

scholarly journals Vocal Cord Leukoplakia: Characteristics and Pathological Significance

2012 ◽  
Vol 2 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Yusuf Kizil ◽  
Utku Aydil ◽  
Metin Yilmaz ◽  
Özgür Ekinci ◽  
Osman Tugrul Güzeldir ◽  
...  
Keyword(s):  
High Risk ◽  
Vocal Cord ◽  
Chronic Inflammation ◽  
Clinical Diagnosis ◽  
Cancer Diagnosis ◽  
Histopathological Examination ◽  
Pathological Finding ◽  
Smoking History ◽  
White Patch ◽  
Mild Dysplasia

ABSTRACT Leukoplakia is a nonspecific clinical term used to describe a mucosal white patch or plaque that cannot be easily scraped off. Leukoplakia of vocal cord represents a chronic inflammation or exposure to irritants which can also stimulate development of precancerous conditions or cancer. This study aimed to determine clinical and histopathological characteristics of vocal cord leukoplakia. A total of 66 patients were included. All patients with a clinical diagnosis of vocal cord leukoplakia who had undergone direct laryngoscopic examination and biopsy were analyzed retrospectively. The most common pathological finding was mild dysplasia (25.8%). Cancer was detected in 18.2% of cases. Malignancy was more frequent in cases with unilateral vocal cord involvement (23.4%) when compared with bilateral cases (5.2%) and in patients with localized lesions (19.3%) when compared with lesions involving whole cord (11.1%), but the differences were not statistically significant (p > 0.05). Smoking history was found to be related with cancer diagnosis (p < 0.001). In the presence of a serious smoking history, there is high-risk for malignancy and leukoplakia should be sampled immediately for histopathological examination. Although statistically not proven, cancer rates are higher in more localized and unilateral lesions. How to cite this article Kizil Y, Aydil U, Yilmaz M, Ekinci Ö, Güzeldir OT, Savas VA, Köybasioglu A. Vocal Cord Leukoplakia: Characteristics and Pathological Significance. Int J Phonosurg Laryngol 2012;2(1):9-13.

scholarly journals MULTI NODULAR GOITER

2010 ◽  
Vol 17 (01) ◽  
pp. 40-43
Author(s):  
SYED ALI AKBAR ◽  
Mohammad Qasim ◽  
NAZIR AHMED ◽  
Zar Khan ◽  
JOHAR ALI ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Cervical Lymphadenopathy ◽  
Nodular Goiter ◽  
Follicular Carcinoma ◽  
Study Patient ◽  
Surgical Department ◽  
Medical College ◽  
Risk Of Malignancy ◽  
Azad Kashmir ◽  
A Prospective Study

Objective: I. To determine the frequency of malignancy in multi nodular goiter. II. To determine the histopathological types.Design: This is a prospective study. Setting: Surgical department of Foundation Hospital Rawalpindi and associated Teaching Hospital ofFrontier Medical College Abbottabad. Period: Aug. 2002 to Aug. 2007. Patients and Methods. One hundred patients with Multi nodular wereincluded in this study. Patient with diffuse goiter, solitary nodules, patient operated somewhere else and suspected cases of malignancy wereexcluded from the study. Tissue were sent to Armed Force Institute for histopathological examination. Patients were followed for 2 weeks aftersurgery with histopathological report, all the preoperative and postoperative findings were recorded in detail. Data was analyzed byusingSPSS 14. Results. Majority of patients studied, belonged to Azad Kashmir and Gilgit which are among the known endemic regions for goitrein Pakistan and other from Chakwal and Jhelum. Histopathology revealed 96 (96%) patients with multi nodular goiter, 3 (3%) papillary carcinomaand 1 (1 %) Follicular carcinoma. Conclusions: Multinodularity of the goitre should not be considered as low risk of malignancy and delay forsurgical intervention. Changes in the size of gland, the appearance of new and hard nodules or cervical lymphadenopathy may indicatemalignant change and prompt indication for surgery.

scholarly journals Study of anaemia profile in a tertiary care hospital in Karnataka, India

2020 ◽  
Vol 7 (4) ◽  
pp. 582
Author(s):  
Appu Patil
Keyword(s):  
Tertiary Care ◽  
Public Health Problem ◽  
Severe Anaemia ◽  
Common Finding ◽  
Major Public Health Problem ◽  
Care Hospital ◽  
Common Cause ◽  
Working Age ◽  
Systemic Examination ◽  
A Prospective Study

Background: Anaemia is a major public health problem worldwide especially in developing countries like India. Nutritional cause of anaemia continues to predominate as the most common cause of anaemia. Objective of this study is to determine the clinical and laboratory profile of anaemia among patients admitted to our hospital.Methods: Our study was a prospective study in which thirty nine patients of anemia admitted to Medicine ward in SNMC and HSK hospital were studied for their clinical and laboratory characteristics. Duration of the study was 7 months from July 2019 to January 2020.Results: Anaemia was more common among females (65.1% of total patients). Patients aged less than 60 years contributed to 85% of patients. Pallor was the universal finding present in 100% of patients. On systemic examination haemic murmurs on auscultation was the most common finding present in 28.2% followed by hepatomegaly (17.94%). Microcytic and dimorphic anaemia constitute the bulk of anaemia.Conclusions: Nutritional anaemia particularly iron deficiency anaemia is the most common cause of anaemia. It tends to affect the working age group and females predominantly. Patients continue to present with severe anaemia to the hospital.

scholarly journals The Frequency and Causes of Subepidermal Gaps or Blisters and the Compliance Rate Between Clinical Diagnosis and Pathology Reports from 2015 to 2019

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Abbas Darjani ◽  
Hojat Eftekhari ◽  
Seyedeh Rojin Amini Rad ◽  
Narges Alizadeh ◽  
Rana Rafiee ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Skin Diseases ◽  
Histopathological Examination ◽  
Compliance Rate ◽  
Clinical Manifestations ◽  
Final Diagnosis ◽  
Direct Immunofluorescence ◽  
Diagnostic Challenge ◽  
Cross Sectional ◽  
Pathology Reports

Background: Skin diseases are the fourth most common cause of human illness, and blisters with different clinical manifestations make a diagnostic challenge. Objectives: This study aimed to evaluate the frequency and causes of subepidermal gaps or blisters, as well as the compliance rate between the initial and final clinical diagnoses based on pathology reports. Methods: In this cross-sectional study, pathology reports of subepidermal blisters or gaps were evaluated in the patients referred to the Razi Laboratory of Rasht from 2015 to 2019. The samples were examined by a pathologist after hematoxylin and eosin staining. The reports included demographic information, clinical differential diagnoses, final diagnosis, direct immunofluorescence findings, and salt split results. Finally, the compliance rate of clinical diagnosis with pathology reports was determined. Results: A total of 183 pathology reports were evaluated, 170 of which contained the final diagnosis. Females were more frequently affected by the disease, and pemphigoid bolus and lichen planus were the most prevalent final diagnoses. The compliance rate between the initial and final diagnoses was 94%. About 37.2% of the reports lacked direct immunofluorescence (DIF) and salt split, and only 42.6% of the samples had undergone DIF examination, while 20.2% had both DIF and salt split. There was no significant association between the compliance rate of the final diagnosis with age, sex, and undergoing diagnostic tests. Conclusions: A high incidence of subepidermal gaps or blisters was seen in middle-aged individuals and females. The compliance rate of the initial clinical diagnosis with the final diagnosis based on pathological reports was high. Our findings emphasize the importance of histopathological examination and the complementary role of direct immunofluorescence and salt split in diagnosis.

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