scholarly journals Endocrine-Disrupting Chemicals Role in Drug Abuser: A Review Study

2020 ◽  
Vol 10 (4) ◽  
pp. 26324.1-26324.8
Author(s):  
Idha Arfianti Wiraagni ◽  
◽  
Mustafa Mustafa Ali Mohd ◽  
Rusdi Abdul Rashid ◽  
Didi Erwandi Bin Mohamad Haron ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Neuronal Excitability ◽  
Endocrine Disrupting Chemicals ◽  
Food Products ◽  
The Body ◽  
Drug Abuser ◽  
Drug Abusers ◽  
Natural Hormone ◽  
Endocrine Disrupting ◽  
Review Study

Endocrine-disrupting Chemicals (EDCs) are exogenous chemicals that influence many aspects of natural hormone actions. Bisphenol is used in the industry, for increasing the thickness and durability of materials in certain plastics and resins. Paraben is used as preservatives in many pharmaceuticals, cosmetics, and some food products. EDCs can increase estrogen levels inside the body, and estrogen itself can increase the monoamine effect (dopamine, serotonin), neuronal excitability, neuropeptide transmitter mechanism, and drug metabolism. In drug abusers, this effect can develop greater craving behavior, addiction, and relapse.

scholarly journals Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids

2020 ◽  
Author(s):  
Chaitanya K. Jaladanki ◽  
Yang He ◽  
Li Na Zhao ◽  
Sebastian Maurer-Stroh ◽  
Lit-Hsin Loo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Virtual Screening ◽  
Nuclear Receptors ◽  
Endocrine Disrupting Chemicals ◽  
Screening Method ◽  
The Body ◽  
Cyclopropane Fatty Acid ◽  
Peroxisome Proliferator ◽  
Endocrine Disrupting ◽  
Multiple Structures

Abstract Nuclear receptors (NRs) are key regulators of energy homeostasis, body development, and sexual reproduction. Xenobiotics binding to NRs may disrupt natural hormonal systems and induce undesired adverse effects in the body. However, many chemicals of concerns have limited or no experimental data on their potential or lack-of-potential endocrine-disrupting effects. Here, we propose a virtual screening method based on molecular docking for predicting potential endocrine-disrupting chemicals (EDCs) that bind to NRs. For 12 NRs, we systematically analyzed how multiple crystal structures can be used to distinguish actives and inactives found in previous high-throughput experiments. Our method is based on (i) consensus docking scores from multiple structures at a single functional state (agonist-bound or antagonist-bound), (ii) multiple functional states (agonist-bound and antagonist-bound), and (iii) multiple pockets (orthosteric site and alternative sites) of these NRs. We found that the consensus enrichment from multiple structures is better than or comparable to the best enrichment from a single structure. The discriminating power of this consensus strategy was further enhanced by a chemical similarity-weighted scoring scheme, yielding better or comparable enrichment for all studied NRs. Applying this optimized method, we screened 252 fatty acids against peroxisome proliferator-activated receptor gamma (PPARγ) and successfully identified 3 previously unknown fatty acids with Kd = 100–250 μM including two furan fatty acids: furannonanoic acid (FNA) and furanundecanoic acid (FUA), and one cyclopropane fatty acid: phytomonic acid (PTA). These results suggested that the proposed method can be used to rapidly screen and prioritize potential EDCs for further experimental evaluations.

scholarly journals Pemanfataan Serbuk Sekam Padi Sebagai Adsorben Untuk Menurunkan Konsentrasi Senyawa Piridaben Pada Pestisida Samite 135EC

2018 ◽  
Vol 2 (2) ◽  
pp. 42-53
Author(s):  
Roni Saputra
Keyword(s):  
Rice Husk ◽  
Contact Time ◽  
Negative Impact ◽  
Endocrine Disrupting Chemicals ◽  
Absorption Efficiency ◽  
The Body ◽  
Sample Treatment ◽  
Metabolic System ◽  
Environment And Health ◽  
Endocrine Disrupting

Pesticides are very useful in many areas of human activities, especially in agriculture to ensure food availability. However, pesticides also have a negative impact on the environment and health. Pesticides are classified as endocrine disrupting chemicals (EDCs), which are chemicals that can interfere with the metabolic system, binding and eliminating hormones in the body, one of which is the danger of carcinogenicity. The concentration hazard present in Pesticide was experiment to decrease the concentration by using rice husk absorbent powder. This research is an experimental research that aims to reduce the concentration of pyridaben compounds contained in pesticides by using rice husk absorbent powder. By varying the sample treatment, variations of optimum concentrations of 10, 20, 30, 40 and 50 mg/L, contact time of 12 hours, 24 hours, 2 days, 4 days and 7 days, and weight of rice husk powder 25, 50, 100, 150, 200 mg. Analysis performed on pesticides is the content of pyridaben in pestisida samite 135EC.             From this research, the best result was obtained at concentration 30 mg/L with 29,74% absorption efficiency, 24 hours contact time with 92,36% absorption efficiency, and 150 mg of rice husk powder with 54,88% absorption efficiency. This condition indicates that rice husk powders are effectively used to decrease the concentration of pyridaben compounds because of their effectiveness above 50%.

scholarly journals Development of a Human Estrogen Receptor Dimerization Assay for the Estrogenic Endocrine-Disrupting Chemicals Using Bioluminescence Resonance Energy Transfer

2021 ◽  
Vol 18 (16) ◽  
pp. 8875
Author(s):  
Hye Mi Kim ◽  
Hyeyeong Seo ◽  
Yooheon Park ◽  
Hee-Seok Lee ◽  
Seok-Hee Lee ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Binding Affinity ◽  
Binding Assay ◽  
Radioligand Binding ◽  
Endocrine Disrupting Chemicals ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
The Body ◽  
Bioluminescence Resonance Energy Transfer ◽  
Endocrine Disrupting

Endocrine-disrupting chemicals (EDCs) are found in food and various other substances, including pesticides and plastics. EDCs are easily absorbed into the body and have the ability to mimic or block hormone function. The radioligand binding assay based on the estrogen receptors binding affinity is widely used to detect estrogenic EDCs but is limited to radioactive substances and requires specific conditions. As an alternative, we developed a human cell-based dimerization assay for detecting EDC-mediated ER-alpha (ERα) dimerization using bioluminescence resonance energy transfer (BRET). The resultant novel BRET-based on the ERα dimerization assay was used to identify the binding affinity of 17β-estradiol (E2), 17α-estradiol, corticosterone, diethylhexyl phthalate, bisphenol A, and 4-nonylphenol with ERα by measuring the corresponding BRET signals. Consequently, the BRET signals from five chemicals except corticosterone showed a dose-dependent sigmoidal curve for ERα, and these chemicals were suggested as positive chemicals for ERα. In contrast, corticosterone, which induced a BRET signal comparable to that of the vehicle control, was suggested as a negative chemical for ERα. Therefore, these results were consistent with the results of the existing binding assay for ERα and suggested that a novel BRET system can provide information about EDCs-mediated dimerization to ERα.

scholarly journals EPIDEMIOLOGICAL, TOXICOLOGICAL AND MOLEСULAR-GENETIC ASPECTS OF ENDOCRINE DISRUPTING CHEMICALS IN THE CHEMICAL SAFETY PROBLEM

2018 ◽  
Vol 97 (3) ◽  
pp. 197-203
Author(s):  
Oksana O. Sinitsyna ◽  
Yu. A. Rakhmanin ◽  
Z. I. Zholdakova ◽  
M. G. Aksenova ◽  
A. V. Kirillov ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Structural Features ◽  
The Body ◽  
Target Cells ◽  
Chemical Safety ◽  
Endocrine Disrupting ◽  
The Impact

The literature review has shown the problem of endocrine disrupting chemicals (EDC) to be associated with their wide distribution in the environment, the abundance, and variety of the chemical structure. Three leading mechanisms of EDCs action are identified as follows: imitation of the naturally occurring hormones action, blocking of receptors within the target cells of hormones, the impact of their kinetics in the body. Epidemiological studies indicate an increase in diseases caused by a disorder of the hormonal system. They are associated with the effect of EDCs. Substances that are completely dissimilar in chemical structure can cause the same effects. According to WHO [6], it is impossible, based on the chemical structure, to determine whether a substance is a disruptor of the endocrine system. However, some structural features determine the estrogenic, thyreogenic and glucocorticoid activity of chemicals. Hence, the need to differentiate the specific (primary) effect of a chemical substance on the endocrine system and the indirect (secondary) effect on it via other mechanisms comes to the fore. In own research, specific mechanisms were shown to be determined in the experiment when studying the complexity of effects, taking into account the processes of adaptation and decompensation, and identifying the effects manifested with the lowest doses. One of the methodological approaches can be the developed “structure-biotransformation-activity” prediction system aimed at revealing the primary types of effects: using quantum-chemical calculations and the plausible reasoning class (called the JSM-reasoning in honour of John Stuart Mill) logico-combinatorial method, it was possible to identify structural fragments of substances responsible for the manifestation of carcinogenic, allergenic effects, methemoglobin formation, etc. The results of clinical studies show the use of pharmacological drugs as models for in vivo study of the effects of EDC to allow not only studying atypical mechanisms of the impact of EDCs from the point of view of molecular genetics but also to predict the individual susceptibility to them taking into account polymorphism of candidate genes. The EDCs problem poses the need for a complex of interdisciplinary research, including three main relationships: exposure assessment-biomonitoring data-the prevalence of endocrine-dependent diseases, taking into account the qualitative and quantitative contribution of individual endocrine disrupters to the development of an ecologically dependent endocrine pathology using molecular genetic methods.

scholarly journals Machine Learning for Investigation on Endocrine-Disrupting Chemicals with Gestational Age and Delivery Time in a Longitudinal Cohort

Research ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Hemi Luan ◽  
Hongzhi Zhao ◽  
Jiufeng Li ◽  
Yanqiu Zhou ◽  
Jing Fang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Pregnant Women ◽  
Gestational Age ◽  
Endocrine Disrupting Chemicals ◽  
Environmental Chemicals ◽  
The Body ◽  
Delivery Time ◽  
Longitudinal Cohort ◽  
Endocrine Disrupting ◽  
Dynamic Concentration

Endocrine-disrupting chemicals (EDCs) are widespread environmental chemicals that are often considered as risk factors with weak activity on the hormone-dependent process of pregnancy. However, the adverse effects of EDCs in the body of pregnant women were underestimated. The interaction between dynamic concentration of EDCs and endogenous hormones (EHs) on gestational age and delivery time remains unclear. To define a temporal interaction between the EDCs and EHs during pregnancy, comprehensive, unbiased, and quantitative analyses of 33 EDCs and 14 EHs were performed for a longitudinal cohort with 2317 pregnant women. We developed a machine learning model with the dynamic concentration information of EDCs and EHs to predict gestational age with high accuracy in the longitudinal cohort of pregnant women. The optimal combination of EHs and EDCs can identify when labor occurs (time to delivery within two and four weeks, AUROC of 0.82). Our results revealed that the bisphenols and phthalates are more potent than partial EHs for gestational age or delivery time. This study represents the use of machine learning methods for quantitative analysis of pregnancy-related EDCs and EHs for understanding the EDCs’ mixture effect on pregnancy with potential clinical utilities.

scholarly journals Dietary Intake of Endocrine Disrupting Substances Presents in Environment and Their Impact on Thyroid Function

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 867
Author(s):  
Aneta Sokal ◽  
Sara Jarmakiewicz-Czaja ◽  
Jacek Tabarkiewicz ◽  
Rafał Filip
Keyword(s):  
Thyroid Gland ◽  
Direct Contact ◽  
Endocrine Disrupting Chemicals ◽  
The Body ◽  
Placental Barrier ◽  
Biodegradable Packaging ◽  
Expression Of Genes ◽  
Endocrine Disrupting ◽  
The World

According to the available data, environmental pollution is a serious problem all over the world. Between 2015 and 2016, pollution was responsible for approximately nine million deaths worldwide. They also include endocrine disrupting chemicals (EDCs) that can interfere with the functioning of the thyroid gland. They are characterized by high persistence in the environment. These substances can enter the body through the gastrointestinal tract, respiratory system, as well as contact with the skin and overcome the placental barrier. EDC can be found in food, water, and personal care products. They can get into food from the environment and as a result of their migration to food products and cosmetics from packaging. EDCs can disrupt the functioning of the thyroid gland through a number of mechanisms, including disrupting the activation of thyroid receptors and the expression of genes that are related to the metabolism, synthesis, and transport of thyroid hormones (HT). There is a need to strengthen the food safety policy that aimed at the use of appropriate materials in direct contact with food. At the same time, an important action is to reduce the production of all waste and, when possible, use biodegradable packaging, which may contribute to the improvement of the quality of the entire ecosystem and the health of food, thus reducing the risk of developing thyroid diseases.

scholarly journals Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions

Toxics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 77
Author(s):  
Dylan J. Wallis ◽  
Lisa Truong ◽  
Jane La Du ◽  
Robyn L. Tanguay ◽  
David M. Reif
Keyword(s):  
High Throughput Screening ◽  
Endocrine Disrupting Chemicals ◽  
Differential Susceptibility ◽  
The Body ◽  
Entire Body ◽  
Individual Susceptibility ◽  
Gene Environment ◽  
Endocrine Disrupting ◽  
Specific Receptors ◽  
Endocrine Signaling

Exposure to endocrine-disrupting chemicals (EDCs) is linked to myriad disorders, characterized by the disruption of the complex endocrine signaling pathways that govern development, physiology, and even behavior across the entire body. The mechanisms of endocrine disruption involve a complex system of pathways that communicate across the body to stimulate specific receptors that bind DNA and regulate the expression of a suite of genes. These mechanisms, including gene regulation, DNA binding, and protein binding, can be tied to differences in individual susceptibility across a genetically diverse population. In this review, we posit that EDCs causing such differential responses may be identified by looking for a signal of population variability after exposure. We begin by summarizing how the biology of EDCs has implications for genetically diverse populations. We then describe how gene-environment interactions (GxE) across the complex pathways of endocrine signaling could lead to differences in susceptibility. We survey examples in the literature of individual susceptibility differences to EDCs, pointing to a need for research in this area, especially regarding the exceedingly complex thyroid pathway. Following a discussion of experimental designs to better identify and study GxE across EDCs, we present a case study of a high-throughput screening signal of putative GxE within known endocrine disruptors. We conclude with a call for further, deeper analysis of the EDCs, particularly the thyroid disruptors, to identify if these chemicals participate in GxE leading to differences in susceptibility.

scholarly journals Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

2020 ◽  
Vol 21 (4) ◽  
pp. 1519 ◽  
Author(s):  
Zi-Run Tang ◽  
Xue-Ling Xu ◽  
Shou-Long Deng ◽  
Zheng-Xing Lian ◽  
Kun Yu
Keyword(s):  
Endocrine Disruptors ◽  
Endocrine Disrupting Chemicals ◽  
Chemical Properties ◽  
Endocrine System ◽  
Maternal Blood ◽  
The Body ◽  
Detection Methods ◽  
Past Half Century ◽  
Endocrine Disrupting ◽  
The Stability

Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the stability and regulation of the endocrine system of the body or its offspring. These substances are generally stable in chemical properties, not easy to be biodegraded, and can be enriched in organisms. In the past half century, EDCs have gradually entered the food chain, and these substances have been frequently found in maternal blood. Perinatal maternal hormone levels are unstable and vulnerable to EDCs. Some EDCs can affect embryonic development through the blood-fetal barrier and cause damage to the neuroendocrine system, liver function, and genital development. Some also effect cross-generational inheritance through epigenetic mechanisms. This article mainly elaborates the mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health.

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