scholarly journals A comparative study between Antioxidant vitamin and Kellgren–Lawrence grading scale in knee osteoarthritis patients

2013 ◽  
Vol 13 (1) ◽  
pp. 30-35
Author(s):  
Indranil Dawn ◽  
Susmita Sarkar ◽  
Chinmoy De
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Knee Joint ◽  
Medical Science ◽  
Serum Vitamin ◽  
Antioxidant Vitamins ◽  
Antioxidant Vitamin ◽  
Plasma Vitamin ◽  
Radiographic Findings ◽  
Grading Scale

Osteoarthritis (OA) is a strongly age-related joint disorder that is defined as a gradual loss of articular cartilage. Current concepts of the pathogenic mechanisms of OA suggest that there isa shift in the homeostatic balance between the destruction and synthesis of bone and cartilage,with a net progressive destruction of these tissues. Recent studies of the biology of chondrocytes show that these cells actively produce reactive oxygen species (ROS). ROS are capable of inducing apoptotic cell death in chondrocytes, but more important, they can result in the degradation of aggrecan and collagen. Micronutrient antioxidants such as alpha- Tocopherol (Vitamin E) and Vitamin C also act to reduce the effects of ROS. A hospital based case control study was conducted in Burdwan Medical College, West Bengal, India on 76 postmenopausal women aged 45–70 years suffering from Osteoarthritis (OA) of the knee joint, which was diagnosed from symptoms, clinical examinations and radiographic findings. The 151 controls were selected from the healthy persons .plasma vitamin C and serum vitamin E ware measured.. Knee joint radiographs were evaluated with the Kellgren–Lawrence grading scale .Furthermore both were correlated with Kellgren–Lawrence grading scale to find out possible association between the antioxidant vitamins and the disease progression. Results showed that there was a significant decrease in antioxidant vitamin levels in patients with knee joint osteoarthritis as compared to the controls suggests that treatment with antioxidants in the initial stages of the disease may be useful as secondary therapy. Both antioxidant vitamins showed negative correlation with Kellgren–Lawrence grading. Both vitamins decreased with increasing Kellgren–Lawrence grade. So antioxidant vitamin can be use to assess the disease severity. DOI: http://dx.doi.org/10.3329/bjms.v13i1.14046 Bangladesh Journal of Medical Science Vol. 13 No. 01 January2014: 30-35

scholarly journals Effect of immunonutritional status, healthcare factors, and lifestyle on acute respiratory infections among under-5 children in Bangladesh

2020 ◽  
Vol 8 ◽  
pp. 205031212094053
Author(s):  
Md. Mustafa Kamal ◽  
Farina Aziz ◽  
Md. Rabiul Islam ◽  
Monira Ahsan ◽  
Sheikh Nazrul Islam
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Vitamin C ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Serum Vitamin ◽  
Antioxidant Vitamins ◽  
Antioxidant Vitamin ◽  
Z Score ◽  
The Impact

Introduction: Acute respiratory infection is a major cause of death for under-5 children in Bangladesh. We aimed to analyze the effect of immunonutritional status, healthcare factors, and lifestyle on the incidence of acute respiratory infection among under-5 children taking individual-level and contextual-level risk factors into consideration. Methods: This study recruited 200 children suffering from acute respiratory infection and 100 healthy controls matched by age, sex, and sociodemographic profile. Serum antioxidant vitamin A (retinol), vitamin C (ascorbic acid), and vitamin E (α-tocopherol) were assessed along with the impact of vaccination, socioeconomic factors, and Z-score on the incidence of acute respiratory infection. Results: Serum antioxidant vitamins were significantly lower in the acute respiratory infection children compared to the non–acute respiratory infection group. Vitamin A was found to be significantly high in acute respiratory infection children who were breastfed for more than 1 year. Vitamin E levels were found to be significantly higher in the acute respiratory infection children who were immunized. Compared to the children living in tin-shed house or huts, serum vitamin E level increased in those acute respiratory infection children who resided in apartments. Vitamin A level was significantly high in those acute respiratory infection children whose height-for-age was −2 SD and above ( Z-score), and vitamin C levels were also significantly high in those acute respiratory infection children whose weight-for-height was −2 SD and below ( Z-score). Conclusion: Deficiencies of antioxidant vitamins along with healthcare and lifestyle factors have a significant influence on the incidence of acute respiratory infection among under-5 children in Bangladesh.

scholarly journals Blood cells as functional markers of antioxidant vitamin status

2006 ◽  
Vol 96 (S1) ◽  
pp. S38-S41 ◽  
Author(s):  
Josep Tur-Marí ◽  
Antoni Sureda ◽  
Antoni Pons
Keyword(s):  
Vitamin E ◽  
Blood Cells ◽  
Plasma Levels ◽  
Antioxidant Vitamins ◽  
Antioxidant Vitamin ◽  
Functional Markers ◽  
Plasma Vitamin ◽  
Beneficial Effects ◽  
Vitamin Status ◽  
Vitamin E Status

Antioxidants have shown beneficial effects in several biological systems, in which they were able to prevent oxidative stress-associated damage. Vitamins C and E are key antioxidants in man. Dietary intake cannot accurately reflect plasma vitamin levels. However, the plasma levels of antioxidant vitamins could also reflect the acute assimilation of these vitamins. It has been pointed out that antioxidant vitamin blood contents reach a saturation level by intake of dietary supplements. Antioxidant vitamin plasma levels are the parameter most used to determine antioxidant status. However, the vitamin plasma levels may not reflect the nutritional status of vitamins. It has been pointed out that the vitamin E in adipose tissue can be used as a measure of vitamin E status. To determinate antioxidant vitamin contents in lymphocytes and neutrophils after exercise is a useful tool to assess the functional status of antioxidant vitamins.

scholarly journals Trace Minerals and Oxidative Stress in Diabetic Retinopathy

2014 ◽  
Vol 13 (2) ◽  
pp. 175-179
Author(s):  
Suchitra Kumari ◽  
Tapaswini Pradhan ◽  
Tarun Kumar Panda
Keyword(s):  
Type 2 Diabetes ◽  
Trace Elements ◽  
Diabetic Retinopathy ◽  
Vitamin E ◽  
Vitamin C ◽  
Medical Science ◽  
Serum Vitamin ◽  
Correlation Study

There is accumulating evidence showing relationship between trace elements and Diabetes mellitus (DM). This study evaluated the role of magnesium, Zinc and other indices of peroxidative status ie MDA, Vitamin C and Vitamin E in pathogenesis of Retinopathy in type 2 diabetes. Seventy two type 2 diabetes cases were enrolled in the study, of which 42 were with retinopathy and 30 without. Patients with nephropathy were excluded. Forty age and sex matched subjects were served as health controls. The results showed that the mean values of Mg and Zn were significantly lower reduced in diabetes more so in diabetic retinopathy cases as compared to control subjects (p<0.05). Lipid peroxidation marker MDA was a significantly higher in both the diabetes groups whereas serum Vitamin C and vitamin E levels were significantly low (p<0.05) as compared to controls. Our correlation study revealed that MDA was negatively associated with serum Mg (r=-0.73, p<0.01) as well as serum Zn (r= -0.82, p<0.01), pointing towards the role of these trace elements in retarding the oxidative process prevailing in diabetic retinopathy. DOI: http://dx.doi.org/10.3329/bjms.v13i2.14963 Bangladesh Journal of Medical Science Vol.13(2) 2014 p.175-179

scholarly journals Maternal to fetal transfer of vitamin C and vitamin E: effect on birth outcome in a Nigerian population

2016 ◽  
Vol 7 (4) ◽  
pp. 49-54
Author(s):  
Ikechukwu Chidiebere Ikaraoha ◽  
Nkeiruka Chigaekwu Mbadiwe ◽  
John Ibhagbemien Anetor ◽  
Constance Nnedimma Nwadike ◽  
Isreal Ojareva Oforofuo
Keyword(s):  
Birth Weight ◽  
Vitamin E ◽  
Vitamin C ◽  
Birth Outcomes ◽  
Head Circumference ◽  
Birth Outcome ◽  
Serum Vitamin ◽  
Birth Length ◽  
Antioxidant Vitamin ◽  
Cord Serum

Background: New evidence suggests that excessive production of reactive oxygen species give rise to oxidative stress which could impair fetal growth. Antioxidant vitamin C and vitamin E have vital role in physiological process of pregnancy and health of the developing fetus.Aims and Objectives: To determine the concentrations of vitamin C and vitamin E in pair-matched maternal and cord serum of newborns and to determine the relationship between maternal/cord serum vitamin C and vitamin E at delivery and birth outcomes.Materials and Methods: A total of 209 maternal and cord blood samples were collected during delivery for serum vitamin C and E determination. Birth outcomes; birth weight, birth length, head circumference, and Apgar score were determined.Result: Newborns had significantly higher levels of vitamin C as compared to their mothers, but had non-significant lower level of vitamin E.  Levels of vitamin C and E in both maternal and cord serum were positively correlated to birth weight, birth length, head circumference and Apgar score.Conclusion: Maternal vitamin C and E had significant effects on birth outcomes. A positive correlation of vitamin C and E indicates that their status in mother does influence newborns status.Asian Journal of Medical Sciences Vol.7(4) 2016 49-54

scholarly journals Antioxidant vitamin status of obese patients in terms of the risk of comorbidities

2020 ◽  
Vol 17 (1) ◽  
pp. 22-32
Author(s):  
Vera M. Kodentsova ◽  
Oksana A. Vrzhesinskaya ◽  
Olga V. Kosheleva ◽  
Nina А. Beketova ◽  
Khaider Kh. Sharafetdinov
Keyword(s):  
Ascorbic Acid ◽  
Vitamin E ◽  
Vitamin C ◽  
Serum Vitamin ◽  
Optimal Level ◽  
Research Centre ◽  
Antioxidant Vitamin ◽  
Obese Patients ◽  
Vitamin Status ◽  
Increased Risk

BACKGROUND: Synchronously optimized concentrations of vitamins C, E, A, carotenoids and their ratios in blood plasma help to prevent or slow down the development of many alimentary-dependent diseases and their complications. AIMS: to characterize the vitamin status of obese patients from the standpoint of the risk of progression of existing and development of associated diseases. MATERIALS AND METHODS: An observational single-site cross-sectional study of the sufficiency with antioxidant vitamins in 81 patients (21 men, 60 women) aged 2075 years with body mass index 40,71,2 kg/m2, enrolled for treatment from April to June in Federal Research Centre of Nutrition, Biotechnology had been conducted. The concentration of - and -tocopherols, retinol, ascorbic acid, -carotene was determined in blood serum and their ratios with lipid profile were calculated. RESULTS: Indicators of vitamin status were determined in 35 patients with obesity, 27 patients with obesity and cardiovascular diseases (CVD), 19 patients with obesity and type 2 diabetes mellitus (T2DM). The concentration of ascorbic acid in more than 50% of patients did not reach the optimal level (50 mol/l). Compared to patients of other groups, patients with T2DM were better supplied with vitamin E, but worse with other vitamins. They have a non-optimal ratio of concentrations of vitamin C and E more often compared with patients of other groups (p0.050). Among them, the combined suboptimal level of vitamin C and -carotene (0.4 mol/l) was detected 1.61.8 fold more often. The lack of antioxidants in patients with T2DM according to simultaneously reduced vitamin C/vitamin E ratio (1.5) and -carotene level was detected 3.3-fold more often, synchronously lowered vitamin C/vitamin E ratio and vitamin C level 2.4-fold. -tocopherol level in serum of patients with T2DM tended to increase compared with that in patients with obesity (p=0.063) and CVD (p=0.081), -tocopherol/triacylglycerides ratio was 1.5-fold higher (respectively р=0.009 и р=0.076). Only in 2 patients with obesity and 2 patients with CVD all serum indicators corresponded to the optimal level of all vitamins. In terms of -tocopherol/cholesterol (5 mol/mol), an increased risk of myocardial infarction was detected in 10.542.9% of the examined patients. Glucose level was positively associated with serum levels of - and -tocopherols, as well as cholesterol-adjusted individual tocopherols; while glycemia was inversely associated with triacylglycerides-standardized individual tocopherols, as well as -carotene and vitamin C/vitamin E ratio. CONCLUSIONS: In most patients, a non-optimal serum vitamin content was found according to one or several parameters. In order to vitamin C/vitamin E ratio, patients with T2DM need to increase vitamin C intake. Increasing serum -carotene and achieving an optimal C/E ratio will help to prevent an increase in glycemia.

scholarly journals Nutritional Antioxidants and Lipid Profile in Newly Diagnosed Rheumatoid Arthritis Patients

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Manjunatha Goud BK ◽  
Sarsina Devi O ◽  
Bhavna N ◽  
Devaki RN ◽  
Deepa K ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin E ◽  
Vitamin C ◽  
Lipid Profile ◽  
Colorimetric Method ◽  
Serum Vitamin ◽  
Control Group ◽  
Antioxidant Vitamin ◽  
Newly Diagnosed ◽  
Nutritional Antioxidants

Introduction: Rheumatoid arthritis (RA) is a chronic progressive autoimmune disorder characterized by symmetric erosive synovitis. The pathogenesis of bone erosion and joint deformities are not fully understood. The aim of this study was to find out vitamin C and E levels along with the lipid profile in newly diagnosed cases of RA. Materials and Methods: The patients for the study were selected from individuals attending the routine checkup in an Outpatient Department. Based on the criteria led by the American Rheumatism Association (ARA), the newly diagnosed patients were taken as cases and other normal individuals were taken as control group in the study. A total of 50 subjects were included in the study with the age group of 48 ± six years for both genders. Serum Vitamin-E was determined by the colorimetric method and serum Vitamin-C was estimated by the dinitro phenyl hydrazine method. Serum total cholesterol, HDL-cholesterol, triglycerides, and VLDL levels were estimated by the enzymatic method. LDL- cholesterol was calculated by the Friedewald's formula. Results: The levels of nutritional antioxidants vitamin E and C were different significantly in RA patients compared to control group. The lipid profile parameters were also different significantly in RA patients compared to the controls. Conclusion: Patients with RA presented with an imbalance in the oxidant-antioxidant system that markedly increased lipid peroxidation products and significantly decreased lipid soluble antioxidant vitamin E. These changes might play a role in the tissue damage and inflammation process in this disease.

scholarly journals Association Between Intake of Antioxidant Vitamins and Metabolic Syndrome Prevalence Among Korean Adults (P24-001-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Seoeun Ahn ◽  
Shinyoung Jun ◽  
Jiae Shin ◽  
Dongwoo Ham ◽  
Eunhee Choi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin E ◽  
Vitamin A ◽  
Vitamin C ◽  
Science Research ◽  
Antioxidant Vitamins ◽  
Antioxidant Vitamin ◽  
Dietary Recall ◽  
Korean Adults ◽  
Funding Sources

Abstract Objectives The purpose of this study was to examine the association between intake of antioxidant vitamins and prevalence of metabolic syndrome among Korean adults. Methods Based on the data from the 2013∼2016 Korea National Health and Nutrition Examination Survey (KNHANES), a total of 10,351 adults aged 19∼64 years were included. Presence of metabolic syndrome was determined using the National Cholesterol Education Program Adult Treatment Panel Ⅲ criteria. Intakes of antioxidant vitamins (vitamin A, vitamin C, and vitamin E) were estimated by combining a 24-h dietary recall data with an antioxidant vitamin database for common Korean foods. We analyzed through the multiple logistic regression method to assess the association between dietary antioxidant vitamins and metabolic syndrome. Results Men in the highest tertile of vitamin C (OR = 0.75, 95% CI = 0.58–0.95, p for trend = 0.0212) and vitamin E (OR = 0.76, 95% CI = 0.60–0.96, p for trend = 0.0212) intakes showed a significantly lower prevalence of metabolic syndrome than those in the lowest tertiles. Women in the highest intake group of vitamin A had a lower OR for increased waist circumference (OR = 0.80, 95% CI = 0.66–0.99, p for trend = 0.0618) than the lowest intake group. The OR for elevated triglycerides was lower among women in the highest tertile of vitamin C compared with those in the lowest tertile (OR = 0.75, 95% CI = 0.61–0.93, p for trend = 0.0016). Conclusions These results suggest that the dietary intake of antioxidant vitamins might be associated with the prevalence of metabolic syndrome among Korean adults. Further prospective research is required to elucidate the association between dietary antioxidants intake and the incidence of metabolic syndrome and other chronic diseases. Funding Sources This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science and ICT(NRF-2018R1A2B6007070). Supporting Tables, Images and/or Graphs

Dietary Intakes and Blood Concentrations of Antioxidant Vitamins in German Vegans

2005 ◽  
Vol 75 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Annika Waldmann ◽  
Jochen W. Koschizke ◽  
Claus Leitzmann ◽  
Andreas Hahn
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Chronic Diseases ◽  
Vegetable Intake ◽  
Antioxidant Vitamins ◽  
Fruit And Vegetable Intake ◽  
Plasma Vitamin ◽  
Fruit And Vegetable ◽  
Blood Concentrations ◽  
Β Carotene

We report on an evaluation of intake and blood concentrations of antioxidant vitamins in a cross-sectional study of 104 German vegans, and examine the association between blood concentration of antioxidant vitamins and their intake as well as fruit and vegetable intake. Comparisons are made with dietary reference intakes and established threshold values (ETV) for blood concentrations. Mean intakes of vitamin C, E, and β-carotene were higher than actual recommendations, but comparable to reported intakes in other vegan cohorts. Mean blood concentrations were 0.76 μmol/L for β-carotene and 117 μmol/L for vitamin C, so that nearly all participants showed concentrations that were above the ETV for the prevention of chronic diseases. Although mean vitamin E intake was 24.8 mg/day, only 32% of female and 18% of male participants showed plasma concentrations above the ETV. However, the mean vitamin E/cholesterol ratio was high (5.97), indicating a good protection of low-density lipoprotein (LDL) against peroxidation. Of the reported antioxidant vitamins, only plasma vitamin C concentration was a good biomarker of fruit and vegetable intake. The high concentration of antioxidative compounds in plasma may be one of the reasons for the lower incidence of chronic diseases in people consuming a plant-only diet.

Feeding antioxidant vitamin and vegetable oils to broilers: vitamin E reduced negative effect of soybean oil on immune response and meat lipid oxidation

2018 ◽  
Vol 58 (10) ◽  
pp. 1829
Author(s):  
M. Mohiti-Asli ◽  
M. Ghanaatparast-Rashti
Keyword(s):  
Immune Response ◽  
Vitamin E ◽  
Vitamin C ◽  
Soybean Oil ◽  
Lipid Oxidation ◽  
Vegetable Oil ◽  
Canola Oil ◽  
Cellular Response ◽  
Dietary Supplementation ◽  
Antioxidant Vitamin

This study investigated the effect of feeding vitamin E, vitamin C, and two sources of vegetable oil on immune response and meat quality of broilers. A total of 320 one-day-old chicks were used in a completely randomised design with eight treatments arranged as a 2 × 2 × 2 factorial with two levels of vitamin E (0 and 200 mg/kg), two levels of vitamin C (0 and 1000 mg/kg), and two sources of vegetable oil (soybean and canola). Dietary supplementation of either vitamin E or C increased (P < 0.05) secondary humoral response, whereas oil sources had no significant effect. Broilers fed soybean oil had lower cellular response to the phytohemagglutinin skin test than those fed canola oil in diet, and supplementation of vitamin E increased cellular immune response. However, fat, cholesterol and pH of meat were not affected by source of oil or antioxidants, lipid oxidation was higher (P < 0.05) in thigh and breast meat of broilers fed soybean oil than canola oil. Dietary supplementation of vitamin E decreased (P < 0.05) lipid oxidation in thigh and breast of broilers fed diet containing soybean oil, without any effect on meat oxidation of those fed canola oil. Dietary supplementation of vitamin C increased lipid oxidation in thigh meat of broilers (P < 0.05). It can be concluded that inclusion of soybean oil to the diet, compared with canola oil, increased need for antioxidant. Vitamin E had beneficial effects on immune response and reduced meat lipid oxidation; nonetheless future studies should explore the antioxidant effect of vitamin C in stored meat.

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation

2006 ◽  
Vol 40 (4) ◽  
pp. 689-697 ◽  
Author(s):  
Richard S. Bruno ◽  
Scott W. Leonard ◽  
Jeffery Atkinson ◽  
Thomas J. Montine ◽  
Rajasekhar Ramakrishnan ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Plasma Vitamin ◽  
Vitamin C Supplementation ◽  
Plasma Vitamin E
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