Effect of Manganese on the Activity of Antibiotic Against Microorganisms

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
S Rahman ◽  
Pinky Karim ◽  
Abu Asad Chowdhury ◽  
Abul Hasnat
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Nucleic Acid ◽  
Biological System ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Optimum Level ◽  
Bacterial Strains ◽  
Key Words Antibiotics ◽  
Life Threatening

Manganese is an important element in biological system. It is essential for enzymatic activity, maintaining three-dimensional structure of protein, for the synthesis of nucleic acid and protein etc. Deficiency of manganese causes different life threatening diseases. Because of this, the optimum level of manganese must be maintained in all biological system. This experiment, therefore, was designed to evaluate the effect of manganese on the activity of different antibiotics (ciprofloxacin, cephradine, amoxicillin, gentamycin, tetracycline, cloxacillin, nalidixic acid, ceftriaxone, metronidazole and carbenicillin) against different microorganisms. It has been observed that antimicrobial activity of an antibiotic increased significantly with concomitant use of manganese salt ranging from 600-6000 ng per antibiotic disc (P < 0.05). It is revealed from the experiment that manganese increases the activity of antibiotic against bacterial strains. Key words: Antibiotics, Manganese, Antibacterial activity. Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Beehive Products as Antibacterial Agents: A Review

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 717
Author(s):  
Rita Abou Nader ◽  
Rawan Mackieh ◽  
Rim Wehbe ◽  
Dany El El Obeid ◽  
Jean Marc Sabatier ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Honey Bee ◽  
Antibacterial Agents ◽  
Royal Jelly ◽  
Biological Activities ◽  
Vital Role ◽  
Bee Venom ◽  
Bacterial Strains ◽  
Wide Range ◽  
Life Threatening

Honeybees are one of the most marvelous and economically beneficial insects. As pollinators, they play a vital role in every aspect of the ecosystem. Beehive products have been used for thousands of years in many cultures for the treatment of various diseases. Their healing properties have been documented in many religious texts like the Noble Quran and the Holy Bible. Honey, bee venom, propolis, pollen and royal jelly all demonstrated a richness in their bioactive compounds which make them effective against a variety of bacterial strains. Furthermore, many studies showed that honey and bee venom work as powerful antibacterial agents against a wide range of bacteria including life-threatening bacteria. Several reports documented the biological activities of honeybee products but none of them emphasized on the antibacterial activity of all beehive products. Therefore, this review aims to highlight the antibacterial activity of honey, bee venom, propolis, pollen and royal jelly, that are produced by honeybees.

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues

2020 ◽  
Vol 13 (636) ◽  
pp. eaaz5599 ◽  
Author(s):  
Kelan Chen ◽  
Richard W. Birkinshaw ◽  
Alexandra D. Gurzau ◽  
Iromi Wanigasuriya ◽  
Ruoyun Wang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Muscular Dystrophy ◽  
Three Dimensional ◽  
Underlying Mechanism ◽  
Structural Features ◽  
Facioscapulohumeral Muscular Dystrophy ◽  
Dimensional Structure ◽  
Nucleic Acid Binding ◽  
X Ray Crystallography ◽  
Hinge Domain

Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) is an epigenetic regulator in which polymorphisms cause the human developmental disorder, Bosma arhinia micropthalmia syndrome, and the degenerative disease, facioscapulohumeral muscular dystrophy. SMCHD1 is considered a noncanonical SMC family member because its hinge domain is C-terminal, because it homodimerizes rather than heterodimerizes, and because SMCHD1 contains a GHKL-type, rather than an ABC-type ATPase domain at its N terminus. The hinge domain has been previously implicated in chromatin association; however, the underlying mechanism involved and the basis for SMCHD1 homodimerization are unclear. Here, we used x-ray crystallography to solve the three-dimensional structure of the Smchd1 hinge domain. Together with structure-guided mutagenesis, we defined structural features of the hinge domain that participated in homodimerization and nucleic acid binding, and we identified a functional hotspot required for chromatin localization in cells. This structure provides a template for interpreting the mechanism by which patient polymorphisms within the SMCHD1 hinge domain could compromise function and lead to facioscapulohumeral muscular dystrophy.

scholarly journals Chemical Composition, Antioxidant and Antibacterial Activity of Bunium persicum, Eucalyptus globulus, and Rose Water on Multidrug-Resistant Listeria Species

2018 ◽  
Vol 23 ◽  
pp. 2515690X1775131 ◽  
Author(s):  
Farhad Sharafati Chaleshtori ◽  
Mohamad Saholi ◽  
Reza Sharafati Chaleshtori
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Eucalyptus Globulus ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Antioxidant Power ◽  
Listeria Species ◽  
Bunium Persicum

This research was aimed at investigating the antioxidant and antibacterial activity of Bunium persicum, Eucalyptus globulus, and rose water on multidrug-resistant Listeria species. The antibiotic resistance of Listeria spp obtained from seafood samples were determined by the Kirby-Bauer method. The antioxidant and antibacterial activity of the essential oils and extracts were evaluated using ferric reducing antioxidant power and microdilution methods, respectively. A total 2 samples (1.88%) were positive for Listeria spp. L monocytogenes was found to be resistant to ampicillin, amoxicillin/clavulanic acid, penicillin, vancomycin, and kanamycin. B persicum essential oil showed the greatest antioxidant activity (248.56 ± 1.09 µM Fe2+/g). The E globulus essential oil showed consistently strong antimicrobial activity against L monocytogenes and L grayi, while rose water showed no antimicrobial activity against any of the tested bacterial strains. The results showed that after adding the B persicum and E globulus essential oils to bacteria, the cell components’ release increased significantly.

Address of the President Lord Blackett, O.M., C.H. at the Anniversary Meeting, 30 November 1970

1971 ◽  
Vol 177 (1046) ◽  
pp. 1-14
Keyword(s):  
Natural Products ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Biological Systems ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Theoretical Knowledge ◽  
Three Dimensional Structure ◽  
Subsequent Determination

Todd has made highly significant contributions to the chemistry of natural products, in particular in relation to compounds which play important roles in biological systems. His researches on vitamins B 1 , E and B 12 were most elegant and have had far-reaching implications, but none more so than his structural and synthetic studies in the nucleic acid field. Here he developed methods for the synthesis of the nucleosides and for their phosphorylation; his work on the way they are combined made possible the subsequent determination of the three-dimensional structure of the nucleic acids thereby providing the basis for much of the exciting activity in the nucleotide field today. Todd’s achievements arise out of a rare combination of theoretical knowledge and outstanding experimental skill, with the most judicious exploitation of modern techniques. His work and his quality as an investigator have been widely recognized by biologists as well as by organic chemists.

scholarly journals Effects of extraction solvent/technique on the antioxidant and antimicrobial activity of spring saffron (Crocus vernus (L.) Hill)

2020 ◽  
Vol 49 (2) ◽  
Author(s):  
Emir Horozić
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Skin Diseases ◽  
Ethanolic Extract ◽  
Early Spring ◽  
Aqueous Extracts ◽  
Bacterial Strains ◽  
Extraction Solvent ◽  
Ethanol Extracts

Spring saffron (lat. Crocus vernus (L.)Hill) is a perennial from the Iridaceae family. Purple or white coloured flowers bloom in the early spring. Saffron is commonly used in cookery, but because of its healing properties, crocus is also used in medicine for improving blood circulation, treating the cardiovascular diseases, preventing tumour and healing skin diseases. This research aimed to determine the influence of solvents (water, ethanol and acetone) on antioxidative, antimicrobial activity and the content of biologically important compounds, such as phenols and flavonoids in saffron. FRAP and DPPH methods were used to examine antioxidative activity. Antibacterial activity was analysed by using diffusion technique on bacterial strains of Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Bacillus subtilis, Listeria monocytogenes, and Pseudomonas aeruginosa. Antifungal activity was examined on Candida albicans. The results showed that the ethanol extracts have the highest antioxidant activity and the aqueous extracts have the lowest one. None of the tested extracts showed antibacterial activity, but aqueous extracts and ethanolic extract of saffron, obtained by maceration, showed antifungal activity.

scholarly journals IDENTIFICATION AND MOLECULAR CHARACTERIZATION OF BACTERIA HAVING ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY

2016 ◽  
Vol 8 (10) ◽  
pp. 111
Author(s):  
Garima Sharma ◽  
Shweta Dang ◽  
Sanjay Gupta ◽  
Reema Gabrani
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Micrococcus Luteus ◽  
Antibiofilm Activity ◽  
Potential Candidate ◽  
Indicator Organisms ◽  
Sequencing Data ◽  
Bacterial Strains ◽  
Rdna Sequencing ◽  
Animal Farm

<p><strong>Objective:</strong> The aim of the current study was to isolate and identify the bacteriocinogenic strain exhibiting broad range antimicrobial activity and antibiofilm activity from soil of animal farms.</p><p><strong>Methods:</strong> In the current study, bacterial strains were isolated from soil of twelve different regions of animal farm all over India and screened for antimicrobial activity against<em> Staphylococcus epidermidis</em>, <em>Micrococcus luteus, Pseudomonas fluorescence</em> and <em>Escherichia coli.</em> Antibiofilm ability of these selected strains was checked on preformed biofilm of <em>S. epidermidis </em>and in addition biofilm disruption potential was also determined. The potent bacterial strain was identified at molecular level by 16S ribosomal DNA (rDNA) sequencing.<strong></strong></p><p><strong>Results: </strong>30 out of<strong> </strong>231 strains isolated from soil were selected on the basis of antibacterial activity against <em>S. epidermidis.</em> One potential candidate (GAS 101) exhibited ≥99% inhibition against <em>S. epidermidis</em>, <em>M. luteus, P. fluorescence</em> and <em>E. coli</em> and also showed antibiofilm activity. GAS 101 16S rDNA sequencing data identified it as <em>Bacillus subtilis.</em> The sequence of <em>B. subtilis </em>was submitted to genbank under accession no. KJ564301.</p><p><strong>Conclusion:</strong> <em>B. subtilis</em> GAS 101 isolated from soil of animal farm showed the antibacterial activity against all indicator organisms and also displayed antibiofilm activity against preformed biofilm and inhibited biofilm formation of <em>S. epidermidis</em>.</p>

scholarly journals Chemical Composition and Antibacterial Activity of the Essential Oils of Blainvillea Rhomboidea (Asteraceae)

2006 ◽  
Vol 1 (5) ◽  
pp. 1934578X0600100
Author(s):  
Andreza Maria L. Pires ◽  
Maria Rose Jane R. Albuquerque ◽  
Edson P. Nunes ◽  
Vânia M. M. Melo ◽  
Edilberto R. Silveira ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Caryophyllene Oxide ◽  
Bacterial Strains ◽  
Aerial Parts ◽  
Leaf Oil

The essential oils of Blainvellea rhomboidea (Asteraceae) were obtained by hydrodistillation and analyzed by GC/MS and GC/FID. Initially, the essential oil from the aerial parts was investigated. From the 18 identified components, 5-indanol (14.5%) followed by p-cymen-8-ol (10.1%), β-caryophyllene (9.6%), caryophyllene oxide (9.6%), limonene (8.6%), terpinolene (7.8%), and spathulenol (7.7%) were the major constituents. The oil was tested against seven bacterial strains and the results showed significant antimicrobial activity. As a consequence, the essential oils from leaves and from flowers were analyzed separately. The major constituents of the leaf oil were terpinolene (21.2%), β-caryophyllene (19.2%), spathulenol (9.1%), caryophyllene oxide (7.4%), and bicyclogermacrene (7.1%), while the oil of the flowers contained terpinolene (28.1%), 5-indanol (16.3%), p-cymen-8-ol (15.3%) and limonene (14.7%) as prevalent compounds. The oils were tested against the same bacterial strains and the flower oil was the more active. These results indicated that the components of the essential oil from flowers seem to be responsible for the activity.

scholarly journals Bioactivity of Isostructural Hydrogen Bonding Frameworks Built from Pipemidic Acid Metal Complexes

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2374
Author(s):  
Paula C. Alves ◽  
Patrícia Rijo ◽  
Catarina Bravo ◽  
Alexandra M. M. Antunes ◽  
Vânia André
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Drug Resistance ◽  
Antibacterial Activity ◽  
Hydrogen Bonding ◽  
Three Dimensional ◽  
Artemia Salina ◽  
Gram Negative Bacteria ◽  
Pipemidic Acid ◽  
Gram Negative

We report herein three novel complexes whose design was based on the approach that consists of combining commercially available antibiotics with metals to attain different physicochemical properties and promote antimicrobial activity. Thus, new isostructural three-dimensional (3D) hydrogen bonding frameworks of pipemidic acid with manganese (II), zinc (II) and calcium (II) have been synthesised by mechanochemistry and are stable under shelf conditions. Notably, the antimicrobial activity of the compounds is maintained or even increased; in particular, the activity of the complexes is augmented against Escherichia coli, a representative of Gram-negative bacteria that have emerged as a major concern in drug resistance. Moreover, the synthesised compounds display similar general toxicity (Artemia salina model) levels to the original antibiotic, pipemidic acid. The increased antibacterial activity of the synthesised compounds, together with their appropriate toxicity levels, are promising outcomes.

Address of the President Lord Blackett, O.M., C.H. at the Anniversary Meeting, 30 November 1970

1971 ◽  
Vol 321 (1544) ◽  
pp. 1-14
Keyword(s):  
Natural Products ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Biological Systems ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Theoretical Knowledge ◽  
Three Dimensional Structure ◽  
Subsequent Determination

The Copley Medal is awarded to Lord Todd, F. R. S. Todd has made highly significant contributions to the chemistry of natural products, in particular in relation to compounds which play important roles in biological systems. His researches on vitamins B 1 , E and B 12 were most elegant and have had far-reaching implications, but none more so than his structural and synthetic studies in the nucleic acid field. Here he developed methods for the synthesis of the nucleosides and for their phosphorylation; his work on the way they are combined made possible the subsequent determination of the three-dimensional structure of the nucleic acids thereby providing the basis for much of the exciting activity in the nucleotide field today. Todd’s achievements arise out of a rare combination of theoretical knowledge and outstanding experimental skill, with the most judicious exploitation of modern techniques. His work and his quality as an investigator have been widely recognized by biologists as well as by organic chemists.

scholarly journals COUROUPITA GUIANENSIS LEAF CALLUS EXTRACT MEDIATED SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SILVER NANOPARTICLES.

2017 ◽  
Vol 10 (5) ◽  
pp. 126
Author(s):  
Jsr Murthy ◽  
Venkata Kumar T ◽  
Narayana Rao V
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Cell Surface ◽  
Size Variation ◽  
Silver Ions ◽  
Bacterial Strains ◽  
Couroupita Guianensis ◽  
Spectral Peaks ◽  
Characteristic Maximum

Objective: Synthesis of varied sized and morphologically distinct silver nanoparticles (AgNPs) using callus/callus extract, and their promising antibacterial and cytotoxicity was reported from very few plant systems. Here, we investigated silver nanoparticle synthetic potential of Couroupita guianensis leaf callus extract and their antibacterial activity.Methods: synthesis of callus mediated silver nanoparticles and characterisation of physical, chemical, and antibacterial activity of AgNPs.Results: Callus extract rapidly reduced silver ions and stabilized nanoparticles have displayed characteristic maximum UV absorbance at 410 nm. SEM and AFM images revealed their spherical morphology and size variation, which is ranged from 30.38 nm to 88.32 nm and were in small aggregates. Capping of AgNPs by the phenolic compounds and proteins revealed from FTIR spectral peaks. Silver nanoparticles displayed significantly high antimicrobial activity against both Gram positive and negative bacterial strains compared to silver ions and gentamicin. This enhanced antimicrobial activity of AgNPs may due their small size leading to efficient molecular contact with cell surface, and uptake and interaction with vital biomolecules.Conclusions: Stable AgNPs were synthesized through reduction and capping of silver ions by polyphenols and proteins present in callus extract. Theenhanced antimicrobial activity of AgNPs may due to their small size leading to efficient molecular contact with the cell surface, penetration, andinteraction, and inactivation of vital biomolecules.KEY WORDS: Couroupita guianensis, callus extract, Silver nanoparticles (AgNPs), antibacterial activity

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