scholarly journals Beehive Products as Antibacterial Agents: A Review

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 717
Author(s):  
Rita Abou Nader ◽  
Rawan Mackieh ◽  
Rim Wehbe ◽  
Dany El El Obeid ◽  
Jean Marc Sabatier ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Honey Bee ◽  
Antibacterial Agents ◽  
Royal Jelly ◽  
Biological Activities ◽  
Vital Role ◽  
Bee Venom ◽  
Bacterial Strains ◽  
Wide Range ◽  
Life Threatening

Honeybees are one of the most marvelous and economically beneficial insects. As pollinators, they play a vital role in every aspect of the ecosystem. Beehive products have been used for thousands of years in many cultures for the treatment of various diseases. Their healing properties have been documented in many religious texts like the Noble Quran and the Holy Bible. Honey, bee venom, propolis, pollen and royal jelly all demonstrated a richness in their bioactive compounds which make them effective against a variety of bacterial strains. Furthermore, many studies showed that honey and bee venom work as powerful antibacterial agents against a wide range of bacteria including life-threatening bacteria. Several reports documented the biological activities of honeybee products but none of them emphasized on the antibacterial activity of all beehive products. Therefore, this review aims to highlight the antibacterial activity of honey, bee venom, propolis, pollen and royal jelly, that are produced by honeybees.

scholarly journals Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections

Toxins ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 511 ◽  
Author(s):  
Bruno Casciaro ◽  
Andrea Calcaterra ◽  
Floriana Cappiello ◽  
Mattia Mori ◽  
Maria Loffredo ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Biological Activities ◽  
Human Keratinocytes ◽  
Chemical Diversity ◽  
Bioactive Molecules ◽  
Bacterial Strains ◽  
Wide Range

Staphylococcus aureus is a major human pathogen causing a wide range of nosocomial infections including pulmonary, urinary, and skin infections. Notably, the emergence of bacterial strains resistant to conventional antibiotics has prompted researchers to find new compounds capable of killing these pathogens. Nature is undoubtedly an invaluable source of bioactive molecules characterized by an ample chemical diversity. They can act as unique platform providing new scaffolds for further chemical modifications in order to obtain compounds with optimized biological activity. A class of natural compounds with a variety of biological activities is represented by alkaloids, important secondary metabolites produced by a large number of organisms including bacteria, fungi, plants, and animals. In this work, starting from the screening of 39 alkaloids retrieved from a unique in-house library, we identified a heterodimer β-carboline alkaloid, nigritanine, with a potent anti-Staphylococcus action. Nigritanine, isolated from Strychnos nigritana, was characterized for its antimicrobial activity against a reference and three clinical isolates of S. aureus. Its potential cytotoxicity was also evaluated at short and long term against mammalian red blood cells and human keratinocytes, respectively. Nigritanine showed a remarkable antimicrobial activity (minimum inhibitory concentration of 128 µM) without being toxic in vitro to both tested cells. The analysis of the antibacterial activity related to the nigritanine scaffold furnished new insights in the structure–activity relationships (SARs) of β-carboline, confirming that dimerization improves its antibacterial activity. Taking into account these interesting results, nigritanine can be considered as a promising candidate for the development of new antimicrobial molecules for the treatment of S. aureus-induced infections.

scholarly journals Synthesis and antibacterial screening of new N-Substituted-9H-β-carboline 6-amine derivatives

2020 ◽  
Vol 11 (3) ◽  
pp. 4146-4151
Author(s):  
Alivelu Samala ◽  
Srinivasa Murthy M ◽  
Krishna Mohan Gottumukkala
Keyword(s):  
Antibacterial Activity ◽  
Biological Activities ◽  
Vital Role ◽  
Diffusion Method ◽  
Oxidative Decarboxylation ◽  
Maillard Reaction Products ◽  
Reaction Products ◽  
Bacterial Strains ◽  
Antibacterial Screening ◽  
Glyoxalic Acid

β-Carboline is also known as nor-harmane. It is a nitrogen-containing heterocyclic compound formed in plants and animals as Maillard reaction products between amino acids and reducing sugars or aldehydes. These tricyclic nitrogen heterocyclics play a vital role in medicinal chemistry, due to significant biological activities of their derivatives. It is also a key pharmacophore present in a large number of natural tricyclic alkaloids. Current work is reported with the synthesis and antibacterial activity screening of a new series of N-Substituted-9H-β-carboline-6-amine derivatives. The title compounds were synthesized according to the well known Pictet Spengler reaction in three steps by taking 5-Chlorotryptamine and glyoxalic acid as starting materials. This is an acid-catalyzed intramolecular condensation of an iminium ion and an aromatic C-nucleophile which resulted in the formation of 6-Chloro-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-ium-1-carboxylate (3). Oxidative decarboxylation and aromatization of compound 3 with iodobenzene diacetate led to the 6-Chloro-β–carboline (4) which were treated with different mono substituted amines gave the title compounds (5 a-J). Structures of the synthesized entities were confirmed spectroscopically (FT-IR, 1H NMR and Mass) and screened for antibacterial activity against various pathogenic bacterial strains ( Streptococcus pyogenes, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) by disc diffusion method. The title compounds showed moderate to good antibacterial activity.

QSAR analysis of 1,3-diaryl-2-propen-1-ones and their indole analogs for designing potent antibacterial agents

2009 ◽  
Vol 63 (4) ◽  
Author(s):  
Neela Bhatia ◽  
Kakasaheb Mahadik ◽  
Manish Bhatia
Keyword(s):  
Antibacterial Activity ◽  
Elemental Analysis ◽  
Antibacterial Agents ◽  
Structure Optimization ◽  
Antibacterial Activities ◽  
Bacterial Strains ◽  
Lower Toxicity ◽  
Qsar Analysis ◽  
Qsar Studies ◽  
Vlife Mds

AbstractA series of 1,3-diaryl-2-propen-1-ones and their indole analogs were synthesized and evaluated for antibacterial activity. Structures of newly synthesized compounds were confirmed by physicochemical, spectral and elemental analysis. All the compounds were screened for their antibacterial activities against four different bacterial strains. The QSAR studies were performed using Vlife MDS 3.5 software. QSAR equation revealed that selected electronic, steric and lipophilic parameters have good correlation with antibacterial activity. Best equations were selected on basis of the correlation coefficient (r 2) and the predictable ability of the equations. The present findings suggest that the 1,3-diaryl-2-propen-1-ones framework is an attractive template for structure optimization to achieve higher potency, lower toxicity, and a wider spectrum of antibacterial activity.

scholarly journals Apitherapy as a New Approach in Treatment of Palmoplantar Psoriasis

2018 ◽  
Vol 6 (6) ◽  
pp. 1059-1061 ◽  
Author(s):  
Egharid El–Gammal ◽  
Veronica Di Nardo ◽  
Farah Daaboul ◽  
Georgi Tchernev ◽  
Uwe Wollina ◽  
...  
Keyword(s):  
Honey Bee ◽  
Treatment Duration ◽  
Royal Jelly ◽  
Overall Response Rate ◽  
Response Rate ◽  
Aloe Vera ◽  
Bee Venom ◽  
New Approach ◽  
Effective Remedy ◽  
Age Range

BACKGROUND: Apitherapy is the medical use of honey bee products, "honey, propolis, royal jelly, bee wax, and bee venom to relieve human ailments. Propolis is one of the most well-documented products derived from the honeybee and has always played an important role in traditional folk medicine.AIM: The aim was to justify the consideration of Aloe Vera as an effective remedy for the treatment of psoriasis.METHODS: The study follows (857) patients (354 females, 503 males) with a mean age range from (9 - 62) years, affected with moderate to severe psoriasis in palms and foot soles treated by a combination mixture of propolis and Aloe in the form of an ointment (Aloreed) and Beauty reed cream. The treatment duration was for 12 weeks. Results were evaluated by using clinical, histological and statistical parameters.RESULTS: After the 12 - week treatment, we observed an 86% overall response rate from which 62% showed excellent results and 24% showed good results, therefore proving the efficiency in the use of the mixture of propolis 50% and aloe vera 3% as topically applied ointment in the treatment of mild to moderate psoriasisCONCLUSION: Patients who have palmoplantar psoriasis, who were treated with a topically applied mixture of propolis (50%) and aloe vera (3%), have shown noteworthy improvement thus proving the efficiency of propolis and aloe vera in the treatment of mild to moderate psoriasis.

scholarly journals Development of Apis cerana District Extractor with innovation of Machinery and Pest control in Kumelembuai Village

2019 ◽  
Vol 12 (6) ◽  
pp. 147-156
Author(s):  
Joice J.I. Rompas ◽  
Betsy Agustina Naomi Pinaria ◽  
Ventje V. Memah
Keyword(s):  
Honey Bee ◽  
Honey Bees ◽  
Royal Jelly ◽  
Apis Cerana ◽  
Cane Sugar ◽  
Bee Venom ◽  
Good Effect ◽  
North Sulawesi ◽  
The Village

This study aims to: 1). Knowing the development of Apis Cerana Honey BeesF.with extractor engine innovation 2). Control of pests that attack honey bees 3). Obtain products from honeybeesApis Cerana F.produced 4). Predict to what extent the quantity and quality of royal jelly products Apis cerana F.produced in the development of beekeeping in North Sulawesi, especially Kumelembuai Village, South Minahasa Regency. This research is expected to develop beekeeping in North Sulawesi, specifically the local bee Apis cerana in Kumelembuai Village. The benefits obtained from beekeeping development activities include increasing the income and nutritional quality of the community from beekeeping products such as honey, pollen, royal jelly, beeswax, propolis, bee venom. Conservation of natural resources, honey bees play an important role in helping the process of pollinating plants, in addition to beekeeping activities can also increase public awareness to participate in conservation efforts. North Sulawesi, especially in the village of Kumelembuai, can be developed using the methodqueen rearing best because it has bright prospects for cultivation in North Sulawesi. Honey bee cultivation is very profitable, in addition to increasing agricultural production (crop yields) and producing products from beesApis cerana namely honey, royal jelly, tepung sari, propolis, wax, bee venom which can all be utilized for human welfare. A number of studies have been carried out by various parties who feel an interest in the development of beekeeping, but the research conducted is still partial and limited to one or two environmental components, not integrated yet. It is hoped that this research can produce the best methods for developing beekeeping in the North Sulawesi kumelembu village. The research location will be conducted in the village of Kumelembuai, South Minahasa regency, North Sulawesi. Laboratory analysis is focused on the content of royal jelly products produced by honey bees Apis cerana F. Based on the results of data analysis and discussion in this study are as follows. 1. Research of the four methods namely Supersedure, Emergency cell, Miller and Doolittle produce superior methods, namely the method Emergency cell. 2. In the methodemergency cell artificial feeds provide queen cell formation and productionroyal jelly with a composition of 100 grams of sugar and 200 grams of water both cane sugar and palm sugar are higher than other treatments, although not significantly different. 3. Artificial feed with a composition of 200 grams of cane sugar and 200 grams of water gives a good effect on the fat content of royal jelly Apis cerana in the method emergency cell. 4. Product of royal jelly as a result of panelist evaluationin this study showed that the preferred odor was not pungent, slightly acidic and sticky taste on the tongue and the white color of the product of royal jelly honey bee Apis cerana

scholarly journals STUDY CYTOTOXICITY, ANTIBACTERIAL ACTIVITY, AND COMPOSITIONS BY FT-IR AND GC-MS FOR ORGANIC EXTRACT OF WHITE IRAQI DESERT TRUFFLE TIRMANIA NIVEA

2020 ◽  
Vol 17 (36) ◽  
pp. 18-31
Author(s):  
Ahmad khadem HACHIM ◽  
Rashid Rahim HATEET ◽  
Tawfik Muhammad MUHSIN
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Cell Line ◽  
Pathogenic Bacteria ◽  
Inhibitory Concentration ◽  
Biological Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Bacterial Strains ◽  
Organic Extract

The purpose of the present work aimed at exploring the potential biochemical components and biological activities of an organic extract of the white truffle Tirmania nivea collected from the Iraqi desert, then test the organic extract against the Cytotoxicity on Human Larynx carcinoma cells and selected strains of pathogenic bacteria. Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectrometry GC/MSS were used to analyze mycochemical compositions. The antibacterial activity and Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) was investigated using a disk diffusion agar method. The truffle extract's cytotoxicity effect against the larynx cell line (Hep-2) was assessed by the MTT assay (in vitro). FTIR results provided the presence of phenol, carboxylic acid, and alkane's functional group, The GC-MS analysis of T. nivea disclose the existence of nineteen compounds that can contribute to the pharmaceutical properties of the truffle. As for antibacterial activity result, A growth inhibition activity of truffle extract at (18-40 mm inhibition zones) against the tested pathogenic bacterial strains was detected, which minimum inhibitory concentration values ranged from 3.12 to 6.25 mg/mL for Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) Respectively. The results of cytotoxicity shown that the organic truffle extract exhibited a high inhibitory rate (52.685%) against cell line (Hep-2) at a concentration of 1.56 ?g/mL. In this work, the results showed that the organic extracts of T. nivea are very promising as cancer cytotoxicity and antibacterial agent for future medical applications.

scholarly journals 1,4-Naphthoquinone Analogues: Potent Antibacterial Agents and Mode of Action Evaluation

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1437 ◽  
Author(s):  
Palanisamy Ravichandiran ◽  
Sunirmal Sheet ◽  
Dhanraj Premnath ◽  
Ae Rhan Kim ◽  
Dong Jin Yoo
Keyword(s):  
Antibacterial Activity ◽  
Mode Of Action ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Annexin V ◽  
Ros Generation ◽  
Redox Potentials ◽  
Bacterial Strains ◽  
E Coli ◽  
New Class

1,4-Naphthoquinones have antibacterial activity and are a promising new class of compound that can be used to treat bacterial infections. The goal was to improve effective antibacterial agents; therefore, we synthesized a new class of naphthoquinone hybrids, which contain phenylamino-phenylthio moieties as significant counterparts. Compound 4 was modified as a substituted aryl amide moiety, which enhanced the antibacterial activity of earlier compounds 3 and 4. In this study, five bacterial strains Staphylococcus aureus (S. aureus), Listeria monocytogenes (L. monocytogenes), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumoniae (K. pneumoniae) were used to evaluate the antibacterial potency of synthesized naphthoquinones using the minimal inhibitory concentration (MIC) method. Most of the studied naphthoquinones demonstrated major antibacterial activity with a MIC of 15.6 µg/mL–500 µg/mL. Selected compounds (5a, 5f and 5x) were studied for the mode of action, using intracellular ROS generation, determination of apoptosis by the Annexin V-FITC/PI assay, a bactericidal kinetic study and in silico molecular modelling. Additionally, the redox potentials of the specified compounds were confirmed by cyclic voltammetry (CV).

scholarly journals Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1487 ◽  
Author(s):  
Tímea Mosolygó ◽  
Annamária Kincses ◽  
Andrea Csonka ◽  
Ádám Szabó Tönki ◽  
Karolina Witek ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Multidrug Resistance ◽  
Carbonyl Compounds ◽  
Antibacterial Agents ◽  
Inhibitory Concentration ◽  
Efflux Pump ◽  
Attractive Potential ◽  
Bacterial Strains ◽  
Gram Positive Bacteria ◽  
Efflux Pump Inhibitors

Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials. In this study, the antibacterial and multidrug resistance reversing activity of a series of seleno-carbonyl compounds has been evaluated. The effects of eleven selenocompounds on bacterial growth were evaluated in Staphylococcus aureus, methicillin resistant S. aureus (MRSA), Enterococcus faecalis, Escherichia coli, and Chlamydia trachomatis D. The combination effect of compounds with antibiotics was examined by the minimum inhibitory concentration reduction assay. Their efflux pump (EP) inhibitory properties were assessed using real-time fluorimetry. Relative expressions of EP and quorum-sensing genes were studied by quantitative PCR. Results showed that a methylketone selenoester had remarkable antibacterial activity against Gram-positive bacteria and potentiated the activity of oxacillin in MRSA. Most of the selenocompounds showed significant anti-chlamydial effects. The selenoanhydride and the diselenodiester were active inhibitors of the AcrAB-TolC system. Based on these results it can be concluded that this group of selenocompounds can be attractive potential antibacterials and EP inhibitors. The discovery of new derivatives with a significant antibacterial activity as novel selenocompounds, is of high impact in the fight against resistant pathogens.

3,4-Dihydroisocoumarins, Interesting Natural Products: Isolation, Organic Syntheses and Biological Activities

2019 ◽  
Vol 16 (1) ◽  
pp. 112-129 ◽  
Author(s):  
Aurelio Ortiz ◽  
Miriam Castro ◽  
Estibaliz Sansinenea
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Natural Compounds ◽  
Biologically Active ◽  
Bacterial Strains ◽  
Drug Candidates ◽  
Heterocyclic Molecules ◽  
Naturally Occurring ◽  
Wide Range ◽  
Different Sources

Background:3,4-dihydroisocoumarins are an important small group belonging to the class of naturally occurring lactones isolated from different bacterial strains, molds, lichens, and plants. The structures of these natural compounds show various types of substitution in their basic skeleton and this variability influences deeply their biological activities. These lactones are structural subunits of several natural products and serve as useful intermediates in the synthesis of different heterocyclic molecules, which exhibit a wide range of biological activities, such as anti-inflammatory, antiplasmodial, antifungal, antimicrobial, antiangiogenic and antitumoral activities, among others. Their syntheses have attracted attention of many researchers reporting many synthetic strategies to achieve 3,4-dihydroisocoumarins and other related structures. </P><P> Objective: In this context, the isolation of these natural compounds from different sources, their syntheses and biological activities are reviewed, adding the most recent advances and related developments.Conclusion:This review aims to encourage further work on the isolation and synthesis of this class of natural products. It would be beneficial for synthetic as well as the medicinal chemists to design selective, optimized dihydroisocoumarin derivatives as potential drug candidates, since dihydroisocoumarin scaffolds have significant utility in the development of therapeutically relevant and biologically active compounds.

The prediction of the spectrum of biological activity and antimicrobial properties of diaminoazoles

2019 ◽  
Vol 65 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Yu.V. Butina ◽  
T.V. Kudayarova ◽  
E.A. Danilova ◽  
M.K. Islyaikin
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Wide Range ◽  
Alternative Drugs

The work is devoted to predicting and studying biological properties of N-substituted analogs of 3,5-diamino-1,2,4-thiadiazole, which, in their turn, include in the composition of many drugs that exhibit a wide range of pharmacological actions. For searching of new alternative drugs with an antibacterial activity, but lacking resistance of microorganism strains to them, a computer screening of 2N-alkyl-substituted 5-amino-3-imino-1,2,4-thiadiazolines previously synthesized by us was carried out. The prediction of the spectrum of biological activity, as well as the determination of the probable toxicity of these compounds, was performed using the freely available computer programs PASS, Anti-Bac-Pred, and GUSAR. The study of the antibacterial activity in vitro against gram-positive (Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus epidermidis) and gram-negative (Escherichia coli, Pseudomonas aeruginosae) bacterial strains was performed by the disco-diffusion method. Experimental data roughly correspond to the predictions.

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