scholarly journals PERBEDAAN EFEKTIVITAS EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorriza Roxb.) DENGAN EKSTRAK DAUN SALAM (Eugenia polyantha Wight) PADA PENURUNAN KADAR KOLESTEROL TOTAL TIKUS PUTIH JANTAN (Rattus norvegicus)

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Ayu Ulan Rizki ◽  
Cholid Cholid ◽  
Muttia Amalia
Keyword(s):  
Total Cholesterol ◽  
Leaf Extract ◽  
Disease Risk ◽  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
Standard Drug ◽  
Cholesterol Levels ◽  
White Rats ◽  
Ginger Rhizome

Dyslipidemia is a coronary heart disease risk factor. Dyslipidemia is characterized by the elevated levels of LDL, triglycerides, total cholesterol, and the decrease in HDL. Ginger rhizome (Curcuma xanthorriza Roxb.) and bay leaf (Eugenia polyantha Wight.) are local plants that have the abilities to decrease total cholesterol. This research design was true experimental with pre- and post-control group design. Criteria of sample were white rats, wistar strain, male, age of 8-12 weeks, and body weight range of 150-200 grams. Sampling method was simple random sampling. The experimental rats were acclimatized for seven days. Hypercholesterol diet was fed two weeks, and then the rats were given intervention and get hypercholesterol diet for two weeks. During intervention, the experimental rats were divided into 6 groups of administrationi.e, rats administered with 1) carboxymethil celluse/CMC, 2) simvastatin 0,9 mg/kg BW/day, 3) ginger rhizome extract 200 mg /kg BW/day, 4) ginger rhizome extract 400 mg/kg BW/day, 5) bay leaf extract 200 mg/kg BW/day, and 6) bay leaf extract 400 mg/kg BW/day. Blood samples were taken from caudal vein and total cholesterol levels were measured by spectrophotometry. The analysis used paired T test, One Way ANOVA test. The results showed ginger rhizome extract did not effectively reduce total cholesterol. However, bay leaf extract effectively decreased total cholesterol levels with the highest total cholesterol reduction was found in rats administered with dose of 400 mg/kg BW/day i.e, 15.4 mg/dl. Bay leaf extract have the same effectivity with simvastatin as a standard drug in lowering cholesterol level.

scholarly journals PENGARUH PEMBERIAN AIR SEDUHAN BERAS YANG DIFERMENTASI OLEH MONASCUS PURPUREUS (ANGKAK) TERHADAP PENURUNAN KADAR KOLESTEROL SERUM PADA TIKUS PUTIH

Biomedika ◽  
2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Adhimass Wicaksono ◽  
Retno Sintowati ◽  
Sa’idatul Fitriyah
Keyword(s):  
Treatment Group ◽  
Serum Cholesterol ◽  
Brown Rice ◽  
Negative Control ◽  
T Test ◽  
Control Group ◽  
Control Group Design ◽  
Cholesterol Levels ◽  
White Rats ◽  
Group A

The using of plant-based medicine is a popular approach to health care. A study presented by American Hearth Association showing that brown rice can lower cholesterol level in bood serum. To know the benefi ts of Angkak’s steeping water to decrease serum cholesterol levels in mice and determine the effects of Angkak’s steeping water to decrease serum cholesterol levels in rats compared with simvastatin. This study used an experimental research design, and using pre and post test control group design, performed in the laboratory of biomedical III FK UMS on November 1, 2012 to date of January 1, 2013. The purposive sampling technique, sampel determinaton using formula Federer by the number of sample of 30 male white rats wistar strain. After the data is collected, analyzed using the Shapiro-Wilk test, ANOVA, LSD, and the unpaired t test. The result of this study demnstrate hypothesis testing using ANOVA test with signifi cant level 95% of the negative control group, the treatment group a dose of 1, 2, and 3, it was found p<0,05 were signifi cantly different meaning. In the test dose of LSD between treatment groups 2 and 3 the value of p=0,839 (p>0,05) wich means no signifi cant difference. In the unpaired T test between the treatment group a dose of 1, 2, and 3 with positive control group were signifi cant difference. The unpaired T test between the treatment group a dose of 1, 2, and 3 with white rice also found signifi cant difference. Conclusion: Angkak’s steeping water can lower serum cholesterol levels of white rat as well as the water steepimg Angkak has the same effectiveness with simvastatin to decrease serum cholesterol levels of mice.Keyword: Cholesterol, Angkak

scholarly journals EFFECTIVENESS OF LEAF EXTRACT REDUCE INFLAMMATION REACTION IN HYPERCHOLESTEROLEMIA RATS

2017 ◽  
Vol 1 (1) ◽  
pp. 12
Author(s):  
Puguh Santoso ◽  
Ni Nyoman Wahyu Udayani ◽  
I Nyoman Gede Tri Sutrisna ◽  
Ketut Agus Adrianta
Keyword(s):  
Free Radicals ◽  
Leaf Extract ◽  
Oxidized Ldl ◽  
Oxidative Modification ◽  
Blood Cholesterol ◽  
Ldl Oxidation ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Group I

Abstract High blood cholesterol is often called hypercholesterolemia is a risk factor for the emergence of pathological conditions such as heart and blood vessel disease. Hypercholesterolemia has an important role in the occurrence of damage to the endothelial cells is mainly caused by oxidized LDL. Oxidation of LDL triggers the formation of TNF - ?. Leaves messengers that allegedly contains flavonoids can improve the situation of hypercholesterolemia through the barriers specifically the expression of TNF - ? increased due to hypercholesterolemia. Plants messengers known to contain alkaloids, flavonoids, tannins, saponins, polyphenols, calcium oxalate, fats, and essential oil. Flavonoids which has the ability to bind the atom to form free radicals not to excess free radicals, thereby inhibiting the oxidative modification of LDL become ox-LDL so it will not be formed atherosclerosis. This study uses the Randomize pattern Pre and Post Test Control Group Design, using white rats (Rattusnovergicus) with Wistar strain aged 3-4 months, weighing 175-200 grams. Divided into four groups: Group I as a control with placebo, Group II treatment using extracts of ethanol leaves a messenger at a concentration of 10%, Group III treatments using extracts of ethanol leaves a messenger at a concentration of 20%, Group IV is to use the extract ethanol leaves errand at a concentration of 30%. It can be concluded at 4 dose group 30% messengers leaf extract significantly different, p <0.05, so it can be said that the provision of effective messengers extract at a dose of 30%.

ANTI-HYPERCHOLESTEROLEMIA ACTIVITY OF ETHANOL EXTRACT Peperomia pellucida

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
Chasanah Mazroatul
Keyword(s):  
Total Cholesterol ◽  
Ethanol Extract ◽  
Positive Control ◽  
Diet Group ◽  
In Vivo Studies ◽  
Control Group ◽  
Antioxidant Compounds ◽  
Control Group Design ◽  
White Rats

<p>Hypercholesterolemia is a major cause of cardiovascular disease such as coronary heart disease. Betel water (Peperomia pellucida) is a type of plants that have antioxidant compounds that could delay, retard and prevent the oxidation of lipids, both enzymatic and non-enzymatic. This study aimed to determine the effect of ethanol extract Peperomia pellucida against total cholesterol, HDL, LDL, and triglycerides in the serum of white rats (Wistar) were given a diet aterogenetik, so it can be used as prevention of atherosclerosis. The active compounds contained in the water after screnning betel phytochemicals includes flavonoids, tannins, alkaloids, steroids and quinones. In vivo studies conducted by true experimental method with pre and post test with control group design. Rats were divided into 3 groups: group A positive control is given aterogenetik diet, group B and C were given diet Peperomia Pellucida aterogenetik and extract orally at a dose of 150 mg/kg and 300 mg/kg. Diet aterogenetik given as much as 20 grams per day for 14 days. Data obtained include total cholesterol, HDL, LDL, and triglycerides were analyzed by statistical methods Paired T Test oneway ANOVA (P &lt; 0,05). The study of total cholesterol, HDL, LDL and triglycerides showed ethanol extract of Peperomia pellucida at a dose of 300 mg/kg body weight can lower total cholesterol and LDL significantly, but there was no significant decline in triglycerides and can increase HDL levels.</p>

scholarly journals RED ROSELLA TEA AND AVOCADO AS SIMVASTATIN THERAPY SUPPORT REDUCE TOTAL CHOLESTEROL

Jurnal NERS ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 113
Author(s):  
Budi Artini ◽  
Elyana Asnar ◽  
Ika Yuni Widyawati
Keyword(s):  
Total Cholesterol ◽  
Health Workers ◽  
Total Cholesterol Level ◽  
Control Group ◽  
Control Group Design ◽  
Simvastatin Therapy ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Before And After ◽  
Quasi Experimental

Introduction: Hypercholesterolemia is a condition characterized by high levels of total cholesterol in the blood. Many studies have proven that steeping tea rosella and flesh of an avocado can reduce total cholesterol levels. This study was conducted to determine the effectiveness of therapy companion rosella tea and  avocado in lowering total cholesterol levels in hypercholesterolemia clients. Method: This type of research is a quasi-experimental study with pre-post test control group design. The population study was a client with hypercholesterolemia in the working area of menganti health centers. First sample group consisted of nine respondents received the drug Simvastatin 10 mg and rosella tea consumed as much as 2 g 1x / day. The second group consisted of nine respondents received the drug Simvastatin 10 mg and avocado meat weighing 330 grams were consumed 1x / day. The control group consisted of 11 respondents have a drug Simvastatin 10 mg oral 1x daily at night before bed. All groups examined total cholesterol levels before treatment and after treatment on day 15. Result: The results of one-way ANOVA test showed a significant difference between before and after treatment in the first group (p=0,001) and second group (p= 0,005), and there is no significant difference before and after treatment in the control group (p= 0,248). The difference between the three groups showed p= 0.025. Conclusion: The conclusion of this study is giving rosella tea and avocado has the same effectiveness in lowering total cholesterol levels so that health workers can suggest the use of rosella tea and avocado as a companion therapy to reduce total cholesterol level.

scholarly journals Effect of Jati Belanda Leaves Extract on Myeloperoxidase Level in Wistar Rat's Lung Induced Contusion Pulmonum

2019 ◽  
Vol 5 (3) ◽  
pp. 116-120
Author(s):  
Nia Savitri Tamzil ◽  
Evi Lusiana ◽  
Desi Oktariana
Keyword(s):  
Leaf Extract ◽  
Positive Control ◽  
Lung Damage ◽  
Control Group ◽  
Alveolar Cells ◽  
Pulmonary Tissue ◽  
Control Group Design ◽  
White Rats ◽  
Guazuma Ulmifolia

Pulmonary contusions are injuries to the lung parenchyma that often result from blunt trauma to the chest wall. This injury will activate the inflammatory response which can produce the effects of oxidative stress so that eventually lung damage occurs. Several studies have identified the effects of Jati Belanda leaves extracts related to the inflammatory process and their effects as antioxidants. This research is an in vivo experimental study with a prepost-test with control group design approach that aims to determine the effectiveness of the extracts of Jati Belanda (Guazuma ulmifolia) in its protection against pulmonary alveolar cells by pretreatment pulmonary contusions. The subjects of this study were white rats (Rattus norvegicus) Wistar strain which were divided into 5 groups namely positive control, negative control, Dutch teak leaf extract 125 mg / kgBB, 250 mg / kgBB and 500 mg / kgBW. Rats were induced by dropping a weight of 400 grams as high as 50 cm. The results of the study of Jati Belanda Leaf Extract (EDJB) all doses and positive control can significantly reduce levels of myeloperoxidase expression (p &lt;0.05). Therefore, it can be concluded that the extracts of Jati Belanda leaves (Guazuma ulmifolia) are all effective doses in reducing the expression of myeloperoxidase in pulmonary tissue of Wistar rats induced by pulmonary contusions.

scholarly journals ANTI-HYPERCHOLESTEROLEMIA ACTIVITY OF ETHANOL EXTRACT Peperomia pellucid

2016 ◽  
Vol 12 (1) ◽  
pp. 88 ◽  
Author(s):  
Chasanah Mazroatul ◽  
Glar Donia Deni ◽  
Nur Ahmad Habibi ◽  
Gita Febri Saputri
Keyword(s):  
Total Cholesterol ◽  
Ethanol Extract ◽  
Positive Control ◽  
Diet Group ◽  
In Vivo Studies ◽  
Control Group ◽  
Antioxidant Compounds ◽  
Control Group Design ◽  
White Rats

Hypercholesterolemia is a major cause of cardiovascular disease such as coronary heart disease. Betel water (Peperomia pellucida) is a type of plants that have antioxidant compounds that could delay, retard and prevent the oxidation of lipids, both enzymatic and non-enzymatic. This study aimed to determine the effect of ethanol extract Peperomia pellucida against total cholesterol, HDL, LDL, and triglycerides in the serum of white rats (Wistar) were given a diet aterogenetik, so it can be used as prevention of atherosclerosis. The active compounds contained in the water after screnning betel phytochemicals includes flavonoids, tannins, alkaloids, steroids and quinones. In vivo studies conducted by true experimental method with pre and post test with control group design. Rats were divided into 3 groups: group A positive control is given aterogenetik diet, group B and C were given diet Peperomia Pellucida aterogenetik and extract orally at a dose of 150 mg/kg and 300 mg/kg. Diet aterogenetik given as much as 20 grams per day for 14 days. Data obtained include total cholesterol, HDL, LDL, and triglycerides were analyzed by statistical methods Paired T Test oneway ANOVA (P &lt; 0.05). The study of total cholesterol, HDL, LDL and triglycerides showed ethanol extract of Peperomia pellucida at a dose of 300 mg/kg body weight can lower total cholesterol and LDL significantly, but there was no significant decline in triglycerides and can increase HDL levels.

scholarly journals PERBEDAAN KADAR KOLESTEROL LDL DARAH TIKUS SPRAGUE DAWLEY PADA PEMBERIAN KOPI FILTER DAN TANPA FILTER

2012 ◽  
Vol 1 (1) ◽  
pp. 72-77
Author(s):  
Raysa Tanjung Sari ◽  
Niken Puruhita
Keyword(s):  
Ldl Cholesterol ◽  
Simple Random Sampling ◽  
Control Group ◽  
Chlorogenic Acids ◽  
Sprague Dawley ◽  
Control Group Design ◽  
Cholesterol Levels ◽  
Sprague Dawley Rats ◽  
Significant Difference ◽  
Filtered Coffee

Background : Coffee contains cafestol and kahweol which can increase LDL cholesterol levels. Effect of cafestol and kahweol with chlorogenic acids are antagonist in coffee. Chlorogenic acids is strong antioxidant in coffee. Unfiltered coffee contains more chlorogenic acids and cafestol than filtered coffee. The study aims to determine the differences of LDL cholesterol levels of Sprague Dawley rats in giving filtered and unfiltered coffee. Methods : a laboratory experimental study, with randomized pre-post test control group design, with a simple random sampling to 28 Sprague Dawley rats were divided into 3 groups. The first treatment was given unfiltered coffee 4x2.7 ml, the second treatment was given filtered coffee 4x2.7 ml and the control was given water 4x2.7 ml for 28 days. LDL cholesterol levels were determined by the homogenous enzyme method. Data were analyzed by paired t-test and Oneway ANOVA test at 95% confident level. Results : Changes levels of LDL cholesterol in filtered coffee (0.85 mg/dl) are higher than unfiltered coffee (0.15 mg/dl). However statistical test shows there is no significant difference of LDL cholesterol in filtered and unfiltered coffee (p>0.05). Conclusion : There is no significant difference of LDL cholesterol levels of Sprague Dawley rats in filtered and unfiltered coffee.

scholarly journals Anti-hypercholesterolemic effect of Zingiber montanum extract

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1798
Author(s):  
Swandari Paramita ◽  
Meiliati Aminyoto ◽  
Sjarif Ismail ◽  
Enos Tangke Arung
Keyword(s):  
Total Cholesterol ◽  
High Fat Diet ◽  
Diet Group ◽  
High Density Lipoproteins ◽  
Control Group ◽  
High Cholesterol ◽  
High Fat ◽  
Cholesterol Levels ◽  
White Rats ◽  
Diet Control

Background: Hypercholesterolemia, high cholesterol levels in the blood, can contribute to many forms of disease, most notably cardiovascular disease. Anti-hypercholesterolemic agents generally used for those conditions have several side effects for patients. Zingiber montanum, known locally as “bangle”, belongs to the family Zingiberaceae and is a potential plants for alternative anti-hypercholesterolemic agents. This plant, from East Kalimantan, is used in traditional medicine for health problems caused by high cholesterol levels. The aim of this research was to find alternatives to anti-hypercholesterolemic agents, especially from natural sources. Methods: This study was an experimental study using 30 Wistar male white rats. Subjects were randomly divided into 6 groups (n=5): (1) normal control group; (2) high fat diet control group; (3) high fat diet with simvastatin; (4-6) high fat diet with Zingiber montanum extracts 100, 200, and 400 mg/kg. After 4 weeks of treatment, blood was collected from all groups, and plasma concentrations of triglycerides, total cholesterol, high density lipoproteins (HDL), and low density lipoproteins (LDL) were measured. Results: The results showed significant differences in total cholesterol (p=0.000), LDL (p=0.000) and triglycerides (p=0.001) in the high-fat diet group with Z. montanum extract, as compared to the high-fat diet control. Meanwhile, there were no significant differences in HDL levels (p=0.830) between the high-fat diet group and other groups. The results also showed significant differences in total cholesterol and LDLs for rats treated with Z. montanum extract, 100 mg/kg (p=0.000), 200 mg/kg (p=0.000), and 400 mg/kg (p=0.000) compared to the high-fat diet group. The result of Z. montanum 400 mg/kg also showed a significant reduction, not only for total cholesterol and LDLs, but also for triglycerides (p=0.030). Conclusion: It could be concluded that Z. montanum extracts have the potency to be further developed as a new natural source of the anti-hypercholesterolemic agents.

scholarly journals THE EFFECT OF GIVING BENGKOANG JUICE (PACHYRRHIZUS EROSUS) ON BLOOD CHOLESTEROL LEVELS AND COMFORT COMPLAINTS TO MENOPAUSE WOMEN IN BENGKULU CITY

2020 ◽  
Vol 9 (1) ◽  
pp. 37-44
Author(s):  
Kurnia Dewiani
Keyword(s):  
Sampling Technique ◽  
Simple Random Sampling ◽  
Study Groups ◽  
Statistical Testing ◽  
Blood Cholesterol ◽  
Control Group ◽  
P Value ◽  
Menopausal Syndrome ◽  
Control Group Design ◽  
Cholesterol Levels

Most of the women have been experienced with menopausal syndrome 70-80 %. Estrogen and progesterone hormones activity decrease which the result of the cessation of menstruation followed by various physical and psychological changes. Blood cholesterol levels and complaints of discomfort are the effects of pre and menopause. Reducing the effect of menopause could be done with non-pharmacologically by utilizing natural materials that are easily available, cheap and minimal negative side effects, namely by consuming Bengkoang juice regularly for 21 days. This research aims to recognize the effect of giving Bengkoang juice by cholesterol levels and complaints of discomfort during menopause This research was a quasi-experimental pre-posttest with control group design. 30 pre and menopausal women participated in their resident of Tanah Patah Village, Bengkulu City with a purposive sampling technique was divided into two groups by simple random sampling. Each group was consisting of 15 women for treatment (Bengkoang juice) and control (soy milk). Assessment of cholesterol levels through an examination used a stick of cholesterol (easy touch), complaints used the questionnaire complaints, and respondents' compliance used the observation sheet. Statistical testing was applied paired T-Test analysis to see differences in cholesterol levels and complaints of discomfort between the two study groups with the significance of the test results based on p <0.05. The results present a decrease in cholesterol levels and complaints in both groups with a p-value <0.05. Furthermore, in terms of decreased levels of cholesterol (33%) and complaints (45%) were higher than the control group namely cholesterol levels (11%) and complaints ( 21%). This research concluded that the effect of Bengkoang juice on cholesterol levels and complaints of discomfort during menopause is confirmed.

scholarly journals EFEKTIVITAS TEH HIJAU DAN SARI KACANG HIJAU DALAM MENURUNKAN KADAR KOLESTEROL TOTAL PADA PENGGUNA KONTRASEPSI SUNTIK PROGESTIN

2021 ◽  
Vol 7 (3) ◽  
pp. 376-382
Author(s):  
Fazdria Fazdria
Keyword(s):  
Family Planning ◽  
Total Cholesterol ◽  
Green Tea ◽  
Mung Bean ◽  
Total Cholesterol Level ◽  
Green Bean ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Cholesterol Levels

 Background: Hypercholesterolemia is a condition of increasing total cholesterol level ≥ 200 mg / dl and has a close relationship with the severity of atherosclerosis or the emergence of heart disease in the blood vessels which is one of the factors in the occurrence of heart and cardiovascular disease. Hypercholesterolemia can be overcome by consuming green tea and green bean juice. This study was conducted to determine the effect of green tea and green bean extract in reducing cholesterol levels in DMPA family planning users.Purpose: To determine the effect of green tea and green bean extract on total cholesterol levels in DMPA family planning acceptorsMethods: The design of this study was a quasi-experimental study with a pretest-posttest control group design approach, namely data collection was carried out before and after treatment. The research subjects were 24 DMPA family planning users according to the inclusion criteria and grouped into 4 groups (control, green tea, green bean extract and a combination of green tea and green bean extract).Results: There was a difference in mean cholesterol levels between pretest and posttest in the mung bean extract group from 252 mg/dl decreased to 179.83 mg/dl and the combination of green tea and mung bean juice decreased from 259.17 mg/dl decreased to 212.33 mg/dl. However, there was no significant mean difference between pretest and posttest cholesterol levels in the control group and the green tea treatment groupConclusion: Green tea and green bean juice consumed separately can reduce cholesterol levels in DMPA family planning acceptorsSuggestion Further research is needed to control confounding factors such as daily diet. Keywords: DMPA, cholesterol, green beans, green tea ABSTRAK Latar Belakang : Hiperkolesterolemia merupakan suatu keadaan peningkatan kadar kolesterol total ≥ 200 mg/dl dan mempunyai hubungan yang erat dengan keparahan aterosklerosis atau timbulnya panyakit jantung di saluran pembuluh darah yang menjadi salah saru faktor terjadinya penyakit jantung dan kardiovaskuler. Hypercholesterolemia bisa diatasi dengan mengkonsumsi teh hijau dan sari kacang hijau. Penelitian ini dilakukan untuk mengetahui pengaruh teh hijau dan sari kacang hijau dalam menurunkan kadar kolesterol pada pengguna KB DMPA.Tujuan : Untuk mengetahui pengaruh teh hijau dan sari kacang hijau terhadap kadar kolesterol total pada akseptor KB DMPAMetode : Rancangan penelitian ini adalah quasi eksperimen dengan pendekatan pretest posttest control group design yaitu pengumpulan data dilakukan sebelum dan sesudah perlakuan. Subjek penelitian adalah pengguna KB DMPA sesuai kriteria inklusi yang berjumlah 24 orang dan dikelompokkan dalam 4 kelompok (kontrol, teh hijau, sari kacang hijau dan kombinasi teh hijau dan sari kacang hijau).Hasil : Terdapat perbedaan rerata kadar kolesterol antara pretest dan posttest pada kelompok sari kacang hijau dari 252 mg/dl turun menjadi 179.83 mg/dl  dan kombinasi teh hijau dan sari kacang hijau turun dari 259.17 mg/dl turun menjadi 212.33 mg/dl. Namun tidak ada perbedaan rerata yang signifikan kadar kolesterol pretest dan posttest pada kelompok kontrol dan kelompok perlakuan teh hijau.Kesimpulan : Teh hijau dan sari kacang hijau yang dikonsumsi secara terpisah mampu menurunkan kadar kolesterol pada ibu akseptor KB DMPA.Saran Perlu dilakukan penelitian lanjutan dengan mengontrol faktor perancu seperti pola makan sehari-hari. Kata Kunci : KB DMPA, Kolesterol, Kacang hijau, Teh Hijau

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