scholarly journals Insights Into Translatomics in the Nervous System

2020 ◽  
Vol 11 ◽  
Author(s):  
Shuxia Zhang ◽  
Yeru Chen ◽  
Yongjie Wang ◽  
Piao Zhang ◽  
Gang Chen ◽  
...  
Keyword(s):  
Nervous System ◽  
Fragile X ◽  
Neurological Diseases ◽  
Chain Complex ◽  
Proteomic Profiling ◽  
Translation Process ◽  
Protein Levels ◽  
Proteomics Approach ◽  
Nascent Chain ◽  
Translational Process

Most neurological disorders are caused by abnormal gene translation. Generally, dysregulation of elements involved in the translational process disrupts homeostasis in neurons and neuroglia. Better understanding of how the gene translation process occurs requires detailed analysis of transcriptomic and proteomic profile data. However, a lack of strictly direct correlations between mRNA and protein levels limits translational investigation by combining transcriptomic and proteomic profiling. The much better correlation between proteins and translated mRNAs than total mRNAs in abundance and insufficiently sensitive proteomics approach promote the requirement of advances in translatomics technology. Translatomics which capture and sequence the mRNAs associated with ribosomes has been effective in identifying translational changes by genetics or projections, ribosome stalling, local translation, and transcript isoforms in the nervous system. Here, we place emphasis on the main three translatomics methods currently used to profile mRNAs attached to ribosome-nascent chain complex (RNC-mRNA). Their prominent applications in neurological diseases including glioma, neuropathic pain, depression, fragile X syndrome (FXS), neurodegenerative disorders are outlined. The content reviewed here expands our understanding on the contributions of aberrant translation to neurological disease development.

scholarly journals CXCL13 levels are more increased in cerebrospinal fluid and plasma of patients with acute infectious than in non-infectious diseases of the central nervous system

2017 ◽  
Vol 25 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Brîndușa Țilea ◽  
Septimiu Voidăzan ◽  
Rodica Bălașa ◽  
Adina Huțanu ◽  
Andrea Fodor
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Infectious Diseases ◽  
Cell Count ◽  
Plasma Levels ◽  
Neurological Diseases ◽  
Protein Levels ◽  
Median Plasma ◽  
The Central Nervous System ◽  
Elisa Technique

Abstract Background: During the acute inflammatory process, the CXCL13 chemokine plays an important role in B cell recruitment within the central nervous system (CNS). Objective: The objective of the study consisted of the evaluation of CXCL13 chemokine cerebral spinal fluid (CSF) and plasma levels in patients with acute infectious and non-infectious neurological diseases correlated with pleocytosis and CSF protein levels. Material and method: This retrospective study was conducted over one year and included 72 patients. Thirty-eight patients (52.8%) suffering from infectious neurological disease, acute viral and bacterial meningitis, meningoencephalitis, and 34 patients (44.2%) diagnosed with non-infectious neurological diseases. CXCL13 chemokine CSF and plasma levels were determined through the ELISA technique with the Human CXCL13/BLC/BCA-1 kit. CSF cell count, glucose and protein levels, along with anti-Borrelia burgdorferi antibodies were monitored using the ELISA technique. Results: CXCL13 chemokine levels in the CSF of patients with acute infectious neurological diseases showed a median value of 23.07 pg/mL, which was significantly higher in comparison with the median value of 11.5 pg/mL of patients with noninfectious neurological diseases (p-0.03). CXCL13 median plasma concentration in patients with infectious neurological diseases was 108.1 pg/mL, in comparison with the second patient category, 50.7 pg/ml (p-0.001). We observed a statistically significant association between CXCL13 concentrations, CSF cell count and proteins. The higher the CXCL13 chemokine level, the more increased the cell count was. Conclusions: CXCL13 levels in the CSF was significantly increased in patients with acute infectious neurological diseases compared with patients with non-infectious diseases. Moreover, CXCL13 chemokine concentration was significantly correlated with the number of cells and proteins in the CSF of patients suffering from neuroinfections.

Mills' syndrome. A clinical case of a rare degenerative pathology of the central nervous system

2020 ◽  
pp. 57-60
Author(s):  
Konstantin Gulyabin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurological Diseases ◽  
Cortical Atrophy ◽  
Primary Lateral Sclerosis ◽  
System A ◽  
The Central Nervous System ◽  
Primary Lateral ◽  
Lateral Sclerosis ◽  
Mills Syndrome

Mills' syndrome is a rare neurological disorder. Its nosological nature is currently not completely determined. Nevertheless, Mills' syndrome is considered to be a rare variant of the degenerative pathology of the central nervous system – a variant of focal cortical atrophy. The true prevalence of this pathology is unknown, since this condition is more often of a syndrome type, observed in the clinical picture of a number of neurological diseases (primary lateral sclerosis, frontotemporal dementia, etc.) and is less common in isolated form.

scholarly journals The role of CPEB family proteins in the nervous system function in the norm and pathology

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eugene Kozlov ◽  
Yulii V. Shidlovskii ◽  
Rudolf Gilmutdinov ◽  
Paul Schedl ◽  
Mariya Zhukova
Keyword(s):  
Nervous System ◽  
Gene Regulation ◽  
Neural Development ◽  
Fragile X ◽  
Autism Spectrum ◽  
Mrna Transport ◽  
Ribonucleoprotein Complexes ◽  
Posttranscriptional Gene Regulation ◽  
Nervous System Function ◽  
Functional Features

AbstractPosttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and mediate poly- and deadenylation of transcripts, activating or repressing protein synthesis. As part of ribonucleoprotein complexes, the CPEB proteins participate in mRNA transport and localization to different sub-cellular compartments. The CPEB proteins are evolutionarily conserved and have similar functions in vertebrates and invertebrates. In the nervous system, the CPEB proteins are involved in cell division, neural development, learning, and memory. Here we consider the functional features of these proteins in the nervous system of phylogenetically distant organisms: Drosophila, a well-studied model, and mammals. Disruption of the CPEB proteins functioning is associated with various pathologies, such as autism spectrum disorder and brain cancer. At the same time, CPEB gene regulation can provide for a recovery of the brain function in patients with fragile X syndrome and Huntington's disease, making the CPEB genes promising targets for gene therapy.

scholarly journals Neonatal Ureaplasma parvum meningitis complicated with subdural hematoma: a case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Canyang Zhan ◽  
Lihua Chen ◽  
Lingling Hu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Subdural Hematoma ◽  
Central Nervous System Infection ◽  
Neonatal Meningitis ◽  
High Morbidity ◽  
Ureaplasma Parvum ◽  
Protein Levels ◽  
Csf Analysis ◽  
Empirical Antibiotics

Abstract Background Neonatal meningitis is a severe infectious disease of the central nervous system with high morbidity and mortality. Ureaplasma parvum is extremely rare in neonatal central nervous system infection. Case presentation We herein report a case of U. parvum meningitis in a full-term neonate who presented with fever and seizure complicated with subdural hematoma. After hematoma evacuation, the seizure disappeared, though the fever remained. Cerebrospinal fluid (CSF) analysis showed inflammation with CSF pleocytosis (1135–1319 leukocytes/μl, mainly lymphocytes), elevated CSF protein levels (1.36–2.259 g/l) and decreased CSF glucose (0.45–1.21 mmol/l). However, no bacterial or viral pathogens in either CSF or blood were detected by routine culture or serology. Additionally, PCR for enteroviruses and herpes simplex virus was negative. Furthermore, the CSF findings did not improve with empirical antibiotics, and the baby experienced repeated fever. Thus, we performed metagenomic next-generation sequencing (mNGS) to identify the etiology of the infection. U. parvum was identified by mNGS in CSF samples and confirmed by culture incubation on mycoplasma identification medium. The patient’s condition improved after treatment with erythromycin for approximately 5 weeks. Conclusions Considering the difficulty of etiological diagnosis in neonatal U. parvum meningitis, mNGS might offer a new strategy for diagnosing neurological infections.

scholarly journals Distribution in the brain and possible neuroprotective effects of intranasally delivered multi-walled carbon nanotubes

2021 ◽  
Author(s):  
Marzia Soligo ◽  
Fausto Maria Felsani ◽  
Tatiana Da Ros ◽  
Susanna Bosi ◽  
Elena Pellizzoni ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Nervous System ◽  
Electrochemical Properties ◽  
Biomedical Applications ◽  
Neurological Diseases ◽  
Neuroprotective Effects ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
The Brain ◽  
Active Investigation

Carbon nanotubes (CNTs) are currently under active investigation for their use in several biomedical applications, especially in neurological diseases and nervous system injury due to their electrochemical properties.

Reclassification of Signs

2018 ◽  
Vol 14 (3) ◽  
pp. 261-273 ◽  
Author(s):  
Hongwei Jia
Keyword(s):  
Nervous System ◽  
Physical World ◽  
Writing System ◽  
Human Language ◽  
Human Communication ◽  
Translation Process ◽  
Text Interpretation ◽  
The Core ◽  
Solid Foundation ◽  
New Research

Abstract Previous semiotic research classified human signs into linguistic signs and non-linguistic signs, with reference to human language and the writing system as the core members of the sign family. However, this classification cannot cover all the types of translation in the broad sense in terms of sign transformation activities. Therefore, it is necessary to reclassify the signs that make meaning into tangible signs and intangible signs based on the medium of the signs. Whereas tangible signs are attached to the outer medium of the physical world, intangible signs are attached to the inner medium of the human cerebral nervous system. The three types of transformation, which are namely from tangible signs into tangible signs, from tangible signs into intangible signs, and from intangible signs into tangible signs, lay a solid foundation for the categorization of sign activities in translation semiotics. Such a reclassification of signs can not only enrich semiotic theories of sign types, human communication, and sign-text interpretation, but also inspire new research on translation types, the translation process, translators’ thinking systems and psychology, and the mechanism of machine translation.

scholarly journals Vesicular dysfunction and pathways to neurodegeneration

2021 ◽  
Author(s):  
Patrick A. Lewis
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Human Brain ◽  
Cell Viability ◽  
Case Studies ◽  
Neurological Diseases ◽  
The Past ◽  
Cellular Events ◽  
The Central Nervous System ◽  
Cellular Control

Abstract Cellular control of vesicle biology and trafficking is critical for cell viability, with disruption of these pathways within the cells of the central nervous system resulting in neurodegeneration and disease. The past two decades have provided important insights into both the genetic and biological links between vesicle trafficking and neurodegeneration. In this essay, the pathways that have emerged as being critical for neuronal survival in the human brain will be discussed – illustrating the diversity of proteins and cellular events with three molecular case studies drawn from different neurological diseases.

scholarly journals Overstimulation of the inhibitory nervous system plays a role in the pathogenesis of neuromuscular and neurological diseases: a novel hypothesis

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1435 ◽  
Author(s):  
Bert Tuk
Keyword(s):  
Nervous System ◽  
Inhibitory Activity ◽  
Neurological Diseases ◽  
Inhibitory System ◽  
Disease Pathogenesis ◽  
Clinical Observations ◽  
Excitatory Activity ◽  
Homeostatic Response

Based upon a thorough review of published clinical observations regarding the inhibitory system, I hypothesize that this system may play a key role in the pathogenesis of a variety of neuromuscular and neurological diseases. Specifically, excitatory overstimulation, which is commonly reported in neuromuscular and neurological diseases, may be a homeostatic response to inhibitory overstimulation. Involvement of the inhibitory system in disease pathogenesis is highly relevant, given that most approaches currently being developed for treating neuromuscular and neurological diseases focus on reducing excitatory activity rather than reducing inhibitory activity.

scholarly journals Traduire l’incertitude

2019 ◽  
Vol 25 (45) ◽  
pp. 77-100
Author(s):  
Spiros Macris
Keyword(s):  
Theoretical Framework ◽  
Intentional Object ◽  
Real Object ◽  
Translation Process ◽  
The Real ◽  
Theoretical Position ◽  
Radical Critique ◽  
French And English ◽  
Translational Process

About Some Poems of Hans Faverey (1933-1990) Representation, as an actualisation of a text, is the real object of translation. In order to better understand the implications of this theoretical position, it is explored through the study of translations into French and English of a few poems by the Dutch writer Hans Faverey (1933-1990) as his work constitutes a radical critique of representation. The means of his critique are: autonomy of the poem considered as a device, referential deviation, syntactic alteration, etc. These elements transform the translation process in the sense of a greater indeterminacy, but also change the nature of the translational process. These multidimensional modifications find an adequate theoretical framework in Roman Ingarden’s analysis of translation as an intentional object.

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