Reclassification of Signs

2018 ◽  
Vol 14 (3) ◽  
pp. 261-273 ◽  
Author(s):  
Hongwei Jia
Keyword(s):  
Nervous System ◽  
Physical World ◽  
Writing System ◽  
Human Language ◽  
Human Communication ◽  
Translation Process ◽  
Text Interpretation ◽  
The Core ◽  
Solid Foundation ◽  
New Research

Abstract Previous semiotic research classified human signs into linguistic signs and non-linguistic signs, with reference to human language and the writing system as the core members of the sign family. However, this classification cannot cover all the types of translation in the broad sense in terms of sign transformation activities. Therefore, it is necessary to reclassify the signs that make meaning into tangible signs and intangible signs based on the medium of the signs. Whereas tangible signs are attached to the outer medium of the physical world, intangible signs are attached to the inner medium of the human cerebral nervous system. The three types of transformation, which are namely from tangible signs into tangible signs, from tangible signs into intangible signs, and from intangible signs into tangible signs, lay a solid foundation for the categorization of sign activities in translation semiotics. Such a reclassification of signs can not only enrich semiotic theories of sign types, human communication, and sign-text interpretation, but also inspire new research on translation types, the translation process, translators’ thinking systems and psychology, and the mechanism of machine translation.

scholarly journals Advances in the role of miRNAs in the occurrence and development of osteosarcoma

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 1003-1011
Author(s):  
Guanyu Zhang ◽  
Yiran Li ◽  
Jiasheng Xu ◽  
Zhenfang Xiong
Keyword(s):  
Target Gene ◽  
Early Stage ◽  
Research Direction ◽  
Research Progress ◽  
Skeletal System ◽  
Translation Process ◽  
Non Coding Rnas ◽  
New Research ◽  
Post Transcriptional Regulation

AbstractOsteosarcoma (OS) is the most common primary malignant tumor of the skeletal system in the clinic. It mainly occurs in adolescent patients and the pathogenesis of the disease is very complicated. The distant metastasis may occur in the early stage, and the prognosis is poor. MicroRNAs (miRNAs) are non-coding RNAs of about 18–25 nt in length that are involved in post-transcriptional regulation of genes. miRNAs can regulate target gene expression by promoting the degradation of target mRNAs or inhibiting the translation process, thereby the proliferation of OS cells can be inhibited and the apoptosis can be promoted; in this way, miRNAs can affect the metabolism of OS cells and can also participate in the occurrence, invasion, metastasis, and recurrence of OS. Some miRNAs have already been found to be closely related to the prognosis of patients with OS. Unlike other reviews, this review summarizes the miRNA molecules closely related to the development, diagnosis, prognosis, and treatment of OS in recent years. The expression and influence of miRNA molecule on OS were discussed in detail, and the related research progress was summarized to provide a new research direction for early diagnosis and treatment of OS.

scholarly journals Ocular Autonomic Nervous System: An Update from Anatomy to Physiological Functions

Vision ◽  
2022 ◽  
Vol 6 (1) ◽  
pp. 6
Author(s):  
Feipeng Wu ◽  
Yin Zhao ◽  
Hong Zhang
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Neural Control ◽  
Entire Body ◽  
Physiological Functions ◽  
Autonomic Nervous ◽  
Parasympathetic Nerves ◽  
Physiological Processes ◽  
New Research ◽  
Almost All

The autonomic nervous system (ANS) confers neural control of the entire body, mainly through the sympathetic and parasympathetic nerves. Several studies have observed that the physiological functions of the eye (pupil size, lens accommodation, ocular circulation, and intraocular pressure regulation) are precisely regulated by the ANS. Almost all parts of the eye have autonomic innervation for the regulation of local homeostasis through synergy and antagonism. With the advent of new research methods, novel anatomical characteristics and numerous physiological processes have been elucidated. Herein, we summarize the anatomical and physiological functions of the ANS in the eye within the context of its intrinsic connections. This review provides novel insights into ocular studies.

scholarly journals An Examination on Cloud Computing Future, Privacy of Data and Possibilities

2019 ◽  
Vol 8 (6S2) ◽  
pp. 949-953
Keyword(s):  
Cloud Computing ◽  
Theoretical Basis ◽  
The Other ◽  
Security And Privacy ◽  
Research Trend ◽  
Computing Environment ◽  
Storage Virtualization ◽  
Security Issues ◽  
The Core ◽  
New Research

Cloud computing is the theoretical basis for future computing. All the global frameworks are now looking up to architecture which is purely based on cloud. Being the core of such a large web of network, it is important to consider the security aspects in a cloud based computing environment. This has resulted in a new research trend on the security issues of cloud. Cloud is a popular paradigm with extreme abilities and benefits for trending ICT environment. On the other end the major concern came in terms of security and privacy while adopting the cloud technology. This article is an effort to cover the challenges in fields like storage, virtualization and communication in cloud .Also it is a try to elaborate relevance of current cryptographic approach in order to increase security of cloud in ICT.

scholarly journals Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins

2021 ◽  
Vol 22 (23) ◽  
pp. 12805
Author(s):  
Yanlu Cao ◽  
Bo Li ◽  
Nafissa Ismail ◽  
Kevin Smith ◽  
Tianmei Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nervous System ◽  
Kynurenine Pathway ◽  
Biological Synthesis ◽  
Mitochondrial Activity ◽  
Abnormal Metabolism ◽  
Toxic Mechanisms ◽  
Underlying Mechanisms ◽  
New Research ◽  
Endogenous Substances

Endogenous and exogenous neurotoxins are important factors leading to neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) contributes to Parkinson’s disease (PD) symptoms led to new research investigations on neurotoxins. An abnormal metabolism of endogenous substances, such as condensation of bioamines with endogenous aldehydes, dopamine (DA) oxidation, and kynurenine pathway, can produce endogenous neurotoxins. Neurotoxins may damage the nervous system by inhibiting mitochondrial activity, increasing oxidative stress, increasing neuroinflammation, and up-regulating proteins related to cell death. This paper reviews the biological synthesis of various known endogenous neurotoxins and their toxic mechanisms.

Thermoregulatory Thresholds for Vasoconstriction in Patients Anesthetized with Various 1-Minimum Alveolar Concentration Combinations of Xenon, Nitrous Oxide, and Isoflurane 

1999 ◽  
Vol 91 (3) ◽  
pp. 626-626 ◽  
Author(s):  
Takahisa Goto ◽  
Takashi Matsukawa ◽  
Daniel I. Sessler ◽  
Shoichi Uezono ◽  
Yoshiki Ishiguro ◽  
...  
Keyword(s):  
Nervous System ◽  
Nitrous Oxide ◽  
Minimum Alveolar Concentration ◽  
Demographic Variables ◽  
Temperature Gradients ◽  
Temperature Threshold ◽  
Sympathetic Activation ◽  
Isoflurane Anesthesia ◽  
The Core ◽  
Sympathetic Nervous

Background Nitrous oxide limits intraoperative hypothermia because the vasoconstriction threshold with nitrous oxide is higher than with equi-minimum alveolar concentrations of sevoflurane or isoflurane, presumably because of its stimulating actions on the sympathetic nervous system. Xenon, in contrast, does not cause sympathetic activation. Therefore, the authors tested the hypothesis that the vasoconstriction threshold during xenon-isoflurane anesthesia is less than during nitrous oxide-isoflurane anesthesia or isoflurane alone. Methods Fifteen patients each were randomly assigned to one of three 1-minimum alveolar concentration anesthetic regimens: (1) xenon, 43% (0.6 minimum alveolar concentration) and isoflurane, 0.5% (0.4 minimum alveolar concentration); (2) nitrous oxide, 63% (0.6 minimum alveolar concentration) and isoflurane 0.5%; or (3) isoflurane, 1.2%. Ambient temperature was maintained near 23 degrees C and the patients were not actively warmed. Thermoregulatory vasoconstriction was evaluated using forearm-minus-fingertip skin temperature gradients. A gradient exceeding 0 degrees C indicated significant vasoconstriction. The core-temperature threshold that would have been observed if skin had been maintained at 33 degrees C was calculated from mean skin and distal esophageal temperatures at the time of vasoconstriction. Results The patients' demographic variables, preinduction core temperatures, ambient operating room temperatures, and fluid balance were comparable among the three groups. Heart rates were significantly less during xenon anesthesia than with nitrous oxide. The calculated vasoconstriction threshold was lowest with xenon (34.6+/-0.8 degrees C, mean +/- SD), intermediate with isoflurane alone (35.1+/-0.6 degrees C), and highest with nitrous oxide (35.7+/-0.6 degrees C). Each of the thresholds differed significantly. Conclusions Xenon inhibits thermoregulatory control more than isoflurane, whereas nitrous oxide is the least effective in this respect.

Negotiations and the Future of Alliance Studies

2019 ◽  
pp. 169-180
Author(s):  
Paul Poast
Keyword(s):  
Explanatory Variable ◽  
Future Research ◽  
Military Force ◽  
Research Directions ◽  
The Core ◽  
Outside Options ◽  
Treaty Negotiations ◽  
The Future ◽  
New Research ◽  
Defense Cooperation

This concluding chapter summarizes the book's main claims and empirical findings, discussing the implications of these findings as well as directions for future research. At their heart, alliance treaties are about using military force. As such, war planning can be conceptualized as the core of alliance treaty negotiations. Equipped with this premise, the book argued that the key variable determining whether conditions are conducive to agreement is the compatibility of the participants' ideal war plans. These plans must be both operationally and strategically compatible. When war plan compatibility is low, the second key explanatory variable comes into play: the number of negotiation participants that have attractive outside options. The chapter then highlights how the arguments and evidence in the book indicate new research directions in four areas related to alliances: alliance treaty design, alliance reliability, NATO expansion, and the formation of defense cooperation agreements.

The Problem

2019 ◽  
pp. 48-58
Author(s):  
Dale Purves
Keyword(s):  
Nervous System ◽  
Real World ◽  
Physical World ◽  
Sensory Systems ◽  
Fundamental Question ◽  
Physical Parameters ◽  
Everyday Experience ◽  
Nervous Systems ◽  
Neural Connections ◽  
Sensory Inputs

Although understanding neural functions has progressed at a remarkable pace in recent decades, a fundamental question remains: How does the nervous system relate the objective world to the subjective domain of perception? Everyday experience implies that the neural connections on which we and other animals depend link physical parameters in the environment with useful responses. But that interpretation won't work: biological sensory systems cannot measure the physical world. Whereas something is linking sensory inputs to useful responses, it is not the physical world that instruments measure. How, then, have we animals met this challenge, and what is it that we end up perceiving? The purpose of this chapter is to suggest how nervous systems have evolved to deal with the inability to convey the objective properties of the real world.

scholarly journals Mechanisms of cell migration in the nervous system

2013 ◽  
Vol 202 (5) ◽  
pp. 725-734 ◽  
Author(s):  
Jonathan A. Cooper
Keyword(s):  
Nervous System ◽  
Cell Migration ◽  
Cell Movement ◽  
Adhesion Proteins ◽  
Space And Time ◽  
Microtubule Motors ◽  
Axon Specification ◽  
New Research ◽  
Migrating Cells

Many neurons resemble other cells in developing embryos in migrating long distances before they differentiate. However, despite shared basic machinery, neurons differ from other migrating cells. Most dramatically, migrating neurons have a long and dynamic leading process, and may extend an axon from the rear while they migrate. Neurons must coordinate the extension and branching of their leading processes, cell movement with axon specification and extension, switching between actin and microtubule motors, and attachment and recycling of diverse adhesion proteins. New research is needed to fully understand how migration of such morphologically complicated cells is coordinated over space and time.

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