scholarly journals First Movers in Molecular Detection: Case Comparison on Harnessing Research and Development, Industry, and Entrepreneurship

2021 ◽  
Vol 8 ◽  
Author(s):  
Kenneth B. Yeh ◽  
Matt Scullion ◽  
Julia M. Michelotti ◽  
Gene Olinger
Keyword(s):  
Research And Development ◽  
Corporate Culture ◽  
Molecular Detection ◽  
New Technologies ◽  
Technology Development ◽  
Panel Discussion ◽  
Lessons Learned ◽  
Nucleic Acid Detection ◽  
Health Security ◽  
First Mover

The current unprecedented COVID-19 pandemic underscores the importance of diagnostic assays in health security preparedness and readiness. Advancing new technologies for rapid molecular detection of high consequence infectious pathogens is an ongoing challenge that requires ingenuity and vision. Sustainment of a robust supply chain for materials and the logistics of timely product delivery further challenge diagnostic kit and device manufacturers. Business economists often characterize technology companies that discover unique breakthroughs in their field and are first to bring related products to market as first movers. From a market perspective, three first mover characteristics include: having the knowledge and capability to address a unique breakthrough, excellent technological leadership, and the ability to capitalize on the opportunity. Current mainstays for molecular detection include using Taq DNA Polymerase enzyme and fluorescent chemistry for quantitative PCR (qPCR). A newer and promising technology uses CRISPR-Cas proteins for nucleic acid detection. Our panel discussion from the 2020 ASM Biothreats conference, which included members from two prototypical first mover companies, explored their respective corporate experiences. Both companies were selected for the discussion based on their revolutionary innovations and similarities in their research and development, corporate culture and trajectory. One company, established over 20 years ago, became a market leader in the biothreat detection market by advancing air thermocycling qPCR across multiple product families. The second company is a rapidly growing start-up and a scientific pioneer in establishing next generation CRISPR technologies. Here we discuss their technology development, product deployment, and customer markets to draw lessons learned for researchers, end users, and funders.

Alstom Gas Turbine Technology Developments

2013 ◽  
Author(s):  
Caroline Marchmont ◽  
Stefan Florjancic ◽  
Wolfgang Kappis
Keyword(s):  
Research And Development ◽  
Gas Turbine ◽  
New Technologies ◽  
Technology Development ◽  
State Of The Art ◽  
Fuel Composition ◽  
Combined Cycles ◽  
Effective Part ◽  
And Performance ◽  
Emission And Performance

In preparation for the next generation combined cycles, gas turbine technology development needs to continue to lower the lifecycle costs through increased efficiency, reduced first costs, extended maintenance cycles, and reduced emissions. It must also develop fast ramping capability, account for a wider variation in fuel composition and provide emission and performance effective part load operation. These needs will be met by refining state of the art technologies and adding new technologies. This paper will provide an overview of the recent research and development activities, the approach to bring them into a product and the resulting trend in Alstom gas turbine technologies.

A Manufacturing Systems Engineering View of IT Research and Development

1987 ◽  
Vol 2 (3) ◽  
pp. 114-118
Author(s):  
M.W. Dale
Keyword(s):  
Information Technology ◽  
Research And Development ◽  
Systems Engineering ◽  
Manufacturing Systems ◽  
Technology Development ◽  
Human Interface ◽  
Real World Applications ◽  
Computing Skills ◽  
Information Technologists ◽  
Information Technology Development

This paper presents a manufacturing systems engineering view of important issues relating to IT research and development. It argues for an approach to the next phase of information technology development which is heavily based on real-world applications with the dominant influences held by educated users and engineers who have added computing skills, rather than information technologists. It argues for ‘consolidation’ with particular attention to total systems integration and an emphasis on the need to professionally engineer the human interface.

scholarly journals Trusting the Corona-Warn-App? Contemplations on trust and trustworthiness at the intersection of technology, politics and public debate

2021 ◽  
pp. 026732312110283
Author(s):  
Judith Simon ◽  
Gernot Rieder
Keyword(s):  
Technology Development ◽  
Public Debate ◽  
Lessons Learned ◽  
Initial Development ◽  
The Public ◽  
Public Debates ◽  
Moral Duties ◽  
Moral Demands

Ever since the outbreak of the COVID-19 pandemic, questions of whom or what to trust have become paramount. This article examines the public debates surrounding the initial development of the German Corona-Warn-App in 2020 as a case study to analyse such questions at the intersection of trust and trustworthiness in technology development, design and oversight. Providing some insights into the nature and dynamics of trust and trustworthiness, we argue that (a) trust is only desirable and justified if placed well, that is, if directed at those being trustworthy; that (b) trust and trustworthiness come in degrees and have both epistemic and moral components; and that (c) such a normatively demanding understanding of trust excludes technologies as proper objects of trust and requires that trust is directed at socio-technical assemblages consisting of both humans and artefacts. We conclude with some lessons learned from our case study, highlighting the epistemic and moral demands for trustworthy technology development as well as for public debates about such technologies, which ultimately requires attributing epistemic and moral duties to all actors involved.

scholarly journals Identification of Technology Diffusion by Citation and Main Paths Analysis: The Possibility of Measuring Open Innovation

2021 ◽  
Vol 7 (1) ◽  
pp. 104
Author(s):  
Wei-Hao Su ◽  
Kai-Ying Chen ◽  
Louis Y. Y. Lu ◽  
Ya-Chi Huang
Keyword(s):  
Research And Development ◽  
Technology Development ◽  
Surgical Navigation ◽  
Future Research ◽  
Integrated Analysis ◽  
Reference Network ◽  
Research Topics ◽  
Academic Literature ◽  
Development Trajectory ◽  
Historic Development

This study collected literature on augmented reality (AR) from academic and patent databases to plot the historic development trajectory of AR and forecast its future research and development trends. A total of 3193 and 13,629 papers were collected from academic and patent databases, respectively. First, a network was established using references from the academic literature; main path analysis was conducted on this reference network to plot the overall development trajectory. Subsequent cluster and word cloud analyses revealed the following five major groups of AR research topics: AR surgical navigation applications, AR education applications, AR applications in manufacturing, AR applications in architecture, and AR applications in visual tracking. Subsequently, the relationships between the overall development trajectory and the five AR research topics were compared. Next, the title and abstract of AR-related academic and patent papers were subjected to text mining to identify keywords with a high frequency of occurrence. The results can provide a reference for industry, government, and academia when planning future development strategies for the AR field. This research adopted an integrated analysis procedure to plot the trajectory of AR technology development and applications successfully and effectively, predict future patent research and development directions and produce technological forecasts.

Paradigmatic Shifts in the Uranium Exploration Process: Knowledge Brokers and the Athabasca Basin Learning Curve

SEG Discovery ◽  
2011 ◽  
pp. 1-23
Author(s):  
James L. Marlatt ◽  
T. Kurt Kyser
Keyword(s):  
Research And Development ◽  
Technology Development ◽  
Current Model ◽  
Development Effort ◽  
Organizational System ◽  
Exploration Process ◽  
Athabasca Basin ◽  
Uranium Exploration ◽  
The Status ◽  
Knowledge Brokers

ABSTRACT Uranium exploration increased over the past decade in response to an increase in the price of uranium, with more than 900 companies engaged in the global exploration on over 3,000 projects. Major economic discoveries of new uranium orebodies have been elusive despite global exploration expenditures of $3.2 billion USD, with most of the effort in historical uranium districts. The increased effort in exploration with minimal return can be described through the example of a cyclical model based on exploration and discovery in the prolific Athabasca Basin, Saskatchewan. The model incorporates exploration expenditure, quantities of discovered uranium, and the sequence of uranium deposit discoveries to reveal that discovery cycles are epochal in nature and that they are also intimately related to the development and deployment of new exploration technologies. Exploration in the Athabasca Basin can be divided into an early “prospector” phase and the current “model-driven”phase. The future of successful uranium exploration is envisaged as the “innovation exploration” stage in which a paradigmatic shift in the exploration approach will take the industry towards new discoveries by leveraging research and technology development. Effective engagement within the “innovation exploration” paradigm requires that exploration organizations recognize knowledge brokers, and adopt research, development, and technology transfer as a long-term, systematic strategy, including critical definition of exploration targets, identification of innovation frontiers needed, enhanced leadership to accurately portray the research and development imperative and elevation of the status of the research and development effort within the organizational system.

BRICS Countries Possible Areas for Scientific Cooperation

2015 ◽  
pp. 14-23
Author(s):  
I. Dezhina
Keyword(s):  
Research And Development ◽  
New Technologies ◽  
Technological Development ◽  
High Tech ◽  
Preliminary Evaluation ◽  
Exploratory Research ◽  
Scientific Cooperation ◽  
Brics Countries ◽  
The World ◽  
A Share

The article evaluates science sectors and effectiveness of scientific research in the countries forming the BRICS group, as well as the current state of scientific and technological cooperation among the group members. The science sectors of the countries under consideration differ markedly, while facing similar problems relating to government regulations and external environments. The differences exist in total expenditures on research and development (as a share of GNP), in the scope of governmental funding (large in Russia and India, but small in China), and in the distribution of allocations among various areas and types of R&D activities. China appears to have the most well-adjusted science sector among the BRICS members. It includes not only strong universities but also high-tech companies that invest actively into research and development. The overall impact (inferred from citation indexes) of fundamental and exploratory research performed in BRICS countries remains low. BRICS's scientists prefer to collaborate with their colleagues from the world-leading countries rather than with their fellows from BRICS. Yet, in contrast to the world trend, in all BRICS countries, except Russia, a share of internationally co-authored publications is now decreasing. BRICS members have more similar interests and priorities in technological development, including infrastructural and large technological projects, than in science. Currently, bilateral cooperation in technology prevails, while the projects involving all members of the group still remain at the stage of preliminary evaluation and discussion. Russia cooperates most closely with China and India, including joint projects in such high-priority directions as new materials, photonics, biomedical, space and information technologies. For Russia, cooperation in technological development appears to be of most interest because it can lead not only to introduction of new technologies but also help to create large Russian innovative companies. Development of successful multilateral cooperation in science and technology among the BRICS members is the key for this group, originally formed for geopolitical reasons, to evolve into an effective economic union.

scholarly journals How to approach a many splendoured thing: Proxy Technology Assessment as a methodological praxis to study virtual experience

2010 ◽  
Vol 3 (1) ◽  
Author(s):  
Lizzy Bleumers ◽  
Kris Naessens ◽  
An Jacobs
Keyword(s):  
Virtual Worlds ◽  
Technology Assessment ◽  
New Technologies ◽  
New Technology ◽  
Methodological Approach ◽  
Lessons Learned ◽  
Practical Implementation ◽  
Natural Setting ◽  
Functional Requirements ◽  
Virtual Experiences

This article introduces Proxy Technology Assessment (PTA) as a methodological approach that can widen the scope of virtual world and game research. Studies of how people experience virtual worlds and games often focus on individual in-world or in-game experiences. However, people do not perceive these worlds and games in isolation. They are embedded within a social context that has strongly intertwined online and offline components. Studying virtual experiences while accounting for these interconnections calls for new methodological approaches. PTA answers this call.Combining several methods, PTA can be used to investigate how new technology may impact and settle within people's everyday life (Pierson et al., 2006). It involves introducing related devices or applications, available today, to users in their natural setting and studying the context-embedded practices they alter or evoke. This allows researchers to detect social and functional requirements to improve the design of new technologies. These requirements, like the practices under investigation, do not stop at the outlines of a magic circle (cf. Huizinga, 1955).We will start this article by contextualizing and defining PTA. Next, we will describe the practical implementation of PTA. Each step of the procedure will be illustrated with examples and supplemented with lessons learned from two interdisciplinary scientific projects, Hi-Masquerade and Teleon, concerned with how people perceive and use virtual worlds and games respectively.

scholarly journals FORECASTING OF BLOCKCHAIN TECHNOLOGY DEVELOPMENT IN ECONOMY: ACCOUNTING POINT OF VIEW

2019 ◽  
pp. 37-44
Author(s):  
L. Shkulipa
Keyword(s):  
Big Data ◽  
New Technologies ◽  
Technology Development ◽  
Local Economy ◽  
Point Of View ◽  
Negative Effects ◽  
Blockchain Technology ◽  
Hype Cycle ◽  
Predictive Assessment ◽  
Further Development

In the article the importance of blockchain technology in the economy and predicting its development from the accounting point of view was investigated. The methods used in the study are based on the analysis of literature related to disclosure issues and a description of existing blockchain claims on the world stage. On the basis of this, a predictive assessment of the considered results for the further development of blockchain technology in the economy, its impact on accounting and the profession of accountant was made. The findings include the positive and negative effects of blockchain technology on the medical and banking sectors, information technology, the financial sector, and accounting. The blockchain in the hype cycle was considered as a phenomenon that all new technologies undergo before stable existing or disappearing. Based on the consideration of the most famous blockchain projects with the combination of Big Data, the estimation of the development technologies of Blockchain and Big Data in finance was discussed. This study suggests to consider blockchain technology as (1) a new way of sending and processing invoices, documents, contracts, and payments, reducing errors, costs and transaction time; (2) a path to financial equality through affordability; (3) investments in the local economy so that developing countries can grow significantly; (4) updating the currency market and the international monetary and financial transaction system; (5) a major breakthrough in the economy together with the Big Data technology.

scholarly journals Talking about the Energy-saving Technical Measures in the Electrical Design of Buildings

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
Zhang Mian
Keyword(s):  
Sustainable Development ◽  
Energy Consumption ◽  
Energy Conservation ◽  
Research And Development ◽  
Energy Saving ◽  
New Technologies ◽  
New Products ◽  
New Energy ◽  
Technical Measures

At present, people pay more attention to the energy consumption of building electrical design, the use of energy-saving design can maximize the energy conservation resources, and ultimately increase the pace of social sustainable development. Therefore, the energy-saving designers involved in the need to follow the economic rational, safe and feasible benchmark to select the appropriate energy-saving measures to increase research and development of new technologies, new products and new energy, the concept of sustainable development to be implemented. In view of this, this paper mainly analyzes the energy saving technical measures in the electrical design of thebuilding.

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