scholarly journals Theacrine From Camellia kucha and Its Health Beneficial Effects

2020 ◽  
Vol 7 ◽  
Author(s):  
Yue-Yue Sheng ◽  
Jing Xiang ◽  
Ze-Shi Wang ◽  
Jing Jin ◽  
Ying-Qi Wang ◽  
...  
Keyword(s):  
Tea Plant ◽  
Research Field ◽  
Antioxidant Effect ◽  
Cognitive Effect ◽  
Beneficial Effects ◽  
Hypnotic Effect ◽  
Purine Alkaloids ◽  
Cell Metastasis ◽  
Locomotor Activation ◽  
Inflammatory Effect

Theacrine, i.e., 1,3,7,9-tetramethyluric acid, is one of the major purine alkaloids found in leaf of a wild tea plant species Camellia kucha Hung T. Chang. Theacrine has been attracted great attentions academically owing to its diverse health benefits. Present review examines the advances in the research on the health beneficial effects of theacrine, including antioxidant effect, anti-inflammatory effect, locomotor activation and reducing fatigue effects, improving cognitive effect, hypnotic effect, ameliorating lipid metabolism and inhibiting breast cancer cell metastasis effect. The inconsistent results in this research field and further expectations were also discussed.

scholarly journals In vitro evidence for the involvement of H2S pathway in the effect of clodronate during inflammatory response

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rosangela Montanaro ◽  
Alessio D’Addona ◽  
Andrea Izzo ◽  
Carlo Ruosi ◽  
Vincenzo Brancaleone
Keyword(s):  
Inflammatory Markers ◽  
In Vitro Study ◽  
Inos Expression ◽  
Beneficial Effects ◽  
Tnf Α ◽  
Inflammatory State ◽  
Anti Inflammatory ◽  
Underlying Mechanisms ◽  
Inflammatory Effect

AbstractClodronate is a bisphosphonate agent commonly used as anti-osteoporotic drug. Throughout its use, additional anti-inflammatory and analgesic properties have been reported, although the benefits described in the literature could not solely relate to their inhibition of bone resorption. Thus, the purpose of our in vitro study is to investigate whether there are underlying mechanisms explaining the anti-inflammatory effect of clodronate and possibly involving hydrogen sulphide (H2S). Immortalised fibroblast-like synoviocyte cells (K4IM) were cultured and treated with clodronate in presence of TNF-α. Clodronate significantly modulated iNOS expression elicited by TNF-α. Inflammatory markers induced by TNF-α, including IL-1, IL-6, MCP-1 and RANTES, were also suppressed following administration of clodronate. Furthermore, the reduction in enzymatic biosynthesis of CSE-derived H2S, together with the reduction in CSE expression associated with TNF-α treatment, was reverted by clodronate, thus rescuing endogenous H2S pathway activity. Clodronate displays antinflammatory properties through the modulation of H2S pathway and cytokines levels, thus assuring the control of the inflammatory state. Although further investigation is needed to stress out how clodronate exerts its control on H2S pathway, here we showed for the first the involvement of H2S in the additive beneficial effects observed following clodronate therapy.

Abstract 493: Correlation Between Cannabis Use and the Prevalence of Cerebrovascular Disease (Cva); Analysis From the National Inpatient Sample (NIS) 2012-2014

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Samson E Alliu ◽  
Adeyinka Adejumo ◽  
Modupeolowa Durojaiye ◽  
Oluwole Adegbala ◽  
Tokunbo Ajayi ◽  
...  
Keyword(s):  
Clinical Information ◽  
Cannabis Use ◽  
Prior History ◽  
National Inpatient Sample ◽  
Cognitive Effect ◽  
Clinical Literature ◽  
The Us ◽  
History Of ◽  
Amphetamine Use ◽  
Inflammatory Effect

Background: With increasing legalization of cannabis, there is a growing number of cannabis users in the US. Cannabidiol - a component of cannabis with no psychoactive or cognitive effect has been proven in animal models to have vasodilatory and anti-inflammatory effect on the blood vessels. However, in clinical literature, the association between cerebrovascular accident (CVA) and cannabis remains inconclusive. Objective: To examine if there is a difference in the prevalence of CVA among patients who use cannabis and non-users. Methods: We identified patients > 18 years (N=12,114,360) from the 2012 -2014 National Inpatient Sample database. Using the ICD-9 code, we categorized patients using cannabis (non-dependent and dependent users) and non-users. Our outcome of interest was prevalence of CVA in this population. Logistic regression analysis was performed to assess the association between cannabis use and CVA. Using multivariate regression model, we adjusted for known confounders of CVA; age, gender, race, insurance type, socioeconomic status, tobacco use, cocaine use, alcohol abuse, amphetamine use, hyperlipidemia, diabetes, hypertension, renal failure, prior history of CVA and family history of CVA. Results: From our study sample (12,114,360 hospitalized patients), 2.1% (253,752) had a diagnosis of CVA, 1.48% (179,576) were non-dependent cannabis users and 0.21% (25,968) dependent users. Among hospitalized patient, non-dependent cannabis use was associated with an 8% increased odds of CVA (AOR 1.08 [1.03-1.13]) compared to non-users. However, dependent cannabis use was associated with a 60% decreased odds of CVA (AOR 0.40 [0.31-0.49]) compared to non-users. Also, In-group comparison shows a 60% decreased odds of CVA among dependent cannabis users (AOR 0.36[0.29-0.46]) compared to non-dependent cannabis users. Conclusions: Non-dependent cannabis use was associated with a slightly increased odd of CVA while dependent cannabis use was independently protective against CVA. Our study used the largest repository of clinical information to explore this association, however we recommend more clinical study to explore this correlation in other to maximize the pharmacological benefit of cannabidiol in cannabis for the prevention of CVA.

scholarly journals A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Elisa Colombo ◽  
Enrico Sangiovanni ◽  
Mario Dell'Agli
Keyword(s):  
Gastrointestinal Tract ◽  
Clinical Studies ◽  
Intestinal Tract ◽  
Biological Activities ◽  
Inflammatory Activity ◽  
Beneficial Effects ◽  
Anti Inflammatory ◽  
Gastro Intestinal Tract ◽  
Inflammatory Effect

Several biological activities of pomegranate have been widely described in the literature, but the anti-inflammatory effect in the gastrointestinal tract has not been reviewed till now. The aim of the present paper is to summarize the evidence for or against the efficacy of pomegranate for coping with inflammatory conditions of the gastro-intestinal tract. The paper has been organized in three parts: (1) the first one is devoted to the modifications of pomegranate active compounds in the gastro-intestinal tract; (2) the second one considering the literature regarding the anti-inflammatory effect of pomegranate at gastric level; (3) the third part considers the anti-inflammatory effect of pomegranate in the gut.In vivostudies performed on the whole fruit or juice, peel, and flowers demonstrate antiulcer effect in a variety of animal models. Ellagic acid was the main responsible for this effect, although other individual ellagitannins could contribute to the biological activity of the mixture. Different preparations of pomegranate, including extracts from peels, flowers, seeds, and juice, show a significant anti-inflammatory activity in the gut. No clinical studies have been found, thus suggesting that future clinical studies are necessary to clarify the beneficial effects of pomegranate in the gastrointestinal tract.

scholarly journals Efficient and Divergent Enantioselective Syntheses of DHPVs and Anti-Inflammatory Effect on IEC-6 Cells

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2215
Author(s):  
Hyun Su Kim ◽  
Sungkyun Chung ◽  
Moon-Young Song ◽  
Changjin Lim ◽  
Hyeyoung Shin ◽  
...  
Keyword(s):  
Beneficial Effects ◽  
Asymmetric Dihydroxylation ◽  
Cross Metathesis ◽  
Molecular Therapeutics ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Enantioselective Syntheses ◽  
Precise Molecular Mechanism ◽  
Significant Attention ◽  
Inflammatory Effect

Despite numerous reports on the beneficial effects of catechin or epicatechin contained in tea and cacao extract on human health, a conclusive and precise molecular mechanism has not been elucidated. Metabolism of chemical compounds in gut microbiota recently gained significant attention, and extensive studies have been devoted in this field. In conjunction with these results, our group focused on the anti-inflammatory effects of both enantiomers of DHPV (5-(3′,4′-dihydroxyphenyl)-γ-valerolactone), produced in the intestine by microbiota metabolism, on IEC-6 cells. Divergent and efficient enantioselective synthesis of (S)- and (R)-DHPV was efficiently achieved by cross-metathesis and Sharpless asymmetric dihydroxylation as a key reaction for four steps in 16% and 14% overall yields, respectively. The anti-inflammatory effects of two enantiomers were tested on IEC-6 cells, and we found that (S)-DHPV was more active than (R)-DHPV. This result implicates that the metabolite produced in the gut has beneficial effects on IEC-6 cells of rat intestines, and the chirality of the metabolite is important for its anti-inflammatory activity. This also provided information for the future discovery of novel small molecular therapeutics for the treatment of inflammatory bowel disease.

Anti-Inflammatory Effect of the Kampo Japanese Traditional Medicine daikenchuto After Colorectal Resection

2015 ◽  
Vol 100 (11-12) ◽  
pp. 1360-1363
Author(s):  
Takaaki Fujii ◽  
Hiroki Morita ◽  
Toshinaga Sutoh ◽  
Reina Yajima ◽  
Soichi Tsutsumi ◽  
...  
Keyword(s):  
Colorectal Resection ◽  
Control Group ◽  
Impaired Liver Function ◽  
Elective Colorectal Surgery ◽  
Inflammatory Reactions ◽  
Beneficial Effects ◽  
Anti Inflammatory ◽  
Japanese Traditional Medicine ◽  
Wbc Count ◽  
Inflammatory Effect

Here we analyzed whether Daikenchuto (DKT) suppresses postoperative inflammatory reactions in patients who have undergone elective colorectal surgery. DKT is one of the most frequently prescribed traditional (Kampo) medicines in Japan. DKT is reported to have various beneficial effects on bowel disorders. It was recently reported that DKT also has an anti-inflammatory effect. Consecutive patients with colorectal cancer who underwent elective colorectal resection were separated into two groups. A total of 67 patients began a DKT regimen after surgery (DKT group) and 53 patients did not begin the DKT regimen after surgery (control group). We observed a steady postsurgery increase in the white blood cell (WBC) count of all patients on postoperative day 1 (POD 1), whereas the WBC count decreased at PODs 3 and 7. When we compared the WBC values of the DKT group (6147.2 ± 2217.3 per microliter) and control (7071.1 ± 2828.0 per microliter) groups on POD 7, we found significant differences (P = 0.038). There was no significant side effect due to DKT, except for one case of mildly impaired liver function. Our results suggest that DKT administration may have an anti-inflammatory effect during the postoperative period. Further studies are warranted to investigate the possibility of using DKT as a therapeutic agent based on its anti-inflammatory effect.

scholarly journals The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2847 ◽  
Author(s):  
Tawar Qaradakhi ◽  
Laura Kate Gadanec ◽  
Kristen Renee McSweeney ◽  
Jemma Rose Abraham ◽  
Vasso Apostolopoulos ◽  
...  
Keyword(s):  
Sulfonic Acid ◽  
Renin Angiotensin System ◽  
Animal Tissues ◽  
Cellular Functions ◽  
Protein Amino Acid ◽  
Angiotensin System ◽  
Beneficial Effects ◽  
Ion Movement ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With its unique sulfonic acid makeup, taurine influences cellular functions, including osmoregulation, antioxidation, ion movement modulation, and conjugation of bile acids. Taurine exerts anti-inflammatory effects that improve diabetes and has shown benefits to the cardiovascular system, possibly by inhibition of the renin angiotensin system. The beneficial effects of taurine are reviewed.

scholarly journals Antioxidant effect of a fermented powder of Lady Joy bean in primary rat hepatocytes

2015 ◽  
Vol 20 (1) ◽  
Author(s):  
Margherita La Marca ◽  
Laura Pucci ◽  
Roberto Bollini ◽  
Rossella Russo ◽  
Francesca Sparvoli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phaseolus Vulgaris ◽  
Bioactive Compounds ◽  
Primary Cultures ◽  
Rat Hepatocytes ◽  
Antioxidant Effect ◽  
Phaseolus Vulgaris L ◽  
Detoxifying Enzymes ◽  
Nrf2 Pathway ◽  
Beneficial Effects

AbstractThe role and beneficial effects of plant and food extracts against various diseases induced by oxidative stress have received much attention in recent years. Legumes are rich in bioactive compounds, and some studies suggest a correlation between their consumption and a reduced incidence of diseases. Primary cultures of rat hepatocytes were used to investigate whether and how an extract obtained from a fermented powder of bean named Lady Joy (Phaseolus vulgaris L.) is able to regulate antioxidant and detoxifying enzymes through the NRF2 pathway, inhibit NF-kB activation, and reduce H

scholarly journals Pistachio Nuts (Pistacia vera L.): Production, Nutrients, Bioactives and Novel Health Effects

Plants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 18
Author(s):  
Giuseppina Mandalari ◽  
Davide Barreca ◽  
Teresa Gervasi ◽  
Michael A. Roussell ◽  
Bob Klein ◽  
...  
Keyword(s):  
Animal Studies ◽  
Health Benefits ◽  
Monounsaturated Fatty Acids ◽  
Pistacia Vera ◽  
Beneficial Effects ◽  
Pistachio Nuts ◽  
Inflammatory Effect

Epidemiological and clinical studies have indicated positive outcomes related to tree nut consumption. Here, we review the production, nutrient, phytochemical composition and emerging research trends on the health benefits of pistachio nuts (Pistacia vera L.). Pistachios are a good source of protein, fiber, monounsaturated fatty acids, minerals and vitamins, as well as carotenoids, phenolic acids, flavonoids and anthocyanins. Polyphenols in pistachios are important contributors to the antioxidant and anti-inflammatory effect, as demonstrated in vitro and in vivo through animal studies and clinical trials. The antimicrobial and antiviral potential of pistachio polyphenols has also been assessed and could help overcome drug resistance. Pistachio consumption may play a role in cognitive function and has been associated with a positive modulation of the human gut microbiota and beneficial effects on skin health. Pistachio polyphenol extracts may affect enzymes involved in glucose regulation and so type 2 diabetes. Taken together, these data demonstrate the health benefits of including pistachios in the diet. Further studies are required to investigate the mechanisms involved.

scholarly journals Health Benefits of Aqueous Extract of Black and Green Tea Leaves

2020 ◽  
Author(s):  
Zainab Khudhur Ahmad Al-Mahdi ◽  
Ruqaya M.J. Ewadh ◽  
Nada Khazal Kadhim Hindi
Keyword(s):  
Cardiovascular Diseases ◽  
Pathogenic Bacteria ◽  
Black Tea ◽  
Epidemiological Studies ◽  
Tea Plant ◽  
Polyphenolic Compounds ◽  
Tea Consumption ◽  
Beneficial Effects ◽  
Green Tea Leaves ◽  
Green And Black Tea

Tea, next to water, is the beverage humans consume. Drinking the beverage tea is great for joining and collecting family members and public communities since ancient times. Tea plant Camellia sinensis has been cultivated for thousands of years, and its leaves have been used for medicinal purposes. Various studies suggest that polyphenolic compounds present in green and black tea are associated with beneficial effects in prevention of cardiovascular diseases, particularly of atherosclerosis and coronary heart disease. Anti-ageing, antidiabetic and many other health beneficial effects associated with tea consumption are described. Evidence is accumulating that catechins and theaflavins, which are the main polyphenolic compounds of green and black tea, respectively, are responsible for most of the physiological effects of tea. This review describes the evidence from clinical and epidemiological studies in the prevention of chronic diseases like cancer and cardiovascular diseases and inhibits pathogenic bacteria and general health promotion associated with tea consumption.

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