scholarly journals The Relationship Between Body Mass Index and Different Regional Patterns of Lymph Node Involvement in Papillary Thyroid Cancers

2021 ◽  
Vol 11 ◽  
Author(s):  
Changlin Li ◽  
Gianlorenzo Dionigi ◽  
Nan Liang ◽  
Haixia Guan ◽  
Hui Sun
Keyword(s):  
Risk Factor ◽  
Lymph Node ◽  
Independent Risk Factor ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Maximum Diameter ◽  
Obese Patients ◽  
Papillary Thyroid ◽  
Regional Patterns ◽  
The Relationship

IntroductionLymph node (LN) metastasis is the first site of metastasis of papillary thyroid cancer (PTC). LN status influences clinical management and the prognosis of patients. We explored the relationship between patient obesity and regional patterns of LN involvement in PTC.Materials and MethodsThis study retrospectively analyzed the data from 12,772 PTC patients. The rate of LN metastasis, number of LN metastasis, maximum diameter of positive LN, number of dissected LN, and LN ratios (LNR) were compared between normal-weight and obese patients. Statistical methods have been adjusted for the confounders in hypothesis testing.ResultsOverweight and obesity were independent risk factor for metastatic LNs (OR1 = 1.125, 95% CI 1.042-1.214, P1 = 0.003; OR2 = 1.554, 95% CI 1.339-1.802, P2<0.001). Obesity was an independent risk factor for the number of metastatic CLNs (OR=1.159, 95% CI 0.975-1.377, P=0.045), however not for number of metastatic lateral LNs (P=0.907). Furthermore, obesity was not an independent risk factor for number of CLNs when dissected more than five (P=0.653), still an independent risk factors for number of metastatic lateral LNs when more than six (OR=1.185, 95% CI 1.010-1.391, P=0.037). As for LNR, obesity was an independent risk factor for the central LNR when more than 0.12 (OR adjusted 1 = 1.099, 95% CI 1.011-1.194, P1 = 0.027; OR adjusted 2 = 1.177, 95% CI 1.003-1.381, P2 = 0.045), for the lateral LNR more than 0.05 (P2 = 0.283).ConclusionsObesity was associated with poor prognoses with PTC respecting LNs. Surgeons should be extreme caution when performing central neck dissection in obese patients.

scholarly journals Obesity Induces Different Regional Patterns of Lymph Node Involvement: Assay on 8,979 Thyroid Cancers

2020 ◽  
Author(s):  
Changlin Li ◽  
Nan Liang ◽  
Gianlorenzo Dionigi ◽  
Haixia Guan ◽  
Hui Sun
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Involvement ◽  
Central Neck Dissection ◽  
Normal Weight ◽  
Obese Group ◽  
Maximum Diameter ◽  
Obese Patients ◽  
Regional Patterns ◽  
Significant Difference

Abstract Introduction Lymph node (LN) metastasis is the first station of extra-gland metastasis of thyroid cancer. LN status can influence clinical decisions and the prognosis of patients. The aim of our study was to explore the relationship between obesity and regional patterns of LN involvement in papillary thyroid carcinoma (PTC).Materials and methods This study retrospectively analyzed the data from 8,979 thyroid cancer patients. The rate of LN metastasis, the number of LN metastasis, the maximum diameter of positive LN, the number of LN dissections, and the LN ratios (LNR) were compared between normal-weight and obese patients.Results LN metastasis was more common in the obese group than normal-weight patients with PTC (52.6 vs. 42.0%, P <0.001). The number of LN metastasis and the maximum diameter of positive LNs were also higher in obese patients (2.41 vs. 1.79, P <0.001; 2.00 vs. 1.60, P =0.007, respectively). The number of lateral neck LN dissections was higher in the obese group (14.37 vs. 12.10, P <0.001), there was no significant difference in the central LNs. The LNR was higher in the central LNs of obese patients (0.18 vs. 0.14, P <0.001), yet there was no difference in the lateral LNs.Conclusions Obesity was associated with poor prognoses with PTC, which was related to the LNs. There was an inverse regional difference (central and lateral LNs) between obesity and the number of LN dissections and LNR, suggesting that caution was needed when performing central neck dissection in obese patients.

scholarly journals Obesity indices as a risk factor of skin diseases: A Case-control study conducted in Cairo, Egypt

2016 ◽  
Vol 5 (2) ◽  
pp. 23-29 ◽  
Author(s):  
Raed M Alazab ◽  
Abdel Raouf M Almohsen
Keyword(s):  
Risk Factor ◽  
Skin Diseases ◽  
Statistical Significance ◽  
Case Control ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
University Hospital ◽  
Obese Patients ◽  
Dermatology Clinic ◽  
Obesity Indices

Overweight and obesity are two major health problems that have been recognized worldwide which affect all ages and have many negative health effects. WHO in year 2010 reported that in Egypt the prevalence of overweight among women is 76% compared to 64.5% for male while the prevalence of obesity among women is 48% compared to 22% for male. The aim of the study was to determine the most prevalent skin diseases among the studied over-weight and obese patients and to examine if overweight and obesity are risk factors for skin diseases. A case-control was carried out on 250 overweight and obese patients compared with another 250 normal weight patients as controls. The participants were selected from the outpatient dermatology clinic of Al Hussein University hospital, Faculty of medicine, Alazhar University, Egypt. All patients were subjected to medical history, clinical dermatological examination and measurement of obesity indices. The most prevalent skin diseases among the studied cases were: striae (68.4%), planter hyperkeratosis (61.6%), skin tags (61.2%), acanthosis nigricans (53.6%), intertrigo (53.6%), tinea pedis (41.2%) with statistical significance difference compared to controls. As a result, overweight and obesity might be a risk factor for some skin diseases. Dermatologists must work with primary health care physicians and nutritional specialists to reduce incidence of obesity or reduce the effects of obesity on the skin.South East Asia Journal of Public Health Vol.5(2) 2015: 23-29

scholarly journals Sonographic Volumetric Assessment Is a More Accurate Measure Than Maximum Diameter Alone in Papillary Thyroid Cancer

2018 ◽  
Vol 2 (11) ◽  
pp. 1284-1292
Author(s):  
Thomas E Pennington ◽  
May Thwin ◽  
Mark Sywak ◽  
Leigh Delbridge ◽  
Stan Sidhu
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Cancer ◽  
Tumor Size ◽  
Maximum Diameter ◽  
Lymph Node Status ◽  
Papillary Thyroid ◽  
Pearson Coefficient ◽  
Staging Systems ◽  
The Relationship

Abstract Background Tumor size is an important prognostic factor in papillary thyroid cancer (PTC). Management guidelines, staging systems, and pathological definitions use maximum diameter (Dmax) as a surrogate marker of tumor size. However, PTC nodules are three-dimensional (3D) structures, with behavior reflective of tumor cell count, which is directly proportional to volume. We explored the relationship between sonographically determined Dmax, volume, and lymph node status (LNS) in a cohort of patients with PTC. Methods All patients treated for PTC between 2003 and 2015 in our institution who had sonographic 3D nodule measurements available were evaluated. We examined the relationship between diameter, volume, and LNS. Results A total of 159 nodules in 153 patients met the inclusion criteria. Mean nodule dimensions were 2.4 × 1.9 × 1.5 cm, giving “ideal” nodule dimensions of y × 0.78y × 0.62y, where y is the Dmax. Observed volumes differed from predicted nodule volumes by an average of 26.2%. For PTC ≤2 cm, the coefficient of variation was 26.7%. Dmax did not correlate with the presence of lymph node metastases (Pearson coefficient 0.08), whereas volume very weakly correlated with LNS (Pearson coefficient 0.22). However, both Dmax and volume correlated very strongly with the number of nodal metastases (Pearson coefficients 0.93 and 0.89, respectively). Conclusions PTC nodules demonstrated significant volume heterogeneity, rendering Dmax an inaccurate marker of true tumor size. Although there was little difference between Dmax and volume in predicting nodal status or nodal disease burden, we propose that a prospective, randomized trial might demonstrate a clear clinical advantage of 3D sonographic nodule measurement over Dmax alone.

Role of obesity and race in predicting recurrence rates and survival in renal cell carcinoma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e16052-e16052
Author(s):  
C. Ritch ◽  
D. J. Lee ◽  
M. Desai ◽  
J. M. McKiernan
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
The Other ◽  
Recurrence Free Survival ◽  
Obese Patients ◽  
Free Survival ◽  
The Relationship

e16052 Background: Two in three Americans are obese or overweight, and African-Americans are 1.4 times as likely to be obese than whites. However, the relationship between obesity, race, and renal cell carcinoma (RCC) is highly debated. We sought to explore the relationship between BMI and race, and determine the predictors for survival and recurrence after nephrectomy (Nx) for RCC. Methods: A retrospective analysis of the Columbia Urologic Oncology Database found that 1118 consecutive patients underwent partial or radical Nx for RCC between 1988 and 2008. Of these, 499 patients had BMI and race data available. 379 (76%) were white, 51 (10.2%) were black, 37 (7.4%) were Hispanic, and 32 (6.4%) were Asian. 341 (68.3%) were male compared to 158 (31.7%) females; 215 (50.3%) had partial Nx while 284 (56.9%) had a radical Nx. Overweight and obesity were defined as having a BMI > 25 kg/m2 and a BMI > 30 kg/m2, respectively. Cox proportional hazards models were used to assess the relationship between BMI, race, and recurrence- free survival (RFS). Results: The 499 patients had a median age of 63 years were followed for a mean of 25 months. Asians had significantly lower BMI than the other races (p=0.02), but the other ethnicities had similar BMI distributions. The two year cancer-specific survival was 89.6%, 92.7%, and 96.1% for normal weight, overweight, and obese patients, respectively (p=0.036). Race did not have a significant impact on predicting RFS. A multivariate Cox regression found that male sex, BMI, size of tumor removed, tumor stage, and margin were independent predictors of RFS. Overweight and obese patients were more likely to survive from RCC without recurrence than normal weight patients (p=0.04). An analysis assessing the effect of an interaction between race and BMI demonstrated that hazard ratios for increased BMI did not differ significantly by race. Conclusions: BMI is an independent predictor of RFS in patients undergoing partial or radical Nx for RCC. Recurrence free-survival did not differ significantly among the different ethnicities, and the impact of race on recurrence-free survival did not vary among different BMI classes. The importance of these findings needs to be addressed in large multi- institutional analyses. No significant financial relationships to disclose.

scholarly journals Overweight and Obesity: Is there a Relationship with Eating Behaviour?

2021 ◽  
Vol 6 (1) ◽  
pp. 84-90
Author(s):  
M. Yu. Zak ◽  
◽  
L. S. Kiro ◽  
O. V. Chernyshov ◽  
M. V. Sverdlova
Keyword(s):  
Eating Disorders ◽  
Eating Behaviour ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
P Value ◽  
Obese Patients ◽  
Gender And Age ◽  
Study Results ◽  
The Relationship ◽  
Restrictive Type

Obesity is a non-infectious epidemic of the XXI century. The social significance of the problem of obesity is determined by the threat of disability of young patients and the reduction of overall life expectancy due to the frequent development of severe diseases. Eating behaviour disorders are the leading factors in the development of overweight and obesity. The purpose of the work was to determine the relationship between overweight and obesity with eating behaviour, taking into account the gender and age characteristics of patients. Material and methods. A survey of 272 people (136 men and 136 women) was conducted. The examined patients were divided into two clinical groups: I group included 90 people (45 women and 45 men) with excess weight (BMI = 27.7±1.31 kg / m2); Group II had 92 people (46 women and 46 men) with obesity of 1 degree (BMI = 31.74±1.03 kg / m2). Evaluation of eating disorders was carried out using the DEBQ questionnaire (Netherlands) adapted to the purpose of the study. Results and discussion. Eating behaviour disorders are one of the leading factors in the development of overweight and obesity: in overweight patients a healthy type of eating behaviour was recorded 4.86 times less often than in normal weight (D = 13.56, p = 2.35 e-14 <0.05), and in obese patients it was 7.14 times less often than in normal weight individuals (D = 21.04, p = 2.2e-16 <0.05). Overweight and obesity are most often associated with a restrictive type of eating behaviour: in overweight people they were met 4 times more often (D = 0.16, p-value = 4.637e-06 <0.05), and in obese patients disorders of the restrictive type of eating behaviour were 4.24 times more often compared to the control group (D = 0.15, p-value = 6.148e-07 <0.05). The type of eating behaviour in all clinical groups, except for body mass index, was influenced by gender and age of the subjects. Thus, in overweight men after the age of 45 a healthy type of eating behaviour occurred 8.09 times more often than in men under the age of 45 (D = 0.11, p-value = 0.03 <0.05) and in overweight women (D = 0.11, p-value = 0.03 <0.05). The relationship between the type of eating behaviour and gender and age characteristics of patients was found and confirmed by correlation analysis in all clinical groups. Conclusions. Healthy eating behaviour disorders are one of the leading factors in the development of overweight and obesity. Correction of eating disorders in obese people must be carried out taking into account the gender and age characteristics of the patient, to obtain positive results for a shorter course of treatment. Medical advice for women and young people, taking into account the prevalence of restrictive eating behaviour disorders, should be aimed at combating strict diets and periods of prolonged starvation; men and people over 45, taking into account the prevalence of external eating behaviour disorders, should follow a balanced diet. The duration of corrective treatment in obese women should be increased through psychotherapy

scholarly journals Expression of stromal cell-derived factor-1α is an independent risk factor for lymph node metastasis in early gastric cancer

2011 ◽  
Vol 2 (6) ◽  
pp. 1197-1202 ◽  
Author(s):  
IK-CHAN SONG ◽  
ZHE-LONG LIANG ◽  
JUNG-CHAN LEE ◽  
SONG-MEI HUANG ◽  
HA-YON KIM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Stromal Cell ◽  
Independent Risk Factor ◽  
Node Metastasis ◽  
Stromal Cell Derived Factor

scholarly journals THE RISK OF FALLS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2017 ◽  
Vol 54 (6) ◽  
pp. 705-711 ◽  
Author(s):  
N. V. Toroptsova ◽  
A. Yu. Feklistov
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Risk Of Falls ◽  
Relationship Of ◽  
The Relationship

The paper discusses the materials of investigations dealing with falls as an independent risk factor for fractures in patients with rheumatoid arthritis (RA). It gives data on the incidence and possible risk factors of falls in this category of patients. According to the data obtained, the prevalence of falls in different countries varies from 10 to 50%, which may be related to differences in the methods of collecting information, and the relationship of the investigated factors with the risk of falls in patients with RA is uniquely unproven and calls for further investigations.

Plasma Nesfatin-1 Level in Obese Patients after Acupuncture: A Randomised Controlled Trial

2014 ◽  
Vol 32 (4) ◽  
pp. 313-317 ◽  
Author(s):  
Yongfang Guo ◽  
Mingqing Xing ◽  
Wenjuan Sun ◽  
Xiaoyan Yuan ◽  
Hongyan Dai ◽  
...  
Keyword(s):  
Weight Control ◽  
Serum Insulin ◽  
Controlled Trial ◽  
Diet Group ◽  
Normal Weight ◽  
Obese Patients ◽  
Obese Adults ◽  
The Difference ◽  
Randomised Controlled ◽  
The Relationship

Background Nesfatin-1 is an anorexigenic hormone suggested to regulate obesity. Objective To investigate the relationship between nesfatin-1 level and anthropometric and metabolic parameters in obese patients, and examine the change in plasma nesfatin-1 level after acupuncture treatment. Methods 64 obese adult patients without diabetes and 58 normal weight control subjects were enrolled in this study. The obese patients were randomly divided into an acupuncture plus diet group (n=32) and a diet only group (n=32). Measurements were repeated after 45 days. Results Body mass index (BMI), waist and hip circumferences, serum insulin, lipoprotein and insulin resistance measures were significantly higher, and plasma nesfatin-1 level was significantly lower, in obese patients than in normal weight controls. In addition, negative correlations were found between plasma nesfatin-1 level and BMI, waist and hip circumferences. Weight reduction in participants after acupuncture and diet restriction was 7.0% and 4.3%, respectively. Plasma nesfatin-1 level increased from 2.75±1.16 to 3.44±1.28 ng/mL and from 2.86±1.07 to 3.23±1.06 ng/mL in acupuncture and diet groups, respectively; the difference was significant, p<0.05. Conclusions Plasma nesfatin-1 level is reduced in obese adults, and is increased after acupuncture. The beneficial effect of acupuncture on obesity is associated with increased plasma nesfatin-1 level.

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