scholarly journals Safety of SGLT2 Inhibitors: A Pharmacovigilance Study from 2013 to 2021 Based on FAERS

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiang Zhou ◽  
Xiaofei Ye ◽  
Xiaojing Guo ◽  
Dongxu Liu ◽  
Jinfang Xu ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
High Frequency ◽  
Medical Event ◽  
Different Types ◽  
Nutrition Disorders ◽  
The Common ◽  
Medical Dictionary ◽  
Definition Of ◽  
Important Medical Event ◽  
System Organ

Background: Sodium-glucose co-transporter-2 inhibitors (SGLT2is) are widely used in clinical practice for their demonstrated cardiorenal benefits, but multiple adverse events (AEs) have been reported. We aimed to describe the distribution of SGLT2i-related AEs in different systems and identify important medical event (IME) signals for SGLT2i.Methods: Data from the first quarter (Q1) of 2013–2021 Q2 in FAERS were selected to conduct disproportionality analysis. The definition of AEs and IMEs relied on the system organ classes (SOCs) and preferred terms (PTs) by the Medical Dictionary for Regulatory Activities (MedDRA-version 24.0). Two signal indicators, the reported odds ratio (ROR) and information component (IC), were used to estimate the association between SGLT2is and IMEs.Results: A total of 57,818 records related to SGLT2i, with 22,537 SGLT2i-IME pairs. Most SGLT2i-related IMEs occurred in monotherapy (N = 21,408, 94.99%). Significant signals emerged at the following SOCs: “metabolism and nutrition disorders” (N = 9,103; IC025 = 4.26), “renal and urinary disorders” (3886; 1.20), “infections and infestations” (3457; 0.85). The common strong signals were observed in diabetic ketoacidosis, ketoacidosis, euglycaemic diabetic ketoacidosis and Fournier’s gangrene. Unexpected safety signals such as cellulitis, osteomyelitis, cerebral infarction and nephrolithiasis were detected.Conclusion: Our pharmacovigilance analysis showed that a high frequency was reported for IMEs triggered by SGLT2i monotherapy. Different SGLT2is caused different types and the association strengths of IMEs, while they also shared some specific PTs. Most of the results are generally consistent with previous studies, and more pharmacoepidemiological studies are needed to validate for unexpected AEs. Based on risk-benefit considerations, clinicians should be well informed about important medical events that may be aggravated by SGLT2is.

Discriminating intra-parasequence stratigraphic units from two-dimensional quantitative parameters

2021 ◽  
Vol 91 (8) ◽  
pp. 887-911
Author(s):  
Manuel F. Isla ◽  
Ernesto Schwarz ◽  
Gonzalo D. Veiga ◽  
Jerónimo J. Zuazo ◽  
Mariano N. Remirez
Keyword(s):  
High Frequency ◽  
Two Dimensional ◽  
Facies Associations ◽  
Different Types ◽  
Lateral Extent ◽  
Successive Wave ◽  
Shell Bed ◽  
Definition Of ◽  
High Resolution Sequence Stratigraphy ◽  
Bounding Surfaces

ABSTRACT The intra-parasequence scale is still relatively unexplored territory in high-resolution sequence stratigraphy. The analysis of internal genetic units of parasequences has commonly been simplified to the definition of bedsets. Such simplification is insufficient to cover the complexity involved in the building of individual parasequences. Different types of intra-parasequence units have been previously identified and characterized in successive wave-dominated shoreface–shelf parasequences in the Lower Cretaceous Pilmatué Member of the Agrio Formation in central Neuquén Basin. Sedimentary and stratigraphic attributes such as the number of intra-parasequence units, their thickness, the proportions of facies associations in the regressive interval, the lateral extent of bounding surfaces, the degree of deepening recorded across these boundaries, and the type and lateral extent of associated transgressive deposits are quantitatively analyzed in this paper. Based on the analysis of these quantified attributes, three different scales of genetic units in parasequences are identified. 1) Bedset complexes are 10–40 m thick, basin to upper-shoreface successions, bounded by 5 to 16 km-long surfaces with a degree of deepening of one to three facies belts. These stratigraphic units represent the highest hierarchy of intra-parasequence stratigraphic units, and the vertical stacking of two or three of them typically forms an individual parasequence. 2) Bedsets are 2–20 m thick, offshore to upper-shoreface successions, bounded by up to 10 km long surfaces with a degree of deepening of zero to one facies belt. Two or three bedsets stack vertically build a bedset complex. 3) Sub-bedsets are 0.5–5 m thick, offshore transition to upper-shoreface successions, bounded by 0.5 to 2 km long surfaces with a degree of deepening of zero to one facies belt. Two or three sub-bedsets commonly stack to form bedsets. The proposed methodology indicates that the combination of thickness with the proportion of facies associations in the regressive interval of stratigraphic units can be used to discriminate between bedsets and sub-bedsets, whereas for higher ranks (bedsets and bedset complexes) the degree of deepening, lateral extent of bounding surfaces, and the characteristics of associated shell-bed deposits become more effective. Finally, the results for the Pilmatué Member are compared with other ancient and Holocene examples to improve understanding of the high-frequency evolution of wave-dominated shoreface–shelf systems.

Three Familial Cases of Hearing Loss Associated with Enlargement of the Vestibular Aqueduct

1997 ◽  
Vol 106 (12) ◽  
pp. 1063-1069 ◽  
Author(s):  
Satoko Abe ◽  
Shin-ichi Usami ◽  
Hideichi Shinkawa
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
High Frequency ◽  
Present Report ◽  
Sensorineural Hearing ◽  
Familial Cases ◽  
Vestibular Aqueduct ◽  
Different Types ◽  
The Common

The present report describes three familial cases of recessive hearing loss associated with enlargement of the vestibular aqueduct (EVA). Six siblings from three families showed EVA. The common characteristic of these patients was the presence of congenital, high-frequency, fluctuating sensorineural hearing loss. These cases suggest that EVA may be a useful discriminator between different types of recessive hearing loss.

scholarly journals Logics of Common Ground

2017 ◽  
Vol 58 ◽  
pp. 859-904 ◽  
Author(s):  
Tim Miller ◽  
Jens Pfau ◽  
Liz Sonenberg ◽  
Yoshihisa Kashima
Keyword(s):  
Common Ground ◽  
Modal Logics ◽  
Joint Activities ◽  
Formal Definitions ◽  
Different Types ◽  
Agent Collaboration ◽  
Shared Information ◽  
Multi Agent ◽  
The Common ◽  
Definition Of

According to Clark's seminal work on common ground and grounding, participants collaborating in a joint activity rely on their shared information, known as common ground, to perform that activity successfully, and continually align and augment this information during their collaboration. Similarly, teams of human and artificial agents require common ground to successfully participate in joint activities. Indeed, without appropriate information being shared, using agent autonomy to reduce the workload on humans may actually increase workload as the humans seek to understand why the agents are behaving as they are. While many researchers have identified the importance of common ground in artificial intelligence, there is no precise definition of common ground on which to build the foundational aspects of multi-agent collaboration. In this paper, building on previously-defined modal logics of belief, we present logic definitions for four different types of common ground. We define modal logics for three existing notions of common ground and introduce a new notion of common ground, called salient common ground. Salient common ground captures the common ground of a group participating in an activity and is based on the common ground that arises from that activity as well as on the common ground they shared prior to the activity. We show that the four definitions share some properties, and our analysis suggests possible refinements of the existing informal and semi-formal definitions.

SIMILARITIES AND DIFFERENT FEATURES OF HAND GESTURES IN AMERICAN AND KYRGYZ CULTURES

2019 ◽  
pp. 19-22
Author(s):  
Avtandil kyzy Ya
Keyword(s):  
Everyday Life ◽  
Facial Expressions ◽  
Main Part ◽  
Body Language ◽  
Hand Gestures ◽  
Common Definition ◽  
The World ◽  
The Common ◽  
Definition Of ◽  
Different Cultures

Abstract: This paper highlights similarities and different features of the category of kinesics “hand gestures”, its frequency usage and acceptance by different individuals in two different cultures. This study shows its similarities, differences and importance of the gestures, for people in both cultures. Consequently, kinesics study was mentioned as a main part of body language. As indicated in the article, the study kinesics was not presented in the Kyrgyz culture well enough, though Kyrgyz people use hand gestures a lot in their everyday life. The research paper begins with the common definition of hand gestures as a part of body language, several handshake categories like: the finger squeeze, the limp fish, the two-handed handshake were explained by several statements in the English and Kyrgyz languages. Furthermore, this article includes definitions and some idioms containing hand, shake, squeeze according to the Oxford and Academic Dictionary to show readers the figurative meanings of these common words. The current study was based on the books of writers Allan and Barbara Pease “The definite book of body language” 2004, Romana Lefevre “Rude hand gestures of the world”2011 etc. Key words: kinesics, body language, gestures, acoustics, applause, paralanguage, non-verbal communication, finger squeeze, perceptions, facial expressions. Аннотация. Бул макалада вербалдык эмес сүйлѳшүүнүн бѳлүгү болуп эсептелген “колдордун жандоо кыймылы”, алардын эки башка маданиятта колдонулушу, айырмачылыгы жана окшош жактары каралган. Макаланын максаты болуп “колдордун жандоо кыймылынын” мааниси, айырмасы жана эки маданиятта колдонулушу эсептелет. Ошону менен бирге, вербалдык эмес сүйлѳшүүнүн бѳлүгү болуп эсептелген “кинесика” илими каралган. Берилген макалада кѳрсѳтүлгѳндѳй, “кинесика” илими кыргыз маданиятында толугу менен изилденген эмес, ошого карабастан “кинесика” илиминин бѳлүгү болуп эсептелген “колдордун жандоо кыймылы” кыргыз элинин маданиятында кѳп колдонулат. Андан тышкары, “колдордун жандоо кыймылынын” бир нече түрү, англис жана кыргыз тилдеринде ма- селен аркылуу берилген.Тѳмѳнкү изилдѳѳ ишин жазууда чет элдик жазуучулардын эмгектери колдонулду. Түйүндүү сѳздѳр: кинесика, жандоо кыймылы, акустика,кол чабуулар, паралингвистика, вербалдык эмес баарлашуу,кол кысуу,кабыл алуу сезими. Аннотация. В данной статье рассматриваются сходства и различия “жестикуляции” и частота ее использования, в американской и кыргызской культурах. Следовательно, здесь было упомянуто понятие “кинесика” как основная часть языка тела. Как указано в статье, “кинесика” не была представлена в кыргызской культуре достаточно хорошо, хотя кыргызский народ часто использует жестикуляцию в повседневной жизни. Исследовательская работа начинается с общего определения “жестикуляции” как части языка тела и несколько категорий жестикуляции, таких как: сжатие пальца, слабое рукопожатие, рукопожатие двумя руками, были объяснены несколькими примерами на английском и кыргызском языках. Кроме того, эта статья включает определения слов “рука”, “рукопожатие”, “сжатие” и некоторые идиомы, содержащие данных слов согласно Оксфордскому и Академическому словарю, чтобы показать читателям их образное значение. Данное исследование было основано на книгах писателей Аллана и Барбары Пиз «Определенная книга языка тела» 2004 года, Романа Лефевра «Грубые жестикуляции мира» 2011 года и т.д. Ключевые слова: кинесика, язык жестов, жесты, акустика, аплодисменты, паралингвистика, невербальная коммуникация, сжатие пальца, чувство восприятия, выражение лиц.

A Strategy for Design of Marine Pollution Monitoring Studies

1986 ◽  
Vol 18 (4-5) ◽  
pp. 15-26 ◽  
Author(s):  
D. A. Segar ◽  
E. Stamman
Keyword(s):  
Information Needs ◽  
Marine Pollution ◽  
Monitoring Program ◽  
Pollution Monitoring ◽  
Systematic Evaluation ◽  
Management Information ◽  
Different Types ◽  
Management Context ◽  
Definition Of ◽  
Scientific Testing

Most historical marine pollution monitoring has proven useless in a management context. A strategy for development of effective marine pollution monitoring programs is outlined. This strategy is based on the following steps: 1) systematic evaluation of the management information needs, 2) identification of the hypothetical impacts associated with those management concerns, and 3) investigation of the feasibility of monitoring those effects such that the existence, or absence, of a specified level of effects can be established in a statistically-valid manner. There are two fundamentally different types of monitoring program: site-specific and regional. These two types of program differ markedly in scope and approach when designed through application of this strategy. The strategy requires development of null hypotheses which address management concerns and which are amenable to scientific testing. In order for the program to be successful, the null hypotheses selected for inclusion in a marine pollution monitoring program must address levels of effect which are predefined to be environmentally significant. The definition of environmentally significant effect levels is a difficult process which must be primarily the responsibility of the managerial community.

Maṣlaḥa as Sovereignty: Fadlallah and Khomeini Compared

2017 ◽  
Vol 9 (1) ◽  
pp. 89-112
Author(s):  
Nachman Alexander
Keyword(s):  
Political Thought ◽  
Common Good ◽  
Islamic History ◽  
The Common Good ◽  
Islamic Political Thought ◽  
Popular Movement ◽  
The Common ◽  
Definition Of

This article examines how Fadlallah and Khomeini’s respective quests for sovereignty are reflected in their political thought, particularly vis-a-vis their notions of maṣlaḥa, which I define as the “common good.” I argue that if, to an extent, Islamic political thought seeks to maximise maṣlaḥa, then this can also constitute a claim to sovereignty, the definition of which remains multidimensional and contentious. By closely examining Fadlallah and Khomeini’s writings and pronouncements on governance, popular movement, and state, I attempt to reveal how discussions regarding Islamic governance demonstrate a broader claim to authority in Islamic history.

scholarly journals Virtual Loom: a tool for the interactive 3D representation of historical fabrics

2021 ◽  
Author(s):  
Cristina Portalés ◽  
Manolo Pérez ◽  
Pablo Casanova-Salas ◽  
Jesús Gimeno
Keyword(s):  
Art History ◽  
3D Modelling ◽  
Current Version ◽  
Close Collaboration ◽  
Design And Implementation ◽  
Different Types ◽  
Interactive 3D ◽  
Silk Fabrics ◽  
Definition Of ◽  
3D Representations

Abstract3D modelling of man-made objects is widely used in the cultural heritage sector, among others. It is relevant for its documentation, dissemination and preservation. Related to historical fabrics, weaves and weaving techniques are still mostly represented in forms of 2D graphics and textual descriptions. However, complex geometries are difficult to represent in such forms, hindering the way this legacy is transmitted to new generations. In this paper, we present the design and implementation of SILKNOW’s Virtual Loom, an interactive tool aimed to document, preserve and represent in interactive 3D forms historical weaves and weaving techniques of silk fabrics, dating from the 15th to the 19th centuries. To that end, our tool only requires an image of a historical fabric. Departing from this image, the tool automatically subtracts the design, and allows the user to apply different weaves and weaving techniques. In its current version, the tool embeds five traditional weaving techniques, 39 weaves and six types of yarns, which have been defined thanks to close collaboration of experts in computer graphics, art history and historical fabrics. Additionally, users can change the color of yarns and produce different 3D representations for a given fabric, which are interactive in real time. In this paper, we bring the details of the design and implementation of this tool, focusing on the input data, the strategy to process images, the 3D modelling of yarns, the definition of weaves and weaving techniques and the graphical user interface. In the results section, we show some examples of image analysis in order to subtract the design of historical fabrics, and then we provide 3D representations for all the considered weaving techniques, combining different types of yarns.

scholarly journals Models Applied to Grapevine Pests: A Review

Insects ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 169
Author(s):  
Federico Lessio ◽  
Alberto Alma
Keyword(s):  
Lobesia Botrana ◽  
Grape Berry ◽  
Homalodisca Vitripennis ◽  
Flavescence Dorée ◽  
Or Groups ◽  
Scaphoideus Titanus ◽  
Different Types ◽  
Computer Based ◽  
Biological Aspects ◽  
Definition Of

This paper reviews the existing predictive models concerning insects and mites harmful to grapevine. A brief conceptual description is given on the definition of a model and about different types of models: deterministic vs. stochastics, continuous vs. discrete, analytical vs. computer-based, and descriptive vs. data-driven. The main biological aspects of grapevine pests covered by different types of models are phenology, population growth and dynamics, species distribution, and invasion risk. A particular emphasis is put on forecasting epidemics of plant disease agents transmitted by insects with sucking-piercing mouthparts. The most investigated species or groups are the glassy-winged sharpshooter Homalodisca vitripennis (Germar) and other vectors of Xylella fastidiosa subsp. fastidiosa, a bacterium agent of Pierce’s disease; the European grape berry moth, Lobesia botrana (Denis and Schiffermuller); and the leafhopper Scaphoideus titanus Ball, the main vector of phytoplasmas agents of Flavescence dorée. Finally, the present and future of decision-support systems (DSS) in viticulture is discussed.

scholarly journals Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review

2021 ◽  
Vol 10 (8) ◽  
pp. 1740
Author(s):  
Marion Bareille ◽  
Michaël Hardy ◽  
Jonathan Douxfils ◽  
Stéphanie Roullet ◽  
Dominique Lasne ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mechanical Strength ◽  
Small Sample ◽  
The Common ◽  
Small Sample Sizes ◽  
Definition Of ◽  
Reported Data ◽  
Prophylactic Anticoagulation ◽  
The Impact ◽  
Heparin Neutralization

Infection by SARS-CoV-2 is associated with a high risk of thrombosis. The laboratory documentation of hypercoagulability and impaired fibrinolysis remains a challenge. Our aim was to assess the potential usefulness of viscoelastometric testing (VET) to predict thrombotic events in COVID-19 patients according to the literature. We also (i) analyzed the impact of anticoagulation and the methods used to neutralize heparin, (ii) analyzed whether maximal clot mechanical strength brings more information than Clauss fibrinogen, and (iii) critically scrutinized the diagnosis of hypofibrinolysis. We performed a systematic search in PubMed and Scopus databases until December 31st, 2020. VET methods and parameters, and patients’ features and outcomes were extracted. VET was performed for 1063 patients (893 intensive care unit (ICU) and 170 non-ICU, 44 studies). There was extensive heterogeneity concerning study design, VET device used (ROTEM, TEG, Quantra and ClotPro) and reagents (with non-systematic use of heparin neutralization), timing of assay, and definition of hypercoagulable state. Notably, only 4 out of 25 studies using ROTEM reported data with heparinase (HEPTEM). The common findings were increased clot mechanical strength mainly due to excessive fibrinogen component and impaired to absent fibrinolysis, more conspicuous in the presence of an added plasminogen activator. Only 4 studies out of the 16 that addressed the point found an association of VETs with thrombotic events. So-called functional fibrinogen assessed by VETs showed a variable correlation with Clauss fibrinogen. Abnormal VET pattern, often evidenced despite standard prophylactic anticoagulation, tended to normalize after increased dosing. VET studies reported heterogeneity, and small sample sizes do not support an association between the poorly defined prothrombotic phenotype of COVID-19 and thrombotic events.

Further Investigation upon the Water Movements in the English Channel. Drift-Bottle Experiments in the Summers of 1927, 1928 and 1929, with Critical Notes on Drift-Bottle Experiments in General.

1930 ◽  
Vol 17 (1) ◽  
pp. 241-275 ◽  
Author(s):  
J. N. Carruthers
Keyword(s):  
Wind Speed ◽  
North Sea ◽  
English Channel ◽  
The North ◽  
Different Types ◽  
The North Sea ◽  
The Common ◽  
Relationship Of ◽  
Great Simplicity ◽  
Simple Surface

In July–August of three different years common surface-floating bottles were set adrift at International Station E2 (49° 27' N.—4° 42' W.). With them, various types of drag-fitted bottles were also put out. The journeys accomplished are discussed, and the striking differences as between year and year in the case of the common surface floaters, and as between the different types in the same year, are commented upon in the light of the prevailing winds. An inter-relationship of great simplicity is deduced between wind speed and the rate of travel of simple surface floating bottles up-Channel and across the North Sea from the results of experiments carried out in four different summers.

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