scholarly journals Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile

2019 ◽  
Vol 10 ◽  
Author(s):  
Marko Tijardović ◽  
Domagoj Marijančević ◽  
Daniel Bok ◽  
Domagoj Kifer ◽  
Gordan Lauc ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Inflammatory Change ◽  
Glycosylation Profile ◽  
Anti Inflammatory

scholarly journals Change in dietary inflammatory index score is associated with control of long-term rheumatoid arthritis disease activity in a Japanese cohort: the TOMORROW study

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Yoshinari Matsumoto ◽  
Nitin Shivappa ◽  
Yuko Sugioka ◽  
Masahiro Tada ◽  
Tadashi Okano ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Quantitative Measure ◽  
Inflammatory Change ◽  
Multivariable Logistic Regression Analysis ◽  
Dietary Inflammatory Index ◽  
Low Disease Activity ◽  
Inflammatory Index ◽  
Rheumatoid Arthritis Disease ◽  
Anti Inflammatory

Abstract Background The dietary inflammatory index (DII®), a quantitative measure of the inflammatory potential of daily food and nutrient intake, and associations between a variety of health outcomes have been reported. However, the association between DII score and disease activity of rheumatoid arthritis (RA) is unclear. Therefore, this study was designed to test whether higher DII score contributes to disease activity and as a corollary, whether reducing DII score helps to achieve or maintain low disease activity or remission in patients with RA. Methods We performed a cross-sectional and longitudinal analysis using 6 years of data (from 2011 to 2017) in TOMORROW, a cohort study consisting of 208 RA patients and 205 gender- and age-matched controls started in 2010. Disease activity of RA patients was assessed annually using DAS28-ESR (disease activity score 28 joints and the erythrocyte sedimentation rate) as a composite measure based on arthritic symptoms in 28 joints plus global health assessment and ESR. Dietary data were collected in 2011 and 2017 using the brief-type self-administered diet history questionnaire (BDHQ). Energy-adjusted DII (E-DII™) score was calculated using 26 nutrients derived from the BDHQ. Data were analyzed with two-group comparisons, correlation analysis, and multivariable logistic regression analysis. Results One hundred and seventy-seven RA patients and 183 controls, for whom clinical and dietary survey data were available, were analyzed. RA patients had significantly higher E-DII (pro-inflammatory) score compared to controls both in 2011 and 2017 (p < 0.05). In RA patients, E-DII score was not a factor associated with significant change in disease activity. However, anti-inflammatory change in E-DII score was associated maintaining low disease activity (DAS28-ESR ≤ 3.2) or less for 6 years (OR 3.46, 95% CI 0.33–8.98, p = 0.011). Conclusions The diets of RA patients had a higher inflammatory potential than controls. Although E-DII score was not a factor associated with significant disease activity change, anti-inflammatory change in E-DII score appeared to be associated with maintaining low disease activity in patients with RA. Trial registration UMIN Clinical Trials Registry, UMIN000003876. Registered 7 Aug 2010—retrospectively registered.

scholarly journals Inflammatory Mechanisms Associated with Skeletal Muscle Sequelae after Stroke: Role of Physical Exercise

2016 ◽  
Vol 2016 ◽  
pp. 1-19 ◽  
Author(s):  
Hélio José Coelho Junior ◽  
Bruno Bavaresco Gambassi ◽  
Tiego Aparecido Diniz ◽  
Isabela Maia da Cruz Fernandes ◽  
Érico Chagas Caperuto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Skeletal Muscle ◽  
Physical Exercise ◽  
Muscle Atrophy ◽  
Inflammatory Markers ◽  
The Other ◽  
Stroke Patients ◽  
Beneficial Effects ◽  
Anti Inflammatory

Inflammatory markers are increased systematically and locally (e.g., skeletal muscle) in stroke patients. Besides being associated with cardiovascular risk factors, proinflammatory cytokines seem to play a key role in muscle atrophy by regulating the pathways involved in this condition. As such, they may cause severe decrease in muscle strength and power, as well as impairment in cardiorespiratory fitness. On the other hand, physical exercise (PE) has been widely suggested as a powerful tool for treating stroke patients, since PE is able to regenerate, even if partially, physical and cognitive functions. However, the mechanisms underlying the beneficial effects of physical exercise in poststroke patients remain poorly understood. Thus, in this study we analyze the candidate mechanisms associated with muscle atrophy in stroke patients, as well as the modulatory effect of inflammation in this condition. Later, we suggest the two strongest anti-inflammatory candidate mechanisms, myokines and the cholinergic anti-inflammatory pathway, which may be activated by physical exercise and may contribute to a decrease in proinflammatory markers of poststroke patients.

Anti-inflammatory Effects of Physical Exercise

2005 ◽  
Vol 25 (6) ◽  
pp. 339-342 ◽  
Author(s):  
Stephan Gielen ◽  
Claudia Walther ◽  
Gerhard Schuler ◽  
Rainer Hambrecht
Keyword(s):  
Physical Exercise ◽  
Anti Inflammatory

scholarly journals Medicinal Plants in Physical Exercise: A Review

2021 ◽  
pp. 1-21
Author(s):  
Nikole Costa Dias ◽  
Natália Pandolfi Marinho ◽  
Sandra Maria Barbalho ◽  
Adriano Cressoni Araújo ◽  
Claudia Rucco Penteado Detregiachi ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Physical Exercise ◽  
Zingiber Officinale ◽  
Fatigue Effect ◽  
Ephedra Sinica ◽  
Muscular Pain ◽  
Energetic State ◽  
Efficient Alternative ◽  
Anti Inflammatory ◽  
Intense Activity

Background: The use of medicinal plants may have an effective action on the performance of athletes. Aims: This review aimed to evaluate the effects of the use of medicinal plants and some phytocompounds on physical performance. Methodology: MEDLINE/PUBMED and EMBASE were consulted following the PRISMA guidelines. Results: Panax ginseng increases the anti-fatigue effect, decreases the stress promoted by the physical exercise, and improves muscular function through gene expression enhancement. Arnica montana has a crucial anti-inflammatory action showing relief of muscular pain a. Zingiber officinale has an anti-inflammatory and analgesic role on muscular pain, and it can be used to speed up the recovery of muscular strength after intense activity. Ephedra sinica is related to thermogenic and sympathomimetic effects, being able to increase the energetic state. Capsaicin increases the energetic expenditure due to fat oxidation, promotes the anti-fatigue effect, and enhances the athlete’s resistance. Caffeine has ergogenic importance related to its antioxidant capacity, and it improves mental alertness condition. Conclusion: The nutritional supplementation with products derived from medicinal plants may be an efficient alternative to improve the athlete’s performance, being a natural substitute for synthetic supplements, which usually are forbidden in competitions.

scholarly journals Anti-inflammatory effects of exercise training. A systematic review

2021 ◽  
pp. 418-425
Author(s):  
Ilie ONU ◽  
Daniel-Andrei IORDAN ◽  
Corneliu Mircea CODREANU ◽  
MATEI Daniela ◽  
GALACTION Anca-Irina
Keyword(s):  
Physical Exercise ◽  
Chronic Inflammation ◽  
Inflammatory Diseases ◽  
Treatment Strategies ◽  
Low Grade ◽  
Clinical Tool ◽  
Immunological Mechanisms ◽  
Long Term Treatment ◽  
Anti Inflammatory ◽  
Low Grade Inflammation

Introduction: The diseases number with a known inflammatory etiology is constantly increasing. Cardiovascular and neurodegenerative diseases, osteoporosis, cancer, asthma, atherosclerosis, type 2 diabetes and obesity are associated with chronic low-grade inflammation. There is evidence that individuals who engage in intense physical activity or who exercise regularly, shows changes in biomarkers associated with chronic inflammation. Physical exercise is useful in preventing many diseases, due to improved cardiorespiratory, metabolic, musculoskeletal function. All these improve the immunity and antioxidant capacity, thus reducing the incidence of acute and chronic inflammatory diseases. Materials and Methods: In this study were included 90 bibliographic sources, of which the title contains the following keywords: exercise - 23, inflammation - 27, anti-inflammatory - 6, IL-6 - 13, IL-10 - 4, myokine - 3, IL-15 - 3, irisin - 6, obesity - 11, chronic inflammation - 7. This study discussed aspects of exercise, pro- and anti-inflammatory cytokines, immunological mechanisms, the dual role of IL-6 cytokine, and the anti-inflammatory effects of physical exercise. Results: Physical exercise is an efficient clinical tool, that limits chronic inflammation activating the immune system that will increase the level of anti-inflammatory IL-6 myokine. There is a direct relationship between the volume and intensity of exercise and the amount of IL-6 myokine in the blood stream. Conclusions: These studies contribute significantly to the understanding of the mechanisms of the anti-inflammatory effect of exercise. More studies on chronic low-grade inflammatory diseases are needed to understand their pathophysiology, and that will inspire the specialists improve long-term treatment strategies. Keywords: physical exercise, chronic low-grade inflammation, anti-inflammatory, IL-6, myokine,

scholarly journals Anti-Inflammatory Effect of Recreational Exercise in TNBS-Induced Colitis in Rats: Role of NOS/HO/MPO System

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Zita Szalai ◽  
András Szász ◽  
István Nagy ◽  
László G. Puskás ◽  
Krisztina Kupai ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Exercise ◽  
Inflammatory Mediators ◽  
Wheel Running ◽  
Treated Group ◽  
Mucosal Damage ◽  
Proinflammatory Mediators ◽  
Male Wistar Rats ◽  
Anti Inflammatory ◽  
Oxide Synthase

There are opposite views in the available literature: Whether physical exercise has a protective effect or not on the onset of inflammatory bowel disease (IBD). Therefore, we investigated the effects of recreational physical exercise before the induction of colitis. After 6 weeks of voluntary physical activity (running wheel), male Wistar rats were treated with TNBS (10 mg). 72 hrs after trinitrobenzene sulphonic acid (TNBS) challenge we measured colonic gene (TNF-α, IL-1β, CXCL1 and IL-10) and protein (TNF-α) expressions of various inflammatory mediators and enzyme activities of heme oxygenase (HO), nitric oxide synthase (NOS), and myeloperoxidase (MPO) enzymes. Wheel running significantly increased the activities of HO, constitutive NOS (cNOS) isoform. Furthermore, 6 weeks of running significantly decreased TNBS-induced inflammatory markers, including extent of lesions, severity of mucosal damage, and gene expression of IL-1β, CXCL1, and MPO activity, while IL-10 gene expression and cNOS activity were increased. iNOS activity decreased and the activity of HO enzyme increased, but not significantly, compared to the sedentary TNBS-treated group. In conclusion, recreational physical exercise can play an anti-inflammatory role by downregulating the gene expression of proinflammatory mediators, inducing anti-inflammatory mediators, and modulating the activities of HO and NOS enzymes in a rat model of colitis.

scholarly journals Anti-Inflammatory Effects of Physical Exercise on Obesity

2017 ◽  
Vol 07 (01) ◽  
pp. 44-51 ◽  
Author(s):  
Lídia Figueiredo ◽  
Ramiro Barcos Nunes ◽  
Bruna Marmett ◽  
Larissa Bianca Paiva Cunha de Sá ◽  
Alberto Krayyem Arbex
Keyword(s):  
Physical Exercise ◽  
Anti Inflammatory

scholarly journals Mechanism of Physical Exercise on Lowering Levels of C-Reactive Protein (CRP) in Overweight and Obese

2021 ◽  
Vol 57 (1) ◽  
pp. 82
Author(s):  
Muchammad Rif’at Fawaid As’ad ◽  
Paulus Liben ◽  
Lilik Herawati
Keyword(s):  
Adipose Tissue ◽  
Physical Exercise ◽  
Overweight And Obesity ◽  
The Body ◽  
Inflammatory Factors ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Increase Energy Expenditure ◽  
Tnf Α ◽  
Anti Inflammatory

Cases of overweight and obesity in the world increased continuously. In 2016, obesity increased by 3% in men and 6% in women compared to 1975. Overweight cases also increased by 20% in men and 23% in women compared to 1975. Overweight and obesity have been linked to an increase in adipose tissue in the body. Increased adipose tissue associated with inflammation, which one of its characteristics is an increase levels of C - Reactive Protein (CRP). This article aim is to describe the mechanism of physical exercise to diminish CRP level in overweight and obesity. Adipose tissue produces and releases various pro-inflammatory and anti-inflammatory factors such as leptin, adiponectin, resistin, TNF-α, IL-6, MCP-1 and CRP. One of the prevention and treatment of inflammatory for overweight and obesity cases is to do physical exercise. In cases of overweight and obesity, the physical exercise aims to increase energy expenditure. Physical exercise decreases the volume and amount of adipose and pre-adipose tissue as well as the number of endothelial cells and macrophages in adipose that contain pro-inflammation such as IL-1, TNF-α, CRP, serum amyloid protein (SAA), and cytokines. Physical exercise rises anti-inflammatory properties such as IL-10, IL-1ra which play a role in inhibiting the transduction of IL-1β signals and inhibiting TNF-α synthesis. Physical exercise also amplifies antioxidant enzymes such as SOD and GPX. The antioxidants play a role in fighting free radicals to reduce inflammation.

scholarly journals Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 424 ◽  
Author(s):  
Javier Diaz-Castro ◽  
Jorge Moreno-Fernandez ◽  
Ignacio Chirosa ◽  
Luis Javier Chirosa ◽  
Rafael Guisado ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Muscle Damage ◽  
Inflammatory Cytokines ◽  
Inflammatory Mediators ◽  
Exercise Test ◽  
Strenuous Exercise ◽  
Inflammatory Signaling ◽  
Metabolic Equivalents ◽  
Anti Inflammatory ◽  
Sports Anemia

Strenuous exercise (any activity that expends six metabolic equivalents per minute or more causing sensations of fatigue and exhaustion to occur, inducing deleterious effects, affecting negatively different cells), induces muscle damage and hematological changes associated with high production of pro-inflammatory mediators related to muscle damage and sports anemia. The objective of this study was to determine whether short-term oral ubiquinol supplementation can prevent accumulation of inflammatory mediators and hematological impairment associated to strenuous exercise. For this purpose, 100 healthy and well-trained firemen were classified in two groups: Ubiquinol (experimental group), and placebo group (control). The protocol was two identical strenuous exercise tests with rest period between tests of 24 h. Blood samples were collected before supplementation (basal value) (T1), after supplementation (T2), after first physical exercise test (T3), after 24 h of rest (T4), and after second physical exercise test (T5). Hematological parameters, pro- and anti-inflammatory cytokines and growth factors were measured. Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased. Ubiquinol supplementation during high intensity exercise could modulate inflammatory signaling, expression of pro-inflammatory, and increasing some anti-inflammatory cytokines. During exercise, RBC, hemoglobin, hematocrit, VEGF, and EGF increased in ubiquinol group, revealing a possible pro-angiogenic effect, improving oxygen supply and exerting a possible protective effect on other physiological alterations.

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