scholarly journals Identifying Distinguishable Clinical Profiles Between Single Suicide Attempters and Re-Attempters

2021 ◽  
Vol 12 ◽  
Author(s):  
Marlehn Lübbert ◽  
Lydia Bahlmann ◽  
Sebastian Josfeld ◽  
Jessica Bürger ◽  
Alexandra Schulz ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Personality Traits ◽  
Suicidal Behavior ◽  
Emotional Abuse ◽  
Specific Treatment ◽  
Individual Characteristics ◽  
Heterogeneous Group ◽  
Suicide Attempters ◽  
Clinical Profiles

More than 800,000 individuals die from suicide each year in the world, which has a devastating impact on families and society. Ten to twenty times more attempt suicide. Previous studies showed that suicide attempters represent a heterogeneous group regarding demographic characteristics, individual characteristics of a suicidal attempt, and the assumed clinical factors, e.g., hopelessness or impulsivity, thus differently contributing to the likelihood of suicidal behavior. Therefore, in the present study, we aim to give a comprehensive clinical description of patients with repeated suicide attempts compared to single attempters. We explored putative differences between groups in clinical variables and personality traits, sociodemographic information, and specific suicide attempt-related information. A sample of patients with a recent suicide attempt (n = 252), defined according to DSM-5 criteria for a suicidal behavior disorder (SBD), was recruited in four psychiatric hospitals in Thuringia, Germany. We used a structured clinical interview to assess the psychiatric diagnosis, sociodemographic data, and to collect information regarding the characteristics of the suicide attempt. Several clinical questionnaires were used to measure the suicide intent and suicidal ideations, depression severity, hopelessness, impulsivity, aggression, anger expression, and the presence of childhood trauma. Univariate and multivariate statistical methods were applied to evaluate the postulated risk factors and, to distinguish groups based on these measures. The performed statistical analyses indicated that suicide attempters represent a relatively heterogeneous group, nevertheless associated with specific clinical profiles. We demonstrated that the re-attempters had more severe psychopathology with significantly higher levels of self-reported depression, suicidal ideation as well as hopelessness. Furthermore, re-attempters had more often first-degree relatives with suicidal behavior and emotional abuse during childhood. They also exhibited a higher degree of specific personality traits, i.e., more “urgency” as a reaction to negative emotions, higher excitability, higher self-aggressiveness, and trait anger. The multivariate discriminant analysis significantly discriminated the re-attempters from single attempters by higher levels of self-aggressiveness and suicidal ideation. The findings might contribute to a better understanding of the complex mechanisms leading to suicidal behavior, which might improve the early identification and specific treatment of subjects at risk for repeated suicidal behavior.

scholarly journals Chromosome 22 Deletions and Suicidal Behavior in Schizophrenia

2021 ◽  
pp. 1-8
Author(s):  
Ali Bani-Fatemi ◽  
Christopher Adanty ◽  
Nasia Dai ◽  
Ariel Graff ◽  
Philip Gerretsen ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Suicidal Behavior ◽  
Copy Number ◽  
Rating Scale ◽  
Copy Number Variant ◽  
Chromosome 22 ◽  
Suicide Attempters ◽  
Severity Rating ◽  
Neuropsychiatric Diseases ◽  
Significant Difference

Background: Studies have shown that the overall copy number variant (CNV) load is associated with schizophrenia. Schizophrenia is a mental disorder that is frequently associated with suicidal behavior. Methods: We recruited 263 patients with schizophrenia from the Centre for Addiction and Mental Health. The Columbia Suicide Severity Rating Scale was used to assess the presence of lifetime suicide attempt. Genotyping was completed using the Illumina Omni 2.5 chip. We tested the association between deletion events on chromosome 22 with suicide attempt in our schizophrenia sample. Results: There was no significant difference between suicide attempters and non-attempters considering the presence/absence of deletion events on chromosome 22. Conclusion: Although our results did not show a significant association between deletions on chromosome 22 and suicide attempt in schizophrenia, CNV studies may reveal important, novel insights and open further investigation for the treatment of neuropsychiatric diseases.

scholarly journals Repetitive negative thinking about suicide: Associations with lifetime suicide attempts

2021 ◽  
Vol 3 (3) ◽  
Author(s):  
Tobias Teismann ◽  
Thomas Forkmann ◽  
Johannes Michalak ◽  
Julia Brailovskaia
Keyword(s):  
Suicide Attempt ◽  
Suicidal Behavior ◽  
Suicide Ideation ◽  
Suicide Attempts ◽  
Clinical Sample ◽  
Cross Sectional Study ◽  
Repetitive Negative Thinking ◽  
Cross Sectional ◽  
Suicide Attempters ◽  
Negative Thinking

Background Repetitive negative thinking has been identified as an important predictor of suicide ideation and suicidal behavior. Yet, only few studies have investigated the effect of suicide-specific rumination, i.e., repetitive thinking about death and/or suicide on suicide attempt history. On this background, the present study investigated, whether suicide-specific rumination differentiates between suicide attempters and suicide ideators, is predictive of suicide attempt history and mediates the association between suicide ideation and suicide attempts. Method A total of 257 participants with a history of suicide ideation (55.6% female; Age M = 30.56, Age SD = 11.23, range: 18–73 years) completed online measures on suicidality, general and suicide-specific rumination. Results Suicide-specific rumination differentiated suicide attempters from suicide ideators, predicted suicide attempt status (above age, gender, suicide ideation, general rumination) and fully mediated the association between suicide ideation and lifetime suicide attempts. Conclusion Overall, though limited by the use of a non-clinical sample and a cross-sectional study design, the present results suggest that suicide-specific rumination might be a factor of central relevance in understanding transitions to suicidal behavior.

Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits

2021 ◽  
pp. 1-9
Author(s):  
Ikuo Otsuka ◽  
Hanga Galfalvy ◽  
Jia Guo ◽  
Masato Akiyama ◽  
Dan Rujescu ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Psychiatric Disorders ◽  
Suicidal Behavior ◽  
Statistical Power ◽  
Small Sample ◽  
European Ancestry ◽  
Risk Scores ◽  
Suicide Attempters ◽  
Polygenic Risk ◽  
Suicide Death

Abstract Background Suicidal behavior is moderately heritable and a consequence of a combination of the diathesis traits for suicidal behavior and suicide-related major psychiatric disorders. Here, we sought to examine shared polygenic effects between various psychiatric disorders/traits and suicidal behavior and to compare the shared polygenic effects of various psychiatric disorders/traits on non-fatal suicide attempt and suicide death. Methods We used our genotyped European ancestry sample of 260 non-fatal suicide attempters, 317 suicide decedents and 874 non-psychiatric controls to test whether polygenic risk scores (PRSs) obtained from large GWASs for 22 suicide-related psychiatric disorders/traits were associated with suicidal behavior. Results were compared between non-fatal suicide attempt and suicide death in a sensitivity analysis. Results PRSs for major depressive disorder, bipolar disorder, schizophrenia, ADHD, alcohol dependence, sensitivity to environmental stress and adversity, educational attainment, cognitive performance, and IQ were associated with suicidal behavior (Bonferroni-corrected p < 2.5 × 10−4). The polygenic effects of all 22 psychiatric disorders/traits had the same direction (p for binomial tests = 4.8 × 10−7) and were correlated (Spearman's ρ = 0.85) between non-fatal suicide attempters and suicide decedents. Conclusions We found that polygenic effects for major psychiatric disorders and diathesis-related traits including stress responsiveness and intellect/cognitive function contributed to suicidal behavior. While we found comparable polygenic architecture between non-fatal suicide attempters and suicide decedents based on correlations with PRSs of suicide-related psychiatric disorders/traits, our analyses are limited by small sample size resulting in low statistical power to detect difference between non-fatal suicide attempt and suicide death.

Wish to Die: Suicide and Its Link to Euthanasia

2019 ◽  
pp. 003022281987118
Author(s):  
Inês Costa-Maia ◽  
Sílvia Marina ◽  
Miguel Ricou
Keyword(s):  
Risk Assessment ◽  
Health Care ◽  
Suicidal Ideation ◽  
Literature Review ◽  
Suicide Attempt ◽  
Suicidal Behavior ◽  
Care Practice ◽  
Health Care Practice ◽  
Wish To Die ◽  
Different Populations

This article analyzes suicidal behavior and how its inherent processes of death ideation can overlap with those seeking euthanasia. We present a literature review of three main events in suicide (suicidal ideation, suicide attempt, and suicide) in different populations and evaluate implications for health-care practice and risk assessment taking into account the context of euthanasia. We ponder upon the motives behind suicide and its link with wish to die requests to hasten death. We discuss the possibility of the reversal of a wish to die as well as a potential process of differentiating between individuals who would maintain their wish and benefit from termination of life and others who would later change their minds.

scholarly journals Vulnerabilidades da população em situação de rua ao comportamento suicida

2019 ◽  
Vol 13 (2) ◽  
pp. 431
Author(s):  
Ramon Azevedo Silva de Castro ◽  
Éllen Bárbara Padilha ◽  
Cássia Maria Dias ◽  
Nadja Cristiane Lappann Botti
Keyword(s):  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Suicidal Behavior ◽  
Homeless People ◽  
Categorical Analysis ◽  
Problematic Use ◽  
Street People ◽  
Analysis Technique ◽  
History Of ◽  
Qualitative Descriptive

RESUMOObjetivo: compreender as vulnerabilidades de adultos em situação de rua ao comportamento suicida. Método: trata-se de um estudo qualitativo, descritivo, realizado com oito pessoas em situação de rua com história de tentativa de suicídio. Fez-se a coleta de dados por meio de entrevista, e os resultados a partir da técnica de Análise de Conteúdo na modalidade Análise Categorial. Resultados: entende-se que as categorias geradas a partir da análise temática dos dados foram os contextos de vulnerabilidade à ideação suicida, tentativa de suicídio e suicídio para pessoas em situação de rua. Observou-se que os entrevistados acreditam que o comportamento suicida ocorre na população em situação de rua em função da tristeza, sofrimento, desesperança, uso problemático de álcool e/ou outras drogas, doenças e falta de fé. Conclusão: expõem-se os adultos em situação de rua a constantes e diversas situações de vulnerabilidades ao comportamento suicida. Descritores: Pessoas em Situação de Rua; Vulnerabilidade em Saúde; Suicídio; Ideação Suicida; Tentativa de Suicídio; Saúde Mental.   ABSTRACT Objective: to understand the vulnerabilities of street adults to suicidal behavior. Method: this is a qualitative, descriptive study carried out with eight street persons with a history of attempted suicide. Data was collected through an interview, and the results were obtained from the Content Analysis technique in the Categorical Analysis modality. Results: it is understood that the categories generated from the thematic analysis of the data were contexts of vulnerability to suicidal ideation, suicide attempt and suicide for street people. It was observed that the interviewees believe that suicidal behavior occurs in the street population due to sadness, suffering, and hopelessness, problematic use of alcohol and / or other drugs, illness and lack of faith. Conclusion: the adults in the street situation are exposed to constant and diverse situations of vulnerability to suicidal behavior. Descriptors: Homeless People; Vulnerability in Health; Suicide; Suicidal Ideation; Suicide attempt; Mental health. RESUMEN Objetivo: comprender las vulnerabilidades de los adultos en situación de calle al comportamiento suicida. Método: se trata de un estudio cualitativo, descriptivo, realizado con ocho personas en situación de calle con historia de intento de suicidio. Se hizo la recolección de datos por medio de entrevista, y los resultados a partir de la técnica de Análisis de Contenido en la modalidad Análisis Categorial. Resultados: se entiende que las categorías generadas a partir del análisis temático de los datos fueron los contextos de vulnerabilidad a la ideación suicida, intento de suicidio y suicidio para personas en situación de calle. Se observó que los entrevistados creen que el comportamiento suicida ocurre en la población en situación de calle en función de la tristeza, sufrimiento, desesperanza, uso problemático de alcohol y / u otras drogas, enfermedades y falta de fe. Conclusión: se exponen los adultos en situación de calle a constantes y diversas situaciones de vulnerabilidades al comportamiento suicida. Descriptores: Personas sin Hogar; Vulnerabilidad em Salud; Suicidio; Ideación Suicida; Intento de Suicidio; Salude Mental.

scholarly journals Factors associated with the transition from suicidal ideation to suicide attempt in prison

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Louis Favril ◽  
Rory C. O’Connor ◽  
Keith Hawton ◽  
Freya Vander Laenen
Keyword(s):  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Suicidal Behavior ◽  
Psychiatric Morbidity ◽  
Self Report ◽  
Suicidal Thoughts ◽  
Factors Associated ◽  
Wide Range ◽  
Report Data ◽  
Self Report Data

Abstract Background Although research has identified a wide range of risk factors for suicidal behavior in prisoners, it does not establish who is most likely to act on their suicidal thoughts while incarcerated. Methods Self-report data were collected from a random sample of 1,203 adult men incarcerated across 15 prisons in Belgium, who represent 12% of all male prisoners nationwide. Results One-third (33%) of participants reported having suicidal thoughts during their incarceration, of whom 26% attempted suicide in prison (9% of all prisoners). Factors independently associated with suicide attempt among prisoners with suicidal ideation were violent offending (adjusted odds ratio [aOR] = 2.64, 95% confidence interval [CI] 1.33–5.23), in-prison drug use (aOR = 2.30, 95% CI 1.25–4.22), exposure to suicidal behavior (aOR = 1.96, 95% CI 1.04–3.68), and a lifetime history of nonsuicidal self-injury (aOR = 1.90, 95% CI 1.08–3.36). While related to suicidal thoughts, markers of psychiatric morbidity and aspects of the prison regime were not associated with the progression to suicide attempt. Conclusions Many prisoners who think about suicide do not attempt suicide while incarcerated. Factors associated with suicidal ideation are distinct from those that govern the transition to suicidal behavior. Our findings lend support to the hypothesis that behavioral disinhibition might act as a catalyst in the translation of suicidal thoughts into action.

Characteristics of Suicidal Behavior in a Turkish Sample

Crisis ◽  
2009 ◽  
Vol 30 (2) ◽  
pp. 90-93 ◽  
Author(s):  
Osman Ozdel ◽  
Gulfizar Varma ◽  
Figen C. Atesci ◽  
Nalan K. Oguzhanoglu ◽  
Filiz Karadag ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Suicidal Behavior ◽  
Clinical Characteristics ◽  
Religious Orientation ◽  
Educational Status ◽  
Suicide Attempters ◽  
Suicide Intent ◽  
Suicidal Intention ◽  
The Family ◽  
Dsm Iv

Background: Suicidal behavior is one of the most important problems in psychiatric clinics. Several sociodemographic and clinical characteristics may have different effects on suicidal behavior. Aims: To examine the sociodemographic and clinical characteristics of a sample of 144 suicide attempters admitted to a Turkish emergency clinic for a suicide attempt. Methods: All subjects were interviewed by a consultant psychiatrist. For all individuals, data on DSM-IV psychiatric diagnoses, sociodemographic data, Beck’s Hopelessness Scale (BHS), Becks’s Suicidal Ideation Scale (SIS), and Beck’s Suicidal Intention Scale (BSIS) were collected. Results: The majority of suicide attempters were females characterized by low educational status and low religious orientation. Drug overdose was the most common method of suicide attempt and conflict within the family was the most fre uent psychological stress factor. Three- uarters of attempters (74.6%) met DSM-IV criteria for at least one psychiatric diagnosis. Of these, 28.5% met criteria for major depressive disorder. Suicide attempters with depression tended to be immigrant, urban dwellers with high scores on the suicide intent scale. Conclusions: In the present study, the findings are useful in showing the risk factors related to suicidal behavior.

scholarly journals Mediation Effect of Suicide-Related Social Media Use Behaviors on the Association Between Suicidal Ideation and Suicide Attempt: Cross-Sectional Questionnaire Study

10.2196/14940 ◽  
2020 ◽  
Vol 22 (4) ◽  
pp. e14940
Author(s):  
Xingyun Liu ◽  
Jiasheng Huang ◽  
Nancy Xiaonan Yu ◽  
Qing Li ◽  
Tingshao Zhu
Keyword(s):  
Social Media ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Social Cognitive Theory ◽  
Social Cognitive ◽  
Cognitive Theory ◽  
Suicide Attempts ◽  
Media Use ◽  
Social Media Use ◽  
Suicide Attempters

Background A limited number of studies have examined the differences in suicide-related social media use behaviors between suicide ideators and suicide attempters or have sought to elucidate how these social media usage behaviors contributed to the transition from suicidal ideation to suicide attempt. Objective Suicide attempts can be acquired through suicide-related social media use behaviors. This study aimed to propose 3 suicide-related social media use behaviors (ie, attending to suicide information, commenting on or reposting suicide information, or talking about suicide) based on social cognitive theory, which proposes that successive processes governing behavior transition include attentional, retention, production, and motivational processes. Methods We aimed to examine the mediating role of suicide-related social media use behaviors in Chinese social media users with suicidal risks. A sample of 569 Chinese social media users with suicidal ideation completed measures on suicidal ideation, suicide attempt, and suicide-related social media use behaviors. Results The results demonstrated that suicide attempters showed a significantly higher level of suicidal ideation (t563.64=5.04; P<.001; two-tailed) and more suicide-related social media use behaviors, which included attending to suicide information (t567=1.94; P=.05; two-tailed), commenting on or reposting suicide information (t567=2.12; P=.03; two-tailed), or talking about suicide (t542.22=5.12; P<.001; two-tailed). Suicidal ideation also affected suicide attempts through the mediational chains. Conclusions Our findings thus support the social cognitive theory, and there are implications for population-based suicide prevention that can be achieved by identifying behavioral signals.

scholarly journals Hippocampal Subfield Volumes in Major Depressive Disorder Adolescents with a History of Suicide Attempt

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Qi Zhang ◽  
Su Hong ◽  
Jun Cao ◽  
Yi Zhou ◽  
Xiaoming Xu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Suicide Attempt ◽  
Depressive Disorder ◽  
Suicidal Behavior ◽  
Clinical Characteristics ◽  
Suicide Attempts ◽  
Healthy Controls ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Functional Studies

Suicidal behavior is a leading cause of death and often commences during adolescence/young adulthood (15~29 years old). The hippocampus, which consists of multiple functionally specialized subfields, may contribute to the pathophysiology of depression and suicidal behavior. We aimed to investigate the differences of hippocampal subfield volume between major depressive disorder (MDD) patients with and without suicide attempts and healthy controls in adolescents and young adults. A total of 40 MDD suicide attempters (MDD+SA), 27 MDD patients without suicide attempt (MDD-SA), and 37 healthy controls (HC) were recruited. High-resolution T1 MRI images were analyzed with the automated hippocampal substructure module in FreeSurfer 6.0. Volume differences among the groups were analyzed by a generalized linear model controlling for intracranial cavity volume (ICV). The relationship between hippocampal subfield volumes and clinical characteristics (HAM-D and SSI scores) was assessed using two-tailed partial correlation controlling for ICV in MDD+SA and MDD-SA. We found that MDD-SA had significantly smaller bilateral hippocampal fissure volume than HC and MDD+SA. No significant correlation was observed between hippocampal subfield volume and clinical characteristics (HAM-D and SSI scores) in MDD+SA and MDD-SA. Adolescent/young adult suicide attempters with MDD suicide attempters have larger bilateral hippocampal fissures than depressed patients without suicide attempts, independently from clinical characteristics. Within the heterogeneous syndrome of major depressive disorder that holds a risk for suicidality for subgroups, hippocampal morphology may help to explain or possibly predict such risk, yet longitudinal and functional studies are needed for understanding the biological mechanisms underlying.

Personality traits in attempted and completed suicide

2012 ◽  
Vol 27 (7) ◽  
pp. 536-541 ◽  
Author(s):  
T. Hirvikoski ◽  
J. Jokinen
Keyword(s):  
Suicide Attempt ◽  
Personality Traits ◽  
Factor Structure ◽  
Principal Component ◽  
Population Based ◽  
University Hospital ◽  
Suicide Attempters ◽  
Completed Suicide ◽  
Biological Studies ◽  
Suicide Completers

AbstractObjectiveThough widely used in clinical and biological studies, no investigation of the factor structure of the Karolinska Scales of Personality (KSP) has been performed in suicide attempters. There are very few studies of personality traits in suicide completers. The aim of the present study was to assess the factor structure of KSP in suicide attempters. A secondary aim was to examine whether the factor structure of the KSP was related to gender and/or to violent method of the suicide attempt or to suicide completion.MethodThe factor structure of the KSP was analysed in data from 165 suicide attempters from the Suicide Prevention Clinic at the Karolinska University Hospital using principal component analysis and orthogonal varimax rotation for the factor extraction. The effect of gender and (1) used method in the suicide attempt (violent versus nonviolent), and (2) later completed suicide on the factors was assessed in two separate series of the two-way ANOVAs.ResultA four-factor solution appeared: (1) Neuroticism, (2) Nonconformity, (3) Psychoticism and (4) Extraversion. Men who later completed suicide reported more Extroversion than male survivors.ConclusionThe obtained factor structure is comparable to a previous factor structure in a group of twins from the population-based Swedish Twin Registry indicating that no specific personality structure characterized the current sample. Differences in personality traits between suicide completers and survivors indicate that these groups may have some distinct characteristics.

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