scholarly journals Effect of Inorganic Zinc on Selected Immune Parameters in Chicken Blood and Jejunum after A. galli Infection

Agriculture ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 551
Author(s):  
Viera Karaffová ◽  
Viera Revajová ◽  
Emília Dvorožňáková ◽  
Ľubomíra Grešáková ◽  
Martin Levkut ◽  
...  
Keyword(s):  
Lamina Propria ◽  
Egg Production ◽  
Body Weight Gain ◽  
Essential Elements ◽  
Ascaridia Galli ◽  
Immune Parameters ◽  
Tnf Α ◽  
Quantitative Changes ◽  
Positive Effect ◽  
Lamina Propria Lymphocytes

Ascaridiosis in poultry results in a reduction in body weight gain, egg production, as well as microelement levels. Infected poultry have higher demands on feed with the addition of essential elements including zinc. The effects of the infection by Ascaridia galli and the supplementation of inorganic zinc on the immune status of broilers were monitored through evaluation of the relative expression of selected genes (interleukins, IFN-γ, and TNF-α) by real-time PCR, haematology parameters by microscopy, and quantitative changes of lamina propria lymphocytes by flow cytometry in day 7 and day 14 of the study. We observed that the enrichment of the diet with inorganic zinc has a positive effect on the relative percentage of CD4+ lamina propria lymphocytes in the jejunum and on heterophil counts in blood. In addition, it was concluded that inorganic zinc has an anti-inflammatory effect (downregulation of TNF-α and IL-17) and activates IgA-producing cells in the jejunum of chicks infected with A. galli.

scholarly journals Serum IL-35 is decreased in overweight patients with rheumatoid arthritis: its correlation with Th1/Th2/Th17-related cytokines

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yuxuan Li ◽  
Yang Jie ◽  
Xiaofei Wang ◽  
Jing Lu
Keyword(s):  
Rheumatoid Arthritis ◽  
Medical Records ◽  
Clinical Information ◽  
Serum Cytokines ◽  
Healthy Donors ◽  
Potential Biomarker ◽  
Tnf Α ◽  
Ifn Γ ◽  
Quantitative Changes ◽  
Anti Inflammatory Cytokine

Abstract Background Obesity is correlated with worse drug responses and high disease activity in patients with rheumatoid arthritis (RA). Interleukin (IL)-35 is a novel anti-inflammatory cytokine that mainly produced by regulatory T (Treg). This study was performed to analyze whether IL-35 was correlated with obesity in RA and investigate the correlation between other Th1/Th2/Th17-related cytokines and obesity in RA. Results The serum IL-35 level was analyzed in RA (n = 81) and healthy donors (n = 53) by ELISA assay, and was compared between three groups (body mass index (BMI) < 18.5,≥18.5 to 25, > 25). Serum cytokines including IL-2, IL-4, IL-10, IL-17, INF-γ, TNF-α levels were measured using Flowcytometry assay. Clinical information was extracted from medical records. Serum IL-35 level in overweight patients were significantly decreased than those in lean patients. Furthermore, Th1/Th2/Th17-related cytokines from overweight patients with RA showed the characteristic immunological features. Serum IL-6, IL-17 and TNF-α levels were positively correlated with BMI. However, serum IL-2, IL-4, IL-10 and IFN-γ concentrations were not correlated with BMI. Conclusions Quantitative changes in serum IL-35 level were characteristic in overweight patients with RA. These findings indicate that IL-35 plays an important role in the development of RA and may prove to be a potential biomarker of active RA.

scholarly journals Behҫet’s Disease, and the Role of TNF-α and TNF-α Blockers

2020 ◽  
Vol 21 (9) ◽  
pp. 3072
Author(s):  
Tim van der Houwen ◽  
Jan van Laar
Keyword(s):  
Systematic Review ◽  
Course Of Disease ◽  
Th22 Cells ◽  
Cochrane Database ◽  
Tnf Α ◽  
Auto Inflammatory Disease ◽  
Effect Of Treatment ◽  
Ifn Γ ◽  
Positive Effect

In this both narrative and systematic review, we explore the role of TNF-α in the immunopathogenesis of Behçet’s disease (BD) and the effect of treatment with TNF-α blockers. BD is an auto-inflammatory disease, characterized by recurrent painful oral ulcerations. The pathogenesis of BD is not yet elucidated; it is assumed that TNF-α may play a key role. In the narrative review, we report an increased production of TNF-α, which may be stimulated via TLR-signaling, or triggered by increased levels of IL-1β and IFN-γ. The abundance of TNF-α is found in both serum and in sites of inflammation. This increased presence of TNF-α stimulates T-cell development toward pro-inflammatory subsets, such as Th17 and Th22 cells. Treatment directed against the surplus of TNF-α is investigated in the systematic review, performed according to the PRISMA guideline. We searched the Pubmed and Cochrane database, including comparative studies only. After including 11 studies, we report a beneficial effect of treatment with TNF-α blockers on the various manifestations of BD. In conclusion, the pivotal role of TNF-α in the immunopathogenesis of BD is reflected in both the evidence of their pro-inflammatory effects in BD and in the evidence of the positive effect of treatment on the course of disease in BD.

scholarly journals The nutritional use of millet grain for food and feed: a review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Z. M. Hassan ◽  
N. A. Sebola ◽  
M. Mabelebele
Keyword(s):  
Phenolic Compounds ◽  
Human Health ◽  
Pearl Millet ◽  
Egg Production ◽  
Positive Impact ◽  
The Body ◽  
Broiler Performance ◽  
Food And Feed ◽  
High Antioxidant Activity ◽  
Positive Effect

AbstractWorldwide, millets are regarded as a significant grain, however, they are the least exploited. Millet grain is abundant in nutrients and health-beneficial phenolic compounds, making it suitable as food and feed. The diverse content of nutrients and phenolic compounds present in finger and pearl millet are good indicators that the variety of millet available is important when selecting it for use as food or feed. The phenolic properties found in millets compromise phenolic acids, flavonoids, and tannins, which are beneficial to human health. Moreover, finger millet has an exceptionally unique, more abundant, and diverse phenolic profile compared to pearl millet. Research has shown that millet phenolic properties have high antioxidant activity. The presence of phytochemicals in millet grains has positive effect on human health by lowering the cholesterol and phytates in the body. The frantic demands on maize and its uses in multiple industries have merited the search for alternative grains, to ease the pressure. Substitution of maize with pearl and finger millets in the diets of different animals resulted in positive impact on the performance. Including these grains in the diet may improve health and decrease the risks of diseases. Pearl millet of 50% or more can be used in broiler diets without adversely affecting broiler performance or egg production. Of late, millet grain has been incorporated in other foods and used to make traditional beverages. Thus, the core aim of this review is to provide insight and comprehension about the nutritional and phenolic status of millets and their impact on human and livestock.

Effects of glycine–metal compounds onAscaridia galli-infected chickens expressed by a kinetic model

2004 ◽  
Vol 78 (1) ◽  
pp. 25-32 ◽  
Author(s):  
M. Gabrashanska ◽  
S.E. Teodorova ◽  
M. Galvez-Morros ◽  
M. Mitov
Keyword(s):  
Body Weight Gain ◽  
Biogenic Elements ◽  
Model Parameters ◽  
Ascaridia Galli ◽  
Mineral Deficiency ◽  
Metal Compounds ◽  
High Infection ◽  
Gain Reduction ◽  
Reduction Of Mortality ◽  
Host Parasite

AbstractThe biogenic elements zinc, manganese and cobalt are essential for metabolic processes in animals. Compounds of nGly.Me2+A. mH2O (Me2+=Zn2+, Mn2+, Co2+; A=Cl−, SO42−, n=1, 2; m=2, 5), as supplements in the diet, were used separately on different experimental groups of male Hisex chickens to correct the mineral deficiency caused byAscaridia galliinfections. An amelioration of body weight gain, reduction of mortality and restoration of trace element levels were estimated in infected chickens. A mathematical model has been proposed forA. gallipopulation kinetics in chickens, taking into account the stimulating effect of these elements on the nematodes. The model parameters are considered as phenomenological constants of the host–parasite system. An agreement with experimental data is observed using, for the parametersψ,α,μandμs, values equal to those calculated in previously investigatedA. galli–chicken systems. For parameterν(immunological constant) the same value was obtained as in a previous experiment with high infection. This model is likely to be suitable for a range of host–nematode systems, including varying degrees of infection and treatment with different trace elements.

scholarly journals PERFORMANCE OF QUAILS (Coturnix-coturnix japonica) GIVEN DRINK CONTAINING MORINGA LEAF SOLUTION IN THEIR GROWING PERIOD

2019 ◽  
Vol 4 (2) ◽  
pp. 75
Author(s):  
Fatkur Rohman ◽  
Ristika Handarini ◽  
Hanafi Nur
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Egg Production ◽  
Body Weight Gain ◽  
Coturnix Japonica ◽  
Feed Conversion ◽  
Coturnix Coturnix ◽  
Growing Period ◽  
Randomized Design ◽  
Completely Randomized Design

Moringa leaves contain phytochemicals which can be used to improve the performance of quails in their growing period.  This study was aimed at assessing the effects of the inclusion of moringa leaf solution in drinking water on the performance of quails.  The study was conducted at Badrupuyuh Farm, Sukajaya Village RT 01/02, Ciomas, Bogor Regency from October to December 2017.  One-hundred quail birds aged 7 days with average initial body weight of 17.87±0.46 g were used.  The birds were fed starter and grower commercial rations.  Moringa leaf solution was given through drinking water.  A completely randomized design with 4 treatments and 5 replicates was used.   Treatments consisted of drinking water containing no moringa leaf solution (R0), drinking water containing 5% moringa leaf solution (R1), drinking water containing 10% moringa leaf solution (R2), drinking water containing 15% moringa leaf solution (R3).  Data were subjected to an analysis of variance and a Duncan test.  Measurements were taken on feed intake, body weight gain (BWG), feed conversion, and mortality rate.  Results showed that there were significant effects (P<0.05) of treatments on BWG in week 2 and 4 and feed conversion in week 2.  No mortality of quails was found.  It was concluded that the inclusion of 10% moringa leaf solution in drinking water could increase BWG in week 2 and 4, improve feed conversion, and maintain the life of quails.  It was recommended that further studies on the effects of moringa leaf solution inclusion in drinking water on egg production in laying period.  Key words: performance, quail, moringa leaf solution

scholarly journals Effect of Diatomaceous Earth on Growth Rate, Egg Production, Feed Conversion Efficiency and Parasitic Load in Hens Raised on Deep Litter

2021 ◽  
Vol 3 (1) ◽  
pp. 97-103
Author(s):  
Robert Alex Isabirye ◽  
Savino Biryomumaisho ◽  
James Okwee-Acai ◽  
Samuel Okello ◽  
George William Nasinyama
Keyword(s):  
Growth Rate ◽  
Conversion Efficiency ◽  
Egg Production ◽  
Diatomaceous Earth ◽  
Agricultural Research ◽  
Ascaridia Galli ◽  
Feed Conversion ◽  
Indigenous Chicken ◽  
Feed Conversion Efficiency ◽  
Treatment Groups

The efficacy of diatomaceous earth (DE) on growth rate, egg production and on increasing feed conversion efficiency in deep litter raised layer hens was evaluated. The study was conducted at Mukono Zonal Agricultural Research and Development Institute (MUZARDI) in Uganda. Worms were collected from fresh intestines of indigenous chicken obtained from Kalerwe chicken market near Kampala. The DE was mined in Pakwach (formerly Nebbi) district in Northern Uganda. Chickens of the Lohmann Brown breed raised on deep litter were studied. At 7 weeks the birds were divided into 5 treatment groups, A, B, C, D and E each composed of 40 birds. Groups C, D and E were given an oral dose containing 250 embryonated eggs of A. galli while groups A and B were not infected. The chicks were weighed; and subjected to feeding trials as arranged below: A – Non-infected birds on DE (4%) supplemented diet; B –non-infected birds on neither piperazine (a conventional de-wormer) nor DE; C – infected birds on DE supplemented diet; D – infected birds on piperazine; and group E – infected birds on neither DE nor piperazine applied. Fecal samples were collected and analysed in the laboratory biweekly at week 16 till week 22 respectively for fecal egg counts. In a subsequent experiment, day-old layer chicks from Lohmann Brown strain but different from those used in earlier experiments, were used to assess the effect of DE on egg production. At 17 weeks of age the 420 were divided as follows: 6 treatment groups each having 7 replicates and each replicate having 10 birds. This study showed that DE can be used successfully in growing pullet diets to correct nutritional mineral imbalance since it supplies more than 14 trace elements and other elements. Diatomaceous earth also enables pullets to cope with Ascaridia galli load; and 2% DE supplementation did not have significant improvement on egg production as compared to no supplementation at all. However, reduction in egg production was experienced when supplementation with levels of DE higher that 2% was applied. Results from biweekly fecal analyses showed significant differences in fecal egg counts (p<0.05); and treatment by group (p<0.05).

scholarly journals Hypoglycemic Effect of Vitexin in C57BL/6J Mice and HepG2 Models

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Weidong Xu ◽  
Jiayao Li ◽  
Weipeng Qi ◽  
Ye Peng
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Glucose Uptake ◽  
Lipid Content ◽  
Hepg2 Cells ◽  
Body Weight Gain ◽  
Tnf Α ◽  
Hepatic Lipid Content

Apigenin-8-C-glucoside (vitexin), a natural phytochemical contained in hawthorn, has been reported to have versatile beneficial bioactivities, such as antioxidation, anticancer property, and adipogenesis inhibition. The present research aimed to determine the influence of vitexin on insulin resistance elicited by HFD in mice and HepG2 cells. Vitexin markedly alleviated body weight gain and improved glucose and insulin intolerance induced by HFD. Vitexin partially normalized blood glucose, cholesterol, TNF-α, and hepatic lipid content. Moreover, vitexin recovered the reduced glucose uptake induced by glucosamine. The present results indicate that vitexin prevents HFD-induced insulin resistance.

Lamina Propria Lymphocytes

1996 ◽  
pp. 227-245 ◽  
Author(s):  
Maria T. Abreu-Martin ◽  
Stephan R. Targan
Keyword(s):  
Lamina Propria ◽  
Lamina Propria Lymphocytes
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