scholarly journals NMR Fingerprint Comparison of Cultivated Sideritis spp. from Cyprus

Agronomy ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1503
Author(s):  
Ekaterina-Michaela Tomou ◽  
Krystalia Lytra ◽  
Antonios Chrysargyris ◽  
Nikolaos Tzortzakis ◽  
Helen Skaltsa
Keyword(s):  
Positive Impact ◽  
Raw Materials ◽  
Research Work ◽  
Herbal Medicines ◽  
2D Nmr ◽  
Medicinal And Aromatic Plants ◽  
Plant Raw Materials ◽  
Chemical Fingerprints ◽  
Cultivation Practices ◽  
Nmr Methods

Medicinal and Aromatic Plants (MAPs) play an essential role in global health systems, since more than 80% of population use natural products in primary healthcare. Given that the global use of herbal medicines is exponentially increasing, as well as many MAPs products are introduced into the market, many cultivation practices are applied to produce high quality and standardized plant raw materials. Thus, the present study focuses on the chemical fingerprints of two cultivated Sideritis species. In Cyprus, Sideritis cypria Post and S. perfoliata L. subsp. perfoliata are widely used in traditional medicine. To date, there is no research work presenting the comparative chemical profiling between the aforesaid species using NMR methods. In this study, 1D and 2D NMR experiments were used to compare the chemical fingerprints of these species originated from conventional cultivation practices. Iridoids (ajugol, monomelittoside, and melittoside) and one flavone (4′-methyl-isoscutellarein 7-O-[6‴-O-acetyl]-β-D-allosyl(1→2)glucoside) were present in the infusion of S. perfoliata subsp. perfoliata. The phenylethanoid glycoside, acteoside, was detected in both samples. The phytochemical profiles of these cultivated species were similar to those of Sideritis species, indicating the positive impact of cultivation practices in MAPs.

Sensitive Determination of C-Alkylated Flavonoids by HPLC-ESI-MS/MS Using Multiple Reaction Monitoring Approach: Pseudarthria hookeri as a Case Study

2019 ◽  
Vol 57 (10) ◽  
pp. 944-949
Author(s):  
Ina Faraz ◽  
Arslan Ali ◽  
Faraz Ul Haq ◽  
Joseph Tchamgoue ◽  
Simeon F Kouam ◽  
...  
Keyword(s):  
Quality Control ◽  
Method Development ◽  
Control Method ◽  
Raw Materials ◽  
Multiple Reaction Monitoring ◽  
Herbal Medicines ◽  
Reaction Monitoring ◽  
Linear Calibration ◽  
Esi Ms ◽  
Plant Raw Materials

Abstract One of the major problems with the formulation of herbal medicines is the quality control of plant material to ensure its efficacy and safety. Quality control of medicinal plants requires analysis of many bioactive compounds present in the plant. C-alkylated flavonoids are an important bioactive subclass of flavonoids. A simple, rapid, sensitive and selective method is presented here for the quantification of bioactive C-alkylated flavonoids. This is the first quantitative method for analysis of C-alkylated flavonoids based on the multiple reaction monitoring (MRM) approach so far. This study focuses on method development for quantification of bioactive C-alkylated flavonoids. Quantification of a total of five C-alkylated flavonoids was done employing the MRM approach on an HPLC-QqQ-MS instrument. LODs and LOQs for quantified flavonoids were in the range of 0.41–1.32 and 1.23–3.96 ng/mL, respectively. Linear calibration curves between 25 and 1500 ng/mL were obtained with the regression coefficients of ≥0.996. Accuracy (% bias) and precision (% RSD) of the analyses were found to be less than 5%. Developed HPLC-ESI-MS/MS can be employed as a quality control method of plant raw materials.

scholarly journals Standardization of Eucalyptus globulus leaves and Cetraria islandica slan

2021 ◽  
pp. 56-63
Author(s):  
Iryna Fito ◽  
Nataliya Stadnytska
Keyword(s):  
Eucalyptus Globulus ◽  
Raw Materials ◽  
Herbal Medicines ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Qualitative And Quantitative ◽  
Plant Raw Materials ◽  
Further Development ◽  
Layer Chromatography ◽  
Active Substances

The aim. The aim of this study was to propose methods of standardization of Eucalyptus globulus leaves and Cetraria islandica slan by the main group of biologically active substances (BAS). This was done for further development of complex medicines based on Eucalyptus globulus leaves and Cetraria islandica slan. These studies provide an opportunity for further development and standardization of extracts from these plants, and the main aim of this study is the development and standardization of a complex medicine. Materials and methods. Thin layer chromatography was used to determine the presence of these markers. Quantitative values of these biologically active substances were determined by spectrophotometric method according to the relevant methods of the State Pharmacopoeia of Ukraine. Results. Markers for the certification of Cetraria islandica and Eucalyptus globulus have been proposed in this study. Chlorophylls and 1,8-cineole were chosen as a marker for the study of Eucalyptus globulus, and polysaccharides were chosen as a marker for Cetraria islandica. The qualitative and quantitative content of these markers in the studied objects was studied. Further research in this direction will be aimed at developing methods for control and standardization of water and alcohol extracts from these plants. Conclusions. Biologically active substances in medicinal plant raw materials were studied. It is proposed to study extracts and finished products from Eucalyptus globulus leaves and Cetraria islandica slan using these methods. The method of qualitative and quantitative determination of polysaccharides in Cetraria islandica slan is easy to apply and easily reproducible. It is important to be able to standardize Eucalyptus globulus leaves for essential oils and chlorophylls. The biologically active substances-markers found in Eucalyptus globulus leaves and Cetraria islandica slan will be used for the development of herbal medicines, the standardization of which will be carried out for the same compounds.

scholarly journals Important Fungal Diseases in Medicinal and Aromatic Plants and Their Control

2021 ◽  
Vol 2 (1) ◽  
pp. 239-259
Author(s):  
Meltem AVAN
Keyword(s):  
Biological Control ◽  
Management Practices ◽  
Raw Materials ◽  
Herbal Medicines ◽  
Fungal Diseases ◽  
Healthy Plant ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Herbal Products ◽  
Industrial Sectors

Aromatic plants constitute the main raw materials of the perfumery, food and cosmetics industry and in recent years with the increasing demand for therapeutic herbal medicines, interest in medicinal and aromatic plants has increased. Raw materials from medicinal and aromatic plants have recently begun to be used and spread in the food sector, especially in industrial sectors such as paint and perfumery. For this reason, growing healthy plant material is very important in terms of the protection of these crops. However, fungal diseases such as root rot, wilt, leaf spots, blight and anthracnose, which are problems during the cultivation of both medicinal and aromatic plants, negatively affect both the quantity and quality of these plants. For this reason, an integrated management practices including cultural measures, herbal products, biological control and, if necessary, chemical control methods with especially these fungal diseases are very important. In this review, 27 medicinal and aromatic plants, 37 fungal diseases, their chemical and biological control were included, and 161 references were used.

scholarly journals Transition to biodegradable composites as a method for solving environmental problems

2020 ◽  
Vol 221 ◽  
pp. 01004
Author(s):  
Gulnaz Sabirova ◽  
Ruslan Safin ◽  
Shamil Mukhametzyanov ◽  
Nour Galyavetdinov
Keyword(s):  
Composite Materials ◽  
Impact Strength ◽  
Negative Impact ◽  
Positive Impact ◽  
Raw Materials ◽  
Polymeric Materials ◽  
Thermal Modification ◽  
Polymer Materials ◽  
Necessary Condition ◽  
Plant Raw Materials

In environmental matters, one of the most pressing problems is the efficient disposal of polymeric materials that have a negative impact on the ecology of soils and oceans. A necessary condition for the sustainable development of industrial production and processing of polymer products is the transition to polymer materials based on renewable plant raw materials, in particular polylactides, polyhydroalkanates, etc. However, the technology for the production of these types of polymers is seriously inferior to synthetic polymers in the field of energy engineering. In this regard, research in the field of creating composite materials by introducing wood filler is currently particularly relevant. This research covers the results of stress-strain behavior of wood filled polylactic wood powder composite materials thermally modified by high temperatures ranged from 200 to 240 °С. Wood impact strength dependence is defined and static bending and composite density dependence on wood filler quantity and the temperature of its thermal modification is also established. It was specified that with the increasing of filler densification and its thermal treatment, the wood impact strength and composite density is decreasing, while with the reduced content of binding, the thermal modification of 200 °С has a positive impact on bending elastic coefficient. The conducted research allows identifying rational areas of use of composite materials as an effective factor in managing natural resources.

scholarly journals Control of elemental impurities in herbal medicines

2018 ◽  
pp. 43-52
Author(s):  
A. P. Baula ◽  
Т. М. Derkach
Keyword(s):  
Medicinal Plants ◽  
Chemical Elements ◽  
Raw Materials ◽  
Herbal Medicines ◽  
World Health ◽  
Human Organism ◽  
Human Consumption ◽  
Limit Values ◽  
Plant Raw Materials ◽  
Elemental Impurities

The standardisation of plant raw materials is among the most important problems of the production of herbal medicines. Medicinal plant raw materials are of complex nature and can be contaminated with impurity elements. Therefore, the content of elemental impurities typical for plants should be controlled in comparison with the existing conceptions of recommended or permitted daily exposures of human consumption of some chemical elements. The paper goal was to study the existing approaches in the world to the fixing of elemental impurity content in herbal medicines and comparative analysis of their permitted daily exposures. The following methods were used to implement the research goal: system approach, bibliographic and information search, statistical methods, as well as generalisation and analysis. The work is based on the analysis of documents of World Health Organisation and appropriate organisations of leading countries. The contents of 28 elements were shown to normalise in these documents. Depending on their toxicity and probability of ingress into drugs, the elements are divided into four classes. This approach creates a clear idea of the potential effects of elements on the human organism and also illustrates the sensitivity requirements for analytical methods to be used for elemental control. In medicinal plants as well as in plants that are used as food additives and spices, the content of the five most toxic elements (As, Hg, Cd, Pb and Cr) is fixed. For other impurities in medicinal plants, there are no universally recognised limit values in contrast to medicinal products. Therefore, when analysing the quality of herbal medicines, one should take into account permitted daily exposures of human consumption of individual chemical elements used for the quality control of foodstuff and drinking water as well as environmental protection.

scholarly journals Technologies of fibrous semi-finished products for various purposes from miscanthus

2020 ◽  
Author(s):  
С.В. Булыгина ◽  
Ю.В. Севастьянова ◽  
М.В. Коваленко
Keyword(s):  
Cross Section ◽  
Raw Materials ◽  
Research Work ◽  
High Yield ◽  
90 C 10 ◽  
Plant Raw Materials ◽  
Alkali Consumption ◽  
Technological Mode ◽  
Production Conditions

В ходе исследовательской работы проанализированы способы получения целлюлозы из недревесного растительного сырья. Отработана технология получения целлюлозы высокого выхода сульфатным способом из мискантуса, пригодной для использования в композиции компонентов тарного картона. Условия получения целлюлозы высокого выхода: расход активной щелочи – 7%, температура – 150 °С, продолжительность – 30 мин, гидромодуль варки – 5, продолжительность горячего размола – 5 мин. Отработана технология получения химико-термомеханической массы из сечки. Условия получения: расход активной щелочи – 3%, продолжительность пропитки при 90 °С – 10 мин, продолжительность обработки при 120 °С – 10 мин, гидромодуль – 5. Отработан технологический режим отбелки химико-термомеханической массы из мискантуса по укороченной схеме Х – ЩП1 – ЩП2 с расходом Н2О2 60 кг/т, белизна образца составила 55% ISO. Отработана технология получения нейтрально-сульфитной полуцеллюлозы из мискантуса, пригодной для использования в композиции компонентов тарного картона. Условия получения нейтрально-сульфитной полуцеллюлозы: расход активной щелочи – 20%, температура – 175 °С, продолжительность – 50 мин, гидромодуль варки – 7, продолжительность горячего размола 5 мин. В соответствии с полученными результатами можно сделать вывод о том, что мискантус может быть использован для получения аналога лиственной сульфатной целлюлозы для применения в композиции различных видов бумаг. In the course of the research work, methods for obtaining cellulose from non-wood plant raw materials were analyzed. The technology of obtaining high yield cellulose by sulphate method from miscanthus, suitable for use in the composition of container cardboard components, has been developed. Conditions for obtaining high yield cellulose: active alkali consumption –7%, temperature-150 °C, duration – 30 minutes, cooking hydromodule – 5, duration of hot grinding – 5 minutes. The technology of obtaining a chemical-thermomechanical mass from a cross-section has been worked out. Production conditions: active alkali consumption – 3%, impregnation duration at 90 °C – 10 min, processing duration at 120 °C – 10 min, hydromodule – 5. The technological mode of bleaching the chemical-thermomechanical mass from miscanthus according to the shortened scheme Q – P1 – P2 with a consumption of H2O2 of 60 kg/t, the sample whiteness was 55% ISO. The technology of obtaining neutral-sulfite semi-cellulose from miscanthus, suitable for use in the composition of container cardboard components, has been developed. Conditions for producing neutral-sulfite semicellulose: active alkali consumption – 20%, temperature – 175 °C, duration – 50 minutes, cooking hydromodule – 7, duration of hot grinding – 5 minutes. In accordance with the results obtained, it can be concluded that miscanthus can be used to obtain an analog of leafy sulphate cellulose for use in the composition of various types of papers.

scholarly journals PROBLEMS OF COMPREHENSIVE CHEMICAL PROFILING OF MEDICINAL PLANTS

2018 ◽  
pp. 5-28 ◽  
Author(s):  
Сергей (Sergey) Владимирович (Vladimirovich) Морозов (Morozov) ◽  
Наталья (Natal'ya) Ивановна (Ivanovna) Ткачева (Tkacheva) ◽  
Алексей (Aleksej) Васильевич (Vasil'evich) Ткачев (Tkachev)
Keyword(s):  
Raw Materials ◽  
Herbal Medicines ◽  
Global Trends ◽  
Chemical Profiling ◽  
Plant Raw Materials ◽  
Identification Evaluation ◽  
Methodological Approaches ◽  
State Of Research ◽  
Instrumental Methods

Interest and attention to phytotherapy in Russia are increasing every year, which is consistent with global trends. Ensuring the growing demand inevitably leads to the appearance of phytopreparations of low quality and efficiency, and sometimes to a complete falsification of plant raw materials and preparations from it. Therefore, the pharmaceutical safety and quality of plant raw materials, herbal preparations and medicines from plant raw materials are among the most important problems in the field of medicine, biomedicine, pharmacognosy and phytochemistry. The review considers modern methodological approaches to solving problems of the problems mentioned, various concepts of identification, evaluation of the authenticity and quality control of herbal medicines using markers of various types and instrumental methods of chromatographic profiling (one of the methods of metabolic research) of plant compositions, spectral and hyphenated methods used to solve these problems, the issues of standardization of plant raw materials, drugs in and medicines based on it, the world experience in solving problems of assessing the quality of plant raw materials and phytopreparations and the state of research in Russia.

scholarly journals The choice of excipients to obtain tablets based on the Primula denticulate Smith. Extract by wet granulation

2021 ◽  
pp. 4-9
Author(s):  
A. Yu. Shyrko ◽  
M.M. Vasenda ◽  
L.I. Будняк ◽  
O.O. Pokotylo
Keyword(s):  
Raw Materials ◽  
Wide Spectrum ◽  
Herbal Medicines ◽  
Latin Square ◽  
Magnesium Stearate ◽  
Modern Medicine ◽  
Wet Granulation ◽  
Technological Parameters ◽  
Mathematical Planning ◽  
Plant Raw Materials

Introduction. Herbal medicines are increasingly being used in the treatment of various diseases. Significant number of resources, high-level availability and the possibility of cultivation have provided high prospects of plant raw materials in the development of new herbal medicines. Primula denticulate Smith. is one of the most interesting medicinal plant raw materials source in modern medicine and pharmacy with the wide spectrum of pharmacotherapeutic action, that is mainly used only in traditional medicine. Thus, nowadays the development of new and effective medicines based on Primula denticulate Smith. in tablet dosage form is the topical task of pharmacy. The aim of the work. To study the influence of excipients on the pharmaco­technological parameters of tablets with Primula denticulate Smith, are obtained by wet granulation method and to substantiate the choosing of the best excipients by the method of mathematical planning of the experiment. Materials and Methods. It was used a self-prepared dense extract of Primula denticulate Smith. and excipients, which are complied with the requirements of State Pharmacopoeia of Ukraine in terms of pharmaco-technological quality parameters, for developing tablets. The hyper Greek-Latin square 4x4 was used to study the four qualitative factors. Results and Discussion. In the course of the experiment, it was determined the dependence of pharmaco­technological parameters (friability, resistance to crushing and disintegration of tablets) on type of excipients. It was selected excipients with the optimal pharmaco-technological parameters for further research the tablets quality. Conclusions. According to the method of mathematical planning of the experiment, it’s chosen the optimal excipients for obtaining tablets based on dense extract of Primula denticulate Smith. Considering the investigated pharmaco-technological properties (friability, resistance to crushing and disintegration of tablets) the qualitative composition of excipients for obtaining tablets by the method of wet granulation was determined: Avicel PH - 105 and MCC 101, croscarmellose sodium, colloidal anhydrous silicon dioxide, magnesium stearate and Prosolv 90.

scholarly journals Changes in analytical characteristics of pectic substances when freezing berries

2021 ◽  
Vol 285 ◽  
pp. 03016
Author(s):  
Irina Sobol ◽  
Ludmila Rodionova ◽  
Ludmila Donchenko ◽  
Albina Varyvoda
Keyword(s):  
Positive Impact ◽  
Raw Materials ◽  
The Body ◽  
Raw Material ◽  
Black Currant ◽  
Plant Raw Materials ◽  
Radioactive Nuclides ◽  
Complexing Ability ◽  
And Storage ◽  
Pectin Substances

Pectin substances are valuable components of plant cells. They have properties that allow them to be used in various industries - water retaining, gel-forming and complexing abilities. The most important property that has a positive impact on human health is the complexing ability. It is the property of pectin substances to bind heavy and toxic metals, radioactive nuclides, free radicals and other toxins in insoluble complexes and remove them from the human body. Due to their complexing ability pectin substances are used in medicines aimed at reducing cholesterol in the body, prolonging the effect of drugs, reducing the body’s allergic reactions to various substances. This property depends on the analytical characteristics of pectin substances and may vary depending on the type of raw material and the method of its processing. Currently, freezing is commonly used to preserve various types of fruits and berries, especially perishable ones. There are data in the literature about changes of pectin substances in various plant raw materials, but there are not enough data about changes of analytical characteristics of pectin substances during freezing and storage and their influence on the complexing ability. The article presents a study of the analytical characteristics of pectin substances contained in red and black currant berries during the process of their freezing and storage at low temperatures. Studies on their influence on the change in the complexing ability are presented.

DOES FOREIGN DIRECT INVESTMENT IMPROVE ECONOMIC GROWTH IN CEMAC COUNTRIES?

2013 ◽  
Vol 8 (2) ◽  
Author(s):  
EMMANUEL BRUNO  ONGO NKOA
Keyword(s):  
Economic Growth ◽  
Positive Impact ◽  
Raw Materials ◽  
Research Work ◽  
Growth Theory ◽  
The Past ◽  
The Impact ◽  
Neoclassical Growth Theory ◽  
Neoclassical Growth ◽  
Selection Of

The aim of this research work is to assess the influence of FDI on economic growth in the CEMAC region. The ratio of FDIs in the actual GDP of countries of the CEMAC region has recorded a steady annual increase for the past three decades. Moreover, the high variability of FDI, given the various crises and fluctuations in the prices of raw materials invites us to reflect and question the impact of FDI on growth by studying the case of CEMAC countries. The theoretical analysis is based on the neoclassical growth theory and its extensions. After the selection of a model crafted from Imoudu (2012) and Boreinsztein et al. (1998). The results show that FDI have a positive impact on the growth of the sub-region and these are conveyed by human capital.

Sign in / Sign up

Export Citation Format

Share Document