scholarly journals Uncoupling Protein-1 (UCP1) in the Adult Horse: Correlations with Body Weight, Rectal Temperature and Lipid Profile

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1836
Author(s):  
Francesca Arfuso ◽  
Claudia Giannetto ◽  
Maria Francesca Panzera ◽  
Francesco Fazio ◽  
Giuseppe Piccione
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rectal Temperature ◽  
Uncoupling Protein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Total Lipids

This study aimed to evaluate the possible relationship among UCP1, body weight, rectal temperature and lipid profile in the horse. Thirty clinically healthy Italian Saddle geldings (6–10 years old) were enrolled after the informed owners’ consent. All horses were blood sampled and their body weight and rectal temperatures were recorded. On the sera obtained after blood centrifugation the concentration of UCP1, total lipids, phospholipids, non-esterified fatty acids (NEFAs), triglycerides, total cholesterol, high density lipoproteins (HDLs), low density lipoproteins (LDLs) and very low density lipoprotein fraction (VLDLs) was evaluated. Pearson’s correlation analysis was applied to assess the possible relationship between serum UCP1 concentration and the values of body weight, rectal temperature and lipid parameters. Serum UCP1 concentration showed no correlation with body weight, rectal temperature, HDLs and LDLs values, whereas it correlated negatively with serum total lipids, phospholipids, NEFAs, total cholesterol, triglycerides and VLDLs values (p < 0.0001). The findings suggest that in the adult horse the role of UCP1 is linked to the lipid metabolism rather than to thermoregulation.

scholarly journals Lipid Profile of Children with Malaria byPlasmodium vivax

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Rosa Maria Dias ◽  
Jose Luiz Fernandes Vieira ◽  
Bianca da Conceição Cabral ◽  
Isameriliam Rosaulem Pereira da Silva ◽  
Laelia Maria Barra Feio Brasil ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Signs And Symptoms ◽  
Low Density ◽  
Lipid Levels ◽  
Colorimetric Measurements ◽  
History Of ◽  
Lipid Abnormalities

Background. Changes in lipid profile are commonly reported in adult patients with malaria. However, a few studies evaluated lipid abnormalities in children continuously exposed toP. vivax.Objective. To evaluate lipid abnormalities in children withP. vivaxinfection and to assess if parasite count or the history of malaria correlates with lipid levels at admission.Methods. A total of 75 children were included in the study, from which 43 were slide confirmed infection byP. vivax. Serial blood samples were collected at admission and, on days 7 and 14, evaluated for the colorimetric measurements of triglycerides, very low-density lipoprotein (VLDL), total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).Results. The levels of total cholesterol, LDL, and HDL were significantly lower in malaria cases. The levels of VLDL and triglycerides were significantly higher in children with malaria. Such changes were transient and were not associated with parasite counting as well as with the history of malaria of patients.Conclusion. There are significant lipid abnormalities in children with low level ofP. vivaxinfection and mild signs and symptoms of the disease, which are not associated with parasitaemia and previous episodes of disease.

scholarly journals Uji Toksisitas Ekstrak Metanolik Kombinasi Daun Benalu Teh Dan Daun Benalu Mangga Terhadap Profil Lipid Tikus Betina (Rattus norvegicus) pada Paparan Sub-Kronik 28 Hari

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Tengku Anggun Lestari ◽  
Nour Athiroh ◽  
Nurul Jadid Mubarakati
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rattus Norvegicus ◽  
Toxicity Test ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
One Way Anova

Tea Benalu (Scurrula atropurpurea [Bl.] Dans.) and Mango Benalu (Dendrophthoe pentandra L. miq.) containssecondary metabolites with potential antioxidant potential. Antioxidants can inhibit the oxidation process and reduce Total Cholesterol, Triglycerides, Low-Density Lipoprotein (LDL) and increase High-Density Lipoprotein (HDL). The safety of the preparations for the combination of parasites of tea and mango leaves was tested to obtain toxic effects after repeated treatment tests over some time. The purpose of this study was to determine the toxic effects of a combination of methanolic extracts of a combination of tea parasites and mangoes in female rats (Rattus norvegicus) subchronically for 28 days by looking at the results of the clinical biochemical examination on lipid profiles, namely total cholesterol levels, triglycerides, high-density lipoproteins (28%). HDL), and Low-Density Lipoprotein (LDL). The method of this study was experimental with a combination dose of methanol extract of tea parasite leaves and mango parasite leaves at a dose of 250 mg / KgBB, 500 mg / KgBB and 1000 mg / KgBB with 5x replications each treatment. The subjects used white rats (Rattus norvegicus) female Wistar strains aged 6-8 weeks with a minimum body weight of 100 grams. The treatment in this study was in the form of each dose given 5 times a week for 28 days (subchronic toxicity test) orally. Lipid profile levels were analyzed using the one-way ANOVA test. The results showed that the level of control blood lipid profile with a treatment dose of 250 mg / KgBW, 500 mg / KgBW, and 1000 mg / KgBW was not significantly different. The toxicity test of combined extracts of tea leaves and mango parasite leaves of female rat Rattus novergicus on subchronic exposure 28 days with those doses showed no difference tangible between treatments of controls. This means it is safe and does not cause toxic properties in the lipid profile of female wistar rats.Keywords: Lipid Profile, Scurrula atropurpurea, Dendophthoe pentandra, Sub-Chronic Toxicity, Rattus norvegicus ABSTRAKBenalu Teh (Scurrula atropurpurea [Bl.] Dans.) dan  Benalu Mangga (Dendrophthoe pentandra L. miq.) mengandung metabolit sekunder berpotensi sebagai antioksidan. Antioksidan dapat memperhambat proses oksidasi dan menurunkan Cholesterol Total, Trigliserida, Low Density Lipoprotein (LDL) dan menaikkan High Density Lipoprotein (HDL). Keamanan sediaan kombinasi daun benalu teh dan mangga diuji memperoleh tentang efek toksik setelah uji perlakuan berulang dalam jangka waktu tertentu. Tujuan dari penelitian ini untuk mengetahui efek toksik kombinasi ekstrak metanolik kombinasi daun benalu teh dan mangga pada tikus betina (Rattus norvegicus) secara subkronik selama 28 hari dengan melihat hasil pemeriksaan biokimia klinis pada profil lipid, yaitu kadar Cholesterol Total, Trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Metode penelitian ini adalah eksperimental dengan perlakuan dosis kombinasi ekstrak metanol daun benalu teh dan daun benalu mangga dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB dengan ulangan 5x tiap perlakuan. Subjek menggunakan tikus putih (Rattus norvegicus) betina strain wistar yang berumur 6-8 minggu dengan berat badan minimal 100 gram. Perlakuan dalam penelitian ini berupa setiap dosis  diberikan 5 kali seminggu selama 28 hari (uji toksisitas subkronik) secara per-oral. Kadar profil lipid dianalisis menggunakan uji One-way ANOVA. Hasil penelitian menunjukkan bahwa kadar profil lipid darah kontrol dengan perlakuan dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB tidak berbeda nyata. Uji”toksisitas”ekstrak kombinasi daun benalu teh dan daun benalu mangga  tikus betina Rattus novergicus pada paparan subkronik 28 hari dengan”dosis”tersebut menunjukkan hasil tidak”beda”nyata antara perlakuan terhadap”kontrol. ”Hal ini berarti aman dan tidak menimbulkan sifat toksik pada profil lipid tikus wistar betina.Kata Kunci : Profil Lipid, Scurrula atropurpurea, Dendophthoe pentandra, Subkronik, Rattus norvegicus

scholarly journals Evaluation of the hypolipidemic effect of Gangaria de flush herbal mixture in streptozotocin-induced diabetic male rats

2021 ◽  
Vol 11 (3) ◽  
pp. 066-071
Author(s):  
Babafemi Tosin Ogunbiyi ◽  
Gogonte Hezekiah Amah ◽  
Laide Omoyiola Olajide ◽  
Olubunmi Esther Ogunbiyi ◽  
Oluwafunmilola Christiana Adetunji ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Herbal Mixture ◽  
Chronic Hyperglycemia

Diabetes mellitus is a complex multifarious metabolic disorder characterized by chronic hyperglycemia that requires non-stop treatment with multiple factors that will reduce the risk of long-term complications and drug side effects. Streptozotocin is well known for its selective pancreatic islet β-cell cytotoxicity used to induce diabetes mellitus in animals. It also interferes with cellular metabolic oxidative mechanisms. Phytomedicine has been in existence since the primitive age and has proven to be effective in treating this condition. This study was aimed at evaluating the effect of Gangaria de flush (Gdf) herbal mixture on lipid profile in streptozotocin (STZ) (60mg/kg) induced diabetic rat. The diabetic rats were treated with Gangaria de flush (0.3ml/kg body weight) and Glibenclamide (5mg/kg body weight) for 7days. The effects of both Gangaria de flush herbal mixture and glibenclamide were analyzed. Gangaria de flush showed a reduction in the lipid profile with a significant percentage reduction of 45.9% for the total cholesterol, 65.7% for the total triglyceride, 63.5% for the low-density lipoprotein, 65.8% for the very low-density lipoprotein as against the negative control and a 7.6% significant increase in the high density lipoprotein. Gangaria de flush showed a significant (p<0.05) positive effect on the lipid profile. Hence, it can be suggested that Gangaria de flush herbal mixture has a significant effect in maintaining the lipid level.

scholarly journals A study on correlation of lipid profile with body mass index in young adults (18-20 years)

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 102-107
Author(s):  
Gurupavan Kumar Ganta ◽  
Divya D ◽  
Kedari G S R
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Young Adults ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Overweight And Obesity ◽  
Low Density

Overweight and obesity in youth is a worldwide public health problem. Predisposition to obesity starts during the first or second decade of life. Overweight and obesity in adolescents have a substantial effect upon many systems, resulting in clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidaemia, hypertension and type 2 diabetes mellitus. Our study was done to find the relation between body mass index (BMI) and lipid profile in young adults (18-20 years) and for the correlation between the various parameters. 150 young adults between 18-20 years of age, who gave written voluntary consent were included in the study. BMI was calculated after measuring height and weight along with fasting blood samples for estimation of blood glucose and lipid profile [Total cholesterol, High density lipoprotein (HDL), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL) and triacylglycerol (TGL)] were measured. The data collected was analysed using Statistical package for the social sciences (SPSS) statistics software version 20. A linear correlation regression analysis was done to know the correlation between the anthropometric measurements and biochemical parameters. ANOVA test was performed to know the significance and a p value of < 0.01 was taken as significant. All the biochemical parameters showed a positive correlation with BMI. Total cholesterol had the highest positive correlation with BMI. There was a prevalence of 39.3% overweight/obesity as per BMI cut-off. Individuals who were in the obese category had a higher prevalence of abnormal lipid profile especially total cholesterol. Stress and lack of physical activity have a detrimental effect on health and are a major risk factor for development of obesity. 90% of the students in this study did not have any regular physical activity. Educating the students about effects of obesity and dyslipidaemia on quality of health can help in bringing life style modifications which can help them in the long run.

scholarly journals Influence of iodine on the indicators of lipid profile of rats’ blood of different age in experimental obesity

2018 ◽  
Author(s):  
N. H. Kopchak ◽  
О. S. Pokotylo ◽  
M. D. Kuhtyn ◽  
M. I. Koval
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
White Male ◽  
Density Lipoprotein ◽  
Biologically Active ◽  
Male Rats ◽  
Low Density ◽  
Inorganic Iodine

Introduction. Today, obesity is an extremely common phenomenon that negatively affects on the functional state of the organism, metabolism, and this in turn leads to the increase of a number of diseases. The thyroid gland has a significant effect on lipid metabolism, and especially negative in the case of iodine deficiency in the diet, which leads to hypothyroidism. Comparative study of the effect of various iodine-derived lipid metabolism in obesity is perspective.The aim of the study – to investigate the comparative affect of biologically active iodine in the composition of “Jodis-Concentrate” and inorganic iodine (J-C) as a part of “Iodomarine” on the indicators of lipid metabolism in blood of white male rats with experimental alimentary obesity.Research Methods. The object of the study was the blood serum of white rats, and the subject – separate indicators of lipid metabolism in it. The study was conducted on 48 white male rats. Animals were divided into 3 age groups of 16 animals in each: 1st group – 1.5 months; 2nd – 2.5 months; 3rd – 5th month. In each age group there were 4 subgroups of 4 animals: 1st – control, had a typical diet; 2nd, 3rd and 4th subgroup were with experimental alimentary obesity (EAO), which was formed through the inductor food craving – the sodium salt of glutamic acid in a ratio of 0.6 : 100.0 and high-calorie diet that included standard meals (47 %), sweet condensed milk (44 %), corn oil (8 %) and vegetable starch (1 %). Daily for 45 days, animals of the 3rd subgroup received biologically active iodine in the composition of “Jodis-Concentrate” (J-C) as of 0.1 ml (0.4 mcg of iodine) per kg of body weight a day and 4th subgroup were intragastric administered in the form of inorganic iodine as potassium iodide in medicine “Iodomarin” (IM) as of 0.4 mcg of potassium iodide per kg of body weight a day. In the serum blood, the content of total lipids, total cholesterol, triglycerides, high and low density lipoprotein were determined.Results and Discussion. The obtained results suggest that with the help of biologically active iodine in the composition of “Jodis-Concentrate” there was a significant decrease of the content of common lipids, triglycerides, total cholesterol, low density lipoprotein in blood serum of males with different age than with “Iodomarin”.Conclusions. Given the effective results of the study of the hypolipidemic effect of J-C it is advisable to use it as a preventive and therapeutic agent for reducing the content of common lipids of triglycerides, total cholesterol, and low density lipoproteins in the blood.

scholarly journals Alterations of Lipid profile levels in 7,12-Dimethylbenz(a)anthracene induced ulcerative colitis rat model.

2017 ◽  
Vol 10 (4) ◽  
pp. 352
Author(s):  
Geetha Palaniswamy ◽  
Lakshman Kumar B ◽  
Indra U ◽  
Pavithra Sheetal B
Keyword(s):  
Ulcerative Colitis ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Intestinal Inflammation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Significant Difference

Objective: Ulcerative colitis is a type of inflammatory bowel disease is a chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. We examined the lipid profile levels in murine model of 7,12 Dimethylbenz(a)anthracene induced ulcerative colitis.Methods: Serum was separated from whole blood and was used to determine the lipid profile such as total cholesterol (TC), phospholipids (PL), triglycerides (TG), free fatty acids, high density lipoprotein (HDL-C) and low density lipoprotein (HDL-C).Results: Ulcerative colitis rats exhibit low level of low density lipoprotein cholesterol and total cholesterol. No significant difference was observed in high density lipoprotein and triglycerides and significant difference was observed in phospholipids and free fatty acid serum levels. This communication highlights the lipid profile that occurs in ulcerative colitis.Conclusion: This study, thus, provides valuable information about the disturbances in the lipids and lipoproteins occur in ulcerative colitis.Keywords: Ulcerative colitis, 7,12-Dimethylbenz(a)anthracene, Lipoprotein, Low-density lipoprotein, Phospholipids.

scholarly journals CLOCK 3111TT Genotype Is Associated with Increased Total Cholesterol and Low-Density Lipoprotein Levels in Menopausal Women with a Body Mass Index of at Least 25 kg/m2

2020 ◽  
Vol 28 (1) ◽  
pp. 1-9
Author(s):  
Natalya Semenova ◽  
Irina Madaeva ◽  
Sergey Kolesnikov ◽  
Lyubov Rychkova ◽  
Tatjana Bairova ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Gene Polymorphism ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Minor Allele ◽  
Low Density ◽  
Menopausal Women

Lipid profile comparative analysis was performed to reveal the interdependence of lipids with Circadian locomoter output cycles protein kaput (CLOCK) 3111T/C gene polymorphism in menopausal women with/without a body mass index (BMI) of ≥25 kg/m2. Methods: A total of 193 female volunteers aged 45 to 60 years were divided into two groups: Those with BMI < 25 kg/m2 (control) and those with BMI ≥ 25 kg/m2. Each group was then divided into two subgroups: Those with the CLOCK TT-genotype and those with the CLOCK TC-, CC-genotypes. Lipid metabolism parameters were determined by the enzymatic method. Single-nucleotide polymorphisms (SNPs) were detected via polymerase chain reaction–restriction fragment length polymorphism technology. Results: There were no differences in CLOCK 3111T/C genotypes or allele frequency between the control and main groups. In addition, there were no differences in lipid profile parameters between women of the control group and different CLOCK 3111T/C genotypes. The total cholesterol (p = 0.041) and low-density lipoprotein cholesterol (p = 0.036) levels were higher in the subgroup of women with a BMI ≥ 25 kg/m2 and CLOCK TT-genotype as compared to the subgroup with a BMI ≥ 25 kg/m2 and minor allele 3111C. Conclusions: SNP 3111T/C of the CLOCK gene is not associated with BMI however, data suggest that the minor allele of the CLOCK 3111T/C gene polymorphism may have a protective role in atherogenic lipid levels in women with a BMI greater than or equal to 25 kg/m2.

scholarly journals Status of Lipid Profile among the Hypertensive Patients in Bangladesh

2014 ◽  
Vol 9 (1) ◽  
pp. 13-17 ◽  
Author(s):  
CM Reza ◽  
ASMA Kabir ◽  
Tuhin Biswas ◽  
Kamrun Nahar Choudhury ◽  
Md Zahidur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Hypertensive Patients

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameter total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/uhj.v9i1.19505 University Heart Journal Vol. 9, No. 1, January 2013; 13-17

scholarly journals Effect of Ramadan Fasting on Serum Lipid Profile of Bangladeshi Female Volunteers

2015 ◽  
Vol 7 (2) ◽  
pp. 47-51 ◽  
Author(s):  
M Akhtaruzzaman ◽  
N Hoque ◽  
MBK Choudhury ◽  
MM Jamal Uddin ◽  
T Parvin
Keyword(s):  
Dietary Intake ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Ramadan Fasting

The study was conducted to evaluate the effects of fasting for a period of one month during Ramadan on the lipid profile of Bangladeshi female volunteers who fasted during the Arabic month of Ramadan, when there occurs a change, both in the pattern and timing of dietary intake. Findings of the study showed that Ramadan fast significantly reduced serum Total cholesterol (TC) (p=0.030) and Low density lipoprotein (LDL-C) (p=0.011). A statistically nonsignificant elevation of triglyceride (TG)) was observed (p=0.598). High density lipoprotein cholesterol (HDL-C) also found to be raised significantly at the end of fasting (p = 0.037). Findings of the study revealed that fasting during the month of Ramadan changes lipid profile pattern in an aniatherogenic direction and may be beneficial to health. DOI: http://dx.doi.org/10.3329/bjmb.v7i2.22412 Bangladesh J Med Biochem 2014; 7(2): 47-51

scholarly journals Association of Lipid Profile with Non-Alcoholic Fatty Liver Disease diagnosed on Ultrasound

2020 ◽  
Vol 24 (4) ◽  
pp. 334-338
Author(s):  
Ambreen Zahoor ◽  
Iram ` Iqbal ◽  
Sajid Naseem ◽  
Zaidan Idrees Choudhary
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Fatty Liver Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Objectives: To evaluate lipid profile parameters in patients with various grades of non-alcoholic fatty liver disease (NAFLD) diagnosed on sonography.  Material and Method: This descriptive cross-sectional study was conducted at HBS General Hospital, Islamabad over a period of six months from January 2018 to June 2018. Seventy-nine adults of either gender diagnosed with NAFLD on ultrasonography were consecutively included. Fasting blood sample of all the subjects was analyzed for total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) Comparison of lipid abnormalities between different grades of NAFLD was done by statistical analysis with p-value <0.05 considered statistically significant. Results: Out of the total 79 patients, grade I, II, and III NAFLD was diagnosed in 56.6%, 45.5%, and 3.9% respectively. Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) were raised in 28 (35.4%), 43 (54.4%) and 43 (54.4%) patients respectively. Low serum high-density lipoprotein cholesterol (HDL-C) levels were seen in 74 (93.6%) of patients. Statistical analysis showed a significant increase in frequency as well as mean values in all serum lipid profile parameters with the severity of NAFLD grades except total cholesterol (TC). Conclusion: Increasing grades of NAFLD showed a significant correlation with higher levels of cholesterol, LDL, and decreasing levels of HDL, which are all associated with cardiovascular problems.

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