scholarly journals Modelling of the Motion and Interaction of a Droplet of an Inkjet Printing Process with Physically Treated Polymers Substrates

2021 ◽  
Vol 11 (23) ◽  
pp. 11465
Author(s):  
Tim Tofan ◽  
Raimondas Jasevičius
Keyword(s):  
Inkjet Printing ◽  
High Density Polyethylene ◽  
Polymer Surface ◽  
Simulation Software ◽  
Adhesion Forces ◽  
Coating Properties ◽  
Good Adhesion ◽  
Pre Treatment ◽  
The Impact ◽  
Visual Changes

This study examines the effect of energetic surface treatment on the adhesion strength of high-density polyethylene (HDPE), polypropylene (PP) and polyethylene terephthalate (PET) substrates. The purpose of this work is to determine the surface wettability of polymers suitable for food contact. These plastics have been treated with various pre-treatment methods to improve surface tension and good adhesion for inkjet printing and avoid any visual changes. It is important to determine the adhesion of the ink to the polymer surface to improve post-consumer recycling. Digital inks have been tested on various treated plastics to analyse coating properties and adhesion forces in accordance with DIN ISO 2409 standards. The impact of the inkjet droplet on the treated and non-treated surface was also investigated using the COMSOL computer simulation software.

The Impact of Surfactants on Separation of Mixed Polymer Wastes in Electrostatic Field

2020 ◽  
Vol 24 (4) ◽  
pp. 25-29
Author(s):  
A.M. Gonopolsky ◽  
E.A. Poluosmak
Keyword(s):  
Electrostatic Field ◽  
Polymer Surface ◽  
Chemical Properties ◽  
Polymer Materials ◽  
Technological Parameters ◽  
Polymer Waste ◽  
Maximum Charge ◽  
Pre Treatment ◽  
The Impact ◽  
Polymer Wastes

A quantitative analysis is carried out of such factors as electrostatic intensity, surface area of particles, dielectric permittivity, size polymer particles, and the type and concentration of surfactants, by the amount of electric charge of the polymer surface, obtained in the electrostatic field after their pre-treatment of surfactants. Dependencies of the maximum charge of polymer waste particles from the basic technological parameters of the drum electrostatic separator and physical-chemical properties of polymers and surfactants are shown. It has been found that degradation of polymeric waste in a surfactants aqueous solutions is an effective preliminary step of technology of electrostatic separation of a mixture of crushed polymer wastes that positive effect on their charging in an electrostatic field. The obtained data allows to develop the technological process precision selective separation of mixed polymer materials in an electrostatic field.

Evaluation of the Aging Behavior of High Density Polyethylene in Thermal Oxidative Environment by Principal Component Analysis

2017 ◽  
Vol 727 ◽  
pp. 447-449 ◽  
Author(s):  
Jun Dai ◽  
Hua Yan ◽  
Jian Jian Yang ◽  
Jun Jun Guo
Keyword(s):  
Principal Component Analysis ◽  
Impact Strength ◽  
High Density Polyethylene ◽  
Tensile Modulus ◽  
Principal Component ◽  
Component Analysis ◽  
High Density ◽  
Aging Behavior ◽  
Data Set ◽  
The Impact

To evaluate the aging behavior of high density polyethylene (HDPE) under an artificial accelerated environment, principal component analysis (PCA) was used to establish a non-dimensional expression Z from a data set of multiple degradation parameters of HDPE. In this study, HDPE samples were exposed to the accelerated thermal oxidative environment for different time intervals up to 64 days. The results showed that the combined evaluating parameter Z was characterized by three-stage changes. The combined evaluating parameter Z increased quickly in the first 16 days of exposure and then leveled off. After 40 days, it began to increase again. Among the 10 degradation parameters, branching degree, carbonyl index and hydroxyl index are strongly associated. The tensile modulus is highly correlated with the impact strength. The tensile strength, tensile modulus and impact strength are negatively correlated with the crystallinity.

scholarly journals Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism

2021 ◽  
Author(s):  
Michael V. Lombardo ◽  
Elena Maria Busuoli ◽  
Laura Schreibman ◽  
Aubyn C. Stahmer ◽  
Tiziano Pramparo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Treatment Outcome ◽  
Early Intervention ◽  
Developmental Change ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Time In Treatment ◽  
Pre Treatment ◽  
Blood Leukocyte ◽  
The Impact

AbstractEarly detection and intervention are believed to be key to facilitating better outcomes in children with autism, yet the impact of age at treatment start on the outcome is poorly understood. While clinical traits such as language ability have been shown to predict treatment outcome, whether or not and how information at the genomic level can predict treatment outcome is unknown. Leveraging a cohort of toddlers with autism who all received the same standardized intervention at a very young age and provided a blood sample, here we find that very early treatment engagement (i.e., <24 months) leads to greater gains while controlling for time in treatment. Pre-treatment clinical behavioral measures predict 21% of the variance in the rate of skill growth during early intervention. Pre-treatment blood leukocyte gene expression patterns also predict the rate of skill growth, accounting for 13% of the variance in treatment slopes. Results indicated that 295 genes can be prioritized as driving this effect. These treatment-relevant genes highly interact at the protein level, are enriched for differentially histone acetylated genes in autism postmortem cortical tissue, and are normatively highly expressed in a variety of subcortical and cortical areas important for social communication and language development. This work suggests that pre-treatment biological and clinical behavioral characteristics are important for predicting developmental change in the context of early intervention and that individualized pre-treatment biology related to histone acetylation may be key.

scholarly journals Time-to-Treatment in Oral Cancer: Causes and Implications for Survival

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1321
Author(s):  
Constanza Saka-Herrán ◽  
Enric Jané-Salas ◽  
Antoni Mari-Roig ◽  
Albert Estrugo-Devesa ◽  
José López-López
Keyword(s):  
Oral Cancer ◽  
Previous Treatment ◽  
Diagnostic Procedures ◽  
Original Data ◽  
Primary Treatment ◽  
Medical Attention ◽  
Time Interval ◽  
Pre Treatment ◽  
The Impact ◽  
Lack Of Knowledge

The purpose of this review was to identify and describe the causes that influence the time-intervals in the pathway of diagnosis and treatment of oral cancer and to assess its impact on prognosis and survival. The review was structured according to the recommendations of the Aarhus statement, considering original data from individual studies and systematic reviews that reported outcomes related to the patient, diagnostic and pre-treatment intervals. The patient interval is the major contributor to the total time-interval. Unawareness of signs and/or symptoms, denial and lack of knowledge about oral cancer are the major contributors to the process of seeking medical attention. The diagnostic interval is influenced by tumor factors, delays in referral due to higher number of consultations and previous treatment with different medicines or dental procedures and by professional factors such as experience and lack of knowledge related to the disease and diagnostic procedures. Patients with advanced stage disease, primary treatment with radiotherapy, treatment at an academic facility and transitions in care are associated with prolonged pre-treatment intervals. An emerging body of evidence supports the impact of prolonged pre-treatment and treatment intervals with poorer survival from oral cancer.

scholarly journals Experimental and Numerical Study of Fracture Behavior of Rock-Like Material Specimens with Single Pre-Set Joint under Dynamic Loading

Materials ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2690
Author(s):  
Bo Pan ◽  
Xuguang Wang ◽  
Zhenyang Xu ◽  
Lianjun Guo ◽  
Xuesong Wang
Keyword(s):  
Crack Initiation ◽  
Crack Propagation ◽  
Joint Angle ◽  
Simulation Software ◽  
Dissipated Energy ◽  
Energy Structure ◽  
Joint Angles ◽  
Crack Penetration ◽  
Before And After ◽  
The Impact

The Split Hopkinson Pressure Bar (SHPB) is an apparatus for testing the dynamic stress-strain response of the cement mortar specimen with pre-set joints at different angles to explore the influence of joint attitudes of underground rock engineering on the failure characteristics of rock mass structure. The nuclear magnetic resonance (NMR) has also been used to measure the pore distribution and internal cracks of the specimen before and after the testing. In combination with numerical analysis, the paper systematically discusses the influence of joint angles on the failure mode of rock-like materials from three aspects of energy dissipation, microscopic damage, and stress field characteristics. The result indicates that the impact energy structure of the SHPB is greatly affected by the pre-set joint angle of the specimen. With the joint angle increasing, the proportion of reflected energy moves in fluctuation, while the ratio of transmitted energy to dissipated energy varies from one to the other. NMR analysis reveals the structural variation of the pores in those cement specimens before and after the impact. Crack propagation direction is correlated with pre-set joint angles of the specimens. With the increase of the pre-set joint angles, the crack initiation angle decreases gradually. When the joint angles are around 30°–75°, the specimens develop obvious cracks. The crushing process of the specimens is simulated by LS-DYNA software. It is concluded that the stresses at the crack initiation time are concentrated between 20 and 40 MPa. The instantaneous stress curve first increases and then decreases with crack propagation, peaking at different times under various joint angles; but most of them occur when the crack penetration ratio reaches 80–90%. With the increment of joint angles in specimens through the simulation software, the changing trend of peak stress is consistent with the test results.

scholarly journals Comparison of Selected Immune and Hematological Parameters and Their Impact on Survival in Patients with HPV-Related and HPV-Unrelated Oropharyngeal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3256
Author(s):  
Adam Brewczyński ◽  
Beata Jabłońska ◽  
Agnieszka Maria Mazurek ◽  
Jolanta Mrochem-Kwarciak ◽  
Sławomir Mrowiec ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Oropharyngeal Cancer ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Post Treatment ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Hpv Status ◽  
Pre Treatment ◽  
The Impact

Several immune and hematological parameters are associated with survival in patients with oropharyngeal cancer (OPC). The aim of the study was to analyze selected immune and hematological parameters of patients with HPV-related (HPV+) and HPV-unrelated (HPV-) OPC, before and after radiotherapy/chemoradiotherapy (RT/CRT) and to assess the impact of these parameters on survival. One hundred twenty seven patients with HPV+ and HPV− OPC, treated with RT alone or concurrent chemoradiotherapy (CRT), were included. Patients were divided according to HPV status. Confirmation of HPV etiology was obtained from FFPE (Formalin-Fixed, Paraffin-Embedded) tissue samples and/or extracellular circulating HPV DNA was determined. The pre-treatment and post-treatment laboratory blood parameters were compared in both groups. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and systemic immune inflammation (SII) index were calculated. The impact of these parameters on overall (OS) and disease-free (DFS) survival was analyzed. In HPV+ patients, a high pre-treatment white blood cells (WBC) count (>8.33 /mm3), NLR (>2.13), SII (>448.60) significantly correlated with reduced OS, whereas high NLR (>2.29), SII (>462.58) significantly correlated with reduced DFS. A higher pre-treatment NLR and SII were significant poor prognostic factors for both OS and DFS in the HPV+ group. These associations were not apparent in HPV− patients. There are different pre-treatment and post-treatment immune and hematological prognostic factors for OS and DFS in HPV+ and HPV− patients. The immune ratios could be considered valuable biomarkers for risk stratification and differentiation for HPV− and HPV+ OPC patients.

A simplified iterative approach for testing the pulse derailment of light rail vehicles across a viaduct to near-fault earthquake scenarios

2021 ◽  
pp. 095440972098741
Author(s):  
Ling-Kun Chen ◽  
Peng Liu ◽  
Li-Ming Zhu ◽  
Jing-Bo Ding ◽  
Yu-Lin Feng ◽  
...  
Keyword(s):  
Ground Motions ◽  
Simulation Software ◽  
Light Rail ◽  
Rail Transit ◽  
Light Rail Transit ◽  
Seismic Responses ◽  
Near Fault ◽  
Rail Vehicle ◽  
Pulse Type ◽  
The Impact

Near-fault (NF) earthquakes cause severe bridge damage, particularly urban bridges subjected to light rail transit (LRT), which could affect the safety of the light rail transit vehicle (“light rail vehicle” or “LRV” for short). Now when a variety of studies on the fault fracture effect on the working protection of LRVs are available for the study of cars subjected to far-reaching soil motion (FFGMs), further examination is appropriate. For the first time, this paper introduced the LRV derailment mechanism caused by pulse-type near-fault ground motions (NFGMs), suggesting the concept of pulse derailment. The effects of near-fault ground motions (NFGMs) are included in an available numerical process developed for the LRV analysis of the VBI system. A simplified iterative algorithm is proposed to assess the stability and nonlinear seismic response of an LRV-reinforced concrete (RC) viaduct (LRVBRCV) system to a long-period NFGMs using the dynamic substructure method (DSM). Furthermore, a computer simulation software was developed to compute the nonlinear seismic responses of the VBI system to pulse-type NFGMs, non-pulse-type NFGMs, and FFGMs named Dynamic Interaction Analysis for Light-Rail-Vehicle Bridge System (DIALRVBS). The nonlinear bridge seismic reaction determines the impact of pulses on lateral peak earth acceleration (Ap) and lateral peak land (Vp) ratios. The analysis results quantify the effects of pulse-type NFGMs seismic responses on the LRV operations' safety. In contrast with the pulse-type non-pulse NFGMs and FFGMs, this article's research shows that pulse-type NFGM derail trains primarily via the transverse velocity pulse effect. Hence, this study's results and the proposed method can improve the LRT bridges' seismic designs.

scholarly journals Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Andoni Garitano-Trojaola ◽  
Ana Sancho ◽  
Ralph Götz ◽  
Patrick Eiring ◽  
Susanne Walz ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Actin Cytoskeleton ◽  
Myeloid Leukemia ◽  
Actin Polymerization ◽  
Cell Stiffness ◽  
Adhesion Forces ◽  
Frequent Mutations ◽  
New Perspective ◽  
The Impact ◽  
Acute Myeloid

AbstractThe presence of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and is associated with an unfavorable prognosis. FLT3 inhibitors, such as midostaurin, are used clinically but fail to entirely eradicate FLT3-ITD + AML. This study introduces a new perspective and highlights the impact of RAC1-dependent actin cytoskeleton remodeling on resistance to midostaurin in AML. RAC1 hyperactivation leads resistance via hyperphosphorylation of the positive regulator of actin polymerization N-WASP and antiapoptotic BCL-2. RAC1/N-WASP, through ARP2/3 complex activation, increases the number of actin filaments, cell stiffness and adhesion forces to mesenchymal stromal cells (MSCs) being identified as a biomarker of resistance. Midostaurin resistance can be overcome by a combination of midostaruin, the BCL-2 inhibitor venetoclax and the RAC1 inhibitor Eht1864 in midostaurin-resistant AML cell lines and primary samples, providing the first evidence of a potential new treatment approach to eradicate FLT3-ITD + AML.

Porphyromonas Gingivalis Infection Induces Synaptic Failure via Increased IL-1β Production in Leptomeningeal Cells

2021 ◽  
pp. 1-17
Author(s):  
Wanyi Huang ◽  
Fan Zeng ◽  
Yebo Gu ◽  
Muzhou Jiang ◽  
Xinwen Zhang ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Nlrp3 Inflammasome ◽  
Cortical Neurons ◽  
Inflammasome Activation ◽  
Memory Decline ◽  
Periodontal Bacteria ◽  
Nlrp3 Inflammasome Activation ◽  
Synaptic Failure ◽  
Pre Treatment ◽  
The Impact

Background: Studies have reported that synaptic failure occurs before the Alzheimer’s disease (AD) onset. The systemic Porphyromonas gingivalis (P. gingivalis) infection is involved in memory decline. We previously showed that leptomeningeal cells, covering the brain, activate glial cells by releasing IL-1β in response to systemic inflammation. Objective: In the present study, we focused on the impact of leptomeningeal cells on neurons during systemic P. gingivalis infection. Methods: The responses of leptomeningeal cells and cortical neurons to systemic P. gingivalis infection were examined in 15-month-old mice. The mechanism of IL-1β production by P. gingivalis infected leptomeningeal cells was examined, and primary cortical neurons were treated with P. gingivalis infected leptomeningeal cells condition medium (Pg LCM). Results: Systemic P. gingivalis infection increased the expression of IL-1β in leptomeninges and reduced the synaptophysin (SYP) expression in leptomeninges proximity cortex in mice. Leptomeningeal cells phagocytosed P. gingivalis resulting in lysosomal rupture and Cathepsin B (CatB) leakage. Leaked CatB mediated NLRP3 inflammasome activation inducing IL-1β secretion in leptomeningeal cells. Pg LCM decreased the expression of synaptic molecules, including SYP, which was inhibited by an IL-1 receptor antagonist pre-treatment. Conclusion: These observations demonstrate that P. gingivalis infection is involved in synaptic failure by inducing CatB/NLRP3 inflammasome-mediated IL-1β production in leptomeningeal cells. The periodontal bacteria-induced synaptic damage may accelerate the onset and cognitive decline of AD.

scholarly journals Mechanical, Thermal and Rheological Properties of Polyethylene-Based Composites Filled with Micrometric Aluminum Powder

Materials ◽  
2020 ◽  
Vol 13 (5) ◽  
pp. 1242
Author(s):  
Olga Mysiukiewicz ◽  
Paulina Kosmela ◽  
Mateusz Barczewski ◽  
Aleksander Hejna
Keyword(s):  
Mechanical Properties ◽  
Melt Flow Index ◽  
Tensile Tests ◽  
Mechanical Analysis ◽  
Flow Index ◽  
Scanning Calorimetry ◽  
Metal Composites ◽  
Pre Treatment ◽  
The Impact ◽  
Properties Of Composites

Investigations related to polymer/metal composites are often limited to the analysis of the electrical and thermal conductivity of the materials. The presented study aims to analyze the impact of aluminum (Al) filler content (from 1 to 20 wt%) on the rarely investigated properties of composites based on the high-density polyethylene (HDPE) matrix. The crystalline structure, rheological (melt flow index and oscillatory rheometry), thermal (differential scanning calorimetry), as well as static (tensile tests, hardness, rebound resilience) and dynamic (dynamical mechanical analysis) mechanical properties of composites were investigated. The incorporation of 1 and 2 wt% of aluminum filler resulted in small enhancements of mechanical properties, while loadings of 5 and 10 wt% provided materials with a similar performance to neat HDPE. Such results were supported by the lack of disturbances in the rheological behavior of composites. The presented results indicate that a significant content of aluminum filler may be introduced into the HDPE matrix without additional pre-treatment and does not cause the deterioration of composites’ performance, which should be considered beneficial when engineering PE/metal composites.

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