scholarly journals Pharmacological Properties of Geraniol – A Review

Planta Medica ◽  
2018 ◽  
Vol 85 (01) ◽  
pp. 48-55 ◽  
Author(s):  
Yu Lei ◽  
Peng Fu ◽  
Xie Jun ◽  
Peng Cheng
Keyword(s):  
Clinical Trial ◽  
Antimicrobial Activities ◽  
Drug Candidate ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Valeriana Officinalis ◽  
Aromatic Plants ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Further Development

AbstractGeraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including Cinnamomum tenuipilum, Valeriana officinalis, and several other plants. The limited source of geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing geraniol production through biotechnology processes. The diverse activities of geraniol suggested that geraniol could treat various diseases as a promising drug candidate. In order to evaluate the potential of geraniol applied in a clinical trial, this review aims at providing a comprehensive summary of the pharmacological effects of geraniol. The publications retrieved from PubMed, ScienceDirect, Springer, and Wiley databases were collected and summarized for the last 6 years. Then, the potential application of geraniol as a drug is discussed based on its pharmacological properties, including antitumor, anti-inflammatory, antioxidative, and antimicrobial activities, and hepatoprotective, cardioprotective, and neuroprotective effects. Hence, this review aims at providing evidence of the pharmacological activities of geraniol in the context of further development as a drug candidate in clinical application.

scholarly journals Rhein: A Review of Pharmacological Activities

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yan-Xi Zhou ◽  
Wei Xia ◽  
Wei Yue ◽  
Cheng Peng ◽  
Khalid Rahman ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Polygonum Multiflorum ◽  
Pharmacological Activities ◽  
Aloe Barbadensis ◽  
Cassia Tora ◽  
Rheum Palmatum

Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid) is a lipophilic anthraquinone extensively found in medicinal herbs, such asRheum palmatumL.,Cassia toraL.,Polygonum multiflorumThunb., andAloe barbadensisMiller, which have been used medicinally in China for more than 1,000 years. Its biological activities related to human health are being explored actively. Emerging evidence suggests that rhein has many pharmacological effects, including hepatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. The present review provides a comprehensive summary and analysis of the pharmacological properties of rhein, supporting the potential uses of rhein as a medicinal agent.

Steroidal pyrazolines as a promising scaffold in drug discovery

2020 ◽  
Vol 12 (10) ◽  
pp. 949-959
Author(s):  
Ranju Bansal ◽  
Ranjit Singh
Keyword(s):  
Drug Discovery ◽  
Broad Spectrum ◽  
Chemical Reactivity ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Review Article ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Wide Range

Steroidal pyrazolines constitute an interesting and promising scaffold for drug discovery as they display diverse chemical reactivity and a wide range of biological activities. Literature reports indicate potent anticancer potential of steroidal pyrazolines along with broad-spectrum antimicrobial activities. Strong neuroprotective effects with steroids possessing pyrazoline moiety have also been observed. Among all the therapeutically active steroidal pyrazolines, D-ring-substituted derivatives are highly potent and the least toxic. The current and futuristic research approaches in this area are focused towards the exploration of this promising scaffold to develop molecules with widespread pharmacological activities. This review article mainly covers the synthetic and pharmacological aspects of steroidal pyrazolines, which will assist the medicinal chemists working in this area in their scientific endeavors.

Pharmacological Properties of Curcumin

2020 ◽  
pp. 235-248
Author(s):  
Anuradha Singh
Keyword(s):  
Clinical Trial ◽  
Natural Product ◽  
Mechanisms Of Action ◽  
Clinical Settings ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
The Poor ◽  
Cellular Factors

Curcumin, the polyphenol natural product, is a constituent of the traditional medicine known as turmeric. Extensive research over the last 50 years has indicated that this polyphenol displays potent pharmacological effects by targeting many critical cellular factors through a diverse array of mechanisms of action. However, there are some obstacles that prevent this wonder molecule to be effective in clinical settings and limit its use to topical applications only. Curcumin has recently been classified as both PAINS (panassay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. Due to likely false activity of curcumin in vitro and in vivo has resulted unsuccessful clinical trial of curcumin against several disease. The chapter will review the essential medicinal chemistry of curcumin as well as envisage a compilation and discussion on the poor bioavailability of curcumin.

scholarly journals Phytochemistry, Traditional Uses and Pharmacological Properties of the Genus Opopanax W. D. J. Koch: A Mini-Review

2020 ◽  
Vol 26 (2) ◽  
pp. 99-106
Author(s):  
Alev Önder ◽  
Lutfun Nahar ◽  
Sushmita Nath ◽  
Satyajit D. Sarker
Keyword(s):  
Traditional Medicine ◽  
Mediterranean Region ◽  
Antimicrobial Activities ◽  
Evidence Based ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
Phytochemical Profile ◽  
The Mediterranean ◽  
Antioxidant And Antimicrobial Activities

The genus Opopanax W.D.J. Koch is a member of the Apiaceae family, distributed throughout the Mediterranean region and comprises only three recognized and well-defined species, O. chironium (L.) W.D.J. Koch, O. hispidus (Friv.) Griseb. and O. persicus Boiss. The species of this genus with yellow flowers are well-known in traditional medicine and consumed as food. This review critically appraises published literature on the phytochemistry, traditional usages, and pharmacological activities of the genus Opopanax. In addition, it provides evidence to suggest that the plants from this genus have potential phytotherapeutic applications. Previous phytochemical and bioactivity studies revealed that the genus Opopanax predominantly produces coumarins, diterpenes, phenolics, and phthalides, and possesses various biological and pharmacological properties, including anticancer, antioxidant and antimicrobial activities. The phytochemical profile and pharmacological activities of the genus Opopanax could be useful for further study and might find additional medicinal applications in evidence-based phytotherapy

scholarly journals Review of the Chemical Properties, Pharmacological Properties, and Development Studies of Cymbopogon sp.

2020 ◽  
Vol 11 (3) ◽  
pp. 10341-10350
Keyword(s):  
Essential Oil ◽  
Chemical Properties ◽  
Development Studies ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Aromatic Plants ◽  
Disease Treatment ◽  
Pharmacological Studies ◽  
The Central Nervous System ◽  
Essential Oil Production

Cymbopogon is a genus of aromatic plants that famed because of the essential oil production that has many benefit in industrial, daily life, or even for disease treatment. The Cymbopogon genus consists of about 180 plants, including different species, subspecies, varieties, and subvarieties. The aim of this review is to present chemical properties, pharmacological, and development of the Cymbopogon genus from books and research studies. There were many types of research that have been done to prove the benefits of the Cymbopogon genus, including studies about the extract, essential oil, the chemical compound biological activity, and development studies. Some pharmacological studies that have been confirmed are regarding the pharmacological effects of Cymbopogon in the central nervous system, anti-inflammatory, antimicrobial, antioxidant, and anticancer activity. In addition, there have been studied to improve Cymbopogon benefits.

scholarly journals Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 20
Author(s):  
Mohammed Dalli ◽  
Oussama Bekkouch ◽  
Salah-eddine Azizi ◽  
Ali Azghar ◽  
Nadia Gseyra ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Nigella Sativa ◽  
Pharmacological Effects ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Pharmacological Activities ◽  
Future Studies ◽  
Therapeutic Activities

Medicinal and aromatic plants are mainly characterized by the presence of different bioactive compounds which exhibit various therapeutic activities. In order to investigate the different pharmacological properties of different Nigella sativa extracts, a multitude of research articles published in the period between 2019 and 2021 were obtained from different databases (Scopus, Science Direct, PubMed, and Web of Science), and then explored and analyzed. The analysis of the collected articles allows us to classify the phytochemicals and the pharmacological activities through their underlying molecular mechanisms, as well as to explore the pharmacological activities exhibited by several identified compounds in Nigella sativa which allow a better understanding, and better elucidation, of the bioactive compounds responsible for the pharmacological effects. Also shown are the existence of other bioactive compounds that are still unexplored and could be of great interest. This review could be taken as a guide for future studies in the field.

scholarly journals Neuroprotective expression of turmeric and curcumin

Food Research ◽  
2020 ◽  
Vol 4 (6) ◽  
pp. 2366-2381
Author(s):  
S. Abbas ◽  
M.S. Latif ◽  
N.S. Shafie ◽  
M.I. Ghazali ◽  
F. Kormin
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurological Disorders ◽  
Curcuma Longa ◽  
Experimental Studies ◽  
Antimicrobial Activities ◽  
Drug Candidate ◽  
Neuroprotective Effects ◽  
Age Related ◽  
Permanent Cure ◽  
Anti Inflammatory

Turmeric (Curcuma longa) is extensively used as a spice and a coloring agent in Southeast Asia. Turmeric is used as a traditional remedy for cough, diabetic wounds, hepatic disorders, and rheumatism due to its antiseptic, antibacterial, and anti-inflammatory properties. Since the last few decades, extensive work has been done on turmeric and its constituents to explore its pharmacological actions. Curcumin is the main constituent of turmeric and is well demonstrated for its anti-inflammatory, hypoglycaemic, antioxidant, wound-healing, and antimicrobial activities. The functional neurons of the brain and synapses are lost in neurodegenerative disorders for which there is no permanent cure. Oxidative damage and inflammation play a role in age-related neurological disorders. The antioxidants have the ability to prevent different neurological disorders. Recent studies have shown that both turmeric and curcumin possess neuroprotective and cognitiveenhancing properties that help to prevent neurodegenerative diseases like Alzheimer's disease and Parkinson’s disease. Different experimental studies have indicated the antioxidant and anti-ageing properties of turmeric and curcumin. Various studies have shown that curcumin acts as a strong barrier against neurological disorders and, hence, it may be a potential drug candidate for the prevention of neurodegenerative diseases. The aim of this review was to present the current pieces of evidence in the literature regarding the neuroprotective effects of turmeric and curcumin.

scholarly journals A review of pharmacological effects of xylopic acid

2020 ◽  
Vol 9 (5) ◽  
pp. 813
Author(s):  
Elizabeth N. Oge ◽  
Ernest Obese ◽  
Robert P. Biney ◽  
Emmanuel Adakudugu ◽  
Mary Agbenyeku ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Reproductive System ◽  
Chronic Exposure ◽  
Toxicity Study ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Cns Depressant

Xylopic acid (15β-acetyloxy-kaur-16-en-19-oic acid) is a kaurene diterpene that can be obtained from various Xylopia spp. Xylopic acid has demonstrated several pharmacological activities in vitro and in vivo. The compound has shown promising effect as a potent analgesic, anti-inflammatory and anti-allergic agent. Xylopic acid is a CNS depressant and was able to ameliorate anxiety-like symptoms in mice in addition to its neuroprotective effects. Deleterious effects of xylopic acid on the reproductive system of mice have been well documented but extensive toxicity study detailing effect of the acid upon chronic exposure needs to be determined. Due to the heavy consumption of X. aethiopica fruits, it is recommended that the pharmacokinetics of xylopic acid be determined to ascertain the possible food-drug interaction that may occur when conventional drugs are taken together with foods containing xylopic acid.

Study of Physico-chemical Characteristics and Pharmacological Effects of 1-Ethyl-Salicyldene-bis-Ethylene-Diamine and Its Complex with Mn(II)

2019 ◽  
Vol 70 (7) ◽  
pp. 2534-2537
Author(s):  
Gladiola Tantaru ◽  
Mihai Apostu ◽  
Antonia Poiata ◽  
Mihai Nichifor ◽  
Nela Bibire ◽  
...  
Keyword(s):  
Schiff Base ◽  
Chemical Structure ◽  
Antimicrobial Activities ◽  
Ethylene Diamine ◽  
Chemical Characteristics ◽  
Gram Negative Bacteria ◽  
Pharmacological Effects ◽  
Physico Chemical ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The paper presents the synthesis of a new complex combination of a Bis-Schiff base with Mn(II) ions with great potential for antimicrobial and anti-inflammatory activity. A new complex of the Salen-type ligand, 1-ethyl-salicylidene-bis-ethylene diamine was synthetized using Mn(II) ions. The chemical structure was confirmed through 1H-NMR and IR spectroscopy. The antimicrobial activities of the Bis-Schiff base and its complex were tested in comparison with Ampicillin, Chloramphenicol, Tetracycline, Ofloxacin and Nystatin. Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.

Tamarix articulata (T. articulata) - An Important Halophytic Medicinal Plant with Potential Pharmacological Properties

2019 ◽  
Vol 20 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Abdullah M. Alnuqaydan ◽  
Bilal Rah
Keyword(s):  
Medicinal Plant ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
In Vivo Model ◽  
Drug Candidate ◽  
Phytochemical Analysis ◽  
Pharmacological Properties

Background:Tamarix Articulata (T. articulata), commonly known as Tamarisk or Athal in Arabic region, belongs to the Tamaricaece species. It is an important halophytic medicinal plant and a good source of polyphenolic phytochemical(s). In traditional medicines, T. articulata extract is commonly used, either singly or in combination with other plant extracts against different ailments since ancient times.Methods:Electronic database survey via Pubmed, Google Scholar, Researchgate, Scopus and Science Direct were used to review the scientific inputs until October 2018, by searching appropriate keywords. Literature related to pharmacological activities of T. articulata, Tamarix species, phytochemical analysis of T. articulata, biological activities of T. articulata extracts. All of these terms were used to search the scientific literature associated with T. articulata; the dosage of extract, route of administration, extract type, and in-vitro and in-vivo model.Results:Numerous reports revealed that T. articulata contains a wide spectrum of phytochemical(s), which enables it to have a wide window of biological properties. Owing to the presence of high content of phytochemical compounds like polyphenolics and flavonoids, T. articulata is a potential source of antioxidant, anti-inflammatory and antiproliferative properties. In view of these pharmacological properties, T. articulata could be a potential drug candidate to treat various clinical conditions including cancer in the near future.Conclusion:In this review, the spectrum of phytochemical(s) has been summarized for their pharmacological properties and the mechanisms of action, and the possible potential therapeutic applications of this plant against various diseases discussed.

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