scholarly journals Positive Impact of Natural Deep Eutectic Solvents on the Biocatalytic Performance of 5-Hydroxymethyl-Furfural Oxidase

Catalysts ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 447 ◽  
Author(s):  
Gonzalo de Gonzalo ◽  
Caterina Martin ◽  
Marco W. Fraaije
Keyword(s):  
Dicarboxylic Acid ◽  
Carbonyl Compounds ◽  
Positive Impact ◽  
Deep Eutectic Solvents ◽  
Redox Enzymes ◽  
Beneficial Effects ◽  
Hydroxymethyl Furfural ◽  
Natural Deep Eutectic Solvents ◽  
The Stability ◽  
Positive Effect

Deep eutectic solvents (DESs) have been applied as cosolvents in various biocatalytic processes during recent years. However, their use in combination with redox enzymes has been limited. In this study, we have explored the beneficial effects of several DES as cosolvents on the performance of 5-hydroxymethylfurfural oxidase (HMFO), a valuable oxidative enzyme for the preparation of furan-2,5-dicarboxylic acid (FDCA), and other compounds, such as carbonyl compounds and carboxylic acids. The use of natural DESs, based on glucose and fructose, was found to have a positive effect. Higher conversions are obtained for the synthesis of several oxidized compounds, including FDCA. Depending on the type of DES, the stability of HMFO could be significantly improved. As the use of DES increases the solubility of many substrates while they only mildly affect dioxygen solubility, this study demonstrates that biocatalysis based on HMFO and other redox biocatalysts can benefit from a carefully selected DES.

scholarly journals Intake of Red Wine in Different Meals Modulates Oxidized LDL Level, Oxidative and Inflammatory Gene Expression in Healthy People: A Randomized Crossover Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Laura Di Renzo ◽  
Alberto Carraro ◽  
Roberto Valente ◽  
Leonardo Iacopino ◽  
Carmen Colica ◽  
...  
Keyword(s):  
Gene Expression ◽  
Red Wine ◽  
Positive Impact ◽  
Oxidized Ldl ◽  
Antioxidant Genes ◽  
Beneficial Effects ◽  
Inflammatory Conditions ◽  
Before And After ◽  
First Time ◽  
Positive Effect

Several studies have found that adherence to the Mediterranean Diet, including consumption of red wine, is associated with beneficial effects on oxidative and inflammatory conditions. We evaluate the outcome of consumption of a McDonald’s Meal (McD) and a Mediterranean Meal (MM), with and without the additive effect of red wine, in order to ascertain whether the addition of the latter has a positive impact on oxidized (ox-) LDL and on expression of oxidative and inflammatory genes. A total of 24 subjects were analyzed for ox-LDL, CAT, GPX1, SOD2, SIRT2, and CCL5 gene expression levels, before and after consumption of the 4 different meal combinations with washout intervals between each meal. When red wine is associated with McD or MM, values of ox-LDL are lowered (P<0.05) and expression of antioxidant genes is increased, while CCL5 expression is decreased (P<0.05). SIRT2 expression after MM and fasting with red wine is significantly correlated with downregulation of CCL5 and upregulation of CAT (P<0.001). GPX1 increased significantly in the comparison between baseline and all conditions with red wine. We highlighted for the first time the positive effect of red wine intake combined with different but widely consumed meal types on ox-LDL and gene expression.Trial Registration. This trial is registered with ClinicalTrials.govNCT01890070.

scholarly journals Aquatic Exercise to Treat Pregnancy Related Issues in Pregnant Women: A Systematic Review

2020 ◽  
Vol 6 (2) ◽  
pp. 391-400
Author(s):  
Asif Ali ◽  
Muhammad Azam ◽  
Zargham ul Hassan Askry
Keyword(s):  
Pregnant Women ◽  
Psychological Factors ◽  
Positive Impact ◽  
Labor Pain ◽  
Assessment Procedure ◽  
Sleep Health ◽  
Beneficial Effects ◽  
Physical Problems ◽  
Health Related ◽  
Positive Effect

Background: Wide ranges of physiological changes occur as a result of pregnancy in women that, in certain cases, may cause variety of psychological and physical problems in pregnant women.  Aquatic exercises believed to be safe for pregnant women and believed to foster positive effect on psychophysical health. Current health care setting and nursing emphasizes on evidence based approaches when developing and implementing interventions to address health related issues of pregnant women. Purpose: This review sought to synthesize qualitatively the existing research evidences concerning association between aquatic exercises and psychophysical problems in pregnant women. Methods: A 1989 records were yielded as result of conducting a systematic search in nine research data bases. After undergoing rigorous screening and assessment procedure of eligibility, and quality appraisal, a total of seventeen research articles were ultimately selected to include in this review. Result: Out of seventeen admissible studies, ten studies found that aquatic exercises exerts positive impact to decreases variety of physical discomforts such as fatigue, pelvic pain, labor pain, and edema. The remaining seven studies presented beneficial effects of aquatic exercises for psychological factors such as body image, stress, depression, feelings, mood, distress, and anxiety in pregnant women. Moreover, among the seventeen studies, only two studies showed effectiveness of aquatic exercises to manage body weight and two studies found improvement in sleep during pregnancy.    Conclusion: This review found some evidence in support of the efficacy of aquatic exercises to reduce physical discomfort and improve psychological factors in pregnant women. More studies essential to reach stronger conclusion. The existing evidence concerning effectiveness of this intervention for weight management and sleep health during pregnancy is insufficient.

scholarly journals Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Plants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2091
Author(s):  
Ni Putu Ermi Hikmawanti ◽  
Delly Ramadon ◽  
Ibrahim Jantan ◽  
Abdul Mun’im
Keyword(s):  
Deep Eutectic Solvents ◽  
Pharmaceutical Formulations ◽  
Green Solvents ◽  
Plant Metabolites ◽  
Natural Deep Eutectic Solvents ◽  
Extraction Performance ◽  
The Stability ◽  
Phytochemical Extraction ◽  
Extracting Solvent ◽  
Selection Of

Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites-based nutraceuticals are discussed.

IMPACT OF GOVERNMENT DEBT ON FINANCIAL SECURITY OF UKRAINE

2017 ◽  
Author(s):  
Olena Pikaliuk ◽  
◽  
Dmitry Kovalenko ◽  
Keyword(s):  
Economic Development ◽  
Public Debt ◽  
Positive Impact ◽  
The State ◽  
Financial Security ◽  
State Budget ◽  
The Public ◽  
Debt Security ◽  
The Stability ◽  
The Impact

One of the main criteria for economic development is the size of the public debt and its dynamics. The article considers the impact of public debt on the financial security of Ukraine. The views of scientists on the essence of public debt and financial security of the state are substantiated. An analysis of the dynamics and structure of public debt of Ukraine for 2014-2019. It is proved that one of the main criteria for economic development is the size of public debt and its dynamics. State budget deficit, attracting and using loans to cover it have led to the formation and significant growth of public debt in Ukraine. The volume of public debt indicates an increase in the debt security of the state, which is a component of financial security. Therefore, the issue of the impact of public debt on the financial security of Ukraine is becoming increasingly relevant. The constant growth and large amounts of debt make it necessary to study it, which will have a positive impact on economic processes that will ensure the stability of the financial system and enhance its security.

Short-Term Ultramicronized Palmitoylethanolamide Therapy in Patients with Myasthenia Gravis: a Pilot Study to Possible Future Implications of Treatment

2019 ◽  
Vol 18 (3) ◽  
pp. 232-238 ◽  
Author(s):  
Emanuela Onesti ◽  
Vittorio Frasca ◽  
Marco Ceccanti ◽  
Giorgio Tartaglia ◽  
Maria Cristina Gori ◽  
...  
Keyword(s):  
Pilot Study ◽  
Myasthenia Gravis ◽  
Repetitive Nerve Stimulation ◽  
Beneficial Effects ◽  
Antibody Titers ◽  
The Stability ◽  
Ultramicronized Palmitoylethanolamide ◽  
Open Pilot

Background: The cannabinoid system may be involved in the humoral mechanisms at the neuromuscular junction. Ultramicronized-palmitoylethanolamide (μm-PEA) has recently been shown to reduce the desensitization of Acetylcholine (ACh)-evoked currents in denervated patients modifying the stability of ACh receptor (AChR) function. <p> Objective: To analyze the possible beneficial effects of μm-PEA in patients with myasthenia gravis (MG) on muscular fatigue and neurophysiological changes. <p> Method: The duration of this open pilot study, which included an intra-individual control, was three weeks. Each patient was assigned to a 1-week treatment period with μm-PEA 600 mg twice a day. A neurophysiological examination based on repetitive nerve stimulation (RNS) of the masseteric and the axillary nerves was performed, and the quantitative MG (QMG) score was calculated in 22 MG patients every week in a three-week follow-up period. AChR antibody titer was investigated to analyze a possible immunomodulatory effect of PEA in MG patients. <p> Results: PEA had a significant effect on the QMG score (p=0.03418) and on RNS of the masseteric nerve (p=0.01763), thus indicating that PEA reduces the level of disability and decremental muscle response. Antibody titers did not change significantly after treatment. <p> Conclusion: According to our observations, μm-PEA as an add-on therapy could improve muscular response to fatigue in MG. The possible modulation of AChR currents as a means of eliciting a direct effect from PEA on the conformation of ACh receptors should be investigated. The co-role of cytokines also warrants an analysis. Given the rapidity and reversibility of the response, we suppose that PEA acts directly on AChR, though further studies are needed to confirm this hypothesis.

A review of sustainable lignocellulose biorefining applying (natural) deep eutectic solvents (DESs) for separations, catalysis and enzymatic biotransformation processes

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ana Bjelić ◽  
Brigita Hočevar ◽  
Miha Grilc ◽  
Uroš Novak ◽  
Blaž Likozar
Keyword(s):  
Special Section ◽  
Cost Effective ◽  
Deep Eutectic Solvents ◽  
Reaction Conditions ◽  
Co Catalysts ◽  
Biomass Fractionation ◽  
Functional Step ◽  
Natural Deep Eutectic Solvents ◽  
Economic Need ◽  
Molecular Compounds

AbstractConventional biorefinery processes are complex, engineered and energy-intensive, where biomass fractionation, a key functional step for the production of biomass-derived chemical substances, demands industrial organic solvents and harsh, environmentally harmful reaction conditions. There is a timely, clear and unmet economic need for a systematic, robust and affordable conversion method technology to become greener, sustainable and cost-effective. In this perspective, deep eutectic solvents (DESs) have been envisaged as the most advanced novel polar liquids that are entirely made of natural, molecular compounds that are capable of an association via hydrogen bonding interactions. DES has quickly emerged in various application functions thanks to a formulations’ simple preparation. These molecules themselves are biobased, renewable, biodegradable and eco-friendly. The present experimental review is providing the state of the art topical overview of trends regarding the employment of DESs in investigated biorefinery-related techniques. This review covers DESs for lignocellulosic component isolation, applications as (co)catalysts and their functionality range in biocatalysis. Furthermore, a special section of the DESs recyclability is included. For DESs to unlock numerous new (reactive) possibilities in future biorefineries, the critical estimation of its complexity in the reaction, separation, or fractionation medium should be addressed more in future studies.

scholarly journals PEER DESIGNERS AS STRONG INFLUENCERS ON THE DESIGN PROCESS OF FOOD STARTUPS

2021 ◽  
Vol 1 ◽  
pp. 2409-2418
Author(s):  
Summer D. Jung ◽  
Erika Perttunen ◽  
Senni Kirjavainen ◽  
Tua Björklund ◽  
Sohyeong Kim
Keyword(s):  
Design Process ◽  
Qualitative Data ◽  
Design Research ◽  
Positive Impact ◽  
Peer Influences ◽  
Design Team ◽  
Food And Beverage ◽  
Design Ideas ◽  
Different Sources ◽  
Positive Effect

AbstractAs design research expands its horizon, there has been a recent rise in studies on nontraditional designers. Previous studies have noted the positive effect of diversity in generating ideas. Among different sources of influence, peers outside the design team have been noted for their positive impact on the design process, yet the research on this topic is still in its early stages. Using qualitative data from 40 small and medium-sized enterprises (SMEs) in the American and Finnish food and beverage industries, the current study examines their interactions with other SMEs, shedding light on the influence of peers on creating new design solutions. The findings suggest that peer companies can act as a frequent and impactful source of inspiration for product design ideas. The most prevalent forms of interaction were co-creating products, sharing information, and sharing ingredients. Furthermore, the interactions were voluntary, organic, and improvisational in nature, and physical proximity or previous connections often initiated the interactions. Taken together, a great number of peer influences contributed towards creative new solutions.

Sign in / Sign up

Export Citation Format

Share Document