scholarly journals Development of Freeze-Thaw Stable Starch through Enzymatic Modification

Foods ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2269
Author(s):  
Seung-Hye Woo ◽  
Ji-Soo Kim ◽  
Hyun-Mo Jeong ◽  
Yu-Jeong Shin ◽  
Jung-Sun Hong ◽  
...  
Keyword(s):  
Water Solubility ◽  
Corn Starch ◽  
Potential Candidate ◽  
Cyclodextrin Glucanotransferase ◽  
Frozen Foods ◽  
Scanning Calorimetry ◽  
Freeze Thaw ◽  
Branching Enzymes ◽  
Textural Changes ◽  
High Level

The use of unmodified starch in frozen foods can cause extremely undesirable textural changes after the freeze-thaw process. In this study, using cyclodextrin glucanotransferase (CGTase) and branching enzymes, an amylopectin cluster with high freeze-thaw stability was produced, and was named CBAC. It was found to have a water solubility seven times higher, and a molecular weight 77 times lower, than corn starch. According to the results of a differential scanning calorimetry (DSC) analysis, dough containing 5% CBAC lost 19% less water than a control dough after three freeze-thaw cycles. During storage for 7 days at 4 °C, bread produced using CBAC-treated dough exhibited a 14% smaller retrogradation peak and 37% less hardness than a control dough, suggesting that CBAC could be a potential candidate for clean label starch, providing high-level food stability under repeated freeze-thaw conditions.

scholarly journals Preparation and characterization of corn starch/PVA/glycerol composite films incorporated with ε-polylysine as a novel antimicrobial packaging material

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 154-161 ◽  
Author(s):  
Gao Yurong ◽  
Li Dapeng
Keyword(s):  
Water Solubility ◽  
Corn Starch ◽  
Composite Films ◽  
Antimicrobial Properties ◽  
Xrd Analysis ◽  
Sem Analysis ◽  
Packaging Material ◽  
Hydroxyl Group ◽  
Electron Microscopic ◽  
Antimicrobial Packaging

AbstractCorn starch/polyvinyl alcohol (PVA)/glycerol composite films incorporated with ε-polylysine were prepared, and their properties were investigated. The Fourier-transform infrared (FTIR) spectroscopy indicated that the interactions happened between the amino group of ε-polylysine and hydroxyl group starch/PVA composite films. X-ray diffraction (XRD) analysis showed that the addition of ε-polylysine decreased the intensity of all crystal peaks. Thermogravimetric (TGA) analysis suggested that ε-polylysine improved the thermal stability of composite films. Scanning electron microscopic (SEM) analysis showed that the upper surface of composite films incorporated with ε-polylysine presented more compact and flat surface. The antimicrobial activity of the composite film progressively increased with the increasing of ε-polylysine concentration (P < 0.05). The tensile strength, elongation at break and water absorption significantly increased, whereas water solubility decreased with the increasing of ε-polylysine concentration (P < 0.05). Therefore, the corn starch/PVA/glycerol composite films incorporated with ε-polylysine had good mechanical, physical and antimicrobial properties and could have potential application as a novel antimicrobial packaging material.

scholarly journals Effect of DMPA and Molecular Weight of Polyethylene Glycol on Water-Soluble Polyurethane

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1915 ◽  
Author(s):  
Eyob Wondu ◽  
Hyun Woo Oh ◽  
Jooheon Kim
Keyword(s):  
Molecular Weight ◽  
Contact Angle ◽  
Polyethylene Glycol ◽  
Photoelectron Spectroscopy ◽  
Water Solubility ◽  
Soft Segment ◽  
Water Soluble ◽  
Size Exclusion ◽  
Resonance Spectroscopy ◽  
Scanning Calorimetry

In this study water-soluble polyurethane (WSPU) was synthesized from isophorone diisocyanate (IPDI), and polyethylene glycol (PEG), 2-bis(hydroxymethyl) propionic acid or dimethylolpropionic acid (DMPA), butane-1,4-diol (BD), and triethylamine (TEA) using an acetone process. The water solubility was investigated by solubilizing the polymer in water and measuring the contact angle and the results indicated that water solubility and contact angle tendency were increased as the molecular weight of the soft segment decreased, the amount of emulsifier was increased, and soft segment to hard segment ratio was lower. The contact angle of samples without emulsifier was greater than 87°, while that of with emulsifier was less than 67°, indicating a shift from highly hydrophobic to hydrophilic. The WSPU was also analyzed using Fourier transform infrared spectroscopy (FT-IR) to identify the absorption of functional groups and further checked by X-ray photoelectron spectroscopy (XPS). The molecular weight of WSPU was measured using size-exclusion chromatography (SEC). The structure of the WSPU was confirmed by nuclear magnetic resonance spectroscopy (NMR). The thermal properties of WSPU were analyzed using thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC).

scholarly journals Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1008 ◽  
Author(s):  
Qilei Yang ◽  
Chang Zu ◽  
Wengang Li ◽  
Weiwei Wu ◽  
Yunlong Ge ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
High Performance ◽  
Water Solubility ◽  
Water Soluble ◽  
Precipitation Process ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Antisolvent Precipitation ◽  
Antisolvent Crystallization ◽  
Artificial Gastric Juice

Paclitaxel (PTX) is a poor water-soluble antineoplastic drug with significant antitumor activity. However, its low bioavailability is a major obstacle for its biomedical applications. Thus, this experiment is designed to prepare PTX crystal powders through an antisolvent precipitation process using 1-hexyl-3-methylimidazolium bromide (HMImBr) as solvent and water as an antisolvent. The factors influencing saturation solubility of PTX crystal powders in water in water were optimized using a single-factor design. The optimum conditions for the antisolvent precipitation process were as follows: 50 mg/mL concentration of the PTX solution, 25 °C temperature, and 1:7 solvent-to-antisolvent ratio. The PTX crystal powders were characterized via scanning electron microscopy, Fourier transform infrared spectroscopy, high-performance liquid chromatography–mass spectrometry, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Raman spectroscopy, solid-state nuclear magnetic resonance, and dissolution and oral bioavailability studies. Results showed that the chemical structure of PTX crystal powders were unchanged; however, precipitation of the crystalline structure changed. The dissolution test showed that the dissolution rate and solubility of PTX crystal powders were nearly 3.21-folds higher compared to raw PTX in water, and 1.27 times higher in artificial gastric juice. Meanwhile, the bioavailability of PTX crystal increased 10.88 times than raw PTX. These results suggested that PTX crystal powders might have potential value to become a new oral PTX formulation with high bioavailability.

scholarly journals The potential use of lightweight cellular concrete in pavement application: a review

2020 ◽  
Vol 13 (6) ◽  
pp. 686-696
Author(s):  
Frank Mi-Way Ni ◽  
Abimbola Grace Oyeyi ◽  
Susan Tighe
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Ease Of Use ◽  
Potential Candidate ◽  
Actual Performance ◽  
Freeze Thaw ◽  
Lower Weight ◽  
And Performance ◽  
Potential Use ◽  
Cellular Concrete

AbstractProtecting the pavement subgrade to increase the service life of road pavements is an aspect currently being explored. Several alternative pavement subbase materials are being considered, including Lightweight Cellular Concrete (LCC). Due to its lower weight, LCC incorporating industrial by-product, making it sustainable, and ease of use amongst other benefits, is seen as a potential candidate. This paper reports reviewing the potential application of LCC within the pavement structure with a specific application as a subbase. It examines the various properties such as modulus of elasticity, compressive and tensile strength, Water absorption, and freeze-thaw resistance necessary for pavement application. It also assesses its use in the field in Canada considering the design methods utilized. Some limitations and gaps for LCC application in pavements are also established and recommendations on how to further its use and performance. This review concludes that LCC possesses potential as a pavement subbase alternative; however, other mechanical properties like LCC’s fatigue life is essential. A comparative field study is also recommended to monitor actual performance and various factors on performance.

Salts of purine alkaloids caffeine and theobromine with 2,6-dihydroxybenzoic acid as coformer: structural, theoretical, thermal and spectroscopic studies

2021 ◽  
Vol 77 (11) ◽  
Author(s):  
Mateusz Gołdyn ◽  
Anna Komasa ◽  
Mateusz Pawlaczyk ◽  
Aneta Lewandowska ◽  
Elżbieta Bartoszak-Adamska
Keyword(s):  
Hydrogen Bonds ◽  
Water Solubility ◽  
Theoretical Calculations ◽  
Spectroscopic Studies ◽  
X Ray Diffraction ◽  
Dihydroxybenzoic Acid ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Purine Alkaloids ◽  
Vis Spectroscopy

The study of various forms of pharmaceutical substances with specific physicochemical properties suitable for putting them on the market is one of the elements of research in the pharmaceutical industry. A large proportion of active pharmaceutical ingredients (APIs) occur in the salt form. The use of an acidic coformer with a given structure and a suitable pK a value towards purine alkaloids containing a basic imidazole N atom can lead to salt formation. In this work, 2,6-dihydroxybenzoic acid (26DHBA) was used for cocrystallization of theobromine (TBR) and caffeine (CAF). Two novel salts, namely, theobrominium 2,6-dihydroxybenzoate, C7H9N4O2 +·C7H5O4 − (I), and caffeinium 2,6-dihydroxybenzoate, C8H11N4O2 +·C7H5O4 − (II), were synthesized. Both salts were obtained independently by slow evaporation from solution, by neat grinding and also by microwave-assisted slurry cocrystallization. Powder X-ray diffraction measurements proved the formation of the new substances. Single-crystal X-ray diffraction studies confirmed proton transfer between the given alkaloid and 26DHBA, and the formation of N—H...O hydrogen bonds in both I and II. Unlike the caffeine cations in II, the theobromine cations in I are paired by noncovalent N—H...O=C interactions and a cyclic array is observed. As expected, the two hydroxy groups in the 26DHBA anion in both salts are involved in two intramolecular O—H...O hydrogen bonds. C—H...O and π–π interactions further stabilize the crystal structures of both compounds. Steady-state UV–Vis spectroscopy showed changes in the water solubility of xanthines after ionizable complex formation. The obtained salts I and II were also characterized by theoretical calculations, Fourier-transform IR spectroscopy (FT–IR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and elemental analysis.

Formulation and Evaluation of Benidipine Nanosuspension

2021 ◽  
pp. 4111-4116
Author(s):  
Sejal Patel ◽  
Anita P. Patel
Keyword(s):  
Particle Size ◽  
Water Solubility ◽  
Polymer Concentration ◽  
Oral Route ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Scanning Calorimetry ◽  
23 Factorial Design ◽  
Selection Of

In the interest of administration of dosage form oral route is most desirable and preferred method. After oral administration to get maximum therapeutic effect, major challenge is their water solubility. Water insoluble drug indicate insufficient bioavailability as well dissolution resulting in fluctuating plasma level. Benidipine (BND) is poorly water soluble antihypertensive drug has lower bioavailability. To improve bioavailability of Benidipine HCL, BND nanosuspension was formulated using media milling technique. HPMC E5 was used to stabilize nanosuspension. The effect of different important process parameters e.g. selection of polymer concentration X1(1.25 mg), stirring time X2 (800 rpm), selection of zirconium beads size X3 (0.4mm) were investigated by 23 factorial design to accomplish desired particle size and saturation solubility. The optimized batch had 408 nm particle size Y1, and showed in-vitro dissolution Y2 95±0.26 % in 30 mins and Zeta potential was -19.6. Differential scanning calorimetry (DSC) and FT-IR analysis was done to confirm there was no interaction between drug and polymer.

scholarly journals Effects of Pectin on the Physicochemical Properties and Freeze-Thaw Stability of Waxy Rice Starch

Foods ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2419
Author(s):  
Yuheng Zhai ◽  
Jiali Xing ◽  
Xiaohu Luo ◽  
Hao Zhang ◽  
Kai Yang ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Loss Modulus ◽  
Rice Starch ◽  
Scanning Calorimetry ◽  
Freeze Thaw ◽  
Textural Parameter ◽  
Waxy Rice ◽  
Pasting Temperature ◽  
Starch Paste ◽  
Waxy Rice Starch

In this study, the effects of the addition of pectin (PEC) on the physicochemical properties and freeze-thaw stability of waxy rice starch (WRS) were investigated. As PEC content increased, the pasting viscosity and pasting temperature of WRS significantly increased (p < 0.05), whereas its breakdown value and setback value decreased. Differential scanning calorimetry showed that the addition of PEC increased the gelatinization temperature of WRS, but decreased its gelatinization enthalpy. Rheological measurements indicated that the addition of PEC did not change the shear-thinning behavior of WRS–PEC blends, and the storage modulus and loss modulus were positively correlated with PEC content. Moreover, the textural parameter of WRS decreased with the increase in PEC content. Furthermore, the addition of PEC decreased the transmittance of starch paste, but enhanced the freeze-thaw stability of WRS to some extent. These results may contribute to the development of WRS-based food products.

scholarly journals THERMAL AND ELECTROCHEMICAL PROPERTIES OF SOLID BIOPOLYMER ELECTROLYTES FROM STARCH OF DIFFERENT BOTANICAL ORIGIN

2021 ◽  
Vol 18 (38) ◽  
pp. 137-148
Author(s):  
Alvaro ARRIETA
Keyword(s):  
Thermal Decomposition ◽  
Corn Starch ◽  
Potato Starch ◽  
Cassava Starch ◽  
Redox Potentials ◽  
Botanical Origin ◽  
Scanning Calorimetry ◽  
Biopolymer Electrolytes ◽  
Starch Films ◽  
Biopolymer Electrolyte

Background: Solid biopolymer electrolytes are a type of material with high technological potential used in the development of solar cells, batteries, fuel cells, among others, due to their biodegradable nature and low environmental impact. Aim: This study aimed to evaluate the effect of the botanical origin of the starch used to prepare solid biopolymeric electrolyte films on its electrochemical and thermal properties and to establish the variations in thermal decomposition temperatures and redox potentials depending on the botanical origin of the starch used. Methods: Films of solid biopolymer electrolyte were made by thermochemical synthesis processes using corn starch, cassava starch, potato starch, glycerol, polyethylene glycol, and glutaraldehyde as plasticizers and lithium perchlorate salt. The synthesis solutions were taken to an oven at 70 °C for 48 hours. The films were characterized electrochemically by cyclic voltammetry using a dry electrochemical cell and thermally by differential scanning calorimetry and thermogravimetric analysis. Results and Discussion: The results showed that the electrochemical behavior of the films was similar in terms of registered redox processes. However, the potential values of the oxidation and reduction were different, as are the stability and intensity of the processes. On the other hand, the thermal analysis allowed establishing two decomposition processes in each of the films studied; the first process was due to dehydration and depolymerization phenomena in the films. The temperatures recorded were 59.0 °C, 58.9 °C, and 89.9 °C for potato starch, cassava starch, and corn starch films. The second process evidenced the thermal decomposition at different temperatures, 267.7 °C in potato starch films, 280.6 °C in corn starch films, and 287.1 °C in cassava starch films. Conclusions: It could be concluded that the botanical origin of the starch used in the synthesis of solid biopolymer electrolyte films affects its behavior and electrochemical and thermal stability.

scholarly journals Preparation, Characterization, and Bioavailability of Host-Guest Inclusion Complex of Ginsenoside Re with Gamma-Cyclodextrin

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7227
Author(s):  
Hui Li ◽  
Guolei Zhang ◽  
Wei Wang ◽  
Changbao Chen ◽  
Lili Jiao ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Water Solubility ◽  
Area Under The Curve ◽  
Relative Bioavailability ◽  
Docking Studies ◽  
Solubility Parameters ◽  
Phase Solubility ◽  
Scanning Calorimetry ◽  
Ginsenoside Re

This work aimed at improving the water solubility of Ginsenoside (G)-Re by forming an inclusion complex. The solubility parameters of G-Re in alpha (α), beta (β), and gamma (γ) cyclodextrin (CD) were investigated. The phase solubility profiles were all classified as AL-type that indicated the 1:1 stoichiometric relationship with the stability constants Ks which were 22 M−1 (α-CD), 612 M−1 (β-CD), and 14,410 M−1 (γ-CD), respectively. Molecular docking studies confirmed the results of phase solubility with the binding energy of −4.7 (α-CD), −5.10 (β-CD), and −6.70 (γ-CD) kcal/mol, respectively. The inclusion complex (IC) of G-Re was prepared with γ-CD via the water-stirring method followed by freeze-drying. The successful preparation of IC was confirmed by powder X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). In-vivo absorption studies were carried out by LC-MS/MS. Dissolution rate of G-Re was increased 9.27 times after inclusion, and the peak blood concentration was 2.7-fold higher than that of pure G-Re powder. The relative bioavailability calculated from the ratio of Area under the curve AUC0–∞ of the inclusion to pure G-Re powder was 171%. This study offers the first report that describes G-Re’s inclusion into γ-CD, and explored the inclusion complex’s mechanism at the molecular level. The results indicated that the solubility could be significantly improved as well as the bioavailability, implying γ-CD was a very suitable inclusion host for complex preparation of G-Re.

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