Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis

Background: Calprotectin (CP) is a protein complex involved in many inflammatory diseases. Obesity is characterized by low-grade inflammation and elevated circulating levels of calprotectin. However, associations between body mass index (BMI) and calprotectin levels have not been explored in otherwise healthy children. Methods: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed and Cochrane Library database up to July 2019. Healthy children’s blood calprotectin values were extracted, and potential correlations were explored. Results: A total of six studies that included data on 593 healthy children were identified. Median calprotectin value was 900.0 (482.0; 1700) ng·mL−1. Multivariable analysis showed no significant associations with age, sample type (serum vs. plasma), or sex. In contrast, a significant effect of BMI z-score (p < 0.001) emerged. Indeed, a positive correlation between BMI z-score and CP, was detected in girls (R: 0.48; p < 0.001) and boys (R: 0.39; p < 0.001). Conclusion: Calprotectin blood levels correlate with the degree of adiposity in healthy children, but are not affected by age, sex, or sample type (serum or plasma).

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Abstract 5714: Influence of Body Mass Index on Early Diastolic Untwisting Velocity in Healthy Children

Circulation ◽

10.1161/circ.118.suppl_18.s_990 ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Christine O’Reilly ◽

Katrina Abhayaratna ◽

Satoru Sakuragi ◽

Richard Telford ◽

Walter P Abhayaratna

Keyword(s):

Body Mass Index ◽

Heart Rate ◽

Body Mass ◽

Univariate Analysis ◽

Multivariable Analysis ◽

Left Ventricular ◽

Lv Function ◽

Healthy Children ◽

Diastolic Relaxation ◽

And Function

Background: Childhood obesity is increasingly prevalent in the community and is predictive of adverse cardiovascular outcomes in adulthood. We hypothesised that increased body mass index (BMI) in children has an adverse influence on left ventricular (LV) untwisting, a sensitive marker of LV function that reflects a key process in the transition between LV relaxation and suction. Methods: Cardiac structure and function were assessed by transthoracic echocardiography. LV twist mechanics were quantitated using 2-dimensional speckle tracking imaging of the LV base and apex in short axis. Univariate associations of LV untwisting velocity (Er) were evaluated using Spearman’s correlation analysis. Significant univariate predictors (p≤0.10) were included into multivariable regression analysis to determine the independent relationship between body mass and Er (rad/s). Results: Of the first 150 children assessed (age 10.2 ± 0.3 years; 83 boys), the mean BMI was 18.2 ± 2.8 kg/m 2 . In univariate analysis, Er was inversely related to BMI (ρ= −0.13, p=0.10), LV end-diastolic diameter (ρ= −0.13, p=0.10) and LV end-systolic diameter (ρ= −0.28, p<0.001); and positively correlated with LV torsion (ρ=0.55, p<0.001), LV twisting velocity (ρ=0.29, p<0.001), early diastolic annular velocity (e′) (ρ=0.13, p=0.10), LV ejection fraction (EF) (ρ=0.14, p=0.09) and heart rate (ρ=0.18, p=0.03). There was no correlation between Er and LV relative wall thickness or mass index (p>0.25). In multivariable analysis, body mass index was independently associated with Er, independent of LV torsion, heart rate, EF, LV chamber size and e′ (Table ). Conclusion: Increased body mass is independently related to lower LV untwisting velocity during early diastole in healthy children. Additional studies are required to evaluate whether lifestyle measures to reduce body mass will attenuate further deterioration in LV diastolic relaxation and suction. Table: Independent Predictors of Left Ventricular Untwisting Velocity in Children

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Assessment of Exercise Capacity in Children with Type 1 Diabetes in the Cooper Running Test

International Journal of Sports Medicine ◽

10.1055/a-0805-1326 ◽

2018 ◽

Vol 40 (02) ◽

pp. 110-115 ◽

Cited By ~ 3

Author(s):

Arkadiusz Michalak ◽

Andrzej Gawrecki ◽

Szymon Gałczyński ◽

Jędrzej Nowaczyk ◽

Beata Mianowska ◽

...

Keyword(s):

Body Mass Index ◽

Type 1 Diabetes ◽

Body Mass ◽

Body Fat ◽

Pediatric Population ◽

Body Fat Percentage ◽

Healthy Children ◽

Z Score ◽

Fat Percentage

AbstractRegular physical activity increases lifespan for those with type 1 diabetes. However, disease-related barriers may deter children from exercise and affect their fitness. This study examined the safety of the Cooper test concerning diabetes-related acute complications in children with type 1 diabetes and their fitness. Blood glucose was recorded before and 0, 30, 60 min after the test. The covered distances were transformed to z-scores based on the national charts. Body mass index, body fat percentage and glycated hemoglobin were measured. The run was completed by 80 individuals (45% boys, age 13.6±2.1 years; diabetes duration 6.3±3.5 years). During the follow-up 11 children reached glucose alert values (3–3.9 mmol/L), 3 presented clinically significant hypoglycemia (<3 mmol/L), none experienced severe hypoglycemia. The covered distance was 1914±298 m, not significantly different from the reference population (z-score −0.12±0.71 vs 0, p=0.12). The study participants were more overweight than general pediatric population in terms of body mass index (z-score 0.48±0.94 vs 0, p<0.001) and body fat percentage (z-score: 0.37±0.85 vs 0, p<0.001). In conclusion, the Cooper test can be safely used in children with diabetes to assess their physical capacity. Youth with type 1 diabetes present fitness similar to healthy children but exhibit increased body mass index and adiposity.

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Effect of individual- versus collective-based nutritional-lifestyle intervention on the atherogenic index of plasma in children with obesity: a randomized trial

Nutrition & Metabolism ◽

10.1186/s12986-020-00537-w ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Elvira Verduci ◽

Giuseppe Banderali ◽

Elisabetta Di Profio ◽

Sara Vizzuso ◽

Gianvincenzo Zuccotti ◽

...

Keyword(s):

Body Mass Index ◽

Lifestyle Intervention ◽

Body Mass ◽

Univariate Analysis ◽

Atherogenic Index ◽

Z Score ◽

Blood Profile ◽

Atherogenic Index Of Plasma ◽

Paediatric Obesity ◽

The Individual

Abstract Background The Atherogenic Index of Plasma is a predictive biomarker of atherosclerosis in adults but there is a lack of studies in paediatric population aimed at evaluating the longitudinal changes of the AIP and of the cardiometabolic blood profile related to nutritional interventions. The aim of this study was to compare the effect of individual- versus collective-based nutritional-lifestyle intervention on the Atherogenic Index of Plasma in schoolchildren with obesity. Methods One-hundred sixty-four children aged 6–12 years with Body Mass Index z-score > 2 referred to the Paediatric Obesity Clinic, San Paolo Hospital, Milan, Italy, were consecutively enrolled and randomized to undergo to either an individual- (n = 82) or a collective- (n = 82) based intervention promoting a balanced normo-caloric diet and physical activity. In addition, the individual intervention included a tailored personalized nutritional advice and education based on the revised Coventry, Aberdeen, and London-Refined taxonomy. Both at baseline and after 12 months of intervention, dietary habits and anthropometric measures were assessed, a fasting blood sample were taken for biochemistry analysis. Results The participation rate at 12 months was 93.3% (n = 153 patients), 76 children in the individual-intervention and 77 children in the collective intervention. At univariate analysis, mean longitudinal change in Atherogenic Index of Plasma was greater in the individual than collective intervention (− 0.12 vs. − 0.05), as well as change in triglyceride-glucose index (− 0.22 vs. − 0.08) and Body Mass Index z-score (− 0.59 vs. − 0.37). At multiple analysis, only change in Body Mass Index z-score remained independently associated with intervention (odds ratio 3.37). Conclusion In children with obesity, an individual-based nutritional and lifestyle intervention, including techniques from the CALO-RE taxonomy, could have an additional beneficial effect over a collective-based intervention, although the actual size of the effect remains to be clarified. Trial Registration Clinical Trials NCT03728621

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Body mass index and neuropsychological function in healthy children and adolescents

Appetite ◽

10.1016/j.appet.2007.07.008 ◽

2008 ◽

Vol 50 (2-3) ◽

pp. 246-251 ◽

Cited By ~ 68

Author(s):

John Gunstad ◽

Mary Beth Spitznagel ◽

Robert H. Paul ◽

Ronald A. Cohen ◽

Michael Kohn ◽

...

Keyword(s):

Body Mass Index ◽

Children And Adolescents ◽

Body Mass ◽

Healthy Children ◽

Neuropsychological Function

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Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study

Annals of the Rheumatic Diseases ◽

10.1136/ard.2011.154021 ◽

2011 ◽

Vol 71 (5) ◽

pp. 655-660 ◽

Cited By ~ 63

Author(s):

Andrew K Wills ◽

Stephanie Black ◽

Rachel Cooper ◽

Russell J Coppack ◽

Rebecca Hardy ◽

...

Keyword(s):

Body Mass Index ◽

Knee Osteoarthritis ◽

Birth Cohort ◽

Body Mass ◽

Prolonged Exposure ◽

Birth Cohort Study ◽

Activity Levels ◽

Z Score ◽

Knee Oa ◽

High Bmi

IntroductionThe authors examined how body mass index (BMI) across life is linked to the risk of midlife knee osteoarthritis (OA), testing whether prolonged exposure to high BMI or high BMI at a particular period has the greatest influence on the risk of knee OA.MethodsA population-based British birth cohort of 3035 men and women underwent clinical examination for knee OA at age 53 years.Heights and weights were measured 10 times from 2 to 53 years. Analyses were stratified by gender and adjusted for occupation and activity levels.ResultsThe prevalence of knee OA was higher in women than in men (12.9% (n=194) vs 7.4% (n=108)). In men, the association between BMI and later knee OA was evident at 20 years (p=0.038) and remained until 53 years (OR per z-score 1.38 (95% CI 1.11 to 1.71)). In women, there was evidence for an association at 15 years (p=0.003); at 53 years, the OR was 1.89 (95% CI 1.59 to 2.24) per z-score increase in BMI. Changes in BMI from childhood in women and from adolescence in men were also positively associated with knee OA. A structured modelling approach to disentange the way in which BMI is linked to knee OA suggested that prolonged exposure to high BMI throughout adulthood carried the highest risk and that there was no additional risk conferred from adolescence once adult BMI had been accounted for.ConclusionThis study suggests that the risk of knee OA accumulates from exposure to a high BMI through adulthood.

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The Associations between Screen Time and Sleep Duration, and Body Mass Index (BMI) in under Five-Year-Old Children

10.20944/preprints201805.0482.v1 ◽

2018 ◽

Author(s):

Hossein Sourtiji ◽

Mehdi Rassafiani ◽

Seyed Ali Hosseini ◽

Mohammad Esmaeil Motlagh ◽

Mehdi Noroozi

Keyword(s):

Body Mass Index ◽

Sleep Duration ◽

Body Mass ◽

Screen Time ◽

Linear Regression Analysis ◽

Cluster Sampling ◽

Healthy Children ◽

Cross Sectional ◽

Under Five ◽

Screen Viewing

Today, due to recent developments in technology, children devote plenty of time for screen viewing. However, its harmful effects are not yet clear. The purpose of present study was to examine the associations among screen viewing and sleep duration, and body mass index (BMI) in under-five years old children. This cross-sectional study was conducted with 322 under-five healthy children that were selected using multistage stratified cluster sampling method in 2017. The data that were gathered by time-use diary method were analyzed using Kolmogorov-Smirnov test, Spearman correlation tests, multiple linear regression analysis, one-way ANCOVA, two-way ANCOVA. There was a negative correlation between screen time and sleep duration (rs = -0.42, p = 0.00), positive correlation between screen time and BMI (rs = 0.38, p = 0.00) and sleep duration negatively correlated with BMI (rs = -0.22, p = 0.00). screen viewing was a predictive factor for both sleep duration (β = -0.26, p = 0.00) and BMI (β = -0.26, p = 0.00). screen viewing had a significant impact on sleep duration (4, 314) = 5.02, P = 0.001) and BMI (F (4, 314) = 1.16, P=0.298). Results of this study indicated that screen viewing is related to sleep duration and BMI in under-five children. furthermore, screen time has an impact on sleep duration and BMI scores of children. findings of our study suggest that sleep duration negatively is associated with BMI in under-five-year-old children.

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The effect of insulin resistance on inflammation markers in individuals with obesity

Medical Science and Discovery ◽

10.36472/msd.v8i10.620 ◽

2021 ◽

Vol 8 (10) ◽

pp. 619-622

Author(s):

Hasan Atlı ◽

Erhan Önalan ◽

Burkay Yakar ◽

Deccane Duzenci ◽

Emir Dönder

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Body Mass ◽

Normal Body Mass Index ◽

Low Grade ◽

Inflammation Markers ◽

Predictive Values ◽

Lymphocyte Ratio ◽

Normal Body ◽

Significant Difference

Objective: Obesity has recently been recognized as a chronic low-grade inflammation condition. We aimed to compare the predictive values of insulin resistance and inflammatory indices in individuals with obesity. Materials and Methods: 124 people who had a health check for obesity-related risk factors in our hospital between June 2018 and September 2019 were included in the study. Inflammatory markers of the patients were evaluated. Results: The study group consists of a total of 224 people, and we compared the demographic data and laboratory parameters of the individuals. C-reactive protein (CRP) levels of obese individuals were statistically higher than those with normal body mass index (p <0.001). There was no statistically significant difference between the groups in terms of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values, among other inflammation markers. A positive and statistically significant correlation was found between body mass index and CRP level (r = 0.334, p <0.001). There was no significant correlation between body mass index and NLR and PLR. Conclusion: As a result, CRP levels of obese individuals were statistically higher than individuals with normal body mass index. No statistically significant difference was found between the groups in terms of NLR and PLR values among other inflammation markers.

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Physical activity and obesity in children with congenital cardiac disease

Cardiology in the Young ◽

10.1017/s1047951111000540 ◽

2011 ◽

Vol 21 (6) ◽

pp. 603-607 ◽

Cited By ~ 13

Author(s):

Trenda D. Ray ◽

Angela Green ◽

Karen Henry

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Body Mass ◽

Cardiac Disease ◽

Self Report ◽

Healthy Children ◽

Cross Sectional ◽

Congenital Cardiac Disease ◽

Significant Difference ◽

Obesity In Children

AbstractBackgroundChildren with congenital cardiac disease experience challenges in developing healthy patterns of physical activity due to decreased exercise capacity and parental fear and confusion about what is permissible. The purpose of this study was to describe physical activity habits in children 10–14 years of age with congenital cardiac disease and the relationship of those habits to obesity as defined by body mass index.MethodsThis cross-sectional study used self-report measures and clinical data to describe the association between physical activity participation and body mass index in 10- to 14-year-old children with congenital cardiac disease. Further, physical activity levels were compared between children who were overweight or obese and those who were not.ResultsChildren (n = 84; 51 males; 33 females) reported low rates of physical activity compared to reports on healthy children. Only 9.5% were overweight (body mass index between the 85th and 94th percentile), and alarmingly 26% were obese (body mass index at or above the 95th percentile). Physical activity and body mass index were not significantly correlated (r = −0.11, p = 0.45) and there was no significant difference in mean physical activity (t = 0.67) between children who were overweight or obese and those who were not.ConclusionsChildren in this study reported low rates of physical activity and a higher obesity rate than was reported in previous studies. However, the two were not significantly correlated. Further research is indicated to determine the specific factors contributing to obesity and to test interventions to combat obesity in children with congenital cardiac disease.

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Effekte von hochintensivem Intervalltraining (HIIT) auf Body-Mass-Index (BMI) und Körperfettanteil von übergewichtigen und adipösen Kindern – eine systematische Übersichtsarbeit

physioscience ◽

10.1055/a-1375-9595 ◽

2021 ◽

Author(s):

Lennert Sitzmann ◽

Gaith Akrama ◽

Christian Baumann

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Klinische Studien ◽

Sports Medicine ◽

Web Of Science ◽

Risk Of Bias ◽

Cochrane Library ◽

Randomisierte Kontrollierte Studien ◽

Systematische Übersichtsarbeit ◽

Kontrollierte Klinische Studien

Zusammenfassung Hintergrund Mehr als 340 Millionen Kinder gelten weltweit als übergewichtig oder adipös, ihre Anzahl nahm in den letzten Jahren – auch durch die Coronapandemie – erheblich zu. Eine alternative Behandlung zur Reduzierung des Übergewichts, die in den Empfehlungen bisher keine große Beachtung findet, stellt das sogenannte hochintensive Intervalltraining (HIIT) dar. Ziel Darstellung der Wirksamkeit von hochintensivem Intervalltraining auf den BMI und Körperfettanteil übergewichtiger und adipöser Kinder im Alter von 6–13 Jahren. Methode Die Erstellung der systematischen Übersichtsarbeit orientierte sich an den PRISMA-Guidelines. Für die Literaturrecherche wurden die Datenbanken MEDLINE, Cochrane Library, CINAHL, Embase, Sports Medicine & Education Index und Web of Science nach Studien mit hochintensivem Intervalltraining für übergewichtige und adipöse Kinder durchsucht. Die Bewertung der methodischen Studienqualität erfolgte mittels PEDro-Skala, MINORS und Risk of Bias. Die Berichtsqualität wurde anhand von CONSORT und TREND bewertet. Ergebnisse Es wurden 6 randomisierte kontrollierte Studien und 2 kontrollierte klinische Studien mit 479 HIIT-Teilnehmenden betrachtet. Diese zeigten, dass hochintensives Intervalltraining positive Auswirkungen auf den BMI und Körperfettanteil übergewichtiger und adipöser Kinder hat. Schlussfolgerung Hochintensives Intervalltraining ist eine kinderfreundliche und zugleich effektive Alternative zur Behandlung von übergewichtigen und adipösen Kindern. Weitere klinische Studien sind erforderlich, um die Ergebnisse zu bekräftigen.

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Completeness and accuracy of anthropometric measurements in electronic medical records for children attending primary care

BMJ Health & Care Informatics ◽

10.14236/jhi.v25i1.963 ◽

2018 ◽

Vol 25 (1) ◽

pp. 19-26 ◽

Cited By ~ 7

Author(s):

Sarah Carsley ◽

Catherine S. Birken ◽

Patricia C. Parkin ◽

Eleanor Pullenayegum ◽

Karen Tu

Keyword(s):

Primary Care ◽

Body Mass Index ◽

Electronic Medical Records ◽

Body Mass ◽

Medical Records ◽

Data Access ◽

World Health ◽

Z Score ◽

Data Completeness ◽

Weight Data

BackgroundElectronic medical records (EMRs) from primary care may be a feasible source of height and weight data. However, the use of EMRs in research has been impeded by lack of standardisation of EMRs systems, data access and concerns about the quality of the data.ObjectivesThe study objectives were to determine the data completeness and accuracy of child heights and weights collected in primary care EMRs, and to identify factors associated with these data quality attributes.MethodsA cross-sectional study examining height and weight data for children <19 years from EMRs through the Electronic Medical Record Administrative data Linked Database (EMRALD), a network of family practices across the province of Ontario. Body mass index z-scores were calculated using the World Health Organization Growth Standards and Reference.ResultsA total of 54,964 children were identified from EMRALD. Overall, 93% had at least one complete set of growth measurements to calculate a body mass index (BMI) z-score. 66.2% of all primary care visits had complete BMI z-score data. After stratifying by visit type 89.9% of well-child visits and 33.9% of sick visits had complete BMI z-score data; incomplete BMI z-score was mainly due to missing height measurements. Only 2.7% of BMI z-score data were excluded due to implausible values.ConclusionsData completeness at well-child visits and overall data accuracy were greater than 90%. EMRs may be a valid source of data to provide estimates of obesity in children who attend primary care.

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