scholarly journals Accurate Blood-Based Diagnostic Biosignatures for Alzheimer’s Disease via Automated Machine Learning

2020 ◽  
Vol 9 (9) ◽  
pp. 3016
Author(s):  
Makrina Karaglani ◽  
Krystallia Gourlia ◽  
Ioannis Tsamardinos ◽  
Ekaterini Chatzaki
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Performance Metrics ◽  
Biomarker Discovery ◽  
Support Vector ◽  
Neurodegenerative Dementia ◽  
Proteomic Dataset ◽  
Automated Machine Learning ◽  
Via Classification

Alzheimer’s disease (AD) is the most common form of neurodegenerative dementia and its timely diagnosis remains a major challenge in biomarker discovery. In the present study, we analyzed publicly available high-throughput low-sample -omics datasets from studies in AD blood, by the AutoML technology Just Add Data Bio (JADBIO), to construct accurate predictive models for use as diagnostic biosignatures. Considering data from AD patients and age–sex matched cognitively healthy individuals, we produced three best performing diagnostic biosignatures specific for the presence of AD: A. A 506-feature transcriptomic dataset from 48 AD and 22 controls led to a miRNA-based biosignature via Support Vector Machines with three miRNA predictors (AUC 0.975 (0.906, 1.000)), B. A 38,327-feature transcriptomic dataset from 134 AD and 100 controls led to six mRNA-based statistically equivalent signatures via Classification Random Forests with 25 mRNA predictors (AUC 0.846 (0.778, 0.905)) and C. A 9483-feature proteomic dataset from 25 AD and 37 controls led to a protein-based biosignature via Ridge Logistic Regression with seven protein predictors (AUC 0.921 (0.849, 0.972)). These performance metrics were also validated through the JADBIO pipeline confirming stability. In conclusion, using the automated machine learning tool JADBIO, we produced accurate predictive biosignatures extrapolating available low sample -omics data. These results offer options for minimally invasive blood-based diagnostic tests for AD, awaiting clinical validation based on respective laboratory assays. They also highlight the value of AutoML in biomarker discovery.

A Comparative Study of Alzheimer Detection Techniques

2021 ◽  
Vol 9 (8) ◽  
pp. 2877-2883
Author(s):  
Adwait Patil
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Deep Learning ◽  
Comparative Study ◽  
Fuzzy System ◽  
Early Stage ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Detection Techniques

Abstract: Alzheimer’s disease is one of the neurodegenerative disorders. It initially starts with innocuous symptoms but gradually becomes severe. This disease is so dangerous because there is no treatment, the disease is detected but typically at a later stage. So it is important to detect Alzheimer at an early stage to counter the disease and for a probable recovery for the patient. There are various approaches currently used to detect symptoms of Alzheimer’s disease (AD) at an early stage. The fuzzy system approach is not widely used as it heavily depends on expert knowledge but is quite efficient in detecting AD as it provides a mathematical foundation for interpreting the human cognitive processes. Another more accurate and widely accepted approach is the machine learning detection of AD stages which uses machine learning algorithms like Support Vector Machines (SVMs) , Decision Tree , Random Forests to detect the stage depending on the data provided. The final approach is the Deep Learning approach using multi-modal data that combines image , genetic data and patient data using deep models and then uses the concatenated data to detect the AD stage more efficiently; this method is obscure as it requires huge volumes of data. This paper elaborates on all the three approaches and provides a comparative study about them and which method is more efficient for AD detection. Keywords: Alzheimer’s Disease (AD), Fuzzy System , Machine Learning , Deep Learning , Multimodal data

scholarly journals Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer’s Disease With High Performance Computing

2021 ◽  
Vol 4 ◽  
Author(s):  
Fan Zhang ◽  
Melissa Petersen ◽  
Leigh Johnson ◽  
James Hall ◽  
Sid E. O’Bryant
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Performance ◽  
Support Vector ◽  
Massive Datasets ◽  
Complexity Of Algorithms ◽  
Magnetic Resonance Imaging Mri ◽  
Research Challenge ◽  
Improved Accuracy

Driven by massive datasets that comprise biomarkers from both blood and magnetic resonance imaging (MRI), the need for advanced learning algorithms and accelerator architectures, such as GPUs and FPGAs has increased. Machine learning (ML) methods have delivered remarkable prediction for the early diagnosis of Alzheimer’s disease (AD). Although ML has improved accuracy of AD prediction, the requirement for the complexity of algorithms in ML increases, for example, hyperparameters tuning, which in turn, increases its computational complexity. Thus, accelerating high performance ML for AD is an important research challenge facing these fields. This work reports a multicore high performance support vector machine (SVM) hyperparameter tuning workflow with 100 times repeated 5-fold cross-validation for speeding up ML for AD. For demonstration and evaluation purposes, the high performance hyperparameter tuning model was applied to public MRI data for AD and included demographic factors such as age, sex and education. Results showed that computational efficiency increased by 96%, which helped to shed light on future diagnostic AD biomarker applications. The high performance hyperparameter tuning model can also be applied to other ML algorithms such as random forest, logistic regression, xgboost, etc.

scholarly journals EEG-Based Emotion Classification for Alzheimer’s Disease Patients Using Conventional Machine Learning and Recurrent Neural Network Models

Sensors ◽  
2020 ◽  
Vol 20 (24) ◽  
pp. 7212
Author(s):  
Jungryul Seo ◽  
Teemu H. Laine ◽  
Gyuhwan Oh ◽  
Kyung-Ah Sohn
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Recurrent Neural Network ◽  
Classification Model ◽  
Support Vector ◽  
Number Of Patients ◽  
Study Results ◽  
Conventional Machine

As the number of patients with Alzheimer’s disease (AD) increases, the effort needed to care for these patients increases as well. At the same time, advances in information and sensor technologies have reduced caring costs, providing a potential pathway for developing healthcare services for AD patients. For instance, if a virtual reality (VR) system can provide emotion-adaptive content, the time that AD patients spend interacting with VR content is expected to be extended, allowing caregivers to focus on other tasks. As the first step towards this goal, in this study, we develop a classification model that detects AD patients’ emotions (e.g., happy, peaceful, or bored). We first collected electroencephalography (EEG) data from 30 Korean female AD patients who watched emotion-evoking videos at a medical rehabilitation center. We applied conventional machine learning algorithms, such as a multilayer perceptron (MLP) and support vector machine, along with deep learning models of recurrent neural network (RNN) architectures. The best performance was obtained from MLP, which achieved an average accuracy of 70.97%; the RNN model’s accuracy reached only 48.18%. Our study results open a new stream of research in the field of EEG-based emotion detection for patients with neurological disorders.

scholarly journals Machine learning methods for predicting progression from mild cognitive impairment to Alzheimer’s disease dementia: a systematic review

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sergio Grueso ◽  
Raquel Viejo-Sobera
Keyword(s):  
Machine Learning ◽  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Neurocognitive Disorders ◽  
Support Vector ◽  
Alzheimer’S Disease Dementia

Abstract Background An increase in lifespan in our society is a double-edged sword that entails a growing number of patients with neurocognitive disorders, Alzheimer’s disease being the most prevalent. Advances in medical imaging and computational power enable new methods for the early detection of neurocognitive disorders with the goal of preventing or reducing cognitive decline. Computer-aided image analysis and early detection of changes in cognition is a promising approach for patients with mild cognitive impairment, sometimes a prodromal stage of Alzheimer’s disease dementia. Methods We conducted a systematic review following PRISMA guidelines of studies where machine learning was applied to neuroimaging data in order to predict whether patients with mild cognitive impairment might develop Alzheimer’s disease dementia or remain stable. After removing duplicates, we screened 452 studies and selected 116 for qualitative analysis. Results Most studies used magnetic resonance image (MRI) and positron emission tomography (PET) data but also magnetoencephalography. The datasets were mainly extracted from the Alzheimer’s disease neuroimaging initiative (ADNI) database with some exceptions. Regarding the algorithms used, the most common was support vector machine with a mean accuracy of 75.4%, but convolutional neural networks achieved a higher mean accuracy of 78.5%. Studies combining MRI and PET achieved overall better classification accuracy than studies that only used one neuroimaging technique. In general, the more complex models such as those based on deep learning, combined with multimodal and multidimensional data (neuroimaging, clinical, cognitive, genetic, and behavioral) achieved the best performance. Conclusions Although the performance of the different methods still has room for improvement, the results are promising and this methodology has a great potential as a support tool for clinicians and healthcare professionals.

scholarly journals A metabolite-based machine learning approach to diagnose Alzheimer’s-type dementia in blood: Results from the European Medical Information Framework for Alzheimer’s Disease biomarker discovery cohort

2019 ◽  
Author(s):  
Daniel Stamate ◽  
Min Kim ◽  
Petroula Proitsi ◽  
Sarah Westwood ◽  
Alison Baird ◽  
...  
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medical Information ◽  
Biomarker Discovery ◽  
Gradient Boosting ◽  
Plasma Metabolites ◽  
Csf Biomarkers ◽  
Extreme Gradient Boosting ◽  
And Gender

AbstractINTRODUCTIONMachine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer’s Disease (AD). Here we set out to test the performance of metabolites in blood to categorise AD when compared to CSF biomarkers.METHODSThis study analysed samples from 242 cognitively normal (CN) people and 115 with AD-type dementia utilizing plasma metabolites (n=883). Deep Learning (DL), Extreme Gradient Boosting (XGBoost) and Random Forest (RF) were used to differentiate AD from CN. These models were internally validated using Nested Cross Validation (NCV).RESULTSOn the test data, DL produced the AUC of 0.85 (0.80-0.89), XGBoost produced 0.88 (0.86-0.89) and RF produced 0.85 (0.83-0.87). By comparison, CSF measures of amyloid, p-tau and t-tau (together with age and gender) produced with XGBoost the AUC values of 0.78, 0.83 and 0.87, respectively.DISCUSSIONThis study showed that plasma metabolites have the potential to match the AUC of well-established AD CSF biomarkers in a relatively small cohort. Further studies in independent cohorts are needed to validate whether this specific panel of blood metabolites can separate AD from controls, and how specific it is for AD as compared with other neurodegenerative disorders

scholarly journals A Comparative Analysis of Machine Learning Algorithms to Predict Alzheimer’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Morshedul Bari Antor ◽  
A. H. M. Shafayet Jamil ◽  
Maliha Mamtaz ◽  
Mohammad Monirujjaman Khan ◽  
Sultan Aljahdali ◽  
...  
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Support Vector Machine ◽  
Machine Learning Algorithms ◽  
Learning System ◽  
Fine Tuning ◽  
Support Vector ◽  
Learning Models ◽  
Machine Learning Models

Alzheimer’s disease has been one of the major concerns recently. Around 45 million people are suffering from this disease. Alzheimer’s is a degenerative brain disease with an unspecified cause and pathogenesis which primarily affects older people. The main cause of Alzheimer’s disease is Dementia, which progressively damages the brain cells. People lost their thinking ability, reading ability, and many more from this disease. A machine learning system can reduce this problem by predicting the disease. The main aim is to recognize Dementia among various patients. This paper represents the result and analysis regarding detecting Dementia from various machine learning models. The Open Access Series of Imaging Studies (OASIS) dataset has been used for the development of the system. The dataset is small, but it has some significant values. The dataset has been analyzed and applied in several machine learning models. Support vector machine, logistic regression, decision tree, and random forest have been used for prediction. First, the system has been run without fine-tuning and then with fine-tuning. Comparing the results, it is found that the support vector machine provides the best results among the models. It has the best accuracy in detecting Dementia among numerous patients. The system is simple and can easily help people by detecting Dementia among them.

scholarly journals Comparison of machine learning approaches for enhancing Alzheimer’s disease classification

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10549
Author(s):  
Qi Li ◽  
Mary Qu Yang
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Structural Changes ◽  
Spatial Information ◽  
Neurodegenerative Disorder ◽  
Brain Regions ◽  
Disease Classification ◽  
Support Vector ◽  
The Brain

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, accounting for nearly 60% of all dementia cases. The occurrence of the disease has been increasing rapidly in recent years. Presently about 46.8 million individuals suffer from AD worldwide. The current absence of effective treatment to reverse or stop AD progression highlights the importance of disease prevention and early diagnosis. Brain structural Magnetic Resonance Imaging (MRI) has been widely used for AD detection as it can display morphometric differences and cerebral structural changes. In this study, we built three machine learning-based MRI data classifiers to predict AD and infer the brain regions that contribute to disease development and progression. We then systematically compared the three distinct classifiers, which were constructed based on Support Vector Machine (SVM), 3D Very Deep Convolutional Network (VGGNet) and 3D Deep Residual Network (ResNet), respectively. To improve the performance of the deep learning classifiers, we applied a transfer learning strategy. The weights of a pre-trained model were transferred and adopted as the initial weights of our models. Transferring the learned features significantly reduced training time and increased network efficiency. The classification accuracy for AD subjects from elderly control subjects was 90%, 95%, and 95% for the SVM, VGGNet and ResNet classifiers, respectively. Gradient-weighted Class Activation Mapping (Grad-CAM) was employed to show discriminative regions that contributed most to the AD classification by utilizing the learned spatial information of the 3D-VGGNet and 3D-ResNet models. The resulted maps consistently highlighted several disease-associated brain regions, particularly the cerebellum which is a relatively neglected brain region in the present AD study. Overall, our comparisons suggested that the ResNet model provided the best classification performance as well as more accurate localization of disease-associated regions in the brain compared to the other two approaches.

scholarly journals Machine Learning Methods for Predicting Conversion from Mild Cognitive Impairment to Alzheimer's Disease. A Systematic Review.

2021 ◽  
Author(s):  
Sergio Grueso ◽  
Raquel Viejo-Sobera
Keyword(s):  
Machine Learning ◽  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Neurocognitive Disorders ◽  
Multidimensional Data ◽  
Support Vector

Abstract Background: Increase in life-span in our society is a double-edged sword that entails a growing number of patients with neurocognitive disorders, Alzheimer’s disease being the most prevalent. Advances in medical imaging and computational power, enable new methods for early detection of neurocognitive disorders with the goal of preventing or reducing cognitive decline. Computer-aided image analysis and early detection of changes in cognition is a promising approach for patients with mild cognitive impairment, sometimes a prodromal stage of Alzheimer’s disease.Methods: We conducted a systematic review following PRISMA guidelines of studies where Machine Learning was applied to neuroimaging data in order to predict the progression from Mild Cognitive Impairment to Alzheimer’s disease. After removing duplicates, we screened 159 studies and selected 47 for a qualitative analysis. Results: Most studies used Magnetic Resonance Image and Positron Emission Tomography data but also Magnetoencephalography. The datasets were mainly extracted from the Alzheimer’s disease Neuroimage Initiative (ADNI) database with some exceptions. Regarding the algorithms used, the most common were support vector machines, but more complex models such as Deep Learning, combined with multimodal and multidimensional data (neuroimaging, clinical, cognitive, biological, and behavioral) achieved the best performance. Conclusions: Although performance of the different models still has room for improvement, the results are promising and this methodology has a great potential as a support tool for clinicians and healthcare professionals.

scholarly journals Applied machine learning in Alzheimer's disease research: omics, imaging, and clinical data

2021 ◽  
Author(s):  
Ziyi Li ◽  
Xiaoqian Jiang ◽  
Yizhuo Wang ◽  
Yejin Kim
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biomarker Discovery ◽  
Treatment Strategies ◽  
Drug Repurposing ◽  
Modern Technology ◽  
Disease Classification ◽  
Future Research ◽  
New Biomarkers

Alzheimer's disease (AD) remains a devastating neurodegenerative disease with few preventive or curative treatments available. Modern technology developments of high-throughput omics platforms and imaging equipment provide unprecedented opportunities to study the etiology and progression of this disease. Meanwhile, the vast amount of data from various modalities, such as genetics, proteomics, transcriptomics, and imaging, as well as clinical features impose great challenges in data integration and analysis. Machine learning (ML) methods offer novel techniques to address high dimensional data, integrate data from different sources, model the etiological and clinical heterogeneity, and discover new biomarkers. These directions have the potential to help us better manage the disease progression and develop novel treatment strategies. This mini-review paper summarizes different ML methods that have been applied to study AD using single-platform or multi-modal data. We review the current state of ML applications for five key directions of AD research: disease classification, drug repurposing, subtyping, progression prediction, and biomarker discovery. This summary provides insights about the current research status of ML-based AD research and highlights potential directions for future research.

scholarly journals Efficient Machine Learning Techniques to Diagnose and Predict Alzheimer’s disease

2020 ◽  
Vol 9 (3) ◽  
pp. 3953-3960
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Image Data ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Mechanisms ◽  
Learning Techniques

Recent research in computational engineering have evidenced the design and development numerous intelligent models to analyze medical data and derive inferences related to early diagnosis and prediction of disease severity. In this context, prediction and diagnosis of fatal neurodegenerative diseases that comes under the class of dementia from medical image data is considered as the challenging area of research for many researchers. Recently Alzheimer’s disease is considered as major category of dementia that affects major population. Despite of the development of numerous machine learning models for early diagnosis of Alzheimer’s disease, it is observed that there is a lot more scope of research. Addressing the same, this article presents a systematic literature review of machine learning techniques developed for early diagnosis of Alzheimer’s disease. Furthermore this article includes major categories of machine learning algorithms that include artificial neural networks, Support vector machines and Deep learning based ensemble models that helps the budding researchers to explore the scope of research in predicting Alzheimer’s disease. Implementation results depict the comparative analysis of state of art machine learning mechanisms.

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