scholarly journals Unraveling the Detoxification Mechanism of 2,4-Dichlorophenol by Marine-Derived Mesophotic Symbiotic Fungi Isolated from Marine Invertebrates

Marine Drugs ◽  
2019 ◽  
Vol 17 (10) ◽  
pp. 564 ◽  
Author(s):  
Efstratios Nikolaivits ◽  
Andreas Agrafiotis ◽  
Aikaterini Termentzi ◽  
Kyriaki Machera ◽  
Géraldine Le Goff ◽  
...  

Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released in high amounts in the environment and has been listed as a priority pollutant by the US Environmental Protection Agency. Bioremediation has been proposed as a sustainable alternative to conventional remediation methods for the detoxification of phenolic compounds. In this work, we studied the potential of fungal strains isolated as symbionts of marine invertebrates from the underexplored mesophotic coral ecosystems. Hence, the unspecific metabolic pathways of these fungal strains are being explored in the present study, using the powerful analytical capabilities of a UHPLC-HRMS/MS. The newly identified 2,4-DCP metabolites add significantly to the knowledge of the transformation of such pollutants by fungi, since such reports are scarce.

2020 ◽  
Vol 21 (9) ◽  
pp. 3317
Author(s):  
Efstratios Nikolaivits ◽  
Andreas Agrafiotis ◽  
Eirini Baira ◽  
Géraldine Le Goff ◽  
Nikolaos Tsafantakis ◽  
...  

2,4-Dichlorophenol (2,4-DCP) is a ubiquitous environmental pollutant categorized as a priority pollutant by the United States (US) Environmental Protection Agency, posing adverse health effects on humans and wildlife. Bioremediation is proposed as an eco-friendly, cost-effective alternative to traditional physicochemical remediation techniques. In the present study, fungal strains were isolated from marine invertebrates and tested for their ability to biotransform 2,4-DCP at a concentration of 1 mM. The most competent strains were studied further for the expression of catechol dioxygenase activities and the produced metabolites. One strain, identified as Tritirachium sp., expressed high levels of extracellular catechol 1,2-dioxygenase activity. The same strain also produced a dechlorinated cleavage product of the starting compound, indicating the assimilation of the xenobiotic by the fungus. This work also enriches the knowledge about the mechanisms employed by marine-derived fungi in order to defend themselves against chlorinated xenobiotics.


2020 ◽  
Vol 5 (3) ◽  
pp. 129-135
Author(s):  
KO Ansah Amano ◽  
AG Ntiri-Asiedu

There has been a rising global concern of mercury because of its persistent nature, long-range transport and toxicity. Mercury possesses serious health effects on living organisms and the environment. Mercury, mostly in inorganic form, is present in almost all categories of rocks. It may be released through natural occurrences and/or anthropogenic activities such as aluminum production. Stable organic mercury compounds, for example methyl mercury (CH3Hg), are formed by the attachment of mercury to one or two carbon atoms. Depending on the source of bauxite, a substantial amount of elemental mercury is released by aluminum industries. Emitted elemental mercury contributes to increasing global atmospheric reserve of mercury hence decreasing mercury emissions plays a key role in lowering the contribution of anthropogenic activities to the global atmospheric mercury budget. In general, all three forms of mercury (elemental, inorganic and organic mercury) have the potential of causing adverse health effects at sufficiently high doses. Mercury emissions are readily absorbed through the alveoli membranes and gastrointestinal tract affecting other systems. Fetuses and individuals often exposed to mercury (chronic exposure) are two classes of people who are more susceptible to harm caused by mercury. This paper discusses mercury metal and oxide emission from the aluminum industry.


2021 ◽  
Vol 13 (13) ◽  
pp. 7513
Author(s):  
Joshua Lozano ◽  
Joonghyeok Heo ◽  
Mijin Seo

The purpose of this study was to evaluate the public water contamination levels of Winkler County, in West Texas. With water scarcity becoming more prevalent in arid climates like West Texas, it is important to ensure the water quality in these areas. The Dockum and Pecos Valley aquifers were analyzed for inorganic pollutants that could inhibit the water. The parameters such as copper, lead, arsenic, nitrate, chloride, and chromium level reports were provided from 1972 to 2018 to analyze and compare to other studies such as the ones conducted in the Midland/Odessa area. The results were compared to the Environmental Protection Agency (EPA) safety standards, and conclusions were made for the safety consumption of water within the county. We found that inorganic pollutants resulted mainly from the mobilization of the contaminant from anthropogenic activities such as chemical fertilizers, oil and gas developments. This research provides important information for inorganic pollutants in the sinkhole region of Winkler County and contributes to understanding the response to the aquifers. The significance of water quality in West Texas is now more important than ever to ensure that everyone has clean drinking water.


2021 ◽  
Vol 2 (1) ◽  
Author(s):  
M. Opoku Amankwa ◽  
E. Kweinor Tetteh ◽  
G. Thabang Mohale ◽  
G. Dagba ◽  
P. Opoku

AbstractGlobal plastic waste generation is about 300 million metric tons annually and poses crucial health and environmental problems. Africa is the second most polluted continent in the world, with over 500 shipping containers of waste being imported every month. The US Environmental Protection Agency (EPA) report suggests that about 75% of this plastic waste ends up in landfills. However, landfills management is associated with high environmental costs and loss of energy. In addition, landfill leachates end up in water bodies, are very detrimental to human health, and poison marine ecosystems. Therefore, it is imperative to explore eco-friendly techniques to transform plastic waste into valuable products in a sustainable environment. The trade-offs of using plastic waste for road construction and as a component in cementitious composites are discussed. The challenges and benefits of producing liquid fuels from plastic waste are also addressed. The recycling of plastic waste to liquid end-products was found to be a sustainable way of helping the environment with beneficial economic impact.


2006 ◽  
Vol 1 (2) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Valery M Dembitsky

This review is intended as a comprehensive survey of iodinated metabolites possessing carbon–iodine covalent bond, which have been obtained from living organisms. Generally thought to be minor components produced by many different organisms these interesting compounds now number more than 110. Many from isolated and identified iodine-containing metabolites showed high biological activities. Recent research, especially in the marine area, indicates this number will increase in the future. Sources of iodinated metabolites include microorganisms, algae, marine invertebrates, and some animals. Their origin and possible biological significance have also been discussed.


Neuroforum ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Julia Tigges ◽  
Tamara Schikowski ◽  
Ellen Fritsche

Abstract Exposure to environmental pollutants like chemicals or air pollution is major health concern for the human population. Especially the nervous system is a sensitive target for environmental toxins with exposures leading to life stage-dependent neurotoxicity. Developmental and adult neurotoxicity are characterized by specific adverse outcomes ranging from neurodevelopmental disorders to neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. The risk assessment process for human health protection is currently undergoing a paradigm change toward new approach methods that allow mechanism-based toxicity assessment. As a flagship project, an in vitro battery of test methods for developmental neurotoxicity evaluation is currently supported by the Organization for Economic Co-operation and Development (OECD). A plethora of stem cell-based methods including brain spheres and organoids are currently further developed to achieve time- and cost-saving tools for linking MoA-based hazards to adverse health effects observed in humans.


Agronomy ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1354 ◽  
Author(s):  
Fanrong Zeng ◽  
Munazza Zahoor ◽  
Muhammad Waseem ◽  
Alia Anayat ◽  
Muhammad Rizwan ◽  
...  

Chromium (Cr) is recognized as a toxic metal that has detrimental effects on living organisms; notably, it is discharged into soil by various industries as a result of anthropogenic activities. Microbe-assisted phytoremediation is one of the most emergent and environmentally friendly methods used for the detoxification of pollutants. In this study, the alleviative role of Staphylococcus aureus strain K1 was evaluated in wheat (Triticum aestivum L.) under Cr stress. For this, various Cr concentrations (0, 25, 50 and 100 mg·kg−1) with and without peat-moss-based bacterial inoculum were applied in the soil. Results depicted that Cr stress reduced the plants’ growth by causing oxidative stress in the absence of S. aureus K1 inoculation. However, the application of S. aureus K1 regulated the plants’ growth and antioxidant enzymatic activities by reducing oxidative stress and Cr toxicity through conversion of Cr6+ to Cr3+. The Cr6+ uptake by wheat was significantly reduced in the S. aureus K1 inoculated plants. It can be concluded that the application of S. aureus K1 could be an effective approach to alleviate the Cr toxicity in wheat and probably in other cereals grown under Cr stress.


2020 ◽  
Author(s):  
Bujin Bekbulat ◽  
Joshua S. Apte ◽  
Dylan B Millet ◽  
Allen Robinson ◽  
Kelley C. Wells ◽  
...  

<p>Analysis of a large national dataset of fine particulate matter (PM2.5) and ozone air pollution from the US Environmental Protection Agency indicate opposing differences in average concentrations during the covid response period, relative to expected levels. These are the two most important pollutants in terms of public health impacts and regulatory non-attainment in the US. Post-covid response, average PM2.5 levels are slightly higher (~5%) than expected; average ozone levels are slightly lower (~5%). The size of post-response ozone anomaly has decreased with time and by week 6 after the first stay-at-home order was enacted (April 29- May 5, 2020), ozone levels were higher than expected. In addition, no individual US state had lower-than-expected PM2.5 and ozone for all weeks post- covid response. Two non-covid factors, meteorology and regional transport, do not fully explain observed trends. These findings are unexpected given the large reduction in many household’s activities associated with “stay at home” and other covid responses. We hypothesize that this result partly arises from the fact that ozone and the majority of PM2.5 are secondary pollutants formed in the atmosphere from emissions from many sources (i.e., not just traffic). Preliminary analysis of nitrogen dioxide (NO2) data in a few cities reveals substantially lower-than-expected (~30%) concentrations post-covid. NO2 is a primary pollutant and is much more strongly associated with traffic than PM2.5 or ozone. </p><p><br></p>


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