scholarly journals A New Propolis Type from Changbai Mountains in North-east China: Chemical Composition, Botanical Origin and Biological Activity

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1369 ◽  
Author(s):  
Xiasen Jiang ◽  
Jing Tian ◽  
Yufei Zheng ◽  
Yanzheng Zhang ◽  
Yuqi Wu ◽  
...  
Keyword(s):  
Biological Activities ◽  
Raw Material ◽  
Changbai Mountains ◽  
Total Phenolic ◽  
Mountain Range ◽  
Unknown Compound ◽  
North East ◽  
Populus Davidiana ◽  
Wide Range ◽  
Unknown Peak

Propolis is a bee product with a wide range of biological activities and its chemical compounds depend highly on the type of plant accessible to the bees. The Changbai Mountains are a major mountain range in Northeast China and are one of the major bee product-producing areas in China. In this study, we evaluated the total phenolic acids and flavonoid contents as well as the antioxidant activity of propolis sampled from the Changbai Mountains area (CBM). We identified the major compounds and qualified their contents by HPLC-ESI/MS and HPLC-UV, and found that the content of p-coumaric acid and an unknown peak (CBE) in CBM propolis was higher than in propolis from other parts of China. The unknown compound CBE was isolated, purified, and identified as benzyl p-coumarate by MS and NMR. Possible plant sources of CBM propolis are Populus davidiana dode and Populus simonii Carr, which widely distributed in the Changbai Mountains area. CBM propolis is a new propolis type, that could be an excellent raw material for health foods and pharmaceuticals.

scholarly journals Polyphenolic Content and Biological Activities of Post-Distillation Waste of Three Sage Species from the Republic of Macedonia

2017 ◽  
Vol 18 (1) ◽  
pp. 27
Author(s):  
Ana Alimpic ◽  
Katarina Šavikin ◽  
Dejan Pljevljakušić ◽  
Vlado Matevski ◽  
Petar D. Marin ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Biological Activities ◽  
Raw Material ◽  
Total Phenolic ◽  
Republic Of Macedonia ◽  
Polyphenolic Content ◽  
The Republic ◽  
First Time ◽  
Phenolic And Flavonoid ◽  
Β Carotene

This research was aimed at investigating polyphenolic content, antioxidant and anti-neurodegenerative activities of post-distillation waste extracts of Macedonian Salvia amplexicaulis, S. jurisicii and S. ringens, for the first time. Total phenolic and flavonoid contents varied in a broad range (3.92-146.49 mg GAE/g and 7.11-67.51 mg QE/g, respectively), with the highest values obtained for S. amplexicaulis and S. ringens extracts. Certain S. amplexicaulis and S. ringens extracts neutralized more than 80% of DPPH radicals at the highest concentration, while S. amplexicaulis extracts showed up to ≈50% inhibition of β-carotene oxidation in β-carotene/linoleic acid assay. Post-distillation waste extracts inhibited acetylcholinesterase (25.94-38.15%) and tyrosinase (18.84-59.52%), with the strongest inhibition of S. amplexicaulis extracts. The obtained results suggest that post-distillation waste of tested species, especially of S. amplexicaulis, show antioxidant and anti-neurodegenerative activities and could be considered as potential raw material rich in polyphenols.

Acetone-water mixture is a competent solvent to extract phenolics and antioxidants from four organs of Eucalyptus camaldulensis

2019 ◽  
Vol 44 (3) ◽  
pp. 231-239
Author(s):  
Alyaa Nasr ◽  
Xinxin Zhou ◽  
Tingting Liu ◽  
Jing Yang ◽  
Guo-Ping Zhu
Keyword(s):  
Phenolic Compounds ◽  
Biological Activities ◽  
Great Influence ◽  
Eucalyptus Camaldulensis ◽  
Total Phenolic ◽  
Water Mixture ◽  
Plant Seed ◽  
Acetone Water ◽  
Phenolic Constituents ◽  
Wide Range

Abstract Objective Eucalyptus camaldulensis is recognized to be one of the major introduced eucalypts, the plant extracts possess a wide range of phytochemicals, which are accountable for its antioxidant and pharmacological activities. The extraction efficiency of such chemical compounds is influenced by the applied extraction conditions. To test the effect of solvent type on the yield of phenolics and antioxidants from E. camaldulensis, seeking for an optimization of the extraction process. Method Dry powders of four plant organs were extracted by some organic solvents besides water. The total phenolic content was detected in the crude extracts of leaf, bud, empty capsule and seed, and was further characterized by GC-MS. Results Acetone-water mixtures yielded high amounts of phenolic compounds with parallel antioxidant activities, correlation coefficients were significant (0.696–0.998). Bud and capsule are first accredited for their antioxidant potentials. The GC-MS analysis revealed the abundance of most detected phenolic constituents in the plant seed. Discussion Acetone-water is a successful and appropriate mixture for the extraction of phenolic compounds from E. camaldulensis. It could give better yields and enhance the biological activities of its corresponding extracts. Conclusion The accurate choice of an extraction solvent has a great influence on the yields of phenolics.

scholarly journals Effect of extraction temperature and solvent type on the bioactive potential of Ocimum gratissimum L. extracts

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Confidence Onyebuchi ◽  
Doğa Kavaz
Keyword(s):  
Biological Activities ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Order Kinetic ◽  
Extraction Temperature ◽  
Ocimum Gratissimum ◽  
Methanolic Extracts ◽  
Bioactive Properties ◽  
Solvent Type ◽  
Wide Range

AbstractOcimum gratissimum is a shrub that belongs to the Lamiaceae family of plants. Despite the known biological activities and ethnomedicinal applications, comparative evaluation of the effects of different extraction techniques on the chemical and bioactive properties of O. gratissimum extracts has not yet been performed. This study adopted different analytical techniques to determine the effect of extraction temperature and solvent type on the phytochemical and bioactive properties of O. gratissimum extracts. Chemical profiling showed increased concentrations of compounds for both the ethanolic and methanolic extracts compared to the water extracts. The results also revealed that the extraction temperature had an effect on the total phenolic content and radical-scavenging properties of the different extracts. The antioxidant kinetic modeling achieved the best fit when using the second-order kinetic model. Methanolic extracts had the highest levels of antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus, and Salmonella typhimurium. At high concentrations, all extracts lowered the viability of the breast cancer cell line MDA-MB-231. In conclusion, the chemical and bioactive properties of all extracts showed significant dependence on the extraction temperature and solvent type. With proper extraction methods, they boast a wide range of promising applications in the medical, pharmaceutical, and food industries.

scholarly journals Green-Sustainable Recovery of Phenolic and Antioxidant Compounds from Industrial Chestnut Shells Using Ultrasound-Assisted Extraction: Optimization and Evaluation of Biological Activities In Vitro

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 267
Author(s):  
Fátima Lameirão ◽  
Diana Pinto ◽  
Elsa F. Vieira ◽  
Andreia F. Peixoto ◽  
Cristina Freire ◽  
...  
Keyword(s):  
Biological Activities ◽  
Radical Scavenging ◽  
Raw Material ◽  
Total Phenolic ◽  
Antioxidant Compounds ◽  
Ultrasound Assisted Extraction ◽  
Antioxidant Power ◽  
Assisted Extraction ◽  
Ultrasound Assisted

Chestnut processing industry generates large amounts of by-products, including leaves, burs and shells that are a source of bioactive compounds. The purpose of this study was to establish an ultrasound-assisted extraction (UAE) of phenolic and antioxidant compounds from industrial chestnut shells. A central composite design (CCD) was conducted to analyze the effects of time (4–46 min) and temperature (34–76 °C) in the antioxidant activity (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP)) and total phenolic compounds (TPC) of chestnut shells extracts. The optimal extraction conditions were obtained at 70 °C for 40 min. The optimal extract was characterized regarding phenolic profile, radical scavenging capacity, and effects on intestinal and dermal cell lines. The optimal extract revealed high amounts of ellagic acid (40.4 µg/mg dw), followed by caffeic acid derivative (15.4 µg/mg dw) and epigallocatechin (15.3 µg/mg dw). Indeed, the extract exhibited the highest scavenging efficiencies against NO● (IC50 = 0.1 µg/mL) and HOCl (IC50 = 0.7 µg/mL) and did not conducted to a decrease on HaCaT and HFF-1 viability up to 100 μg/mL. Oppositely, a decrease on Caco-2 and HT29-MTX viability was observed. This study suggests that UAE could be a sustainable option to valorize chestnut shells as raw material for different industries.

scholarly journals Traditional Uses, Phytochemistry, and Bioactivities ofCananga odorata(Ylang-Ylang)

2015 ◽  
Vol 2015 ◽  
pp. 1-30 ◽  
Author(s):  
Loh Teng Hern Tan ◽  
Learn Han Lee ◽  
Wai Fong Yin ◽  
Chim Kei Chan ◽  
Habsah Abdul Kadir ◽  
...  
Keyword(s):  
Essential Oils ◽  
Large Scale ◽  
Steam Distillation ◽  
Biological Activities ◽  
Raw Material ◽  
Traditional Uses ◽  
Cosmetic Industry ◽  
Wide Range ◽  
Phytochemical Studies ◽  
Cananga Odorata

Ylang-ylang (Cananga odorataHook. F. & Thomson) is one of the plants that are exploited at a large scale for its essential oil which is an important raw material for the fragrance industry. The essential oils extracted via steam distillation from the plant have been used mainly in cosmetic industry but also in food industry. Traditionally,C. odoratais used to treat malaria, stomach ailments, asthma, gout, and rheumatism. The essential oils or ylang-ylang oil is used in aromatherapy and is believed to be effective in treating depression, high blood pressure, and anxiety. Many phytochemical studies have identified the constituents present in the essential oils ofC. odorata. A wide range of chemical compounds including monoterpene, sesquiterpenes, and phenylpropanoids have been isolated from this plant. Recent studies have shown a wide variety of bioactivities exhibited by the essential oils and the extracts ofC. odorataincluding antimicrobial, antibiofilm, anti-inflammatory, antivector, insect-repellent, antidiabetic, antifertility and antimelanogenesis activities. Thus, the present review summarizes the information concerning the traditional uses, phytochemistry, and biological activities ofC. odorata. This review is aimed at demonstrating thatC. odoratanot only is an important raw material for perfume industry but also considered as a prospective useful plant to agriculture and medicine.

scholarly journals Assessment of the phytochemical, antioxidant and antibacterial activities of Heteromorpha arborescens (Spreng.) Cham & Schltdl. leaf extracts

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1079
Author(s):  
Taiwo Oluwafunmilola Abifarin ◽  
Gloria Aderonke Otunola ◽  
Anthony Jide Afolayan
Keyword(s):  
Biological Activities ◽  
Radical Scavenging ◽  
Antibacterial Activities ◽  
Eastern Africa ◽  
Total Phenolic ◽  
Phytochemical Analysis ◽  
Leaf Extracts ◽  
Wide Range ◽  
Total Antioxidant ◽  
Phytochemical Contents

Background: Heteromorpha arborescens (Spreng.) Cham. and Schltdl (Apiaceae) is widely used traditionally for the treatment of a wide range of diseases in Southern and Eastern Africa. Although previous studies have reported the biological activities of hexane, ethyl acetate and methanol extracts of H. arborescens leaves, there is no scientific information on the phytochemical contents, antioxidant and antibacterial activities of acetone, ethanol, aqueous and blanched extracts. This study is therefore aimed to investigate and compare the phytochemical contents, antioxidant and antibacterial activities of acetone, ethanol, aqueous and blanched extracts of H. arborescens leaves. Methods: Phytochemical analysis for the total phenolic, flavonoid, proanthocyanidin, alkaloid and saponin contents of all the fractions were determined by spectroscopic methods, while the free radical scavenging potential of the extracts were evaluated using DPPH, ABTS radical scavenging and total antioxidant capacity assays. Micro dilution method was used to determine the Minimum Inhibitory Concentrations (MIC) of H. arborescens leaf extracts against Bacillus pumilus, Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. Results: Total phenol content of the extracts ranged between 15.10 mg GAE/g- 42.50 mg GAE/g, proanthocyanidin was 459-8402.1 mg QE/g, and flavonoid content of 109.24-235.79 mg QE/g. In addition, alkaloids (5.59%) and saponins (23.33%) were present in significant amounts. Based on the IC50 values, the ethanol extract exhibited the highest total antioxidant activity (0.013 mg/mL) with highest inhibition against DPPH and ABTS radicals (0.06 and 0.049 mg/mL respectively). Considerable antibacterial activities were observed in the acetone, ethanol and blanched extracts with MIC values ranging from 1.563-12.5 mg/mL; however, the aqueous extract was inactive against all the bacteria strains. Conclusion: The study suggests that H. arborescens leaves could be a valuable source of bioactive compounds. Although the blanching process significantly decreased polyphenolic contents and antioxidant activities of the extracts, it increased the antibacterial compounds.

Automation of Process Control in Chemical Plant

2015 ◽  
Vol 2 (1) ◽  
pp. 6-12
Author(s):  
Agus Sugiarta ◽  
Houtman P. Siregar ◽  
Dedy Loebis
Keyword(s):  
Process Control ◽  
Pid Control ◽  
Control Algorithm ◽  
Chemical Engineering ◽  
Chemical Plant ◽  
Raw Material ◽  
Flow Rates ◽  
Material Supply ◽  
Wide Range ◽  
Inherent Problem

Automation of process control in chemical plant is an inspiring application field of mechatronicengineering. In order to understand the complexity of the automation and its application requireknowledges of chemical engineering, mechatronic and other numerous interconnected studies.The background of this paper is an inherent problem of overheating due to lack of level controlsystem. The objective of this research is to control the dynamic process of desired level more tightlywhich is able to stabilize raw material supply into the chemical plant system.The chemical plant is operated within a wide range of feed compositions and flow rates whichmake the process control become difficult. This research uses modelling for efficiency reason andanalyzes the model by PID control algorithm along with its simulations by using Matlab.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative

2017 ◽  
Vol 68 (4) ◽  
pp. 745-747 ◽  
Author(s):  
Marius Mioc ◽  
Sorin Avram ◽  
Vasile Bercean ◽  
Mihaela Balan Porcarasu ◽  
Codruta Soica ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Biological Activities ◽  
Cancer Cell Line ◽  
Vascular Endothelial ◽  
Triazole Derivative ◽  
Activity Assessment ◽  
Wide Range ◽  
Specific Receptors ◽  
Endothelial Growth Factor ◽  
Selection Of

Angiogenesis plays an important function in tumor proliferation, one of the main angiogenic promoters being the vascular endothelial growth factor (VEGF) which activates specific receptors, particularly VEGFR-2. Thus, VEGFR-2 has become an essential therapeutic target in the development of new antitumor drugs. 1,2,4-triazoles show a wide range of biological activities, including antitumor effect, which was documented by numerous reports. In the current study the selection of 5-mercapto-1,2,4-triazole structure (1H-3-styryl-5-benzylidenehydrazino-carbonyl-methylsulfanil-1,2,4-triazole, Tz3a.7) was conducted based on molecular docking that emphasized it as suitable ligand for VEGFR-2 and EGFR1 receptors. Compound Tz3a.7 was synthesized and physicochemically and biologically evaluated thus revealing a moderate antiproliferative activity against breast cancer cell line MDA-MB-231.

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