scholarly journals Genetic Polymorphism of GSTP-1 Affects Cyclophosphamide Treatment of Autoimmune Diseases

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1542
Author(s):  
Péter Hajdinák ◽  
Melinda Szabó ◽  
Emese Kiss ◽  
Lili Veress ◽  
Lívius Wunderlich ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Response Rate ◽  
Allelic Variation ◽  
Immunosuppressive Drugs ◽  
Disease Treatment ◽  
Anti Cancer ◽  
Cyclophosphamide Treatment ◽  
The Individual ◽  
The Given ◽  
Gstp1 Genes

Cyclophosphamide is one of the most potent and reliable anti-cancer and immunosuppressive drugs. In our study, 33 individuals with different autoimmune diseases were treated with cyclophosphamide according to standard protocols. The responses to the treatments were determined by measuring the alteration of several typical parameters characterizing the given autoimmune diseases over time. We concluded that about 45% of the patients responded to the treatment. Patients were genotyped for polymorphisms of the CYP3A4, CYP2B6, GSTM1, GSTT1, and GSTP1 genes and disease remission cases were compared to the individual polymorphic genotypes. It was found that the GSTP1 I105V allelic variation significantly associated with the cyclophosphamide treatment-dependent disease-remissions. At the same time the GSH content of the erythrocytes in the patients with I105V allelic variation did not change. It appears that the individuals carrying the Ile105Val SNP in at least one copy had a significantly higher response rate to the treatment. Since this variant of GSTP1 can be characterized by lower conjugation capacity that results in an elongated and higher therapeutic dose of cyclophosphamide, our data suggest that the decreased activity of this variant of GSTP1 can be in the background of the more effective disease treatment.

Evidence-based Practice regarding knowledge, attitude and perceived barriers of Mangalore Physical Therapists: A Survey

2020 ◽  
Vol 11 (4) ◽  
pp. 7056-7063
Author(s):  
Vineel P ◽  
Gopala Krishna Alaparthi ◽  
Kalyana Chakravarthy Bairapareddy ◽  
Sampath Kumar Amaravadi
Keyword(s):  
Response Rate ◽  
Evidence Based Practice ◽  
Physical Therapists ◽  
Medical Profession ◽  
Demographic Data ◽  
Perceived Barriers ◽  
Hard Copy ◽  
Evidence Based ◽  
Research Committee ◽  
The Individual

  Evidence-based Practice is defined as usage of current best evidence which is conscientious, explicit and judicious in deciding on the care of the individual. It is one of the vital decision-making processes in the medical profession. Though India is renowned as a center for medical education, there is scarcity regarding the literature on evidence-based practice. The survey aims to identify the prevalence of evidence-based practice among the physical therapists of Mangalore. The study protocol submitted to scientific research committee and Ethical institutional committee, K.M.C. Mangalore Manipal University. On approval, the questionnaire had been distributed among the physical therapists of Mangalore through mails and in the written form. The questionnaire consists of questions divided into eight sections: 1) consent form 2) current practice status; 3) demographic data; 4) behavior; 5) previous knowledge of E.B.P. resources; 6) skills and available resources; 7) Opinions regarding E.B.P.; 8)Perceived barriers regarding E.B.P. The emails were sent through Google forms to all the physical therapists, and hard copies were distributed among the selected physical therapists. The response rate for the emails was 13.1%. The response collected through hard copies was 178, whereas total hard copies distributed was 320, the participants rejected some due to lack of interest. In total, including emails and hard copy questionnaire 205 was the response rate in which all were practicing physical therapy as their primary profession. The findings of the study will pave the way to identify the status of evidence-based practice as well as help in designing promotional programmers for evidence-based practice.

Application of the turbidity ratio method in the spherical particle size determination in the range m ∈ and α ∈

1979 ◽  
Vol 44 (7) ◽  
pp. 2064-2078 ◽  
Author(s):  
Blahoslav Sedláček ◽  
Břetislav Verner ◽  
Miroslav Bárta ◽  
Karel Zimmermann
Keyword(s):  
Refractive Index ◽  
Spherical Particle ◽  
Ratio Method ◽  
Refractive Indices ◽  
Relative Refractive Index ◽  
Particle Size Determination ◽  
The Individual ◽  
The Given ◽  
Turbidity Ratio ◽  
Selection Of

Basic scattering functions were used in a novel calculation of the turbidity ratios for particles having the relative refractive index m = 1.001, 1.005 (0.005) 1.315 and the size α = 0.05 (0.05) 6.00 (0.10) 15.00 (0.50) 70.00 (1.00) 100, where α = πL/λ, L is the diameter of the spherical particle, λ = Λ/μ1 is the wavelength of light in a medium with the refractive index μ1 and Λ is the wavelength of light in vacuo. The data are tabulated for the wavelength λ = 546.1/μw = 409.357 nm, where μw is the refractive index of water. A procedure has been suggested how to extend the applicability of Tables to various refractive indices of the medium and to various turbidity ratios τa/τb obtained with the individual pairs of wavelengths λa and λb. The selection of these pairs is bound to the sequence condition λa = λ0χa and λb = λ0χb, in which b-a = δ = 1, 2, 3; a = -2, -1, 0, 1, 2, ..., b = a + δ = -1, 0, 1, 2, ...; λ0 = λa=0 = 326.675 nm; χ = 546.1 : 435.8 = 1.2531 is the quotient of the given sequence.

scholarly journals Preoperative Group Consultation Prior to Surgery for Colorectal Cancer—an Explorative Study of a New Patient Education Method

2021 ◽  
Author(s):  
Sofie Walming ◽  
Eva Angenete ◽  
David Bock ◽  
Mattias Block ◽  
Hanna de la Croix ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Patient Education ◽  
Response Rate ◽  
University Hospital ◽  
Sense Of Control ◽  
Structured Interviews ◽  
Group Setting ◽  
Disease Treatment ◽  
Explorative Study ◽  
Group Consultation

Abstract Patients with colorectal cancer may lack information about the disease and treatment. In 2017, a group consultation before start of surgery was introduced at a university hospital in western Sweden to inform about the disease, treatment, and ongoing scientific studies. The primary aim of this study was to explore the experience of the patients attending the group consultation. Based on semi-structured interviews with patients with colorectal cancer, a questionnaire was constructed and administered to patients, both those attending and those not attending the group consultation. In total, 124 patients were included and the response rate was 86%. A majority of patients attending the group consultation would recommend it to someone else with the same illness. Of the patients attending the group consultation, 81% (30/37) patients agreed, fully or partially, that attending the group consultation had increased their sense of control and 89% (33/37) that the information they received at the group consultation increased their feeling of participation in the treatment. Preoperative group consultation is a feasible modality for informing and discussing the upcoming treatment for colorectal cancer with the patients, and the patients who attended the group setting appreciated it. Attending the group consultation increased the patients’ feeling of active participation in their treatment and their sense of control, which could possibly both improve their experience of their illness and facilitate recovery. ClinicalTrials.gov identifier NCT03888313

scholarly journals Finding an easy way to harmonize: a review of advances in clinical research and combination strategies of EZH2 inhibitors

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Chen Li ◽  
Yan Wang ◽  
Yueqing Gong ◽  
Tengrui Zhang ◽  
Jiaqi Huang ◽  
...  
Keyword(s):  
Treatment Modalities ◽  
Preclinical Studies ◽  
Combination Therapies ◽  
Tumor Treatment ◽  
Antitumor Effects ◽  
Therapeutic Modalities ◽  
Combination Strategies ◽  
Anti Cancer ◽  
Underlying Mechanisms ◽  
The Individual

AbstractEnhancer of zeste homolog 2 inhibitors (EZH2i) have garnered increased attention owing to their anticancer activity by targeting EZH2, a well-known cancer-promoting factor. However, some lymphomas are resistant to EZH2i, and EZH2i treatment alone is ineffective in case of EZH2-overexpressing solid tumors. The anti-cancer efficacy of EZH2i may be improved through safe and effective combinations of these drugs with other treatment modalities. Preclinical evidence indicates that combining EZH2i with other therapies, such as immunotherapy, chemotherapy, targeted therapy, and endocrine therapy, has complementary or synergistic antitumor effects. Therefore, elucidating the underlying mechanisms of the individual constituents of the combination therapies is fundamental for their clinical application. In this review, we have summarized notable clinical trials and preclinical studies using EZH2i, their progress, and combinations of EZH2i with different therapeutic modalities, aiming to provide new insights for tumor treatment.

ALTERNATIVE ROUTES TO INNOVATION — THE EFFECTS OF CULTURAL AND STRUCTURAL FIT

2019 ◽  
Vol 24 (01) ◽  
pp. 2050006
Author(s):  
DAG INGVAR JACOBSEN ◽  
TORE HILLESTAD ◽  
BIRGITTE YTTRI ◽  
JARLE HILDRUM
Keyword(s):  
Response Rate ◽  
Organic Structure ◽  
Configurational Approach ◽  
Culture Strength ◽  
Individual Effects ◽  
Collective Phenomenon ◽  
The Individual ◽  
Alternative Routes ◽  
Innovative Culture ◽  
The Empirical Analysis

A configurational approach to organizations assumes that structural and cultural characteristics must be in “fit” to produce the wanted outcome. With a focus on innovation, this study examines empirically to what extent innovative activities with a large, global telecom company are produced by an innovative culture, an innovative structure, as well as the fit between the two. Based on an extensive survey (N = 21064, response rate = 65) of employees in seven countries in Europe and Asia, data was aggregated to unit level as culture by nature is a collective phenomenon. The empirical analysis detected both the individual effects of culture strength and homogeneity, structure, as well as the fit between the two. The results indicate that an innovative culture and an organic structure indeed fosters innovation, but that, somewhat surprisingly, there are not effects of the fit between the two. Both practical and theoretical implications are discussed.

Structural study of anhydrous and hydrated 5-fluorouracil co-crystals with nicotinamide and isonicotinamide

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tobias Heinen ◽  
Sandra Hoelscher ◽  
Vera Vasylyeva
Keyword(s):  
Structural Study ◽  
Solvent Free ◽  
Cancer Drug ◽  
Pharmaceutical Applications ◽  
Synthetic Accessibility ◽  
Anti Cancer ◽  
Component Systems ◽  
The Given

Abstract 5-Fluorouracil is a widely used anti-cancer drug which exhibits diverse polymorphic and co-crystalline behavior. Here we report two new solvent-free co-crystals of 5-fluorouracil with model co-formers nicotinamide and isonicotinamide, along with the redetermination of their hydrated analogues. Selected co-formers are categorized as safe and therefore suitable for pharmaceutical applications. Differences and similarities in supramolecular topology of the given structures are discussed. A special emphasis is set on the influence of fluorine moieties on the overall packing and synthetic accessibility of the presented multi-component systems.

scholarly journals Pre filtering techniques for face recognition based on edge detection algorithm

2017 ◽  
Vol 7 (1.1) ◽  
pp. 213
Author(s):  
Sheela Rani ◽  
Vuyyuru Tejaswi ◽  
Bonthu Rohitha ◽  
Bhimavarapu Akhil
Keyword(s):  
Face Recognition ◽  
Face Detection ◽  
Detection Algorithm ◽  
Facial Features ◽  
Human Face ◽  
Video Frames ◽  
Similar Idea ◽  
The Individual ◽  
The Given ◽  
Interesting Area

Recognition of face has been turned out to be the most important and interesting area in research. A face recognition framework is a PC application that is apt for recognizing or confirming the presence of human face from a computerized picture, from the video frames etc. One of the approaches to do this is by matching the chosen facial features with the pictures in the database. It is normally utilized as a part of security frameworks and can be implemented in different biometrics, for example, unique finger impression or eye iris acknowledgment frameworks. A picture is a mix of edges. The curved line potions where the brightness of the image change intensely are known as edges. We utilize a similar idea in the field of face-detection, the force of facial colours are utilized as a consistent value. Face recognition includes examination of a picture with a database of stored faces keeping in mind the end goal to recognize the individual in the given input picture. The entire procedure covers in three phases face detection, feature extraction and recognition and different strategies are required according to the specified requirements.

scholarly journals Factors Determining Income among Real Estate Salespersons: The Impacts of Individual Conditions, Franchises, and Regular Chains

2015 ◽  
Vol 7 (11) ◽  
pp. 94
Author(s):  
Chun-Chang Lee ◽  
Cheng-Huang Tung ◽  
Yu-Heng Lee ◽  
Shu-Man You
Keyword(s):  
Real Estate ◽  
Hierarchical Linear Modeling ◽  
Positive Impact ◽  
Working Hours ◽  
Education Level ◽  
Linear Modeling ◽  
Individual Level ◽  
The Individual ◽  
The Given ◽  
Regular Chains

<p>This study explores the factors that affect the incomes of real estate salespersons by applying hierarchical linear modeling (HLM) to investigate the incomes of real estate salespersons in Kaohsiung. A total of 510 questionnaires were distributed to large chain housing agencies, of which a total of 319 effective samples were retrieved from 54 branch stores, for an effective return rate of 62.55%. The empirical results showed that individual incomes vary significantly from store to store. About 4.8% of the variation in individual incomes was due to differences among different branch stores. The individual income of a real estate salesperson is also significantly affected by individual-level factors such as age, working hours, and working experience. The marginal impact of education level, age, working hours, and working experience on real estate salesperson income is moderated by the type of store at which the given salesperson works. In addition, a branch store’s location has a direct, significant, and positive impact on a real estate salesperson’s income.</p>

scholarly journals METHODOLOGY FOR DESIGNING AN EDUCATIONAL SUBSYSTEM AS A POLL FROM THE HOUSE OF QUALITY IN MACEDONIAN COMPANIES

2012 ◽  
Vol 3 (1) ◽  
pp. 81-90
Author(s):  
Elizabeta Mitreva
Keyword(s):  
Collective Learning ◽  
Quality System ◽  
House Of Quality ◽  
Total Quality ◽  
Management Philosophy ◽  
Continued Education ◽  
The Individual ◽  
The Given ◽  
A Company ◽  
Satisfactory Manner

The education of the employees in each instance of a company comes along with a purpose to gain competence and experience in order to realize every business process according to the demands of the products/services, the legal obligation as well as the criteria of competitiveness. Furthermore, it is directly conjoined with the very act of foundation setting of the employees’ requests with a unique intention - to achieve quality, stressing the vital need to affiliate everyone in their own field. This analysis presents the research inputs which are being given in order to get a clear picture whether the Macedonian companies are eager to learn and stimulate both the individual and the collective learning in order to improve the results in general. According to the given results in the research, it is stated that the Macedonian companies do not pay much attention to quality. They are insufficiently concerned with the continuous education, which is evident in the small investments they make in regard to the innovations. Hence, the quality system has been built in a very small number of companies. The following model presented in this elaborate has been suggested for a more successful designing and implementation of the educational system as a subsystem of the house of quality. This methodology is integral and has a universal notion which is applicable to all types of companies and institutions as well. Without a conducted training about TQM (Total Quality Management) philosophy and a continued education provided firstly for the managers and further on for all of the employees, the TQM strategy could not be implemented in a satisfactory manner. Also, the benefits that come along with the quality system could not be visible as a result. Key words: educational subsystem, leadership, methodology, quality system, TQM strategy.

scholarly journals Time Coordination of Periodic Passenger Train Connections in Conditions of Single-Track Lines

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Filip Lorenz ◽  
Vit Janos ◽  
Dusan Teichmann ◽  
Michal Dorda
Keyword(s):  
Mathematical Model ◽  
Mathematical Programming ◽  
Real Data ◽  
Real Problem ◽  
Single Track ◽  
Railway Stations ◽  
Optimization Software ◽  
Proposed Model ◽  
The Individual ◽  
The Given

The article addresses creation of a mathematical model for a real problem regarding time coordination of periodic train connections operated on single-track lines. The individual train connections are dispatched with a predefined tact, and their arrivals at and departures to predefined railway stations (transfer nodes) need to be coordinated one another. In addition, because the train connections are operated on single-track lines, trains that pass each other in a predefined railway stations must be also coordinated. To optimize the process, mathematical programming methods are used. The presented article includes a mathematical model of the given task, and the proposed model is tested with real data. The calculation experiments were implemented using optimization software Xpress-IVE.

Sign in / Sign up

Export Citation Format

Share Document