scholarly journals Nanoantioxidants: Pioneer Types, Advantages, Limitations, and Future Insights

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 7031
Author(s):  
Basma Omran ◽  
Kwang-Hyun Baek
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Transition Metal Oxides ◽  
Targeted Delivery ◽  
Antioxidant Properties ◽  
Environmental Pollutants ◽  
Chemical Properties ◽  
Volume Ratio ◽  
Cellular Damage ◽  
Physico Chemical

Free radicals are generated as byproducts of normal metabolic processes as well as due to exposure to several environmental pollutants. They are highly reactive species, causing cellular damage and are associated with a plethora of oxidative stress-related diseases and disorders. Antioxidants can control autoxidation by interfering with free radical propagation or inhibiting free radical formation, reducing oxidative stress, improving immune function, and increasing health longevity. Antioxidant functionalized metal nanoparticles, transition metal oxides, and nanocomposites have been identified as potent nanoantioxidants. They can be formulated in monometallic, bimetallic, and multi-metallic combinations via chemical and green synthesis techniques. The intrinsic antioxidant properties of nanomaterials are dependent on their tunable configuration, physico-chemical properties, crystallinity, surface charge, particle size, surface-to-volume ratio, and surface coating. Nanoantioxidants have several advantages over conventional antioxidants, involving increased bioavailability, controlled release, and targeted delivery to the site of action. This review emphasizes the most pioneering types of nanoantioxidants such as nanoceria, silica nanoparticles, polydopamine nanoparticles, and nanocomposite-, polysaccharide-, and protein-based nanoantioxidants. This review overviews the antioxidant potential of biologically synthesized nanomaterials, which have emerged as significant alternatives due to their biocompatibility and high stability. The promising nanoencapsulation nanosystems such as solid lipid nanoparticles, nanostructured lipid carriers, and liposome nanoparticles are highlighted. The advantages, limitations, and future insights of nanoantioxidant applications are discussed.

scholarly journals Ethanol Extract of Maclura tricuspidata Fruit Protects SH-SY5Y Neuroblastoma Cells against H2O2-Induced Oxidative Damage via Inhibiting MAPK and NF-κB Signaling

2021 ◽  
Vol 22 (13) ◽  
pp. 6946
Author(s):  
Weishun Tian ◽  
Suyoung Heo ◽  
Dae-Woon Kim ◽  
In-Shik Kim ◽  
Dongchoon Ahn ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Oxidative Damage ◽  
Cell Damage ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Biologically Active ◽  
Mitogen Activated Protein Kinase ◽  
Protective Effects ◽  
Neuroprotective Effects

Free radical generation and oxidative stress push forward an immense influence on the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Maclura tricuspidata fruit (MT) contains many biologically active substances, including compounds with antioxidant properties. The current study aimed to investigate the neuroprotective effects of MT fruit on hydrogen peroxide (H2O2)-induced neurotoxicity in SH-SY5Y cells. SH-SY5Y cells were pretreated with MT, and cell damage was induced by H2O2. First, the chemical composition and free radical scavenging properties of MT were analyzed. MT attenuated oxidative stress-induced damage in cells based on the assessment of cell viability. The H2O2-induced toxicity caused by ROS production and lactate dehydrogenase (LDH) release was ameliorated by MT pretreatment. MT also promoted an increase in the expression of genes encoding the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). MT pretreatment was associated with an increase in the expression of neuronal genes downregulated by H2O2. Mechanistically, MT dramatically suppressed H2O2-induced Bcl-2 downregulation, Bax upregulation, apoptotic factor caspase-3 activation, Mitogen-activated protein kinase (MAPK) (JNK, ERK, and p38), and Nuclear factor-κB (NF-κB) activation, thereby preventing H2O2-induced neurotoxicity. These results indicate that MT has protective effects against H2O2-induced oxidative damage in SH-SY5Y cells and can be used to prevent and protect against neurodegeneration.

scholarly journals Effects of Caloric Restriction on Cardiac Oxidative Stress and Mitochondrial Bioenergetics: Potential Role of Cardiac Sirtuins

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Ken Shinmura
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Oxidative Damage ◽  
Caloric Restriction ◽  
Functional Decline ◽  
Cellular Damage ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Stress Theory

The biology of aging has not been fully clarified, but the free radical theory of aging is one of the strongest aging theories proposed to date. The free radical theory has been expanded to the oxidative stress theory, in which mitochondria play a central role in the development of the aging process because of their critical roles in bioenergetics, oxidant production, and regulation of cell death. A decline in cardiac mitochondrial function associated with the accumulation of oxidative damage might be responsible, at least in part, for the decline in cardiac performance with age. In contrast, lifelong caloric restriction can attenuate functional decline with age, delay the onset of morbidity, and extend lifespan in various species. The effect of caloric restriction appears to be related to a reduction in cellular damage induced by reactive oxygen species. There is increasing evidence that sirtuins play an essential role in the reduction of mitochondrial oxidative stress during caloric restriction. We speculate that cardiac sirtuins attenuate the accumulation of oxidative damage associated with age by modifying specific mitochondrial proteins posttranscriptionally. Therefore, the distinct role of each sirtuin in the heart subjected to caloric restriction should be clarified to translate sirtuin biology into clinical practice.

scholarly journals The Simultaneous Removal of Zinc and Cadmium from Multicomponent Aqueous Solutions by Their Sorption onto Selected Natural and Synthetic Zeolites

Minerals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 343 ◽  
Author(s):  
Bożena Kozera-Sucharda ◽  
Barbara Gworek ◽  
Igor Kondzielski
Keyword(s):  
Aqueous Solutions ◽  
Low Cost ◽  
Environmental Pollutants ◽  
Chemical Properties ◽  
Simultaneous Removal ◽  
Physico Chemical ◽  
Synthetic Zeolites ◽  
Sorption Mechanisms ◽  
Synthetic Aluminosilicate ◽  
Natural And Synthetic

Natural and synthetic aluminosilicate minerals, in particular zeolites, are considered to be very useful in remediation processes, such as purification of waters polluted with heavy metals. That is due to their unique and outstanding physico-chemical properties, rendering them highly efficient, low-cost, and environmentally friendly sorbents of various environmental pollutants. The aim of this study was to examine the sorption capacity of four selected zeolites: A natural zeolite and three synthetic zeolites (3A, 10A, and 13X), towards zinc and cadmium present in multicomponent aqueous solutions, in relation to identified sorption mechanisms. It was stated that synthetic zeolites 3A and 10A were the most efficient in simultaneous removal of zinc and cadmium from aqueous solutions. Additionally, zeolite 10A was demonstrated to be the mineral best coping with prolonged pollution of water with those elements. The mechanism of sorption identified for tested minerals was physisorption.

scholarly journals Inhibition of Digestive Enzymes, Antioxidant and Free Radical Scavenging Capacities of Stem Bark Extracts of Coula edulis Baill (Olacaceae)

2021 ◽  
Vol 10 (5) ◽  
pp. 1
Author(s):  
Eric Beyegue ◽  
Boris G. K. Azantsa ◽  
Angie M-A Mbong ◽  
Julius E. Oben
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Alpha Amylase ◽  
In Vitro Assays ◽  
Oh Radicals

Prolonged hyperglycemia enhances oxidative stress. Bioactive compounds extracted possess antioxidant, anti-free radical potentials or the ability to reduce blood sugar levels. The objective of this study was to evaluate the antioxidant properties of extracts of stem bark of Coula edulis Baill., their abilities to trap free radicals and glucose, as well as their ability to inhibit α-amylase and invertase activities. In vitro assays were used to test the trapping capacity of extracts on DPPH, ABTS, NO, and OH radicals; to evaluate the antioxidant capacity, the activity of glycosylation and the capacity of inhibition of the activities of α-amylase and invertase were conducted. Also, phenolic, flavonoid and alkaloid contents of extracts were determined. Results showed that extracts of the stem bark of C. edulis have anti-radical properties. The extracts chelate DPPH, hydroxyl (OH), nitrite oxide (NO), ABTS radicals, and even glucose. The IC50 values varied depending on the nature of the extraction solvent. Ethanolic extract has the highest polyphenolic content (289.12 ± 30.31 µg catechin equivalent/g), flavonoids (1.12 ± 0.09 µg quercetin equivalent/g) and alkaloids (5.54 ± 0.59 µg quinin equivalent/g). The extracts also reduce invertase and α-amylase activities. C. edulis extracts present strong antioxidant potentials and can be used as a source of natural antioxidants for the prevention of oxidative stress and hyperglycemia.

Abstract 13916: A Novel Biomarker of Oxidative Stress is Predictive of Incident Death and Myocardial Infarction in Patients with Coronary Artery Disease

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Riyaz S Patel ◽  
Nima Ghasemzadeh ◽  
Danny J Eapen ◽  
Salman Sher ◽  
Shawn Arshad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
High Performance ◽  
Composite Endpoint ◽  
Cardiovascular Death ◽  
Adverse Outcomes ◽  
Cellular Damage ◽  
Free Radical Scavengers ◽  
C Statistic ◽  
Artery Disease

Introduction: Oxidative stress (OS) is implicated in cellular damage and atherosclerosis, yet clinical experience of free radical scavengers has been uniformly disappointing, promoting the concept that clinically important OS may be mediated by alternative non-free radical processes. Hypothesis: We hypothesized that novel aminothiol markers of non-free radical mediated OS would predict incident adverse outcomes in patients at high risk for CAD Methods: 1411 consecutive patients undergoing coronary angiography (mean age 63 years, male 66%), were recruited from the Emory Cardiovascular Biobank study. Plasma levels of reduced (cysteine and glutathione) and oxidized (cystine and glutathione disulphide) aminothiols were measured by high performance liquid chromatography at baseline and patients followed prospectively for a primary composite endpoint of death or non-fatal MI. Results: During a mean follow up of 3.9± 2.2 years, 19% died or suffered a non-fatal MI. The adjusted hazard ratios for all cause death/MI based on high vs low cut-points for the oxidized disulphide cystine was 1.65 (95% CI, 1.27-2.15); for reduced glutathione was 0.69 (0.52-0.92), and for the ratio of cystine/glutathione was 1.79 (1.39-2.30). Compared to a model containing clinical risk factors and CRP, addition of the cystine/glutathione ratio improved the C-Statistic (p=0.03) and also correctly reclassified 17% of events and 23% of non-events. When combined with high/low CRP into a 3 level multi-marker score, those with 2 high markers had an annualized event rate of 12.8% compared to 4.5% and 1.4% for those with 1 raised marker or none, respectively. Similar associations were found for all-cause and cardiovascular death endpoints and also in stratified analysis for those with and without significant CAD. Conclusions: A high extracellular oxidant burden and reduced intracellular antioxidant capacity quantified by the plasma aminothiols, cystine, glutathione and their respective ratio, is associated with adverse events in patients with CAD, a finding that is independent of and additive to any inflammatory burden. Further studies are needed to validate these findings, which support an alternative model of oxidative stress independent of free radical biology.

scholarly journals Discovering the Health Promoting Potential of Fermented Papaya Preparation—Its Future Perspectives for the Dietary Management of Oxidative Stress During Diabetes

Fermentation ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 83 ◽  
Author(s):  
Jhoti Somanah ◽  
Manish Putteeraj ◽  
Okezie Aruoma ◽  
Theeshan Bahorun
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Stress Reduction ◽  
Senile Dementia ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Morphological Characteristics ◽  
Holistic Approach ◽  
Amino Acid Profile ◽  
Protective Effects

The simplistic morphological characteristics of Carica papaya fruit or “pawpaw” should not be the cause for underestimating its potential as a nutraceutical. The market for papaya has been expanding at a staggering rate, partly due to its applicability as a biofortified product, but also due to its phytochemical properties and traditional health benefits. Papaya or formulations of fermented papaya promotion (FPP) display effective free radical scavenging abilities thought to be influenced by its phenolic, carotenoid, flavonoid, or amino acid profile. The antioxidant properties of FPP have been extensively reported in literature to potently target a broad spectrum of free radical-induced diseases ranging from neurological impairments, such as senile dementia, to systemic diseases, to its interference at the cellular level and the support of normal biological ageing processes. FPP has thus been extensively investigated for its ability to exert cellular protective effects and reduce oxidative stress via the mitigation of genetic damage, reduction of lipid peroxidation, and enzymatic inactivation in specific diseases. The focus of this review is to appraise the potential of oxidative stress reduction strategies of FPP and discuss its holistic approach in disease prevention and management, with a particular focus on diabetes and cancer. However, with the current lack of information surrounding its mechanism of action, this review wishes to set the stage and aspire researchers to more profoundly investigate molecular pathways related to how FPP can unequivocally contribute to wellness in an aging population.

scholarly journals Antioxidant Functionalized Nanoparticles: A Combat against Oxidative Stress

Nanomaterials ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1334 ◽  
Author(s):  
Harsh Kumar ◽  
Kanchan Bhardwaj ◽  
Eugenie Nepovimova ◽  
Kamil Kuča ◽  
Daljeet Singh Dhanjal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Targeted Delivery ◽  
Abiotic Stresses ◽  
Antioxidant Properties ◽  
Oxygen Species ◽  
Synthetic Antioxidants ◽  
Functionalized Nanoparticles ◽  
Biological Origin ◽  
Poor Absorption ◽  
Significant Attention

Numerous abiotic stresses trigger the overproduction of reactive oxygen species (ROS) that are highly toxic and reactive. These ROS are known to cause damage to carbohydrates, DNA, lipids and proteins, and build the oxidative stress and results in the induction of various diseases. To resolve this issue, antioxidants molecules have gained significant attention to scavenge these free radicals and ROS. However, poor absorption ability, difficulty in crossing the cell membranes and degradation of these antioxidants during delivery are the few challenges associated with both natural and synthetic antioxidants that limit their bioavailability. Moreover, the use of nanoparticles as an antioxidant is overlooked, and is limited to a few nanomaterials. To address these issues, antioxidant functionalized nanoparticles derived from various biological origin have emerged as an important alternative, because of properties like biocompatibility, high stability and targeted delivery. Algae, bacteria, fungi, lichens and plants are known as the producers of diverse secondary metabolites and phenolic compounds with extraordinary antioxidant properties. Hence, these compounds could be used in amalgamation with biogenic derived nanoparticles (NPs) for better antioxidant potential. This review intends to increase our knowledge about the antioxidant functionalized nanoparticles and the mechanism by which antioxidants empower nanoparticles to combat oxidative stress.

scholarly journals An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose

2018 ◽  
Vol 15 (144) ◽  
pp. 20180364 ◽  
Author(s):  
Stuart T. Johnston ◽  
Matthew Faria ◽  
Edmund J. Crampin
Keyword(s):  
Targeted Delivery ◽  
Chemical Properties ◽  
The Body ◽  
Nanoparticle Transport ◽  
Standard Assumption ◽  
Modified Model ◽  
Physico Chemical ◽  
Cell Association ◽  
Association Data ◽  
Delivered Dose

Nanoparticles provide a promising approach for the targeted delivery of therapeutic, diagnostic and imaging agents in the body. However, it is not yet fully understood how the physico-chemical properties of the nanoparticles influence cellular association and uptake. Cellular association experiments are routinely performed in an effort to determine how nanoparticle properties impact the rate of nanoparticle–cell association. To compare experiments in a meaningful manner, the association data must be normalized by the amount of nanoparticles that arrive at the cells, a measure referred to as the delivered dose. The delivered dose is calculated from a model of nanoparticle transport through fluid. A standard assumption is that all nanoparticles within the population are monodisperse, namely the nanoparticles have the same physico-chemical properties. We present a semi-analytic solution to a modified model of nanoparticle transport that allows for the nanoparticle population to be polydisperse. This solution allows us to efficiently analyse the influence of polydispersity on the delivered dose. Combining characterization data obtained from a range of commonly used nanoparticles and our model, we find that the delivered dose changes by more than a factor of 2 if realistic amounts of polydispersity are considered.

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