scholarly journals The Associations of Dietary Iron, Zinc and Magnesium with Metabolic Syndrome in China’s Mega Cities

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 659
Author(s):  
Zhenni Zhu ◽  
Yuna He ◽  
Fan Wu ◽  
Liyun Zhao ◽  
Chunfeng Wu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Smoking Status ◽  
Positive Association ◽  
Activity Level ◽  
P Value ◽  
Dietary Iron ◽  
Logistic Regression Models ◽  
Dietary Recall ◽  
Hierarchical Logistic Regression ◽  
Mega Cities

Background: Iron, zinc and magnesium perform differently in body metabolism but exist in similar food. This study was to evaluate the associations of dietary iron, zinc and magnesium with metabolic syndrome (MetS). Methods: A sample of a total of 5323 participants from four of China’s mega cities was included in the current study. Both a 3-day 24-h dietary recall and household condiment weighing were applied to assess dietary intake, respectively. Hierarchical logistic regression models were used to evaluate the associations of dietary iron, zinc and magnesium with MetS. Results: After adjusting for age, sex, region, years of education, physical activity level, intended physical exercises, smoking status, alcohol use, daily energy intake and mutual adjustment for dietary iron, zinc and magnesium, significant positive trends were found across quartiles of total dietary iron and the risk of MetS, as well as for magnesium and MetS (p value for trends = 0.01 and 0.02, respectively); dietary zinc was inversely associated with MetS risk (p value for trend < 0.01). Magnesium from grains and potato was positively associated with MetS (p value for trend < 0.01). Conclusions: Dietary iron and magnesium were positively associated with the risk of MetS, while zinc was inversely associated with the risk of MetS, in China’s mega cities. The positive association of magnesium with MetS could be a result confounding by other factors correlated with magnesium in grains and potato, which warrants further study.

scholarly journals Dietary and lifestyle inflammatory scores are associated with increased risk of metabolic syndrome in Iranian adults

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Hossein Farhadnejad ◽  
Karim Parastouei ◽  
Hosein Rostami ◽  
Parvin Mirmiran ◽  
Fereidoun Azizi
Keyword(s):  
Metabolic Syndrome ◽  
Positive Association ◽  
Population Based ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
Increased Risk ◽  
Confounding Variables ◽  
Adjusted Model ◽  
Diet And Lifestyle

Abstract Background In the current study, we aimed to investigate the association of dietary inflammation scores (DIS) and lifestyle inflammation scores (LIS) with the risk of metabolic syndrome (MetS) in a prospective population-based study. Methods A total of 1625 participants without MetS were recruited from among participants of the Tehran Lipid and Glucose Study(2006–2008) and followed a mean of 6.1 years. Dietary data of subjects were collected using a food frequency questionnaire at baseline to determine LIS and DIS. Multivariable logistic regression models, were used to calculate the odds ratio (ORs) and 95 % confidence interval (CI) of MetS across tertiles of DIS and LIS. Results Mean ± SD age of individuals (45.8 % men) was 37.5 ± 13.4 years. Median (25–75 interquartile range) DIS and LIS for all participants was 0.80 (− 2.94, 3.64) and 0.48 (− 0.18, − 0.89), respectively. During the study follow-up, 291 (17.9 %) new cases of MetS were identified. Based on the age and sex-adjusted model, a positive association was found between LIS (OR = 7.56; 95% CI 5.10–11.22, P for trend < 0.001) and risk of MetS, however, the association of DIS and risk of MetS development was not statistically significant (OR = 1.30;95% CI 0.93–1.80, P for trend = 0.127). In the multivariable model, after adjustment for confounding variables, including age, sex, body mass index, physical activity, smoking, and energy intake, the risk of MetS is increased across tertiles of DIS (OR = 1.59; 95% CI 1.09–2.33, P for trend = 0.015) and LIS(OR = 8.38; 95% CI 5.51–12.7, P for trend < 0.001). Conclusions The findings of the current study showed that greater adherence to LIS and DIS, determined to indicate the inflammatory potential of diet and lifestyle, are associated with increased the risk of MetS.

scholarly journals A Positive Association of Overactivated Immunity with Metabolic Syndrome Risk and Mitigation of Its Association by a Plant-Based Diet and Physical Activity in a Large Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2308
Author(s):  
Sunmin Park ◽  
Ting Zhang
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Cohort Study ◽  
Large Scale ◽  
Smoking Status ◽  
Characteristic Curve ◽  
Daily Intake ◽  
Positive Association ◽  
Cell Counts ◽  
High Hba1c

The association between immunity and metabolic syndrome (MetS) has been studied, but its interaction with lifestyles remains unclear. We studied their association and interactions with lifestyles in 40,768 adults aged over 40 years from a large-scale, hospital-based cohort study collected during 2010–2013. White blood cell counts (WBC) and serum C-reactive protein concentrations (CRP) were used as indexes of immune status. The participants were categorized into four groups by the cutoff points of 6.2 × 109/L WBC(L-WBC) and <0.5 mg/dL CRP(L-CRP): L-WBC+L-CRP(n = 25,604), H-WBC+L-CRP(n = 13,880), L-WBC+H-CRP(n = 464), and H-WBC+H-CRP(n = 820). The participants in the H-WBC+L-CRP were younger and had higher numbers of males than the L-WBC+L-CRP. MetS risk was higher by 1.75- and 1.86-fold in the H-WBC+L-CRP and H-WBC+H-CRP, respectively, than the L-WBC+L-CRP. MetS components, including plasma glucose and triglyceride concentrations, and SBP were elevated in H-WBC+L-CRP and H-WBC+H-CRP compared with L-WBC+L-CR+P. The risk of hyperglycemia and high HbA1c was the highest in the H-WBC+H-CRP among all groups. Areas of WBC counts and serum CRP concentrations were 0.637 and 0.672, respectively, in the receiver operating characteristic curve. Daily intake of energy, carbohydrate, protein, and fat was not significantly different in the groups based on WBC counts and CRP. However, a plant-based diet (PBD), physical activity, and non-smoking were related to lowering WBC counts and CRP, but a Western-style diet was linked to elevating CRP. A high PBD intake and smoking status interacted with immunity to influence MetS risk: a low PBD and current smoking were associated with a higher MetS risk in the H-WBC+H-CRP. In conclusion, overactivated immunity determined by CRP and WBC was associated with MetS risk. Behavior modification with PBD and physical activity might be related to immunity regulation.

Plasma glycerophospholipid profile, erythrocyte n–3 PUFAs, and metabolic syndrome incidence: a prospective study in Chinese men and women

2021 ◽  
Author(s):  
Shuangshuang Chen ◽  
Qingqing Wu ◽  
Li Zhu ◽  
Geng Zong ◽  
Huaixing Li ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Animal Studies ◽  
Plasma Concentrations ◽  
Positive Association ◽  
Community Dwelling ◽  
P Value ◽  
Total N ◽  
Long Chain

ABSTRACT Background Animal studies have highlighted critical roles of glycerophospholipid (GP) metabolism in various metabolic syndrome (MetS)-related features such as dyslipidemia, obesity, and insulin resistance. However, human prospective studies of associations between circulating GPs and risks of MetS are scarce. Objectives We aimed to investigate whether GPs are associated with incidence of MetS in a well-established cohort. Methods A total of 1243 community-dwelling Chinese aged 50–70 y without MetS at baseline and followed up for 6 y were included in current analyses. A total of 145 plasma GPs were quantified by high-throughput targeted lipidomics. MetS was defined using the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Results After 6 y, 429 participants developed MetS. Eleven GPs, especially those with long-chain polyunsaturated fatty acids (LCPUFAs) or very-long-chain polyunsaturated fatty acids (VLCPUFAs) at the sn-2 position, including 1 phosphatidylcholine (PC) [PC(18:0/22:6)], 9 phosphatidylethanolamines (PEs) [PE(16:0/22:6), PE(18:0/14:0), PE(18:0/18:1), PE(18:0/18:2), PE(18:0/20:3), PE(18:0/22:5), PE(18:0/22:6), PE(18:1/22:6), and PE(18:2/22:6)], and 1 phosphatidylserine (PS) [PS(18:0/18:0)], were positively associated with incident MetS (RRs: 1.16–1.30 per SD change; Bonferroni-corrected P &lt; 0.05). In network analysis, the strongest positive association for MetS incidence was evidenced in a module mainly composed of PEs containing C22:6 and PSs [RR: 1.21; 95% CI: 1.12, 1.31 per SD change; Bonferroni-corrected P &lt; 0.05]. This association was more pronounced in participants with lower erythrocyte total n–3 PUFA concentrations [Bonferroni-corrected Pinter(P value for the interaction)&lt; 0.05]. Conclusions Elevated plasma concentrations of GPs, especially PEs with LCPUFAs or VLCPUFAs at the sn-2 position, are associated with higher risk of incident MetS. Future studies are merited to confirm our findings.

Trends in the prevalence of metabolic syndrome and its components in Mexican adults, 2006-2018

2021 ◽  
Vol 63 (6, Nov-Dic) ◽  
pp. 713-724
Author(s):  
Rosalba Rojas-Martínez ◽  
Carlos A Aguilar-Salinas ◽  
Martín Romero-Martínez ◽  
Lilia Castro-Porras ◽  
Donaji Gómez-Velasco ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Regression Models ◽  
Significant Risk ◽  
P Value ◽  
Logistic Regression Models ◽  
Mexican Adults ◽  
Diabetes Risk Score ◽  
Linear Trends

Objective. To examine trends in the prevalence of metabolic syndrome (MS) and its components. Materials and methods. Data from 27 800 Mexican adults who participated in Ensanut 2006, 2012, 2016 and 2018 were analyzed. Linear regression was used across each Ensanut period to assess temporal linear trends in the prevalence of MS. Logistic regression models were obtained to calculate the percentage change, p-value for the trend and the association between the presence of MS and the risk of developing type 2 diabetes mellitus (T2DM) over 10 years using the Finnish Diabetes Risk Score (FINDRISC) and cardiovascular disease (CVD) using Globorisk. Results. The prevalence of MS in Mexican adults according to the harmonized definition was: 40.2, 57.3, 59.99 and 56.31%, in 2006, 2012, 2016 and 2018 respectively (p for trend <0.0001). In 2018, 7.62% of metabolic syndrome cases had a significant risk for incident DM2 and 11.6% for CVD. Conclusion. It is estimated that there are 36.5 million Mexican adults living with metabolic syndrome, of which 2 million and 2.5 million have a high risk of developing T2DM or cardiovascular disease respectively, over the next 10 years.

scholarly journals Total and Nonheme Dietary Iron Intake Is Associated with Metabolic Syndrome and Its Components in Chinese Men and Women

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1663 ◽  
Author(s):  
Zhenni Zhu ◽  
Fan Wu ◽  
Ye Lu ◽  
Chunfeng Wu ◽  
Zhengyuan Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serum Ferritin ◽  
Smoking Status ◽  
Heme Iron ◽  
Nonheme Iron ◽  
Total Iron ◽  
Positive Trend ◽  
Dietary Iron ◽  
Iron Intake ◽  
Men And Women

The causal relationship between serum ferritin and metabolic syndrome (MetS) remains inconclusive. Dietary iron intake increases serum ferritin. The objective of this study was to evaluate associations of total, heme, and nonheme dietary iron intake with MetS and its components in men and women in metropolitan China. Data from 3099 participants in the Shanghai Diet and Health Survey (SDHS) obtained during 2012–2013 were included in this analysis. Dietary intake was assessed by 24-h diet records from 3 consecutive days. Multivariate generalized linear mixed models were used to evaluate the associations of dietary iron intake with MetS and its components. After adjustment for potential confounders as age, sex, income, physical exercise, smoking status, alcohol use, and energy intake, a positive trend was observed across quartiles of total iron intake and risk of MetS (p for trend = 0.022). Compared with the lowest quartile of total iron intake (<12.72 mg/day), the highest quartile (≥21.88 mg/day) had an odds ratio (95% confidence interval), OR (95% CI), of 1.59 (1.15,2.20). In addition, the highest quartile of nonheme iron intake (≥20.10 mg/day) had a 1.44-fold higher risk of MetS compared with the lowest quartile (<11.62 mg/day), and higher risks of MetS components were associated with the third quartiles of total and nonheme iron intake. There was no association between heme iron intake and risk of MetS (p for trend = 0.895). Associations for total and nonheme iron intake with MetS risk were found in men but not in women. Total and nonheme dietary iron intake was found to be positively associated with MetS and its components in the adult population in metropolitan China. This research also revealed a gender difference in the association between dietary iron intake and MetS.

scholarly journals Change in Perceived Stress Moderates the Association Between Weight Change and HbA1c Change in Puerto Rican Women (P21-035-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Andrea Lopez-Cepero ◽  
Christine Frisard ◽  
Sharina Person ◽  
Ira Ockene ◽  
Katherine Tucker ◽  
...  
Keyword(s):  
Puerto Rican ◽  
Perceived Stress ◽  
Weight Change ◽  
Smoking Status ◽  
Positive Association ◽  
Health Study ◽  
P Value ◽  
Linear Regression Models ◽  
Men And Women ◽  
Diabetes Status

Abstract Objectives To assess the association between weight change and change in HbA1c in Puerto Rican men and women, and to evaluate the moderating role of perceived stress in this association Methods Baseline and 2-year data from the Boston Puerto Rican Health Study were used. Individuals on diabetes medications were excluded. The sample included 218 men and 549 women with complete measures at baseline and 2-year follow up. Stress was assessed with the Perceived Stress Scale-14 and HbA1c from fasting blood samples. Changes in weight, perceived stress, and HbA1c from baseline to year 2 were calculated (i.e., year 2 – baseline). Analyses included linear regression models stratified by sex and adjusted for baseline age, education, smoking status, diet quality, physical activity, body mass index (BMI), baseline HbA1c, diabetes status, menopause status and use of medications for hypertension, hyperlipidemia, depression and thyroid disease. Likelihood ratio (LR) tests were used to evaluate the interaction between weight change and change in perceived stress. Results Mean baseline to year 2 change in weight was −0.3 kg + 6.1 for women and 0.3 kg + 4.7 for men. Mean change in HbA1c was 0.03% + 0.87 for women and −0.07% + 1.16 for men. Weight change was associated with HbA1c change in women (= 0.037; P < 0.001) but not in men. In women, there was an interaction between weight change and change in perceived stress (p value LR test = 0.005) on change in HbA1c. The coefficient for the interaction was positive and statistically significant (= 0.002; p value = 0.006), indicating that the positive association between weight change on HbA1c change was greater with increasing changes in perceived stress. Conclusions In this sample of Puerto Rican men and women, weight change was positively associated with change in HbA1c in women but not in men. Change in perceived stress increased HbA1c sensitivity to weight change. Future studies are needed to replicate our findings and examine pathways that explain this interaction. Funding Sources Research was supported by NIH P50 HL105185, P01 AG023394, R01 AG055948, and the University of Massachusetts CCTS (TL1, UL1TR001453). Supporting Tables, Images and/or Graphs

scholarly journals The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 48
Author(s):  
José Carlos Flores ◽  
Esther Gracia-Lavedan ◽  
Yolanda Benavente ◽  
Pilar Amiano ◽  
Dora Romaguera ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Chronic Inflammation ◽  
Lymphocytic Leukaemia ◽  
Positive Association ◽  
Future Research ◽  
P Value ◽  
Dietary Inflammatory Index ◽  
Significant Positive Association ◽  
Logistic Regression Models ◽  
Inflammatory Index

Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.

scholarly journals Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age

2021 ◽  
Vol 10 (14) ◽  
pp. 3130
Author(s):  
François Laurent ◽  
Ilyes Benlala ◽  
Gael Dournes ◽  
Celine Gramond ◽  
Isabelle Thaon ◽  
...  
Keyword(s):  
Smoking Status ◽  
Asbestos Exposure ◽  
Positive Association ◽  
Chest Ct ◽  
Cumulative Exposure ◽  
Exposure Index ◽  
Significant Positive Association ◽  
Logistic Regression Models ◽  
Lung Abnormalities ◽  
Occupationally Exposed

Objective: the aim of this study was to evaluate the association between interstitial lung abnormalities, asbestos exposure and age in a population of retired workers previously occupationally exposed to asbestos. Methods: previously occupationally exposed former workers to asbestos eligible for a survey conducted between 2003 and 2005 in four regions of France, underwent chest CT examinations and pulmonary function testing. Industrial hygienists evaluated asbestos exposure and calculated for each subject a cumulative exposure index (CEI) to asbestos. Smoking status information was also collected in this second round of screening. Expert radiologists performed blinded independent double reading of chest CT-scans and classified interstitial lung abnormalities into: no abnormality, minor interstitial findings, interstitial findings inconsistent with UIP, possible or definite UIP. In addition, emphysema was assessed visually (none, minor: emphysema <25%, moderate: between 25 and 50% and severe: >50% of the lung). Logistic regression models adjusted for age and smoking were used to assess the relationship between interstitial lung abnormalities and occupational asbestos exposure. Results: the study population consisted of 2157 male subjects. Interstitial lung abnormalities were present in 365 (16.7%) and emphysema in 444 (20.4%). Significant positive association was found between definite or possible UIP pattern and age (OR adjusted =1.08 (95% CI: 1.02–1.13)). No association was found between interstitial abnormalities and CEI or the level of asbestos exposure. Conclusion: presence of interstitial abnormalities at HRCT was associated to aging but not to cumulative exposure index in this cohort of former workers previously occupationally exposed to asbestos.

scholarly journals Association of Low Back Pain With Self-Reported Risk Factors Among Patients Seeking Physical Therapy Services

1999 ◽  
Vol 79 (8) ◽  
pp. 757-766 ◽  
Author(s):  
Pamela K Levangie
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Physical Therapy ◽  
Smoking Status ◽  
Positive Association ◽  
Risk Groups ◽  
Activity Level ◽  
Low Back ◽  
Odds Ratios ◽  
Back Care

Abstract Background and Purpose. This study investigated the magnitude of association between low back pain (LBP) and self-reported factors thought to increase the risk of LBP. Subjects and Methods. Questionnaires were completed by 150 patients who were receiving physical therapy for LBP and by 138 patients who were being treated for other reasons. The solicited information was used to estimate odds ratios and 95% confidence intervals for the LBP-risk factor association. Results. Low back pain was positively associated with smoking status, pregnancy, industrial vibration exposure, and time spent in a car (odds ratios ≥ 2.21). Daily lifting, body mass index, activity level, and time sitting or standing showed at most a weak positive association with LBP. Comparisons with estimated associations from other studies were made. Conclusion and Discussion. Data from this study support a statistically significant association between LBP and some factors found in other research to increase the risk of LBP. Study findings may have implications for targeting at-risk groups for back care education or intervention programs.

scholarly journals The Prevalence of Metabolic Syndrome, Scoring and Comparison in People with and without COPD: Evidence From Shahrekord PERSIAN Cohort Study

2021 ◽  
Author(s):  
Fatemeh Zeynab Kiani ◽  
Ali Ahmadi
Keyword(s):  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Population Based ◽  
Chronic Obstructive ◽  
P Value ◽  
Chi Square ◽  
Common Component ◽  
Respiratory Problems ◽  
Logistic Regression Models ◽  
Significant Difference

Abstract Background Comorbidities are common in patients with Chronic obstructive pulmonary disease (COPD), including metabolic syndrome (MetS). This study aimed to determine the prevalence of MetS and its components in people with and without COPD. Methods This population-based study was performed on 6961 adult years in the Shahrekord Prospective epidemiological research studies in Iran. Data collection, spirometry indexes and COPD diagnosis were performed according to the cohort protocol from 2015 to 2019. The data were analyzed by two-independent sample t-tests, chi-square, and logistic regression models. P-value < 0.05 was considered as statistically significant. All analyses were conducted using stata statistical software: release 16 (stata Corp, College Station, Texas 77845 USA). Result The prevalence of MetS in patients with and without COPD was 28.4% and 31%, respectively. The most common component of MetS in people with COPD was low high-density lipoprotein cholesterol (HDL-c) (47.4%), waist circumference (WC) (43.9%), and High fasting blood sugar (FBS) (39.3%). There was a statistically significant difference in the frequency of respiratory problems between people with and without MetS. The age above 60 years (OR = 2.20, 95% CI: 1.72–2.80), woman gender (OR = 1.36, 95%CI: 1.49–1.97), obesity (OR = 11.17, 95%CI: 9.02–13.62), illiterate education (OR = 1.80, 95%CI: 1.49–2.17), and living in urban (OR = 1.96, 95%CI: 1.64–2.35) are stronger predictors of MetS in this population. Conclusion There was no significant difference in the prevalence of MetS between patients with and without COPD. spirometry parameters and respiratory problems in subjects with and without metabolic syndrome were significance.

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