Boswellia sacra Extract-Loaded Mesoporous Bioactive Glass Nano Particles: Synthesis and Biological Effects

Bioactive glasses (BGs) are being increasingly considered for numerous biomedical applications. The loading of natural compounds onto BGs to increase the BG biological activity is receiving increasing attention. However, achieving efficient loading of phytotherapeutic compounds onto the surface of bioactive glass is challenging. The present work aimed to prepare novel amino-functionalized mesoporous bioactive glass nanoparticles (MBGNs) loaded with the phytotherapeutic agent Boswellia sacra extract. The prepared amino-functionalized MBGNs showed suitable loading capacity and releasing time. MBGNs (nominal composition: 58 wt% SiO2, 37 wt% CaO, 5 wt% P2O5) were prepared by sol-gel-modified co-precipitation method and were successfully surface-modified by using 3-aminopropyltriethoxysilane (APTES). In order to evaluate MBGNs loaded with Boswellia sacra, morphological analysis, biological studies, physico-chemical and release studies were performed. The successful functionalization and loading of the natural compound were confirmed with FTIR, zeta-potential measurements and UV-Vis spectroscopy, respectively. Structural and morphological evaluation of MBGNs was done by XRD, SEM and BET analyses, whereas the chemical analysis of the plant extract was done using GC/MS technique. The functionalized MBGNs showed high loading capacity as compared to non-functionalized MBGNs. The release studies revealed that Boswellia sacra molecules were released via controlled diffusion and led to antibacterial effects against S. aureus (Gram-positive) bacteria. Results of cell culture studies using human osteoblastic-like cells (MG-63) indicated better cell viability of the Boswellia sacra-loaded MBGNs as compared to the unloaded MBGNs. Therefore, the strategy of combining the properties of MBGNs with the therapeutic effects of Boswellia sacra represents a novel, convenient step towards the development of phytotherapeutic-loaded antibacterial, inorganic materials to improve tissue healing and regeneration.

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Physico-chemical and biological studies on three-dimensional porous silk/spray-dried mesoporous bioactive glass scaffolds

Ceramics International ◽

10.1016/j.ceramint.2016.05.176 ◽

2016 ◽

Vol 42 (12) ◽

pp. 13761-13772 ◽

Cited By ~ 13

Author(s):

Arunseshan Chandrasekaran ◽

Giorgia Novajra ◽

Irene Carmagnola ◽

Piergiorgio Gentile ◽

Sonia Fiorilli ◽

...

Keyword(s):

Bioactive Glass ◽

Three Dimensional ◽

Physico Chemical ◽

Biological Studies ◽

Spray Dried ◽

Mesoporous Bioactive Glass

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Green synthesis of mixed metallic nanoparticles using room temperature self-assembly

JOURNAL OF ADVANCES IN PHYSICS ◽

10.24297/jap.v13i2.5942 ◽

2017 ◽

Vol 13 (2) ◽

pp. 4671-4677 ◽

Cited By ~ 2

Author(s):

A. M. Abdelghany ◽

A.H. Oraby ◽

Awatif A Hindi ◽

Doaa M El-Nagar ◽

Fathia S Alhakami

Keyword(s):

Self Assembly ◽

Metallic Nanoparticles ◽

Room Temperature ◽

Bimetallic Nanoparticles ◽

Reduction Process ◽

Nano Particles ◽

Nano Structure ◽

Small Shift ◽

Molar Ratios ◽

Vis Spectroscopy

Bimetallic nanoparticles of silver (Ag) and gold (Au) were synthesized at room temperature using Curcumin. Reduction process of silver and gold ions with different molar ratios leads to production of different nanostructures including alloys and core-shells. Produced nanoparticles were characterized simultaneously with FTIR, UV/vis. spectroscopy, transmission electron microscopy (TEM), and Energy-dispersive X-ray (EDAX). UV/vis. optical absorption spectra of as synthesized nanoparticles reveals presence of surface palsmon resonance (SPR) of both silver at (425 nm) and gold at (540 nm) with small shift and broadness of gold band after mixing with resucing and capping agent in natural extract which suggest presence of bimetallic nano structure (Au/Ag). FTIR and EDAX data approve the presence of bimetallic nano structure combined with curcumin extract. TEM micrographs shows that silver and gold can be synthesized separately in the form of nano particles using curcumin extract. Synthesis of gold nano particles in presence of silver effectively enhance and control formation of bi-metallic structure.

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Novel Hydrogels of Chitosan and Poly (vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass

Polymers ◽

10.3390/polym13050691 ◽

2021 ◽

Vol 13 (5) ◽

pp. 691

Author(s):

O. Sánchez-Aguinagalde ◽

Ainhoa Lejardi ◽

Emilio Meaurio ◽

Rebeca Hernández ◽

Carmen Mijangos ◽

...

Keyword(s):

Mechanical Properties ◽

Drug Release ◽

Bioactive Glass ◽

Vinyl Alcohol ◽

Release Kinetics ◽

The Body ◽

Poly Vinyl Alcohol ◽

X Ray Diffraction ◽

Inorganic Particles ◽

Release Studies

Chitosan (CS) and poly (vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics.

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Anti-Microbial and Remineralizing Properties of Self-Adhesive Orthodontic Resin Containing Mesoporous Bioactive Glass

Materials ◽

10.3390/ma14133550 ◽

2021 ◽

Vol 14 (13) ◽

pp. 3550

Author(s):

Aerin Choi ◽

Kyung-Hyeon Yoo ◽

Seog-Young Yoon ◽

Bong-Soo Park ◽

In-Ryoung Kim ◽

...

Keyword(s):

Bond Strength ◽

Physical Properties ◽

Bioactive Glass ◽

Shear Bond Strength ◽

Antibacterial Effect ◽

Gram Positive ◽

Gram Negative ◽

Gram Positive Bacteria ◽

Significant Difference ◽

Mesoporous Bioactive Glass

Self-adhesive resins (SARs) contain adhesives, which simplify the procedures of resin application, and primers, which provide sufficient bonding ability. In this study, mesoporous bioactive glass nanoparticles (MBN) were added to a SAR to easily improve the physical properties and remineralization ability. The experimental resins comprised 1%, 3%, and 5% MBN mixed in Ortho Connect Flow (GC Corp, Tokyo, Japan). As the MBN content in the SAR increased, the microhardness increased, and a statistically significant difference was observed between the cases of 1% and 5% MBN addition. Shear bond strength increased for 1% and 3% MBN samples and decreased for 5% MBN. The addition of MBN indicated a statistically significant antibacterial effect on both gram-negative and gram-positive bacteria. The anti-demineralization experiment showed that the remineralization length increased with the MBN content of the sample. Through the above results, we found that SAR containing MBN has antibacterial and remineralization effects. Thus, by adding MBN to the SAR, we investigated the possibility of orthodontic resin development, wherein the strength is enhanced and the drawbacks of the conventional SAR addressed.

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Ions release behavior of vanadium-doped mesoporous bioactive glass particles and effect on BMSCs osteogenic differentiation via FAK/MAPK signaling pathway

Journal of Materials Chemistry B ◽

10.1039/d1tb01479j ◽

2021 ◽

Author(s):

Jiangfeng Li ◽

Junying Li ◽

Yuhao Wei ◽

Na Xu ◽

Jingtao Li ◽

...

Keyword(s):

Bone Formation ◽

Bioactive Glass ◽

Osteogenic Differentiation ◽

Bone Growth ◽

Mapk Signaling ◽

Release Behavior ◽

Pentavalent Vanadium ◽

Important Trace Element ◽

Vanadium Ions ◽

Mesoporous Bioactive Glass

Vanadium is an important trace element in bone to involve in bone metabolism, bone formation, and bone growth, but roles of various vanadium ions, especially pentavalent vanadium, in bone tissue...

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A facile synthesis of mono-dispersed, spherical and mesoporous bioactive glass nanoparticles for biomedical applications

Journal of Non-Crystalline Solids ◽

10.1016/j.jnoncrysol.2020.120598 ◽

2021 ◽

Vol 554 ◽

pp. 120598

Author(s):

Mahboubeh Firuzeh ◽

Sheyda Labbaf ◽

Zahra Sabouri

Keyword(s):

Bioactive Glass ◽

Biomedical Applications ◽

Facile Synthesis ◽

Mesoporous Bioactive Glass

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Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

Gels ◽

10.3390/gels7020034 ◽

2021 ◽

Vol 7 (2) ◽

pp. 34

Author(s):

Shaher Bano ◽

Memoona Akhtar ◽

Muhammad Yasir ◽

Muhammad Salman Maqbool ◽

Akbar Niaz ◽

...

Keyword(s):

Bioactive Glass ◽

Composite Coatings ◽

Antibacterial Properties ◽

Bone Diseases ◽

Osteogenic Potential ◽

Diffusion Method ◽

Charge Composition ◽

In Vitro Bioactivity ◽

Mesoporous Bioactive Glass

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag)- and strontium (Sr)-doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ and Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in vitro bioactivity. The Ag-Sr MBGNs synthesized in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

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