scholarly journals A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1759 ◽  
Author(s):  
H.P.S. Abdul Khalil ◽  
A.S. Adnan ◽  
Esam Bashir Yahya ◽  
N.G. Olaiya ◽  
Safrida Safrida ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Functional Materials ◽  
Plant Fibre ◽  
Potential Applications ◽  
Antimicrobial Film ◽  
Cellulose Nanomaterials ◽  
Dressing Materials ◽  
Antibiotic Delivery

Cellulose nanomaterials from plant fibre provide various potential applications (i.e., biomedical, automotive, packaging, etc.). The biomedical application of nanocellulose isolated from plant fibre, which is a carbohydrate-based source, is very viable in the 21st century. The essential characteristics of plant fibre-based nanocellulose, which include its molecular, tensile and mechanical properties, as well as its biodegradability potential, have been widely explored for functional materials in the preparation of aerogel. Plant cellulose nano fibre (CNF)-based aerogels are novel functional materials that have attracted remarkable interest. In recent years, CNF aerogel has been extensively used in the biomedical field due to its biocompatibility, renewability and biodegradability. The effective surface area of CNFs influences broad applications in biological and medical studies such as sustainable antibiotic delivery for wound healing, the preparation of scaffolds for tissue cultures, the development of drug delivery systems, biosensing and an antimicrobial film for wound healing. Many researchers have a growing interest in using CNF-based aerogels in the mentioned applications. The application of cellulose-based materials is widely reported in the literature. However, only a few studies discuss the potential of cellulose nanofibre aerogel in detail. The potential applications of CNF aerogel include composites, organic–inorganic hybrids, gels, foams, aerogels/xerogels, coatings and nano-paper, bioactive and wound dressing materials and bioconversion. The potential applications of CNF have rarely been a subject of extensive review. Thus, extensive studies to develop materials with cheaper and better properties, high prospects and effectiveness for many applications are the focus of the present work. The present review focuses on the evolution of aerogels via characterisation studies on the isolation of CNF-based aerogels. The study concludes with a description of the potential and challenges of developing sustainable materials for biomedical applications.

Calcium Carbonate and Cellulose/Calcium Carbonate Composites: Synthesis, Characterization, and Biomedical Applications

2016 ◽  
Vol 875 ◽  
pp. 24-44
Author(s):  
Ming Guo Ma ◽  
Shan Liu ◽  
Lian Hua Fu
Keyword(s):  
Calcium Carbonate ◽  
Biomedical Applications ◽  
Value Added ◽  
Functional Materials ◽  
Industrial Applications ◽  
Precipitation Method ◽  
Synthesis Methods ◽  
Water Pretreatment ◽  
Potential Applications ◽  
Co Precipitation

CaCO3 has six polymorphs such as vaterite, aragonite, calcite, amorphous, crystalline monohydrate, and hexahydrate CaCO3. CaCO3 is a typical biomineral that is abundant in both organisms and nature and has important industrial applications. Cellulose could be used as feedstocks for producing biofuels, bio-based chemicals, and high value-added bio-based materials. In the past, more attentions have been paid to the synthesis and applications of CaCO3 and cellulose/CaCO3 nanocomposites due to its relating properties such as mechanical strength, biocompatibility, and biodegradation, and bioactivity, and potential applications including biomedical, antibacterial, and water pretreatment fields as functional materials. A variety of synthesis methods such as the hydrothermal/solvothermal method, biomimetic mineralization method, microwave-assisted method, (co-) precipitation method, and sonochemistry method, were employed to the preparation of CaCO3 and cellulose/CaCO3 nanocomposites. In this chapter, the recent development of CaCO3 and cellulose/CaCO3 nanocomposites has been reviewed. The synthesis, characterization, and biomedical applications of CaCO3 and cellulose/CaCO3 nanocomposites are summarized. The future developments of CaCO3 and cellulose/CaCO3 nanocomposites are also suggested.

scholarly journals Technology Overview and Current Biomedical Application of Polymeric Nanoparticles

2018 ◽  
Vol 8 (6) ◽  
pp. 285-295
Author(s):  
Gurpreet Singh ◽  
Abdul Faruk ◽  
Preet Mohinder Singh Bedi
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Polymeric Nanoparticles ◽  
Preparation Methods ◽  
Polymeric Nanoparticle ◽  
Potential Applications ◽  
Dialysis Method ◽  
Novel Drug ◽  
Current Potential

Polymeric nanoparticle are of great importance in the treatment of various diseases, due to the flexibility in the  modification of their structures. Recent advances in the field of nanotechnology facilitate the engineering of multifunctional polymeric nanoparticles. All the scientific efforts of the pharmaceuticals companies are mainly focusing on two basic aspects, one is to discover new molecules of potential therapeutic interest and second is to develop of a new drug delivery system. In the last few decades,  research and development (R&D) scientists has directed their efforts toward formulating novel drug delivery systems that includes sustained and controlled release, modified release and targeted drug release dosage forms. Application of nanoscience and nanotechnology has opened several new possibilities in development of formulation This review compiles the different preparation methods of polymeric nanoparticles and then briefly explained their current potential applications. Keywords: Polymeric nanoparticles, PLGA, Biomedical applications, Biodegradable, Dialysis method

APPLICATIONS OF IONIC LIQUIDS IN BIOMEDICINE

2012 ◽  
Vol 07 (03n04) ◽  
pp. 121-134 ◽  
Author(s):  
GUILI LIU ◽  
RUIBO ZHONG ◽  
RUISHENG HU ◽  
FENG ZHANG
Keyword(s):  
Ionic Liquids ◽  
Anticancer Agents ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Current State ◽  
Wide Range ◽  
Potential Applications ◽  
State Of Art

(Ionic liquids) ILs have unique properties compared with conventional solvents, opening a wide range of application as solvents and catalysts. ILs' cytotoxicity extend their application in biomedicine by acting as antimicrobial and anticancer agents. This article reviews the current research advances of ILs' biomedical application from the following four aspects: solvents, catalysts, antimicrobial and anticancer agents. By introducing ILs' interesting structures and their corresponding unique properties, this review concludes the current state-of-art of ILs biomedical applications. We also try to point out the ILs issues and solutions for more potential applications in biomedicine.

scholarly journals Optimized Synthesis of Biodegradable Elastomer PEGylated Poly(glycerol sebacate) and Their Biomedical Application

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 965 ◽  
Author(s):  
Yanxiang Wang ◽  
Haiwa Wu ◽  
Zihao Wang ◽  
Jingjing Zhang ◽  
Jing Zhu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Biomedical Applications ◽  
Bone Repair ◽  
Biomedical Application ◽  
Vascular Reconstruction ◽  
Curing Process ◽  
Thermal Curing ◽  
Potential Applications ◽  
Degradation Behaviors

Poly(glycerol sebacate) (PGS), a biodegradable elastomer, has been extensively explored in biomedical applications for its favorable mechanical properties and biocompatibility. Efforts have been made to fabricate multifunctional PGS copolymer in recent years, in particular PGS-co-PEG (poly(glycerol sebacate)-co-polyethylene glycol) polymers. However, rare research has been systematically conducted on the effect of reactant ratios on physicochemical properties and biocompatibility of PGS copolymer till now. In this study, a serial of PEGylated PGS (PEGS) with PEG content from 20% to 40% and carboxyl to hydroxyl from 0.67 to 2 were synthesized by thermal curing process. The effects of various PEGS on the mechanical strength and biological activity were further compared and optimized. The results showed that the PEGS elastomers around 20PEGS-1.0C/H and 40PEGS-1.5C/H exhibited the desirable hydrophilicity, degradation behaviors, mechanical properties and cell viability. Subsequently, the potential applications of the 20PEGS-1.0C/H and 40PEGS-1.5C/H in bone repair scaffold and vascular reconstruction were investigated and the results showed that 20PEGS-1.0C/H and 40PEGS-1.5C/H could significantly improve the mechanical strength for the calcium phosphate scaffolds and exhibited preferable molding capability for fabrication of the vascular substitute. These results confirmed that the optimized PEGS elastomers should be promising multifunctional substrates in biomedical applications.

scholarly journals Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiao Zhang ◽  
Guanghui Ma ◽  
Wei Wei
Keyword(s):  
Cell Membrane ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Atomic Level ◽  
Structural Basis ◽  
Physiological Effects ◽  
Dynamic Changes ◽  
Potential Applications ◽  
A Cell ◽  
Theoretical Analyses

AbstractNanoparticles (NPs), owing to their ultrasmall size, have been extensively researched for potential applications in biomedicine. During their delivery and functionalization within the organism, they frequently interact with cells. The resulting nano-bio interfaces between the NPs and cell membrane play an important role in dominating the physiological effects of NPs. Therefore, understanding how the properties of NPs affect their nano-bio interface interactions with the cell membrane is important. Compared to experimental and theoretical analyses, simulations can provide atomic-level accuracy regarding dynamic changes in structure, which can reveal the mechanisms of nano-bio interface interactions for feasible modulation. Thus, we reviewed the current advances in nano-bio interfaces from the perspective of simulations. This study will determine how the properties of NPs affect their interactions with cell membranes to provide insights for the design of NPs and summarize their corresponding biomedical applications.

scholarly journals Atomic Resolution Electron Microscopy: A Key Tool for Understanding the Activity of Nano-Oxides for Biomedical Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2073
Author(s):  
Alberto Azor-Lafarga ◽  
Isabel Gómez-Recio ◽  
M. Luisa Ruiz-González ◽  
José M. González-Calbet
Keyword(s):  
Electron Microscopy ◽  
Transition Metal ◽  
Oxidation State ◽  
Transition Metal Oxides ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Atomic Resolution ◽  
Local Composition ◽  
Resolution Electron ◽  
Potential Applications

Transition metal oxides constitute one of the most fruitful sources of materials with continuously increasing potential applications prompted by the expectations derived from the reduction of the particle size. The recent advances in transmission electron microscopy, because of the development of lenses, have made it possible to reach atomic resolution, which can provide answers regarding the performance of the transition metal nano-oxides. This critical information is related not only to the ability to study their microstructural characteristics but also their local composition and the oxidation state of the transition metal. Exploring these features is a well-known task in nano-oxides for energy and electronic technologies, but they are not so commonly used for elucidating the activity of these oxides for biomedical applications. Nevertheless, the identification at the atomic level of a certain dopant or the unambiguous determination of the oxidation state of a transition metal in a nano-oxide can be important questions to be answered in a certain biomedical application. In this work, we provide several examples in transition metal nano-oxides to show how atomic-resolution electron microscopy can be a key tool for its understanding.

Mikania micrantha mixed woven fabric for quick blood clotting and wound healing

2020 ◽  
Vol 6 (5) ◽  
Author(s):  
Shaikh Md Mominul Alam ◽  
Shilpi Akter ◽  
Md Lutfor Rahman
Keyword(s):  
Wound Healing ◽  
Blood Clotting ◽  
Woven Fabric ◽  
Excessive Bleeding ◽  
Sustainable Operations ◽  
Environment Friendly ◽  
Mikania Micrantha ◽  
Leaf Powder ◽  
Medical Textile ◽  
Dressing Materials

The aim of this paper is to introduce novel dressing with Mikania Micrantha for quick blood clotting and wound healing. When epidermis of human skin is cut or scrapped, sometimes too much bleeding occurs. Excessive bleeding may cause death, if bleeding is not stopped immediately. To promote blood clotting & wound healing natural based bio materials are still insufficient in medical textile sector. To fill up this scarcity, woven fabric treated with Mikania micrantha leaf juice & leaf powder was examined. M. micrantha exhibits good blood clotting time in comparison with available dressing materials. Woven fabric (bandage) that contains M. micrantha can be used for cut wounds healing purpose. The experiments were carried out in environment friendly way which indicates the production & processing of these dressing materials can have enormous contribution to sustainable operations and products.

Graphene and Graphene-Based Materials in Biomedical Applications

2019 ◽  
Vol 26 (38) ◽  
pp. 6834-6850 ◽  
Author(s):  
Mohammad Omaish Ansari ◽  
Kalamegam Gauthaman ◽  
Abdurahman Essa ◽  
Sidi A. Bencherif ◽  
Adnan Memic
Keyword(s):  
Tissue Engineering ◽  
Thermal Properties ◽  
Gene Delivery ◽  
Regenerative Medicine ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Two Dimensional ◽  
Drug And Gene Delivery ◽  
Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges

2020 ◽  
Vol 27 (28) ◽  
pp. 4622-4646 ◽  
Author(s):  
Huayu Liu ◽  
Kun Liu ◽  
Xiao Han ◽  
Hongxiang Xie ◽  
Chuanling Si ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cellulose Nanofibrils ◽  
Wound Dressings ◽  
Preparation Methods ◽  
Tissue Scaffold ◽  
Surface Areas ◽  
Mechanical Methods

Background: Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances. Methods: By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings. Results: CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue. Conclusion: By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.

Biomedical Applications and Patents on Metallic Nanoparticles

2020 ◽  
Vol 10 ◽  
Author(s):  
Geetanjali Singh ◽  
Pramod Kumar Sharma ◽  
Rishabha Malviya
Keyword(s):  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Size Range ◽  
Biomedical Application ◽  
Chemical Reduction ◽  
Chemical Methods ◽  
Future Challenges ◽  
Biological Methods ◽  
Cancer Diagnosis And Therapy ◽  
Physical And Chemical

Aim/Objective: The author writes the manuscript by reviewing the literatures related to the biomedical application of metallic nanoparticles. The term metal nanoparticles are used to describe the nanosized metals with the dimension within the size range of 1-100 nm. Methods: The preparation of metallic nanoparticles and their application is an influential area for research. Among various physical and chemical methods (viz. chemical reduction, thermal decomposition, etc.) for synthesizing silver nanoparticles, biological methods have been suggested as possible eco-friendly alternatives. The synthesis of metallic nanoparticles is having many problems inclusive of solvent toxicity, the formation of hazardous byproducts and consumption of energy. So it is important to design eco-friendly benign procedures for the synthesis of metallic nanoparticles. Results: From the literature survey, we concluded that metallic nanoparticles have applications in the treatment of different diseases. Metallic nanoparticles are having a great advantage in the detection of cancer, diagnosis, and therapy. And it can also have properties such as antifungal, antibacterial, anti-inflammatory, antiviral and anti-angiogenic. Conclusion: In this review, recent upcoming advancement of biomedical application of nanotechnology and their future challenges has been discussed.

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