Mikania micrantha mixed woven fabric for quick blood clotting and wound healing

2020 ◽  
Vol 6 (5) ◽  
Author(s):  
Shaikh Md Mominul Alam ◽  
Shilpi Akter ◽  
Md Lutfor Rahman
Keyword(s):  
Wound Healing ◽  
Blood Clotting ◽  
Woven Fabric ◽  
Excessive Bleeding ◽  
Sustainable Operations ◽  
Environment Friendly ◽  
Mikania Micrantha ◽  
Leaf Powder ◽  
Medical Textile ◽  
Dressing Materials

The aim of this paper is to introduce novel dressing with Mikania Micrantha for quick blood clotting and wound healing. When epidermis of human skin is cut or scrapped, sometimes too much bleeding occurs. Excessive bleeding may cause death, if bleeding is not stopped immediately. To promote blood clotting & wound healing natural based bio materials are still insufficient in medical textile sector. To fill up this scarcity, woven fabric treated with Mikania micrantha leaf juice & leaf powder was examined. M. micrantha exhibits good blood clotting time in comparison with available dressing materials. Woven fabric (bandage) that contains M. micrantha can be used for cut wounds healing purpose. The experiments were carried out in environment friendly way which indicates the production & processing of these dressing materials can have enormous contribution to sustainable operations and products.

In Vivo Testing of Sericin-Polyurethane Nanofiber Mats for Wound Healing in Rats

2017 ◽  
Vol 751 ◽  
pp. 581-585 ◽  
Author(s):  
Piyaporn Kampeerapappun ◽  
Pornpen Siridamrong
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Active Agent ◽  
L929 Cell ◽  
Wound Healing Process ◽  
Original Size ◽  
Nanofiber Mats ◽  
Dressing Materials

The objective of this study was to investigate sericin-polyurethane nanofiber cover (SUC) for wound dressing materials in a rat skin. Sericin-polyurethane blended nanofibers were fabricated by using electrospinning. The composition of 3%w/v polyurethane in ethanol and 19% w/v sericin were blended and electrospun at 15 kV, 20 cm from tip to collector with a feed rate of 6.2 ml/hr. The mats, approximately 1.5 mm thick, were sterile by gamma irradiation with a radiation dose of 15 kGy. The samples of in vitro and in vivo testing were separated into three groups; gauze, polyurethane nanofiber cover (UC), and SUC. In vitro cultured L929 cell lines were investigated with inverted microscope. It was found that cells migrated to SCU. For in vivo tests, the remaining wound in rats was measured on day 2-14 after excision. Compared to original size of wound samples, the size of the wound remained 24% for SUC, 33% for gauze, and 34% for UC at day 8. The sericin, an active agent, contained in SUC mats was about 5 µl at 1.5 ×1.5 cm. It can be concluded that sericin is non-toxic to cells and can promote wound healing process in rats.

scholarly journals Biohydrogel Based on Dynamic Covalent Bonds for Wound Healing Applications

2021 ◽  
Vol 11 (15) ◽  
pp. 6945
Author(s):  
Chukwuma O. Agubata ◽  
Cynthia C. Mbaoji ◽  
Ifeanyi T. Nzekwe ◽  
César Saldías ◽  
David Díaz Díaz
Keyword(s):  
Wound Healing ◽  
Interfacial Tension ◽  
Blood Clotting ◽  
Phenylboronic Acid ◽  
Moisture Loss ◽  
Self Healing ◽  
Covalent Bonds ◽  
Treatment Groups ◽  
Acid Soluble Collagen ◽  
Thixotropic Behavior

In this work, a biohydrogel based on alginate and dynamic covalent B-O bonds, and derived composites, has been evaluated for wound healing applications. In particular, a phenylboronic acid–alginate (PBA-Alg) complex was synthesized by coupling 3-aminophenylboronic acid onto alginate, and used to prepare varied concentrations of hydrogels and silicate-based nanocomposites in PBS. The resulting hydrogels were characterized in terms of interfacial tension, moisture uptake and loss, interaction with fresh acid-soluble collagen, self-healing ability, effects on blood clotting and wound healing. The interfacial tension between the hydrogels and biorelevant fluids was low and moisture loss of 55%–60% was evident without uptake from the environment. The components of the hydrogels and their mixtures with collagen were found to be compatible. These hydrogels showed efficient self-healing and thixotropic behavior, and the animals in the treatment groups displayed blood clotting times between 9.1 min and 10.7 min. In contrast, the composites showed much longer or shorter clotting times depending on the silicate content. A significant improvement in wound healing was observed in 3% w/v PBA-Alg formulations. Overall, the PBA-Alg hydrogels exhibit self-healing dynamic covalent interactions and may be useful in dressings for incision wounds.

Nanofiber Wound Dressing Materials—A Comparative Study of Wound Healing on a Porcine Model

2021 ◽  
Author(s):  
Katerina Menclová ◽  
Petr Svoboda ◽  
Jan Hadač ◽  
Štefan Juhás ◽  
Jana Juhásová ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Blood Count ◽  
Serum Amyloid A ◽  
Porcine Model ◽  
Serum Amyloid ◽  
Wound Dressings ◽  
Amyloid A ◽  
Inflammatory Phase ◽  
Dressing Materials

ABSTRACT Background Nanofiber wound dressings remain the domain of in vitro studies. The purpose of our study was to verify the benefits of chitosan (CTS) and polylactide (PLA)-based nanofiber wound dressings on a porcine model of a naturally contaminated standardized wound and compare them with the conventional dressings, i.e., gauze and Inadine. Material and Methods The study group included 32 pigs randomized into four homogeneous groups according to the wound dressing type. Standardized wounds were created on their backs, and wound dressings were regularly changed. We evaluated difficulty of handling individual dressing materials and macroscopic appearance of the wounds. Wound swabs were taken for bacteriological examination. Blood samples were obtained to determine blood count values and serum levels of acute phase proteins (serum amyloid A, C-reactive protein, and haptoglobin). The crucial point of the study was histological analysis. Microscopic evaluation was focused on the defect depth and tissue reactions, including formation of the fibrin exudate with neutrophil granulocytes, the layer of granulation and cellular connective tissue, and the reepithelialization. Statistical analysis was performed by using SPSS software. The analysis was based on the Kruskal–Wallis H test and Mann–Whitney U test followed by Bonferroni correction. Significance was set at P < .05. Results Macroscopic examination did not show any difference in wound healing among the groups. However, evaluation of histological findings demonstrated that PLA-based nanofiber dressing accelerated the proliferative (P = .025) and reepithelialization (P < .001) healing phases, while chitosan-based nanofiber dressing potentiated and accelerated the inflammatory phase (P = .006). No statistically significant changes were observed in the blood count or acute inflammatory phase proteins during the trial. Different dynamics were noted in serum amyloid A values in the group treated with PLA-based nanofiber dressing (P = .006). Conclusion Based on the microscopic examination, we have documented a positive effect of nanofiber wound dressings on acceleration of individual phases of the healing process. Nanofiber wound dressings have a potential to become in future part of the common wound care practice.

Development and Comfort Characterization of 2D-Woven Auxetic Fabric for Wearable and Medical Textile Applications

2018 ◽  
Vol 36 (3) ◽  
pp. 199-214 ◽  
Author(s):  
Mumtaz Ali ◽  
Muhammad Zeeshan ◽  
Sheraz Ahmed ◽  
Bilal Qadir ◽  
Yasir Nawab ◽  
...  
Keyword(s):  
Air Permeability ◽  
Woven Fabric ◽  
Medical Applications ◽  
Simple Method ◽  
Fabric Structure ◽  
Medical Textile ◽  
Commercial Applications ◽  
Auxetic Structure ◽  
Higher Sensitivity

Knitted auxetic fabrics (AF) are in common practice but their stability and thickness are major problems in commercial applications. Therefore, a simple method of developing woven AF is proposed here. Differential shrinking property of different weaves is utilized to visualize auxetic honey comb geometry in fabric structure. Based on this fabric structure, auxeticity is induced in 2-D-woven fabric. AF is developed using conventional nonauxetic materials (i.e., cotton in warp and elastane [Lycra] yarn in the weft). Auxetic nature and auxetic structure in the fabric were characterized by microscope. Comfort properties (air permeability, thermal resistance, stiffness, and wicking) of AF were compared with conventional nonauxetic fabrics (NAF). Piezoresistive nature of conductive AF and NAF is also compared. AF showed superior comfort properties and higher sensitivity as compared to conventional NAF. Based on results, AF can be considered better replacement of conventional NAF in wearable and medical applications.

scholarly journals Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine

2019 ◽  
Vol 5 (2) ◽  
pp. 185-197 ◽  
Author(s):  
Yunfeng Chen ◽  
Lining Arnold Ju
Keyword(s):  
Platelet Aggregation ◽  
Blood Clotting ◽  
Thrombus Formation ◽  
Dark Side ◽  
Atherosclerotic Plaques ◽  
Excessive Bleeding ◽  
Glycoprotein Vi ◽  
Device Implantation ◽  
Platelet Binding ◽  
Platelet Thrombus

Arterial thrombosis is in part contributed by excessive platelet aggregation, which can lead to blood clotting and subsequent heart attack and stroke. Platelets are sensitive to the haemodynamic environment. Rapid haemodynamcis and disturbed blood flow, which occur in vessels with growing thrombi and atherosclerotic plaques or is caused by medical device implantation and intervention, promotes platelet aggregation and thrombus formation. In such situations, conventional antiplatelet drugs often have suboptimal efficacy and a serious side effect of excessive bleeding. Investigating the mechanisms of platelet biomechanical activation provides insights distinct from the classic views of agonist-stimulated platelet thrombus formation. In this work, we review the recent discoveries underlying haemodynamic force-reinforced platelet binding and mechanosensing primarily mediated by three platelet receptors: glycoprotein Ib (GPIb), glycoprotein IIb/IIIa (GPIIb/IIIa) and glycoprotein VI (GPVI), and their implications for development of antithrombotic ‘mechano-medicine’ .

The accelerating effect of chitosan-silica hybrid dressing materials on the early phase of wound healing

2016 ◽  
Vol 105 (7) ◽  
pp. 1828-1839 ◽  
Author(s):  
Ji-Ung Park ◽  
Hyun-Do Jung ◽  
Eun-Ho Song ◽  
Tae-Hyun Choi ◽  
Hyoun-Ee Kim ◽  
...  
Keyword(s):  
Wound Healing ◽  
Early Phase ◽  
Dressing Materials ◽  
Silica Hybrid

scholarly journals Fibrin gels and their clinical and bioengineering applications

2008 ◽  
Vol 6 (30) ◽  
pp. 1-10 ◽  
Author(s):  
Paul A Janmey ◽  
Jessamine P Winer ◽  
John W Weisel
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Cell Migration ◽  
Network Architecture ◽  
Blood Clotting ◽  
Reaction Conditions ◽  
Fibrin Gels ◽  
Physiological Conditions ◽  
Small Strains ◽  
Fibrin Network

Fibrin gels, prepared from fibrinogen and thrombin, the key proteins involved in blood clotting, were among the first biomaterials used to prevent bleeding and promote wound healing. The unique polymerization mechanism of fibrin, which allows control of gelation times and network architecture by variation in reaction conditions, allows formation of a wide array of soft substrates under physiological conditions. Fibrin gels have been extensively studied rheologically in part because their nonlinear elasticity, characterized by soft compliance at small strains and impressive stiffening to resist larger deformations, appears essential for their function as haemostatic plugs and as matrices for cell migration and wound healing. The filaments forming a fibrin network are among the softest in nature, allowing them to deform to large extents and stiffen but not break. The biochemical and mechanical properties of fibrin have recently been exploited in numerous studies that suggest its potential for applications in medicine and bioengineering.

scholarly journals THE USE OF CHITIN AND CHITOSAN IN MANUFACTURING DRESSING MATERIALS

2020 ◽  
Vol XXV ◽  
pp. 16-36
Author(s):  
Ilona Latańska ◽  
Beata Kolesińska ◽  
Zbigniew Draczyński ◽  
Witold Sujka
Keyword(s):  
Wound Healing ◽  
Medical Device ◽  
Chronic Wounds ◽  
Raw Materials ◽  
Healing Process ◽  
Accelerate Wound Healing ◽  
Continuous Progress ◽  
Chitin And Chitosan ◽  
Dressing Materials ◽  
Healing Processes

Despite continuous progress in the development of advanced dressing materials, there is a constant need for dressings used in an environment of infected and hard-to-heal wounds. Dressings that meet the above described requirements are products based on chitin and its derivatives. Chitosan and chitin derivative dressings are now becoming a very effective medical device in healing hard-to-heal wounds, as well as in the control of severely bleeding wounds. Chitosan and chitin are particularly valuable raw materials that accelerate wound healing processes, and they are also biocompatible and antibacterial. Dressings made of butyric-acetic chitin copolyester are intended for treating wounds of various aetiologies, including chronic wounds in which the healing process is disturbed by concomitant diseases. Materials based on chitosan are also widely used in the area of heavily bleeding and chronic wounds.

scholarly journals Observational study of the effects of silver-based dressing materials in 50 cases of diabetic foot ulcers

2019 ◽  
Vol 6 (2) ◽  
pp. 508
Author(s):  
Rushabh Maisuria ◽  
Jawansing Manza ◽  
Devendra Chaudhari ◽  
Divyang Dave
Keyword(s):  
Wound Healing ◽  
Observational Study ◽  
Granulation Tissue ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Foot Ulcer ◽  
Purulent Discharge ◽  
Diabetic Patients ◽  
Wide Range ◽  
Dressing Materials

Background: Diabetic foot remains the most common chronic medical problem being the most common cause of the hospital visit and/or admission, amongst the diabetic patients. Topical antimicrobial dressings, including those that contain silver are used to prevent or manage infection in a wide range of wounds.Methods: This is the prospective, observational study which included 50 cases of diabetic foot ulcer patients and effects of silver-based dressing materials will be evaluated.Results: After application of silver based dressing materials for two weeks, wound was evaluated on the basis of discharge from the wound, healing rate, appearance of the granulation tissue and culture and sensitivity report which showed that out of 50 cases studied, 3 cases (6%) had purulent discharge from the wound, absent granulation tissue, culture report showed presence of micro-organism and thus poor healing rate while other 47 cases (94%) had minimal/serous discharge, presence of healthy granulation tissue, no organism on culture report and thus good healing rate.Conclusions: Silver based dressing materials are effective in terms of promoting wound healing and more patient compliance.

scholarly journals A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1759 ◽  
Author(s):  
H.P.S. Abdul Khalil ◽  
A.S. Adnan ◽  
Esam Bashir Yahya ◽  
N.G. Olaiya ◽  
Safrida Safrida ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Functional Materials ◽  
Plant Fibre ◽  
Potential Applications ◽  
Antimicrobial Film ◽  
Cellulose Nanomaterials ◽  
Dressing Materials ◽  
Antibiotic Delivery

Cellulose nanomaterials from plant fibre provide various potential applications (i.e., biomedical, automotive, packaging, etc.). The biomedical application of nanocellulose isolated from plant fibre, which is a carbohydrate-based source, is very viable in the 21st century. The essential characteristics of plant fibre-based nanocellulose, which include its molecular, tensile and mechanical properties, as well as its biodegradability potential, have been widely explored for functional materials in the preparation of aerogel. Plant cellulose nano fibre (CNF)-based aerogels are novel functional materials that have attracted remarkable interest. In recent years, CNF aerogel has been extensively used in the biomedical field due to its biocompatibility, renewability and biodegradability. The effective surface area of CNFs influences broad applications in biological and medical studies such as sustainable antibiotic delivery for wound healing, the preparation of scaffolds for tissue cultures, the development of drug delivery systems, biosensing and an antimicrobial film for wound healing. Many researchers have a growing interest in using CNF-based aerogels in the mentioned applications. The application of cellulose-based materials is widely reported in the literature. However, only a few studies discuss the potential of cellulose nanofibre aerogel in detail. The potential applications of CNF aerogel include composites, organic–inorganic hybrids, gels, foams, aerogels/xerogels, coatings and nano-paper, bioactive and wound dressing materials and bioconversion. The potential applications of CNF have rarely been a subject of extensive review. Thus, extensive studies to develop materials with cheaper and better properties, high prospects and effectiveness for many applications are the focus of the present work. The present review focuses on the evolution of aerogels via characterisation studies on the isolation of CNF-based aerogels. The study concludes with a description of the potential and challenges of developing sustainable materials for biomedical applications.

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